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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： Carlos M Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip Microorganism identification Diagnostics Point-ofcare testing Biosensors

Numerical Simulation of Blood Flow Dynamics in a Stenosed Artery Enhanced by Copper and Alumina Nanoparticles

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1839-1864页

作者： Haris Alam Zuberi Madan Lal Amol Singh Nurul Amira Zainal Ali J.Chamkha Department of Applied Mathematics M.J.P.Rohilkhand UniversityBareilly243006India Fakulti Teknologi dan Kejuruteraan Mekanikal Universiti Teknikal MalaysiaMelaka76100Malaysia Forecasting and Engineering Technology Analysis(FETA)research group Universiti Teknikal MalaysiaMelaka76100Malaysia Faculty of Engineering Kuwait College of Science and TechnologyDoha35004Kuwait

Nanotechnology holds immense importance in the biomedical field due to its ability to revolutionize healthcare on a molecular *** by the imperative of enhancing patient outcomes,a comprehensive numerical simulation study on the dynamics of blood flow in a stenosed artery,focusing on the effects of copper and alumina nanoparticles,is *** study employs a 2-dimensional Newtonian blood flow model infused with copper and alumina nanoparticles,considering the influence of a magnetic field,thermal radiation,and various flow *** governing differential equations are first non-dimensionalized to facilitate analysis and subsequently solved using the 4th order collocation method,bvp4c module in *** approach obtains velocity and temperature profiles,revealing the impact of relevant parameters crucial in the biomedical *** findings of this study underscore the significance of understanding blood flow dynamics in stenosed arteries and the potential benefits of utilizing copper and alumina nanoparticles in treatment *** incorporation of nanoparticles introduces novel avenues for enhancing therapeutic interventions,particularly in mitigating the effects of *** elucidation of velocity and temperature profiles provides valuable insights into the behavior of blood flow under different conditions,thereby informing the development of targeted biomedical *** arterial curvature flow parameter influences temperature profiles,with increased parameters promoting more efficient heat *** elevated values of Prandtl number and thermal radiation parameter showcase the diminished temperature profiles,indicating stronger dominance of momentum diffusion over thermal diffusion and radiative heat transfer *** analysis of the pertinent physical parameters reveals that the Prandtl number has the most significant impact on blood flow dynamics.A statistical analysis of the present results and exist

关键词： Blood flow simulation stenosis copper and alumina nanoparticles thermal radiation curvature parameter

Perspectives from a publishing ethics and research integrity team for required improvements

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Journal of Data and Information Science 2023年第3期8卷 1-14页

作者： Sabina Alam Laura Wilson Publishing ethics and research Integrity Taylor and Francis GroupJournalsUK

It is imperative that all stakeholders within the research ecosystem take responsibility to improve research integrity and reliability of published *** on the unique experiences of a specialist publishing ethics and research integrity team within a major publisher,this article provides insights into the observed trends of misconduct and how those have evolved over time,and addresses key actions needed to improve the interface between researchers,funders,institutions and publishers to collectively improve research integrity on a global scale.

关键词： research integrity Publishing ethics Training Education

Reversibility of diabetes mellitus: Narrative review of the evidence

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World Journal of Diabetes 2018年第7期9卷 127-131页

作者： Gary Yee Ang Health Services and Outcomes research National Healthcare Group

The global disease burden of diabetes mellitus is high. It is well-established that prediabetes is reversible but it is unclear whether diabetes is reversible once it has been diagnosed. The objective of this narrative review is to review the evidence of reversibility of diabetes me-llitus and stimulate interest in prolonged remission as a treatment target. The current evidence for bariatric surgery is stronger than intensive medical management and the evidence is stronger for type 2 diabetes pa-tients compared with type 1 diabetes patients. It is also unclear whether non obese diabetes patients would benefit from such interventions and the duration of diabetes before diabetes become irreversible. Further research is needed in this area especially with regards to the subgroup of diabetes patient who will benefit from these interventions and the long term safety and efficacy remains unknown especially with intensive me-dical management.

