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Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy

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Chinese Chemical Letters 2024年第6期35卷 445-450页

作者： Leichen Wang Anqing Mei Na Li Xiaohong Ruan Xu Sun Yu Cai Jinjun Shao Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211800China School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhou 221116China Center for rehabilitation Medicine Rehabilitation&Sports Medicine Research Institute of Zhejiang ProvinceDepartment of Rehabilitation MedicineZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014China

Introducing heavy halogen atoms into organic small molecules is a practical strategy for efficient singlet oxygen(^(1)O_(2))***,bromine or iodine atoms are introduced on the aza-borondipyrromethene(aza-BODIPY)core,rather than on the periphery aryl rings for efficient~1O_(2) ***,an aza-BODIPY dye NBDPBr with unexpected bromination on the periphery aryl rings was synthesized for photoacoustic(PA)imaging-guided synergistic photothermal therapy(PTT)and photodynamic therapy(PDT)in tumor *** to unexcepted bromination at the periphery aryl rings,NBDPBr demonstrated an outstanding singlet oxygen quantum yield(Φ_(Δ))of 66% which was superior to similar brominated photosensitizers previously *** encapsulation with amphiphilic polymer F-127,hydrophilic NBDPBr nanoparticles(NPs)were fabricated and exhibited an excellent photothermal conversion efficiency(η)of 43.0% under 660 nm *** vivo PA imaging results demonstrated that NBDPBr NPs could specifically accumulate at tumor sites and realized the maximum tumor retention at 7 h *** the in vitro and in vivo results indicated the significant potence of NBDPBr with unexpected bis-bromination for PA imaging-guided synergetic PDT/PTT.

关键词： Unexpected bromination Aza-BODIPY Photodynamic therapy Photothermal therapy Synergetic therapy

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Jackson-type inequalities on high-dimensional spheres

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Science China Mathematics 2024年第11期67卷 2571-2586页

作者： Yeli Niu Feng Dai department of Mathematics Shanghai Normal University department of Mathematical and Statistical sciences University of Alberta

We study Jackson's inequality on high-dimensional spheres with respect to the modulus of smoothness defined via the rotation *** obtain a version of Jackson's inequality with a dimensionfree constant,extending Newman and Shapiro's well-known results in 1964 from the case of r = 1 and p = ∞ to more general *** results partially overcome the curse of *** also establish similar results on the equivalence of the K-functional and modulus of smoothness.

关键词： modulus of smoothness $K$-functional Jackson's inequality high-dimensional approximation

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Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)

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Oncology Research 2024年第3期32卷 503-515页

作者： XING YE ZHOUTING TUO KAI CHEN RUICHENG WU JIE WANG QINGXIN YU LUXIA YE AKIRA MIYAMOTO KOO HAN YOO CHI ZHANG WURAN WEI DENGXIONG LI DECHAO FENG Samuel Oschin Comprehensive Cancer Institute Department of MedicineDepartment of Biomedical SciencesCedars-Sinai Medical CenterLos AngelesCA90048USA department of Urology The Second Afiliated Hospital of Anhui Medical UniversityHefei230601China department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu610041China department of Pathology Ningbo Diagnostic Pathology Center Ningbo315021China department of Public Research Platfom Taizhou Hospital of Zhejiang Province Afliated to Wenzhou Medical UniversityLinhai317000China department of rehabilitation West Kyushu UniversityKanzaki shi842-8585Japan department of Urology Kyung Hee UniversitySeoul446701South Korea department of rehabilitation The Afliated Hospital of Southwest Medical UniversityLuwzhou646000China

The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic *** study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer analysis,enhancing understanding of this gene's role in *** observed differential ALYREF expression between tumor and normal samples,correl ating strongly with prognosis in various cancers,particularly kidney renal papillary cell carcinoma(KIRP)and liver hepatocellular carcinoma(LIHC).ALYREF showed a negative correlation with most tumor-infitrating cells in lung squamous cell carcinoma(LUSC)and lymphoid neoplasm difuse large B-cell lymphoma(DLBC),while positive correlations were noted in IIHC,kidney chromophobe(KICH),mesothelioma(MESO),KIRP,pheochromocytoma and paraganglioma(PARD),and glioma(GBMLGG).Aditionally,ALYREF expression was closely associated with tumor heterogeneity,stemness indices,and a high mutation rate in TP53 across these *** conclusion,ALYREF may serve as an oncogenic biomarker in numerous cancers,meriting further research attention.

