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Chip 2022年第2期1卷 1-6页

作者： Jun Gao Xiao-Wei Wang Wen-Hao Zhou Zhi-Qiang jiao Ruo-Jing Ren Yu-Xuan Fu Lu-Feng Qiao Xiao-Yun Xu Chao-Ni Zhang Xiao-Ling Pang Hang Li Yao Wang Xian-Min Jin center for integrated Quantum Information Technologies(IQIT) School of Physics and Astronomy and State Key Laboratory of Advanced Optical Com-munication Systems and NetworksShanghai Jiao Tong UniversityShanghai 200240China CAS center for Excellence and Synergetic Innovation center in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefeiAnhui 230026China

Quantum computer,harnessing quantum superposition to boost a parallel computational power,promises to outperform its classical counterparts and offer an exponentially increased *** term“quantum advantage”was proposed to mark the key point when peo-ple can solve a classically intractable problem by artificially control-ling a quantum system in an unprecedented scale,even without er-ror correction or known practical *** sampling,a problem about quantum evolutions of multi-photons on multimode photonic networks,as well as its variants,has been considered as a promising candidate to reach this ***,the current photonic platforms suffer from the scaling problems,both in pho-ton numbers and circuit ***,we propose a new variant of the problem,membosonsampling,exploiting the scaling of the prob-lem can be in principle extended to a large *** experimentally verify the scheme on a self-looped photonic chip inspired by mem-ristor,and obtain multi-photon registrations up to 56-fold in 750,000 modes with a Hilbert space up to *** results exhibit an inte-grated and cost-efficient shortcut stepping into the“quantum advan-tage”regimeina photonic systemfarbeyondpreviousscenarios,and provide a scalable and controllable platform for quantum information processing.

关键词： quantum scaling boson

未用药强迫症患者前额叶γ-氨基丁酸水平的磁共振波谱研究（英文）

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上海精神医学 2016年第5期28卷 263-270页

作者：张宗凤范青白艳乐王振张海音肖泽萍 shanghai Mental Health center Shanghai Jiao Tong University School of Medicine

背景:近年来,大量的神经影像学研究发现强迫症(obsessive-compulsive disorder,OCD)在皮层-纹状体-丘脑-皮层(cortico-striato-thalamo-cortical,CSTC)环路存在代谢方面的异常,前额叶是CSTC环路的重要脑区。目的:本研究采用磁共振波谱... 详细信息

背景:近年来,大量的神经影像学研究发现强迫症(obsessive-compulsive disorder,OCD)在皮层-纹状体-丘脑-皮层(cortico-striato-thalamo-cortical,CSTC)环路存在代谢方面的异常,前额叶是CSTC环路的重要脑区。目的:本研究采用磁共振波谱技术研究OCD患者前额叶神经代谢的特点及其与临床特征之间的关系。方法:研究入组未用药(8周及以上)的OCD患者78例以及76例健康对,性别、年龄及受教育年限无统计学差异。采用3.0 T西门子磁共振扫描仪分别收集眶额回(orbito frontal cortex,OFC)及前扣带回(anterior cingulate cortex,ACC)部位的磁共振波谱数据,采集序列为mega-press序列,基于LCmodel6.3的分析方法得到OFC及ACC部位的γ-氨基丁酸(gamma-aminobutyric acid,GABA)、谷氨酸复合物(glutamine/glutamate,Glx)及N-乙酰天门冬氨酸(NAA)比水的相对浓度进行统计分析;采用两样本t检验分析OCD组与健康对照组代谢物质浓度的差异,基于Pearson相关分析的方法,分析相关的代谢物质浓度与耶鲁-布朗强迫量表(Y-BOCS),汉密尔顿焦虑、抑郁量表(HAMA、HAMD)得分的相关性。结果:与健康对照组相比,OCD患者OFC部位的GABA/W、NAA/W显著减少(p=0.031,t=-2.193;p=0.002,t=-3.223);ACC部位的GABA/W有减少趋势(p=0.059,t=-1.921)。OFC部位的GABA/W与耶鲁-布朗强迫思维、行为及强迫总分(Y-BOCS-O、Y-BOCS-C、Y-BOCS-T)负相关(p=0.037,r=-0.221;p=0.007,r=-0.283;p=0.014,r=-0.259)。结论:OCD患者OFC部位的GABA相对水平存在显著减少,ACC存在减少趋势,且与临床症状相关,提示GABA与OCD精神病理相关。