关键词： Diabetes Reversibility Remission Bariatric surgery Obesity

healthcare providers’perspectives on factors influencing their critical care decision-making during the COVID-19 pandemic:An international pilot survey

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World Journal of Critical Care Medicine 2025年第1期14卷 100-110页

作者： Sonali Vadi Neha Sanwalka Pramod Thaker Department of Critical Care Medicine Kokilaben Dhirubhai Ambani Hospital and Medical Research InstituteMumbai 400053MahārāshtraIndia Department of Statistics HCJMRIJehangir HospitalPune 411001MahārāshtraIndia Medical ethics Fellowship Harvard Medical SchoolBostonMA 02138United States

BACKGROUND Understanding a patient's clinical status and setting priorities for their care are two aspects of the constantly changing process of clinical *** analytical technique that can be helpful in uncertain situations is clinical *** must deal with contradictory information,lack of time to make decisions,and long-term factors when emergencies *** To examine the ethical issues healthcare professionals faced during the coronavirus disease 2019(COVID-19)pandemic and the factors affecting clinical *** This pilot study,which means it was a preliminary investigation to gather information and test the feasibility of a larger investigation was conducted over 6 months and we invited responses from clinicians worldwide who managed patients with *** survey focused on topics related to their professional roles and personal *** examined five core areas influencing critical care decision-making:Patients'personal factors,family-related factors,informed consent,communication and media,and hospital administrative policies on clinical *** collected data were analyzed using the χ^(2) test for categorical *** A total of 102 clinicians from 23 specialties and 17 countries responded to the *** was a significant factor in treatment planning(n=88)and ventilator access(n=78).Sex had no bearing on how decisions were *** doctors reported maintaining patient confidentiality regarding privacy and informed *** 50%of clinicians reported a moderate influence of clinical work,with many citing it as one of the most important factors affecting their health and *** from developing countries had a significantly higher score for considering a patient's financial status when creating a treatment plan than their counterparts from developed *** personal experiences,some respondents noted that treatment plans and preferences ch

关键词： Survey Clinical decision-making COVID-19 pandemic

Evaluating the impact of virtual reality on reducing restrictive practices in psychiatric wards

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World Journal of Psychiatry 2025年第2期15卷 268-273页

作者： Akpoveta Eguono Deborah Uchenna Esther Okpete Haewon Byeon Department of Medical Centre Alex Ekwueme Federal UniversityNdufu-Alike Ikwo 1111Ebonyi StateNigeria Department of Digital Anti-aging healthcare(BK21) Inje UniversityGimhae 50834South Korea

This manuscript critically evaluates the randomized controlled trial(RCT)conducted by Phiri et al,which assessed the effectiveness of virtual reality(VR)training for psychiatric staff in reducing restrictive practices(RPs).Specifically,this RCT investigated the impact of VR on the handling of aggressive patients by psychiatric staff compared to traditional training *** significant reductions in perceived discrimination in the VR group,there were no major improvements in self-efficacy or anxiety *** system usability scale rated the VR platform highly,but it did not consistently outperform traditional training ***,the study shows the potential for VR to reduce RPs,although fluctuations in RP rates suggest that external factors,such as staff turnover,influenced the *** manuscript evaluates the study’s methodology,results,and broader implications for mental health ***,it highlights the need for more comprehensive research to establish VR as a standard tool for psychiatric staff education,focusing on patient care outcomes and real-world ***,this study explores future research di-rections,technological improvements,and the potential impact of policies that could enhance the integration of VR in clinical training.