关键词： Pan-cancer RNA 5-methylcytosine ALYREF Immwno-oncological efects

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Influence of cardiorespiratory fitness and body composition on resting and post-exercise indices of vascular health in young adults

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Sports Medicine and Health Science 2024年第1期6卷 54-62页

作者： Rian Q.Landers-Ramos Kathleen Dondero Ian Imery Nicholas Reveille Hannah A.Zabriskie Devon A.Dobrosielski Towson University Department of KinesiologyTowsonMDUSA University of Maryland School of Medicine Department of Physical Therapy and Rehabilitation SciencesBaltimoreMDUSA Johns Hopkins University Department of Cell BiologyBaltimoreMDUSA University of Florida Department of Applied Physiology and KinesiologyGainesvilleFLUSA

Poor cardiorespiratory fitness may mediate vascular impairments at rest and following an acute bout of exercise in young healthy *** study aimed to compare flow mediated dilation(FMD)and vascular augmentation index(AIx75)between young adults with low,moderate,and high levels of cardiorespiratory fitness before and after an acute bout of aerobic ***-three participants(22 men;21 women)between 18 and 29 years of age completed the *** were classified into low,moderate,and high health-related cardiorespiratory fitness groups according to age-and sex-based relative maximal oxygen consumption(V_O2 max)percentile *** was performed using Doppler ultrasound and AIx75 was performed using pulse wave analysis at baseline and 60-min after a 30-min bout of treadmill running at 70%V_O2 max.A significant interaction(p=0.047;ηp 2=0.142)was observed,with the moderate fitness group exhibiting a higher FMD post-exercise compared with baseline([6.7%3.1%]vs.[8.5%2.8%],p=0.028;d=0.598).We found a significant main effect of group for AIx75(p=0.023;ηp 2=0.168),with the high fitness group exhibiting lower AIx75 compared to low fitness group([10%10%]vs.[2%10%],respectively,p=0.019;g=1.07).This was eliminated after covarying for body fat percentage(p=0.489).Our findings suggest that resting FMD and AIx75 responses are not significantly influenced by cardiorespiratory fitness,but FMD recovery responses to exercise may be enhanced in individuals with moderate cardiorespiratory fitness levels.

关键词： Cardiorespiratory fitness Flow mediated dilation Augmentation index Vascular Acute exercise Body composition

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Nutritional Support under the Neuman Systems Model for Stroke Patients

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Open Journal of Nursing 2024年第7期14卷 329-343页

作者： Meifen Lv Jinyue Jiang Luoqiong Lei Yuhua Gui Qiongfang Hu Fang Ye Lijuan Lu Hong Yang Na Yan Shiying Zhang department of rehabilitation Medicine Qujing No.1 Hospital Qujing China department of rehabilitation Medicine Qujing Multi-Rehabilitation Hospital Qujing China

Objective: To explore nutritional support under the Neuman systems model in treating dysphagia in stroke patients. Methods: In this retrospective study, we enrolled 97 patients with dysphagia after stroke admitted to our hospital, and randomly divided them into the Neuman group (n = 51) given nursing intervention based on Neuman systems model and a control group (n = 46) given routine nursing intervention. Both groups received nutritional support for 3 months. Nutritional indexes (serum total protein, plasma albumin, serum albumin, hemoglobin and transferrin levels) and immune indexes (immunoglobulin (Ig) A, IgG, IgM and total lymphocyte count (TLC) in both groups were recorded and compared. Pulmonary function recovery, video fluoroscopic swallowing study score, water swallowing test score, complication rate, and health knowledge mastery level were also compared between the two groups. Results: After the intervention, the Neuman group showed less decrease in the nutritional and immune index scores (serum total protein, plasma albumin, hemoglobin, serum albumin;IgA, IgG, IgM, and TLC;all P Conclusion: For patients with stroke and dysphagia, comprehensive nursing intervention (e.g., nutritional support) under theNeuman systems model can promote the recovery of immune, swallowing, and pulmonary function, reduce complication incidence and facilitate comprehensive rehabilitation, ensuring adequate nutritional intake.

