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Food Science and Human Wellness 2025年

作者： Lu Chen Yueqi Yang Ning Zhang Bin Sun Hongxia Che Zhengping Wang Jun Han Min Wen Institute of Biopharmaceutical Research， Liaocheng University College of Marine Science and Biological Engineering， Qingdao University of Science and Technology Pet nutrition R research and Development Center Gambol Pet Group Co.，ltd.

The cognitive impairments resulting from insufficient sleep have emerged as a significant public health concern in contemporary society， lacking effective treatments due to the absence of elucidation regarding its molecular mechanism. This study aimed to investigate the efficacy of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) against cognitive deficits in a mouse model of chronic sleep deprivation (CSD)， and to elucidate the underlying mechanisms. CSD mice display significant cognitive deficits in the Morris water maze task with obviously neuronal damage. We observed that dysregulation of iron transport proteins (IRP1， TfR1， DMT1， and FPN1) in CSD mice resulted in iron deposition in the cortex. Subsequent assessment revealed upregulation of mitophagy and neuronal lipid peroxidation and downregulation of proteins in the mitochondrial respiratory chain complexes (I-V). Further molecular analysis revealed inhibition of the Sirt3-Nrf2 pathway and its downstream antioxidant molecules (e.g. GPX4， HO-1， SOD2， and NQO1). In contrast， dietary supplementation with DHA or EPA alleviated CSD-induced cognitive impairment by inhibiting neuronal ferroptosis through regulating iron-mitophagy homeostasis. Notably， EPA showed superior efficiency in ameliorating cognitive impairment， potentially due to its stronger interaction with Sirt3 compared to DHA.

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Bifidobacterium breve CCFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

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Food Science and Human Wellness 2025年第1期14卷 307-331页

作者： Bowen Li Mengfan Ding Xiaoming Liu Haiqin Chen Jianxin Zhao RPaul Ross Catherine Stanton Shilong Jiang Wei Chen Bo Yang State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China APC Microbiome Ireland University College CorkCork T12 K8AFIreland Teagasc Food Research Centre Cork P61 C996Ireland nutrition and Metabolism Research Division Innovation CenterHeilongjiang Feihe Dairy Co.Ltd.Beijing 100015China PKUHSC-China Feihe Joint Research Institute of nutrition and Healthy Lifespan Development Beijing 100083China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c *** BALB/c mice were assigned to the control group(administration saline)and the CCFM1078 group(administration *** CCFM1078,3×10^(9) CFU/day)in 3-,4-,and 5-week *** the groups have male and female *** findings demonstrate that *** CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites(hexadecanamide,linoleoyl ethanolamide,and palmitoyl ethanolamide),the genes and proteins expression related to the growth hormone(GH)/insulin-like growth factors-1(IGF-1)axis and Gs/PKA/CREB signaling pathways,as well as downstream osteogenic and osteoclastic differentiation *** effects of *** CCFM1078 were different with age and gender *** finding suggests *** CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.

关键词： Bifidobacterium breve Bone development Gut microbiota GH/IGF-1 axis Gs/PKA/CREB signaling pathway

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β-酪蛋白与婴幼儿生长和发育

临床儿科杂志 2014年第2期32卷 198-200页

作者： Michele J. Sadler Nicholas Smith rank nutrition ltd Bethersden Kent Edanz Group ltd Kwun Tong Hong Kong

母乳是婴幼儿的首选营养源。世界卫生组织（WHO）建议婴儿出生后头6个月应完全以母乳喂养。此外，应坚持母乳辅以适当的固体食物喂养至少两年[1]。然而，并非所有婴儿均可得到母乳喂养，一些婴儿也无法获得捐赠母乳。在这种情况下需要... 详细信息

母乳是婴幼儿的首选营养源。世界卫生组织（WHO）建议婴儿出生后头6个月应完全以母乳喂养。此外，应坚持母乳辅以适当的固体食物喂养至少两年[1]。然而，并非所有婴儿均可得到母乳喂养，一些婴儿也无法获得捐赠母乳。在这种情况下需要用婴幼儿配方奶代替母乳。牛奶含有相对价廉的蛋白质与营养素且来源丰富，因此大多数婴幼儿配方奶均产自牛奶。但是，牛奶与母乳的蛋白质成分差异颇大。如，母乳主要含乳清蛋白，酪蛋白∶乳清蛋白约为40∶60（泌乳早期10∶90，泌乳后期50∶50），而牛奶的酪蛋白∶乳清蛋白则高达80∶20[2]。

关键词：婴幼儿酪蛋白母乳喂养发育生长世界卫生组织乳清蛋白固体食物

Bifidobacterium longum *** CCFM1269 promotes intestinal barrier and release of IFN-β through TLR4-TRIF dependent way in growing mice

