Risk Factors for the Development of Hepatocellular Carcinoma in Thailand

作     者：Taned Chitapanarux Kannika Phornphutkul 

作者机构：Division of Gastrohepatology Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai Thailand Division of Gastrohepatology Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai Thailand Gastrohepatology unit Rajavej Chiang Mai Hospital Chiang Mai Thailand 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2015年第3卷第3期

页      面：182-188页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Risk factors Hepatocellular carcinoma Etiology 

摘      要：Hepatocellular carcinoma (HCC) is the most common type of liver cancer *** incidence of HCC is on the rise in Thailand,where it has become the most common malignancy in males and the third most common in ***,we review some of the risk factors that have contributed to this increase in HCC incidence in the Thai *** B virus (HBV) is the main etiologic risk factor for HCC,followed by hepatitis C virus (HCV).Patients with HBV genotype C have a higher positive rate of hepatitis B early antigen (HBeAg) and progress to cirrhosis and HCC earlier than genotype *** HCV patients,16% developed HCC associated cirrhosis by year 5 after diagnosis,and the cumulative risk for death from HCC at year 10 was 60%.Dietary exposure to the fungal hepatocarcinogen aflatoxin B1 has been shown to interact synergistically with HBV infection to increase the risk of early onset *** alcohol abuse remains an important risk factor for malignant transformation of hepatocytes,frequently in association with alcohol-induced *** recent years,obesity and metabolic syndrome have markedly increased the incidence of HCC and are important causes of HCC in some resource-rich regions.