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Risk Factors for the Development of Hepatocellular Carcinoma in Thailand

Journal of Clinical and Translational Hepatology 2015年第3期3卷 182-188页

作者： Taned Chitapanarux Kannika Phornphutkul Division of Gastrohepatology Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai Thailand Division of Gastrohepatology Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai Thailand Gastrohepatology unit Rajavej Chiang Mai Hospital Chiang Mai Thailand

Hepatocellular carcinoma (HCC) is the most common type of liver cancer *** incidence of HCC is on the rise in Thailand,where it has become the most common malignancy in males and the third most common in ***,we review some of the risk factors that have contributed to this increase in HCC incidence in the Thai *** B virus (HBV) is the main etiologic risk factor for HCC,followed by hepatitis C virus (HCV).Patients with HBV genotype C have a higher positive rate of hepatitis B early antigen (HBeAg) and progress to cirrhosis and HCC earlier than genotype *** HCV patients,16% developed HCC associated cirrhosis by year 5 after diagnosis,and the cumulative risk for death from HCC at year 10 was 60%.Dietary exposure to the fungal hepatocarcinogen aflatoxin B1 has been shown to interact synergistically with HBV infection to increase the risk of early onset *** alcohol abuse remains an important risk factor for malignant transformation of hepatocytes,frequently in association with alcohol-induced *** recent years,obesity and metabolic syndrome have markedly increased the incidence of HCC and are important causes of HCC in some resource-rich regions.

关键词： Risk factors Hepatocellular carcinoma Etiology

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Global tissue and serum metabolomics reveals altered tumor biochemical activity in molecular subtypes of hepatocellular carcinoma and cholangiocarcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 13-14页

作者： Xinwei Wang Thaniya Mathuros Ruchirawat Anuradha Budhu Yotsawat Pomyen Jittiporn Chaisaingmongkoll Hien Dang Siritida Rabibhadana Benjarath Pupacdi Marshonna Forgues Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Anon Chotirosniramit Chawalit Pairojkul Chirayu Auewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang Chulabhorn Mahidol The Liver Carcinogenesis Section Laboratory of Human CarcinogenesisCenter for Cancer ResearchNational Cancer InstituteBethesdaMDUSA Chulabhorn Research Institute BangkokThailand Khon Kaen University Khon KaenThailand Chiang Mai University Chiang MaiThailand Chulabhorn hospital BangkokThailand rajavej hospital and Lampang Cancer Center Chiang MaiThailand

Objective:Cancer metabolite profiling(or cancer metabolomics),the global view of the biochemical end products of cellular processes,is a promising approach to identify biomarkers and tumor subgroups,and to understand ... 详细信息

关键词： Global tissue metabolomics

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Pathway analysis of metabolic genes and serum metabolites in HCC reveal aberrations associated with fatty acid and lipid metabolism

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Cancer Biology & Medicine 2018年第S1期15卷 12-13页

作者： Yotsawat Pomyen Anuradha Budhu Jittiporn Chaisaingmongkol Hien Dang Siritida Rabibhadana Benjarath Pupacdi Marshonna Forgues Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Chirayu Auewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang Chulabhorn Mahidol Mathuros Ruchirawat Xinwei Wang The Liver Carcinogenesis Section Laboratory of Human CarcinogenesisCenter for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Chulabhorn Research Institute BangkokThailand Khon Kaen University Khon KaenThailand Chiang Mai University Chiang MaiThailand Chulabhorn hospital BangkokThailand rajavej hospital and Lampang Cancer Center Chiang MaiThailand National Cancer Institute BangkokThailand

Objective:Hepatocellular carcinoma(HCC)is among the deadliest cancers in *** Thailand Initiative in Genomics and Expression Research for Liver Cancer(TIGER-LC)cohort was established to discover molecular markers that can be used for early detection and diagnosis and to understand possible molecular mechanisms underlying the disease.

关键词： Pathway analysis metabolic

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Common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 10-11页

作者： Jittiporn Chaisaingmongkol Anuradha Budhu Hien Dang Siritida Rabibhadana Benjarath Pupacdi So Mee Kwon Marshonna Forgues Yotsawat Pomyen Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Anon Chotirosniramit Chawalit Pairojkul Chirayu UAuewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang Maggie Cam Ping He Stephen M.Hewitt Kris Ylaya Xiaolin Wu Jesper B.Andersen Snorri S.Thorgeirsson Joshua J.Waterfall Yuelin J.Zhu Jennifer Walling Holly S.Stevenson Daniel Edelman Paul S.Meltzer Christopher A.Loffredo Natsuko Hama Tatsuhiro Shibata Robert H.Wiltrout Curtis C.Harris Chulabhorn Mahidol Mathuros Ruchirawat Xinwei Wang Laboratory of Human Carcinogenesis Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Laboratory of Chemical Carcinogenesis Chulabhorn Research InstituteBangkokThailand Center of Excellence on Environmental Health and Toxicology Office of Higher Education CommissionMinistry of EducationBangkokThailand Faculty of Medicine Khon Kaen UniversityKhon KaenThailand Faculty of Medicine Chiang Mai UniversityChiang MaiThailand HRH Princess Chulabhorn College of Medical Science BangkokThailand Chulabhorn hospital BangkokThailand rajavej hospital Chiang MaiThailand National Cancer Institute BangkokThailand Center for Cancer Research National Cancer InstituteBethesdaMarylandUSA FDA Silver SpringMarylandUSA Laboratory of Pathology Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Frederick National Laboratory for Cancer Research FrederickMarylandUSA Biotech Research and Innovation Center(BRIC) Department of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Genetics Branch Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Georgetown University Medical Center WashingtonDCUSA Division of Cancer Genomics National Cancer Center Research InstituteThe University of TokyoTokyoJapan Laboratory of Molecular Medicine Human Genome CenterThe Institute of Medical ScienceThe University of TokyoTokyoJapan Cancer Inflammation Program Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA

Objective:Intrahepatic cholangiocarcinoma(ICC)and hepatocellular carcinoma(HCC)are clinically disparate primary liver cancers with etiological and biological *** Thailand,both cancer types represent the primary cause ... 详细信息

关键词： Common molecular subtypes

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