关键词： Stroke Dysphagia Neuman Systems Model Nutritional Support Pulmonary Function

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Clinical efficacy and safety of double-channel anastomosis and tubular gastroesophageal anastomosis in gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2012-2022页

作者： Bei-Ying Liu Shuai Wu Yu Xu department of Operation Room The Affiliated HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina department of Urology Qingdao HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Municipal Hospital)Qingdao 266001Shangdong ProvinceChina department of Gastrointestinal Surgery Fujian Provincial HospitalFuzhou 350013Fujian ProvinceChina

BACKGROUND With the continuous progress of surgical technology and improvements in medical standards,the treatment of gastric cancer surgery is also *** gastrectomy is a common treatment,but double-channel anastomosis and tubular gastroesophageal anastomosis have attracted much attention in terms of surgical *** of these two surgical methods has advantages and disadvantages,so it is particularly important to compare and analyze their clinical efficacy and *** To compare the surgical safety,clinical efficacy,and safety of double-channel anastomosis and tubular gastroesophageal anastomosis in proximal *** The clinical and follow-up data of 99 patients with proximal gastric cancer who underwent proximal gastrectomy and were admitted to our hospital between January 2018 and September 2023 were included in this retrospective cohort *** to the different anastomosis methods used,the patients were divided into a double-channel anastomosis group(50 patients)and a tubular gastroesophageal anastomosis group(49 patients).In the double-channel anastomosis,Roux-en-Y anastomosis of the esophagus and jejunum was performed after proximal gastric dissection,and then side-to-side anastomosis was performed between the residual stomach and jejunum to establish an antireflux barrier and reduce postoperative gastroesophageal *** the tubular gastroesophageal anastomosis group,after the proximal end of the stomach was cut,tubular gastroplasty was performed on the distal stump of the stomach and a linear stapler was used to anastomose the posterior wall of the esophagus and the anterior wall of the stomach *** main outcome measure was quality of life 1 year after surgery in both groups,and the evaluation criteria were based on the postgastrectomy syndrome assessment *** greater the changes in body mass,food intake per meal,meal quality subscale score,and total measures of physical and mental health score,the better th

关键词： Gastric neoplasms Proximal gastrectomy Digestive tract reconstruction Dual channel reconstruction Tubular stomach reconstruction Retrospective cohort study

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Neuronomodulation of Excitable Neurons

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Neuroscience Bulletin 2024年第1期40卷 103-112页

作者： Yizhang Chen Lin Xiao Jian Qiu Institute of Neuroscience Second Military Medical UniversityShanghai 200433China Institute for Brain Research and rehabilitation Key Laboratory of BrainCognition and Education Sciences of Ministry of EducationSouth China Normal UniversityGuangzhou 510631China department of Chemical Physiology and Biochemistry Oregon Health and Science UniversityPortlandOR 97239USA

Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in response to chemical substances,from spillover neuro-transmitters to paracrine or endocrine hormones circulating in the *** can be direct or indirect,depending on the transduction pathways from the ligand binding site to the ion pore,either on the same molecule,*** ion channel,or through an intermediate step on different *** major players in direct neurono-modulation are ligand-gated or voltage-gated ion *** key process of direct neuronomodulation is the binding and chemoactivation of ligand-gated or voltage-gated ion channels,either orthosterically or allosterically,by various *** neuronomodulation involves metabotropic receptor-mediated slow potentials,where steroid hormones,cytokines,and chemokines can implement these *** neuronomodulation is of great significance for understanding the physiological mechanisms of brain function,and the occurrence and treatment of diseases.

关键词： Neuron Membrane potential Excitability Chemoactivation Neuronomodulation

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Impact of Action Observation Therapy along with Usual Physiotherapy Intervention of Individual with Alzheimer’s Disease

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Advances in Alzheimer's Disease 2024年第1期13卷 1-10页

作者： Zahid Bin Sultan Nahid Faruq Ahmed Tuhin Ahammed Md Kutub Uddin Md Sirazul Islam S M Maruf Hossain Sajib Md Rafiqul Islam department of Physiotherapy Saic College of Medical Science and Technology Mirpur Bangladesh department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP) Savar Bangladesh department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP) Mymensingh Bangladesh department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP) Mirpur Bangladesh department of Physiotherapy State College of Health Sciences Dhaka Bangladesh

