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Pathological and Etiological Aspects of Nephrotic Syndrome at the niamey general reference hospital

Open Journal of Nephrology 2024年第3期14卷 340-349页

作者： Djibrilla Gani Salamatou Amadou Niaouro Oumarou Ali Diallo Nephrology-Dialysis Department Niamey General Reference Hospital Niamey Niger Environmental Health and Climate Epidemiology Unit (UESEC)-CERMES Niamey Niger

Introduction: Studies have been conducted on nephrotic syndrome in Niger. The study aimed to determine the histological and etiological aspects of nephrotic syndrome. Patients and Method: This was a retrospective study from February 1st, 2018 to January 31st, 2024. All patients with nephrotic syndrome who underwent renal biopsy were included. Samples were analyzed at the anatomy-cytology pathology laboratory of the Faculty of Medicine in Dakar (Senegal). The variables studied included clinical, biological, histological and etiological characteristics. Data were analyzed using Excel 2013 and Epi-info 7.2.0 software. Results: The study included 119 patients with nephrotic syndrome. Prevalence of nephrotic syndrome was 11.24%. The male-to-female ratio was 2.25:1. The mean age at diagnosis was between 34.5 ± 18.84 years. Edema was the reason for admission in 40.34% of cases. The nephrotic syndrome was impure in 63.86% of cases. Nine histological lesions were identified. Focal and segmental glomerulosclerosis (40.09%), minimal change disease (23.53%), membranous nephropathy (13.45%), diabetic nephropathy (10.92%), membranous proliferative glomerulonephritis (3.36%), acute glomerulonephritis (3.36%), glomerular thrombotic microangiopathy (2.52%), non-IgA mesengial proliferative glomerulonephritis (1.68%) and amyloidosis (0.84%). Nephrotic syndrome was primary in 57.98% of cases. Secondary etiologies were dominated by diabetes (11.76%), followed by hepatitis B virus (9.24%), lupus, lymphoma, malaria, syphilis, cryoglobulinemia, sickle cell disease and HIV. Conclusion: Future studies should investigate the causes of glomerulopathy secondary to chronic tubulointerstitial lesions.

关键词： Nephrotic Syndrome Anatomopathology niamey general reference hospital

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Antibiotic Resistance in the Uropathogenic Enterobacteria Isolated from Patients Attending general reference hospital (GRH) of niamey, Niger

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Open Journal of Medical Microbiology 2023年第1期13卷 78-90页

作者： Alassane Halawen Mohamed René Dembélé Chaibou Salaou Alix Bénédicte Kagambèga Hiliassa Coulibaly Frédéric François Bado Alio Mahamadou Fody Laouali Boubou Alkassoum Ibrahim Eric Adehossi Omar Mauricio Arcos Holzinger Nicolas Barro Microbiology Laboratory of the general reference hospital (GRH) Niamey Niger Laboratory of Molecular Biology Epidemiology and Surveillance of Foodborne Bacteria and Viruses (LaBESTA) University Joseph KI-ZERBO of Ouagadougou Ouagadougou Burkina Faso Training and Research Unit in Applied Sciences and Technologies University of Dedougou Dedougou Burkina Faso Superior Normal School University Abdou Moumouni of Niamey Niamey Niger Bacteriology Laboratory of the niamey National hospital (NNH) Niamey Niger Direction of Surveillance and Response to Epidemics Ministry of Public Health Niamey Niger Faculty of Health Sciences University Abdou Moumouni of Niamey Niamey Niger Center for Medical and Health Research Niamey Niger Instituto de Ciencias Médicas Las Tablas Panama