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Food Science and Human Wellness 2025年第1期14卷 345-360页

作者： Mengfan Ding Bo Yang Bowen Li Haiqin Chen Renqiang Yu RPaul Ross Catherine Stanton Shilong Jiang Jianxin Zhao Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China Department of Neonatology Wuxi Maternity and Child Health Care HospitalAffi liated Women’s Hospital of Jiangnan UniversityWuxi 214122China APC Microbiome Ireland University College CorkCork T12 R229Ireland Teagasc Food Research Centre Cork P61 C996Ireland nutrition and Metabolism Research Division Innovation CenterHeilongjiang Feihe Dairy Co.Ltd.Beijing 100015China PKUHSC-China Feihe Joint Research Institute of nutrition and Healthy Lifespan Development Beijing 100083China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Bifidobacterium longum *** is a commensal bacterium that predominates in the infant gut,playing a critical role in both preventing foreign infections and facilitating immune *** study aimed to explore the effects of *** *** supplementation on interferon-beta(IFN-β)secretion and intestinal barrier improvement in growing *** and male mice were orally administered either saline or *** *** CCFM1269 or I5TI(1×10^(9) CFU/mice per day,n=8)from 1-week-age until 3-,4-,and *** sequencing analysis revealed that CCFM1269 exhibited potential antiviral capacity through increasing 2'-5'oligoadenylate synthetase(OAS).Additionally,CCFM1269 supplementation significantly increased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLR4-TRIF-dependent signaling ***,this effect was not observed in 4-and 5-week-old ***,both CCFM1269 were found to modulate the gut microbiota composition and enhance the intestinal barrier function in 3-,4-,and 5-week-old *** summary,the results of this study suggested that *** *** CCFM1269 promoting intestinal barrier and releasing IFN-β in growing mice was in a strain-specific and time-dependent manner.

关键词： Bifidobacterium longum subsp.infantis Intestinal barrier interferon-beta(IFN-β)secretion Age dependence

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Effects of a multi-enzyme complex on growth performance,nutrient utilization and bone mineralization of meat duck

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Journal of Animal Science and Biotechnology 2015年第4期6卷 402-409页

作者： Qiufeng Zeng Xueqin Huang Yuheng Luo Xuemei Ding Shiping Bai Jianping Wang Yue Xuan Zhuowei Su Yonggang Liu Keying Zhang Institute of Animal nutrition Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationSichuan Agricultural University Adisseo Asia Pacific Pte ltd

Background： Previous studies with broiler have shown dietary supplementation with multi-enzyme complex containing non-starch polysaccharides （NSP） degrading enzymes and phytase is efficient in releasing phosphorus （P）, calcium （Ca）, energy and amino acids from corn-soybean meal diets or corn-sorghum diets, hence compensating considerable levels of nutrients in formulation. Notwithstanding, such potentials have not been well defined in duck nutrition. Giving China being the largest duck producing country, we conducted this study to establish adequate specifications of major nutrients along with multi-enzyme complex to meat duck from day-old to slaughter, focusing on performance, utilization of nutrients and bone mineralization. Five dietary treatments were： Positive control （PC,T1）： the nutrients concentration of diet for 1 to 14 d of age were apparent metabolizable energy（AME） 2,800 kcal/kg, crude protein （CP）1 9.39%, Ca 0.85%, available phosphorus （avP） 0.42%; for 15 to 35 d of age these parameters were AME 2,900 kcal/kg, CP 16.47%,Ca 0.76%,avP 0.38%; Negative control 1（NC1,7-2）, the AME and digestible amino acids （DAA） were reduced by 70 kcal/kg and 2.0%, avP and Ca by 1.0 g/kg from PC diet; Negative control 2（NC2,T4）, the down- spec from PC diet was AME 100 kcal/kg, DAA 2.5%, avP 1.5 g/kg and Ca 1.2 g/kg; The enzyme complex was added at the same dosage （200 mL/1,000 kg） on NC1 （T3） and NC2 （T5） diets. Results： Comparing with the ducks fed on T1, T3 and T5 diets, the birds fed on NC2 diet showed the lowest （P 〈 0.05） body weight （ d 14 and 35）, feed intake （d 35）, tibia ash, Ca and P contents （d 14 and 35）, and the utilization of nutrients （P 〈 0.05）. The supplementation with the enzyme complex to the NC diets restored growth rate, utilization of nutrients and bone mineralization to the level of the PC diet, and increased AME by 60 kcal/kg and 117 kcal/kg, respectively for the NC1 and NC2 diets. Conclusion： These results suggest that down-spec AME by 100 kcal/kg,

关键词： Formulation specification Growth Phytase Meat duck Non-starch polysaccharides enzyme

Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets

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Science China(Life Sciences) 2022年第10期65卷 2062-2075页

作者： Wen Ren Bing Yu Jie Yu Ping Zheng Zhiqing Huang Junqiu Luo Xiangbing Mao Jun He Hui Yan Jinlong Wu Daiwen Chen Yuheng Luo Key Laboratory for Animal Disease-Resistance nutrition of Ministry of Education of China Key Laboratory for Animal Disease-Resistance Nutrition and Feed of Ministry of Agriculture of ChinaKey Laboratory of Animal Disease-resistant Nutrition of Sichuan Provinceand Animal Nutrition InstituteSichuan Agricultural UniversityChengdu61l130China DSM(China)Animal nutrition Research Center Co. LtdBazhou 065799China

Growing evidences show a direct link between diarrhea and disorders of gut microbiota in ***,whether there are microbial markers associated with post-weaning diarrhea remains *** the current study,we compared the microbial community,functions and metabolites between healthy weaned piglets(group H,n=7)and piglets with post-weaning diarrhea(group D,n=7),in order to find out diarrhea associated microbial *** of 7 fecal samples was collected from H and D piglets(weaned at 21 d and sampled at 26 d).The metagenomic and untargeted metabolomic analysis revealed that the microbial composition,function and metabolic profile in D pigs was considerably reshaped,including the reduced abundance and number of Bacteroides,which significantly correlated with the diarrhea status of *** carbohydrate metabolism,biosynthesis and metabolism,lipid metabolism,amino acid metabolism,and the activity of glycan and carbohydrates digestion related enzymes showed extensively down-regulated in D pigs compared with H *** significantly changed the metabolic profiles of fecal microbiota,and most of the altered metabolites were negatively or positively correlated with the change in the abundance of *** conclusion,the lower abundance of Bacteroides and its associated metabolic dysfunction may be regarded as microbial markers of physiological post-weaning diarrhea in piglets.

关键词： post-weaning piglet diarrhea Bacteroides metabolic dysfunction commensal microbiota

Potential of essential oils for poultry and pigs

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Animal nutrition 2018年第2期4卷 179-186页

作者： Hengxiao Zhai Hong Liu Shikui Wang Jinlong Wu Anna-Maria Kluenter DSM(China)Animal nutrition Research Center DSM nutritional Products ltd.

The increasing pressure of abolishing and/or decreasing the use of antibiotics as antimicrobial growth promoters for livestock calls for alternative solutions to sustain the efficiency of current livestock *** the alternatives, essential oils have a great potential and are generally considered natural, less toxic, and free from *** oils have been proven in numerous in vitro studies to exert antimicrobial effects on various *** current review touched on the basics of essential oils, and the in vivo effects of essential oils on growth, intestinal microflora, anti-oxidation, immune functionality, meat qualities as well as the possible modes of action in poultry and pigs, and the future research areas were proposed.

关键词： Antibiotics Chickens Essential oils Pathogens Pigs

Supplementing daidzein in diets improves the reproductive performance, endocrine hormones and antioxidant capacity of multiparous sows

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Animal nutrition 2021年第4期7卷 1052-1060页

作者： Yan Li Guoru He Daiwen Chen Bing Yu Jie Yu Ping Zheng Zhiqing Huang Yuheng Luo Junqiu Luo Xiangbing Mao Hui Yan Jun He Institute of Animal nutrition Sichuan Agricultural UniversityKey Laboratory of Animal Disease-Resistance NutritionMinistry of EducationChengdu 611130China New Hope Liuhe Co.ltd. China

Certain hormones play important roles in modulating mammalian reproductive *** is a well-known isoflavonic phytoestrogen that possesses oestrogenic *** study was conducted to probe the effects of daidzein supplementation in gestation diets on the reproductive performance in sows.A total of 120 multiparous sows(Landrace x Yorkshire)were randomly assigned to 2 groups(n=60)and fed either a base diet(control)or one containing 200 mg/kg daidzein during *** discovered that daidzein supplementation significantly increased the total number of piglets born per litter and number of piglets born alive per litter(P<0.05),decreased the farrowing time(P<0.05)and increased the serum oestrogen and progesterone concentrations(P<0.05)at 35 d of ***,serum immunoglobulin G(IgG)concentration and superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)activities were higher in the daidzein-treated group than in the control group at35 d of gestation(P<0.05).Daidzein increased the serum SOD activity and total anti-oxidative capacity(T-AOC)at 85 d of gestation(P<0.05).Interestingly,daidzein elevated the expression levels of the sodium-coupled neutral amino acid transporter 1(SLC38 A1)and insulin-like growth factor 1(IGF-1)genes in the placenta(P<0.05).These results suggest that daidzein ingestion could improve sow reproductive performance by changing serum hormones,elevating anti-oxidative capacity and upregulating critical functional genes in the placenta.