关键词：强迫症磁共振波谱技术眶额回前扣带回 γ-氨基丁酸

Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation

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Neural Regeneration research 2020年第8期15卷 1437-1450页

作者： Ya Zheng Ye-Ran Mao Ti-Fei Yuan Dong-Sheng Xu Li-Ming Cheng Rehabilitation Section Spine Surgery Division of Department of OrthopedicsTongji Hospital Affiliated to Tongji University School of MedicineShanghaiChina shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-innovation center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education of the People’s Republic of China Tongji UniversityShanghaiChina Spine Surgery Division of Department of Orthopedics Tongji Hospital Affiliated to Tongji University School of MedicineShanghaiChina

Spinal cord injury is linked to the interruption of neural pathways,which results in irreversible neural *** repair and neuroregeneration are critical goals and issues for rehabilitation in spinal cord injury,which require neural stem cell repair and multimodal neuromodulation techniques involving personalized rehabilitation *** the involvement of endogenous stem cells in neurogenesis and neural repair,exogenous neural stem cell transplantation is an emerging effective method for repairing and replacing damaged tissues in central nervous system ***,to ensure that endogenous or exogenous neural stem cells truly participate in neural repair following spinal cord injury,appropriate interventional measures(e.g.,neuromodulation)should be *** techniques,such as noninvasive magnetic stimulation and electrical stimulation,have been safely applied in many neuropsychiatric *** is increasing evidence to suggest that neuromagnetic/electrical modulation promotes neuroregeneration and neural repair by affecting signaling in the nervous system;namely,by exciting,inhibiting,or regulating neuronal and neural network activities to improve motor function and motor learning following spinal cord *** studies have indicated that fine motor skill rehabilitation training makes use of residual nerve fibers for collateral growth,encourages the formation of new synaptic connections to promote neural plasticity,and improves motor function recovery in patients with spinal cord *** the development of biomaterial technology and biomechanical engineering,several emerging treatments have been developed,such as robots,brain-computer interfaces,and *** treatments have the potential to help millions of patients suffering from motor dysfunction caused by spinal cord ***,large-scale clinical trials need to be conducted to validate their *** review evaluated the efficacy of ne

关键词： brain-computer interface technology multimodal rehabilitation nerve regeneration neural circuit reconstruction neural regeneration neuromodulation rehabilitation training spinal cord injury stem cells transcranial direct current stimulation transcranial magnetic stimulation

Advancing pathogen detection for airborne diseases

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Fundamental research 2023年第4期3卷 520-524页

作者： Tingting Zhai Yuhan Wei Lihua Wang Jiang Li Chunhai Fan School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Institute of Materiobiology Department of ChemistryCollege of ScienceShanghai UniversityShanghai 200444China The Interdisciplinary research center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

Airborne diseases including SARS,bird flu,and the ongoing Coronavirus Disease 2019(COVID-19)have stimulated the demand for developing novel bioassay methods competent for early-stage diagnosis and large-scale ***,we briefly summarize the state-of-the-art methods for the detection of infectious pathogens and discuss key *** highlight the trend for next-generation technologies benefiting from multidisciplinary advances in microfabrication,nanotechnology and synthetic biology,which allow sensitive,rapid yet inexpensive pathogen assays with portable intelligent device.

关键词： Infectious disease Pathogen assay Biosensor Synthetic biological circuit Smart device

Synergistic effect of fluorination on both donor and acceptor materials for high performance non-fullerene polymer solar cells with 13.5% efficiency

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Science China Chemistry 2018年第5期61卷 531-537页

作者： Qunping Fan Wenyan Su Yan Wang Bing Guo Yufeng Jiang Xia Guo Feng Liu Thomas P.Russell Maojie Zhang Yongfang Li State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Department of Physics and Astronomy Collaborative Innovation Center of IFSA Shanghai Jiao Tong University Shanghai 200240 China Materials Sctences Division Lawrence Berkeley National Laboratory Berkeley California 94720 United States CAS research/Education center for Excellence in Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