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive impairments in the initial stage, which lead to severe cognitive dysfunction in the later stage. Action observation therapy (AOT) is a multisensory cognitive rehabilitation technique where the patient initially observes the actions and then tries to perform. The study aimed to examine the impact of AOT along with usual physiotherapy interventions to reduce depression, improve cognition and balance of a patient with AD. A 67 years old patient with AD was selected for this study because the patient has been suffering from depression, dementia, and physical dysfunction along with some other health conditions like diabetes and hypertension. Before starting intervention, a baseline assessment was done through the Beck Depression Inventory (BDI) tool, the Mini-Cog Scale, and the Berg Balance Scale (BBS). The patient received 12 sessions of AOT along with usual physiotherapy interventions thrice a week for four weeks, which included 45 minutes of each session. After four weeks of intervention, the patient demonstrated significant improvement in depression, cognition, and balance, whereas the BDI score declined from moderate 21/63 to mild 15/63 level of depression. The Mini-Cog score improved from 2/5 to 4/5, and the BBS score increased from 18/56 to 37/56. It is concluded that AOT along with usual physiotherapy intervention helps to reduce depression, improve cognition and balance of people with AD.

关键词： Alzheimer’s Disease Action Observation Therapy Physiotherapy Intervention

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A Hybrid SIR-Fuzzy Model for Epidemic Dynamics:A Numerical Study

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Computer Modeling in Engineering & sciences 2024年第6期139卷 3417-3434页

作者： Muhammad Shoaib Arif Kamaleldin Abodayeh Yasir Nawaz department of Mathematics and sciences College of Humanities and SciencesPrince Sultan UniversityRiyadh11586Saudi Arabia department of Mathematics Air UniversityIslamabad44000Pakistan

This study focuses on the urgent requirement for improved accuracy in diseasemodeling by introducing a newcomputational framework called the Hybrid SIR-Fuzzy *** integrating the traditional Susceptible-Infectious-Recovered(SIR)modelwith fuzzy logic,ourmethod effectively addresses the complex nature of epidemic dynamics by accurately accounting for uncertainties and imprecisions in both data and model *** main aim of this research is to provide a model for disease transmission using fuzzy theory,which can successfully address uncertainty in mathematical *** main emphasis is on the imprecise transmission rate parameter,utilizing a three-part description of its membership *** enhances the representation of disease processes with greater complexity and tackles the difficulties related to quantifying uncertainty in mathematical *** investigate equilibrium points for three separate scenarios and perform a comprehensive sensitivity analysis,providing insight into the complex correlation betweenmodel parameters and epidemic *** order to facilitate a quantitative analysis of the fuzzy model,we propose the implementation of a resilient numerical *** convergence study of the scheme demonstrates its trustworthiness,providing a conditionally positive solution,which represents a significant improvement compared to current forward Euler *** numerical findings demonstrate themodel’s effectiveness in accurately representing the dynamics of disease ***,when the mortality coefficient rises,both the susceptible and infected populations decrease,highlighting the model’s sensitivity to important epidemiological ***,there is a direct relationship between higher Holling type rate values and a decrease in the number of individuals who are infected,as well as an increase in the number of susceptible *** correlation offers a significant understanding of how many elements affect the con

关键词： Fuzzy-based model sensitivity equilibriumpoints proposed numerical scheme convergence and stability analysis

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High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

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Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye Li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang Lizhen Zheng Jiali Wang Le Huang Haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu Li Patrick Shu-hang Yung Guangyin Yuan Ling Qin Musculoskeletal Research Laboratory of department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory of Li Ka Shing Institute of Health sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of Light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic department Peking University Third HospitalBeijingChina department of rehabilitation sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing *** good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG21)wires are developed to bunch the tendon graft for matching the bone tunnel during ***,tensile strength,degradation,and cytotoxicity of ZG21 wire are *** rabbit model is used for assessing the biological effects of ZG21 wire by Micro-CT,histology,and mechanical *** SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying *** tests demonstrate the high formability of ZG21 wire as surgical ***-CT shows ZG21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing *** mechanical test shows higher ultimate load in the ZG21 *** SEM/EDS presents ZG21 wire degradation triggered calcium phosphate(Ca-P)*** results demonstrate upregulation of Wnt3a,BMP2,and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of *** vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate *** vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon *** conclusion,the ZG21 wire is feasible for tendon graft *** degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy Biomaterials Endochondral ossification

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