关键词： Daidzein Immunity Anti-oxidative Reproductive performance Sow

Growth performance of nursery and grower-finisher pigs fed diets supplemented with benzoic acid

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Animal nutrition 2017年第3期3卷 232-235页

作者： Hengxiao Zhai Wen Ren Shikui Wang Jinlong Wu Patrick Guggenbuhl Anna-Maria Kluenter DSM (China) Animal nutrition Research Center Co.ltd. DSM nutritional Products France Centre de Recherche en Nutrition Animale DSM nutritional Products ltd.

Two experiments were conducted to investigate the efficacy of benzoic acid on the growth performance of nursery and grower-finisher pigs. A randomized complete block design was used in both experiments with the initial body weight as the blocking factor. There were 3 treatments corresponding to 3 dietary levels of benzoic acid: 0, 0.3%, and 0.5%. In experiment 1, a total of 144 PIC L1050 barrows(initial body weight 7.1 ± 0.6 kg) were used with each treatment replicated 8 times. In experiment 2, a total of 288 PIC L1050 barrows(initial body weight 36.1 ± 3.6 kg) were used with each treatment replicated 16 *** were 6 barrows in each replicate pen for both experiments. Experiments 1 and 2 lasted 28 and 70 days, respectively. In experiment 1, average daily gain(ADG) of all growth phases increased linearly(P < 0.05) with increasing supplementation of benzoic acid, which led to a linear improvement in average body weight on d 28(P < 0.05). There was also an improvement in feed conversion ratio(FCR) of d 0 to 14(linear effect: P < 0.05) and in average daily feed intake(ADFI) of d 14 to 28 and d 0 to 28(linear effect:P < 0.01). In experiment 2, ADG during d 0 to 35 and d 35 to 70 and average body weight on d 35 improved linearly(P < 0.05) with increasing supplementation of benzoic acid. Average daily gain of d 0 to70 and average body weight on d 70 increased significantly in a both linear and quadratic manner. There was a linear improvement in FCR in all growth phases(P < 0.05). In conclusion, the dietary inclusion of benzoic acid at the supplementation levels of 0.3% and 0.5% significantly improved the growth performance of nursery and grower-finisher pigs in the current study; the nursery pigs responded to the dietary supplementation of benzoic acid up to 0.5% linearly while the grower-finisher pigs achieved the optimal ADG at the calculated supplementation level of 0.36%.

关键词： Benzoic acid Nursery pig Grower-finisher pig Average daily gain Average daily feed intake Feed conversion ratio

Dendrobium officinale polysaccharide attenuates type 2 diabetes in mice model by modulating gut microbiota and alleviating intestinal mucosal barrier damage

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Food Science and Human Wellness 2025年第1期14卷 112-123页

作者： Xiaoxia Chen Chun Chen Changyang Ma Wenyi Kang Junlin Wu Xiong Fu Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety Guangzhou 510640China SCUT-Zhuhai Institute of Modern Industrial Innovation School of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640China Guangzhou Institute of Modern Industrial Technology Guangzhou 511458China Overseas Expertise Introduction Center for Discipline Innovation of Food nutrition and Human Health(111 Center) Guangzhou 510640China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Guangzhou Wondfo Health Science and Technology Co. Ltd.Guangzhou 510640China

The purpose of this study was to investigate the hypoglycemic effect and mechanism of D endrobium officinale polysaccharide(DOP)on type 2 diabetes mellitus(T2DM)mice established by high-fat diet and *** results showed that DOP improved glycolipid metabolism and serum inflammation levels,and inhibited intestinal-derived lipopolysaccharide(LPS)translocation,suggesting that inhibiting LPS-mediated intestinal barrier damage may be a key target for DOP to alleviate ***,the study found that DOP reduced intestinal inflammation and oxidative stress levels,significantly up-regulated the mRNA expression of tight junction proteins Claudin-1,Occludin and zonula occluden-1(ZO-1),and ameliorated intestinal epithelial *** addition,DOP strongly inhibited the intestinal pathogenic bacteria and LPS-producing bacteria Helicobacter,Enterococcus and Desulfovibrio with a reduction rate of 95%,73% and 9%,respectively,and promoted the proliferation of anti-inflammatory bacteria Bifidobacterium and Lactobacillus by 139% and 8%,*** together,the hypoglycemic effect of DOP was related to the protection of intestinal mucosal barrier,and its underlying mechanism lied in its excellent anti-inflammatory and gut microbiotamodulatory effects,providing a theoretical basis for developing DOP as a novel prebiotic in functional food for diabetes.

关键词： Dendrobium officinale polysaccharide Hypoglycemic Mechanism Lipopolysaccharide Gut microbiota

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