Background: Urinary tract infections (UTIs) are a frequent reason for consultation and lead to a significant and sometimes inappropriate prescription of antibiotics. The latter favors antibiotic resistance and an increase in mortality as well as the cost of treatment. The present study aims to contribute to the fight against antibiotic resistance of enterobacteria. Methods: This is a prospective study from January to December, 2021 in the Microbiology laboratory of the general reference hospital (GRH) of niamey including 3369 urine samples. The antibiotic resistance of enterobacteria was determined using the Viteck-2 method. Results: At least 280 strains of Enterobacteriaceae were isolated from the patient’s urine. Among these strains, Escherichia coli was the most predominant (74.64%), followed by Klebsiella pneumoniae (16.07%) and Enterobacter cloacae (7.14%) and other enterobacteria 2.15%. These Enterobacteriaceae are more common in community patients than in hospitalized patients. The average age of patients is 52 years and the age group most affected by these enterobacteria is 46 - 60 years (23.33%). The female sex is the most affected sex with (51.07%) against (48.97%) for the male sex with 1.04 as sex ratio. The hospitalization departments most affected by these enterobacteria are Nephrology (29.23%) and Endocrinology (21.54%). Up to 75% of the Enterobacteriaceae isolates show high resistance to ampicillin, amoxicillin-clavulanic acid, ticarcillin, piperacillin-tazobactam, cefoxitin, cefixime, ceftazidime, ceftriaxone, cotrimoxazole, nalidixic acid and ofloxacin. Conclusion: The high rate of antibiotic resistance among enterobacteria in urine is of concern. Only a few Enterobacteriaceae show low resistance to ertapenem, imipenem, amikacin, gentamicin, fosfomycin and nitrofurantoin. Therefore, these antibiotics are recommended as first line treatment for urinary tract infections.

关键词： Antibiotic Resistance Urinary Tract Infections Enterobacteriaceae Viteck-2 Niger

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First Case of Von Willebrand Disease in Niger

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Open Journal of Blood Diseases 2021年第1期11卷 1-5页

作者： Amadou Djibrilla-Almoustapha Moustapha Maman-Brah Moustapha Elhadji-Chefou Maman Rabiou Badé Amal Al-Azhari Youssoufa Seydou-Moussa Maman Aminou Mahamane Sani Mamane Daou Souleymane Brah Badé Malam-Abdou Hematology Department of the niamey National hospital Niamey Niger Department of Internal Medicine of the National hospital of niamey Niamey Niger Endocrinology Department of the niamey general reference hospital Niamey Niger Department of Internal Medicine of the general reference hospital of niamey Niamey Niger

Von Willebrand’s disease was first described in 1926 by Erik Von Willebrand. It is a genetic, constitutional defect of hemostasis that is different from hemophilia. It is classified among the rare diseases whose clinical manifestations are dominated by a hemorrhagic profile, which varies from patient to patient. It is an easily diagnosed disease based on a quantitative and qualitative bioassay of VWF. Treatment is multidisciplinary and is based on well-structured prevention. We report the first case of von Willebrand disease in Niger, diagnosed in the Hematology Department of niamey’s National hospital.

关键词： Willebrand Disease Onco Hematology niamey Niger

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Torsion of a Large Ovariancyst during the Postpartum Period: A Case Report from the Niger-Turkey Friendship hospital in niamey

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Open Journal of Obstetrics and Gynecology 2022年第11期12卷 1134-1139页

作者： Rahamatou Madeleine Garba Hamidou Soumana Diaouga Nafiou Idi Bibata Boukari Bako Salamatou Guédé Maina Oumara Madi Nayama Niger-Turkey Friendship hospital Niamey Niger Abdou Moumouni University Niamey Niger Issaka Gazobi Maternity hospital Niamey Niger general reference hospital of niamey Niamey Niger

Adnexal torsion is defined by the existence of a partial or complete torsion of the ovary and a tubal portion around its vascular pedicle. It is a rare gynecological emergency. We report the case of adnexal torsion on a large postpartum ovarian cyst in a 40-year-old patient. The diagnosis was suspected based on clinical and ultrasound signs and confirmed by exploratory laparotomy. The appearance of the cyst was suggestive of a mucinous cystadenoma of the ovary. The treatment was radical by performing an adnexectomy. The surgical piece weighed 5.2 kg. The postoperative course was simple. Anatomopathological examination had not been carried out;the parents had buried the operating piece.