关键词： Virtual reality Restrictive practices Psychiatric wards De-escalation techniques Staff training Generalized anxiety disorder System usability scale Burnout prevention

Age of onset of diabetes and all-cause mortality

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World Journal of Diabetes 2020年第4期11卷 95-99页

作者： Gary Yee Ang Health Services and Outcomes research National Healthcare GroupSingapore 138543Singapore

Diabetes mellitus continues to present a large social,financial and health system burden across the *** relationship between age of onset of the different types of diabetes and all-cause mortality is *** this review paper,the relationship between age of onset of the different types of diabetes and all-cause mortality will be reviewed and an update of the current evidence will be *** is strong evidence of the relationship between age of onset of type 2 diabetes mellitus(T2 DM) and all-cause mortality,good evidence of the relationship between age of onset of T1 DM and all-cause mortality and no evidence of the relationship between age of onset of gestational diabetes or prediabetes and all-cause *** research is needed to look at whether aggressive management of earlier onset of T2 DM can help to reduce premature mortality.

关键词： Diabetes mellitus Age of onset Mortality Type 1 diabetes Type 2 diabetes Gestational diabetes Prediabetes

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan Kim Hyemi Eo Sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative Bioresearch group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Voices that matter:The impact of patient-reported outcome measures on clinical decision-making

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World Journal of Methodology 2025年第2期15卷 54-61页

作者： Naveen Jeyaraman Madhan Jeyaraman Swaminathan Ramasubramanian Sangeetha Balaji Sathish Muthu Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTN 600077India Department of research Methods Orthopaedic Research GroupCoimbatoreTN 641045India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTN 600002India Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatoreTN 641021India Department of Orthopaedics Government Medical CollegeKarurTN 639004India

The critical role of patient-reported outcome measures(PROMs)in enhancing clinical decision-making and promoting patient-centered care has gained a profound significance in scientific *** encapsulate a patient's health status directly from their perspective,encompassing various domains such as symptom severity,functional status,and overall quality of *** integrating PROMs into routine clinical practice and research,healthcare providers can achieve a more nuanced understanding of patient experiences and tailor treatments *** deployment of PROMs supports dynamic patient-provider interactions,fostering better patient engagement and adherence to tre-atment ***,PROMs are pivotal in clinical settings for monitoring disease progression and treatment efficacy,particularly in chronic and mental health ***,challenges in implementing PROMs include data collection and management,integration into existing health systems,and acceptance by patients and *** these barriers necessitates technological advancements,policy development,and continuous education to enhance the acceptability and effectiveness of *** paper concludes with recommendations for future research and policy-making aimed at optimizing the use and impact of PROMs across healthcare settings.

关键词： Patient-reported outcome measures Clinical decision-making Patient-centered care healthcare technology Data management Policy development

Beyond statistical significance:Embracing minimal clinically important difference for better patient care

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World Journal of Methodology 2025年第1期15卷 33-41页

作者： Naveen Jeyaraman Madhan Jeyaraman Swaminathan Ramasubramanian Sangeetha Balaji Sathish Muthu Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of research Methods Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia

The minimal clinically important difference(MCID)represents a pivotal metric in bridging the gap between statistical significance and clinical relevance,addressing the direct impact of medical interventions from the patient's *** comprehensive review analyzes the evolution,applications,and challenges of MCID across medical specialties,emphasizing its necessity in ensuring that clinical outcomes not only demonstrate statistical significance but also offer genuine clinical utility that aligns with patient expectations and *** discuss the evolution of MCID since its inception in the 1980s,its current applications across various medical specialties,and the methodologies used in its calculation,highlighting both anchor-based and distribution-based ***,the paper delves into the challenges associated with the application of MCID,such as methodological variability and the interpretation difficulties that arise in clinical *** for the future include standardizing MCID calculation methods,enhancing patient involvement in setting MCID thresholds,and extending research to incorporate diverse global *** steps are critical to refining the role of MCID in patient-centered healthcare,addressing existing gaps in methodology and interpretation,and ensuring that medical interventions lead to significant,patient-perceived improvements.

关键词： Minimal clinically important difference Patient-centered care Clinical relevance Global health