A high performance polymer solar cells(PSCs) based on polymer donor PM6 containing fluorinated thienyl benzodithiophene unit and n-type organic semiconductor acceptor IT-4 F containing fluorinated end-groups were developed. In addition to complementary absorption spectra(300–830 nm) with IT-4 F, the PM6 also has a deep HOMO(the highest occupied molecular) level(-5.50 e V), which will lower the open-circuit voltage(V_(oc)) sacrifice and reduce the E_(loss) of the IT-4 F-based PSCs. Moreover, the strong crystallinity of PM6 is beneficial to form favorable blend morphology and hence to suppress recombination. As a result, in comparison with the PSCs based on a non-fluorinated D/A pair of PBDB-T:ITIC with a medium PCE of 11.2%, the PM6:IT-4 Fbased PSCs yielded an impressive PCE of 13.5% due to the synergistic effect of fluorination on both donor and acceptor, which is among the highest values recorded in the literatures for PSCs to date. Furthermore, a PCE of 12.2% was remained with the active layer thickness of up to 285 nm and a high PCE of 11.4% was also obtained with a large device area of 1 cm^2. In addition, the devices also showed good storage, thermal and illumination stabilities with respect to the efficiency. These results indicate that fluorination is an effective strategy to improve the photovoltaic performance of materials, as well as the both fluorinated donor and acceptor pair-PM6:IT-4 F is an ideal candidate for the large scale roll-to-roll production of efficient PSCs in the future.

关键词： polymer solar cells fluorine substitution non-fullerene wide bandgap conjugated polymer power conversion efficiency

11.2% Efficiency all-polymer solar cells with high open-circuit voltage

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Science China Chemistry 2019年第7期62卷 845-850页

作者： Yuan Meng Jingnan Wu Xia Guo Wenyan Su Lei Zhu Jin Fang Zhi-Guo Zhang Feng Liu Maojie Zhang Thomas P. Russell Yongfang Li State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Department of Physics and Astronomy and Collaborative Innovation center of IFSA Shanghai Jiao Tong University Shanghai 200240 China Polymer Science and Engineering Department University of Massachusetts Amherst MA 01003 USA Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley California 94720 USA CAS research/Education center for Excellence in Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Herein,we fabricated all-polymer solar cells(all-PSCs)based on a fluorinated wide-bandgap p-type conjugated polymer PM6 as the donor,and a narrow bandgap n-type conjugated polymer PZ1 as the *** addition to the complementary absorption and matching energy levels,the optimized blend films possess high cystallinity,predominantly face-on stacking,and a suitable phase separated *** this active layer,the devices exhibited a high Vocof 0.96 V,a superior Jscof 17.1 mA cm^-2,a fine fill factor(FF)of 68.2%,and thus an excellent power conversion efficiency(PCE)of 11.2%,which is the highest value reported to date for single-junction ***,the devices showed good storage *** 80 d of storage in the N2-filled glovebox,the PCE still remained over 90%of the original ***-area devices(1.1 cm^2)also demonstrated an outstanding performance with a PCE of 9.2%,among the highest values for the reported large-area *** results indicate that the PM6:PZ1 blend is a promising candidate for scale-up production of large area high-performance all-PSCs.

关键词： all-polymer solar cells fluorine substitution power conversion efficiency wide bandgap polymer polymer acceptor

Silicon photonics for high-capacity data communications

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Photonics research 2022年第9期10卷 I0002-I0030页

作者： YAOCHENG SHI YONG ZHANG YATING WAN YU YU YUGUANG ZHANG XIAO HU XI XIAO HONGNAN XU LONG ZHANG BINGCHENG PAN Centre for Optical and Electromagnetic research State Key Laboratory for Modern Optical InstrumentationCollege of Optical Science and EngineeringZhejiang UniversityZijingang CampusHangzhou 310058China State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China Institute for Energy Efficiency University of California Santa BarbaraSanta BarbaraCalifornia 93106USA Electrical and Computer Engineering Department King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Wuhan National Laboratory for Optoelectronics&School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China National Information Optoelectronics Innovation center China Information and Communication Technologies Group Corporation(CICT)Wuhan 430074China State Key Laboratory of Optical Communication Technologies and Networks China Information and Communication Technologies Group Corporation(CICT)Wuhan 430074China Department of Electronic Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongChina

In recent years,optical modulators,photodetectors,(de)multiplexers,and heterogeneously integrated lasers based on silicon optical platforms have been *** performance of some devices even surpasses the traditional III-V and photonic integrated circuit(PIC)platforms,laying the foundation for large-scale photonic *** photonic technology can overcome the limitations of traditional transceiver technology in high-speed transmission networks to support faster interconnection between data *** this article,we will review recent progress for silicon *** first part gives an overview of recent achievements in silicon *** second part introduces the silicon photonic building blocks,including low-loss waveguides,passive devices,modulators,photodetectors,heterogeneously integrated lasers,and so *** the third part,the recent progress on high-capacity silicon photonic transceivers is *** the fourth part,we give a review of high-capacity silicon photonic networks on chip.

关键词： interconnection passive networks