关键词： Pelvic Pain Adnexal Torsion Postpartum Period Mucinous Cystadenoma

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Preliminary Results of Dementia Prevalence among Elderly People at Home by Cognitive Disorder Adapted Test of niamey (Niger)

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Open Journal of Internal Medicine 2023年第4期13卷 471-480页

作者： Abdoulkader Andia Maman Sani Bako Maiga Zara Garba Kané Karima R. Saïdou Daou Mamane Brah Souleymane Eric Adehossi Department of Internal Medicine and Geriatric Niamey General Reference Hospital Niamey Niger Department of Internal Medicine Maradi General Reference Hospital de Maradi Maradi Niger Department of Internal Medicine Niamey National Hospital Niamey Niger

Introduction: Neurocognitive disorders are frequent with aging and are often seen at advancing stages in our context. It is really difficult to evaluate rapidly Nigerien elderly persons according to tools available on cognitive status while there is a great number of uneducated elderly people who suffer from cognitive deficiency. The purpose was to determine neurocognitive disorders prevalence in uneducated groups and Muslim elderly people by using the cognitive disorder examination (Codex) test adopted in the population living at home in niamey (Niger). Materials and Methods: These are the results of a preliminary prospective study with simple three (3) random sampling concerning elderly people aged 60 and over living at home in whom the codex test adapted to niamey was administered in uneducated Muslim elderly people for a total duration of four (4) minutes. This screen-adapted test should be completed by the mini-mental test of Senegal which is adapted globally to uneducated people in hospitals. The basic Codex test was developed in France for educated people, so we used this basic test in our educated people in the same study. Results: A total of 198 patients had been collected, of which 51.5% were female with an average age of 68 years with extremes of 60 to 84 years. 40 were educated. Among educated persons, 62.5% had a very low probability of dementia and 5% had a very high probability of dementia in the first step of the Codex. In the second step, 12.5% had a low probability of dementia and 20% had a high probability in the same group, while 51.3% had a very low probability of dementia and 21.3% had a very high probability of dementia in the first step of CODEX in uneducated elderly. In the second step in the same group, 12.6% had a low probability and 14.5% had a high probability of dementia. Conclusion: The adapted codex test of niamey is simple and could be rapidly used to screen dementia among uneducated elderly Muslim prayers, and then could confirm it

关键词： Dementia Elderly Adapted Codex of niamey Prevalence Niger

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Experience of Menopause for Women in the niamey Region, Republic of Niger

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Open Journal of Obstetrics and Gynecology 2022年第11期12卷 1147-1154页

作者： Rahamatou Madeleine Garba Daddy Gaoh Nassira Salamatou Guédé Hamidou Soumana Diaouga Nafiou Idi Maina Oumara Madi Nayama Niger-Turkey Friendship hospital Niamey Niger Abdou Moumouni University Niamey Niger Issaka Gazobi Maternity hospital in niamey Niger general reference hospital of niamey Niamey Niger

Introduction: Menopause is poorly documented in Africa. For most of the women living there, the experience of this period does not seem to be very problematic. For women living in rural areas, other concerns are more prominent. Methods: The study was prospective, quantitative and qualitative about 500 cases collected over a period of 6 months. The study involved postmenopausal women in the niamey region of public services, in certain residential areas, or accompanying people in health structures. Parameters taken into account were sociocultural, antecedents, experience, knowledge, and management of menopause. The data was entered and analyzed using Microsoft Office Word 2010 and Microsoft Office Excel 2010 software. Results: The average age was 56.4 years with extremes of 40 and 80 years;57% were still living with their husbands and 39% widows;60.2% housewives;53% uneducated, 17% have higher education;60.2% had had at least 6 children and 39.6% had used contraception. The comorbidities observed were arterial hypertension (24.4%) and diabetes (7%). As for the representation that women made of menopause, for all of them, this stage is the beginning of old age. The most frequent signs were asthenia (86.2%) and mood disorders (70.6%). Almost all of the patients (99.8%) had not used hormonal treatment for the menopause and among them 27% the management of the menopause was with traditional means. Conclusion: Menopausal disorders are certainly a reality in our socio-cultural context. They are not a primary concern either through ignorance or resignation of the women concerned.

关键词： Menopausal Experience Climacteric Syndrome HTM niamey

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Plasma Cell Leukemia: A Case Report and Literature Review

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Open Journal of Blood Diseases 2020年第3期10卷 71-76页

作者： B. Malam-Abdou A. Djibrilla Almoustapha M. Chefou S. Brah M. Maman Brah F. Abba Ousmane M. Daou M. A. Mahamane Sani M. R. Badé E. O. Adehossi Onco-Hematology Department of niamey National hospital Niamey Niger Department of Internal Medicine at the general reference hospital of niamey Niamey Niger Department of Internal Medicine at niamey National hospital Niamey Niger

Plasma cell leukemia is a rare malignant hemopathy, characterized by a peripheral plasma cell proliferation of more than 20% of the leukocyte formula. A few rare cases have been described. From which we report a case of plasma cell leukemia in a 52-year-old Nigerien subject initially in a coma, whose anemia led to the diagnosis in the Onco-Hematology department of the National hospital of niamey and the evolution was marked by clinical and biological remission after 3 cures of CTD, but died in an infectious picture after 6 cures.

关键词： Plasma Cell Leukemia Onco-Hematology HNN niamey-Niger

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Rhupus: About Two Clinical Cases in Niger and Literature Review

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Open Journal of Internal Medicine 2022年第1期12卷 46-51页

作者： Andia Abdoulkader Brah Souleymane Daou Mamane Tahirou Harouna Migita Moctar Adehossi Eric Department of Internal Medicine and Geriatric Reference General Hospital Niamey Niger Department of Internal Medicine H&ocirc pital National de niamey Niamey Niger

Background: Rhupus is the rare association of two autoimmune diseases, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) diagnosed according to validated ACR criteria. We present the first series of rhupus in Niger. Observation 1: This is a patient suffering from chronic polyarthritis in whom the diagnosis of active seropositive, erosive and deforming RA had been made according to the 1987 ACR criteria and SLE on the presence of 4 criteria according to the 1997 ARA criteria and putting under conventional synthetic DMARDs. The outcome was favorable with a remission achieved after 8 weeks with a disease activity score (DAS) 28 at 2.2. Observation 2: 58-year-old patient with known diabetes type 2 in whom the diagnosis of rhupus was made according to the ACR/EULAR 2010 criteria for RA with a DAS28 of 3.6 and the 2019 LES criteria at 18 points with a SLEDAI score of 6. The evolution was marked by the occurrence of a myocardial infarction with a favorable outcome under medical management. Conclusion: Rhupus is a rare entity that can be complicated by cardiovascular events with the presence of an independent cardiovascular risk factor.

关键词： Rhupus ACR/EULAR Criteria Niger

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Epidemiological Aspects of Osteoarticular and Rheumatological Diseases Related to Diabetes in Niger

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Journal of Diabetes Mellitus 2022年第4期12卷 263-270页

作者： Mahamane Aminou Mahamane Sani Maman Daou Rachida Hamma Alzouma Moussa Elh Ibrahim Aboubacar Mamane Barga Moctar Midjitaba Hassan Maman Larwanou Maazou Amadou Djibrilla Souleymane Brah Eric Adehossi Department of Endocrinology Diabetology Nutrition H&#244 pital Général de Référence (general reference hospital) Niamey Niger Department of Internal Medicine National Hospital of Niamey Niamey Niger Department of Onco-Hematology National Hospital of Niamey Niamey Niger Department of Internal Medicine General Hospital of Niamey Niamey Niger

Type 1 or 2 diabetes can be complicated by numerous non-specific joint conditions. Sometimes revealing, these affections are frequent but often remain unrecognized. However, they are the cause of a significant functional handicap. The objective of this work is to describe the osteoarticular rheumatological disorders in diabetics consulting or hospitalized in the rheumatology and internal medicine departments of the National hospital of niamey and the Magori Polyclinic. This was a cross-sectional study at the Rheumatology Department in collaboration with the Internal Medicine Department within the National hospital of niamey and Polyclinic Magori over a period of 7 months (December 2018 to July 2019). One hundred (100) diabetic patients with osteoarticular diseases were collected, 75% of whom were women with a female/male sex ratio of 0.33. The average age was 56 years with extremes of 21 and 90 years. Forty-three percent (43%) of the patients had diabetes for more than 10 years, with an average age of 13 years. The average BMI was 28.08 ± 5.42 kg/m2. Poor glycemic control was found in the majority of patients (92%). Gonarthrosis was the most common disease associated with diabetes (89%). In the context of joint stiffening syndrome, the most frequent problem was a protruding finger, found in 4% of patients, followed by retractile capsulitis in 3% of the 100 cases. Infectious complications were dominated by septic arthritis in 4% of patients. The presence of one or more degenerative complications of diabetes (nephropathy, retinopathy, nephropathy) was the most frequent factor associated with osteoarticular diseases in our diabetic patients. This work underlines the great variety and frequency of osteoarticular affections during diabetes, hence the interest in optimal glycemic control of a close collaboration between rheumatologists and endocrinologists in order to avoid as much as possible the development of these rheumatological affections which are the so

关键词： Diabetes Osteoarticular Rheumatological Diseases niamey

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Carcinosarcoma of the breast:Facing the challenge of a rare nosologic entity

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World Journal of Clinical Cases 2025年第2期13卷 14-20页

作者： Aikaterini Mastoraki Maria Tsamopoulou Foivos-Konstantinos Stamatis Alexios Strimpakos Ero Mouchtouri Christiana Panagi Evgenia Mela Sotiria Mastoraki Aristotelis Kechagias Dimitrios Schizas Department of Surgery National and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece Department of Surgery National and Kapodistrian University of AthensAthens 11527Greece Department of Medical Oncology Hygeia HospitalAthens 15123Greece Department of Radiology Henry Dunant Hospital CenterAthens 11526Greece Department of Surgery Athens Metropolitan HospitalAthens 15562Greece

Carcinosarcoma(CS),also known as metaplastic breast carcinoma with mesenchymal differentiation,is one of the five distinct subtypes of metaplastic breast *** is considered as a mixed,biphasic neoplasm consisting of a carcinomatous component combined with a malignant nonepithelial element of mesenchymal origin without an intermediate transition *** cellular origin of this neoplasm remains controversial,most researchers declare that neoplastic cells derive from a cellular structure with potential biphasic *** recent research on the therapeutic strategies against CS neoplastic disorders,surgical resection appears the only potentially curative *** CS metastasize by the lymphatic route,axillary assessment with sentinel lymph node biopsy and/or axillary lymph node dissection is always ***,the tumor also presents a hematogenous metastatic pattern including pleural,pulmonary,liver,brain and less commonly bone ***,surgical removal of breast CS does not necessarily ensure patient’s long-term ***,alternative therapies,such as radio-and chemotherapy proved insufficient and 5-year survival rate is ***,there is evidence that following surgery,the combination of radio and chemotherapy is associated with a better prognosis than either treatment *** aim of this review is to evaluate the results of surgical treatment for breast CS with special reference to the extent of its histological *** features,histogenesis,morphological and immunochemical findings are discussed,while the role of current diagnostic and therapeutic management of this aggressive neoplasm is emphasized.

关键词： Carcinosarcoma Breast Diagnostic approach Therapeutic management Prognostic parameters

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