BACKGROUND Immunosuppression(IS)therapy may contribute to cancer *** authors have proposed to reduce immunosuppression drugs dose in case of viral infections,in immunosuppression-related diseases,and in patients under...
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BACKGROUND Immunosuppression(IS)therapy may contribute to cancer *** authors have proposed to reduce immunosuppression drugs dose in case of viral infections,in immunosuppression-related diseases,and in patients undergoing *** present analysis reports the results of a systematic review on kidney transplant recipients undergoing immunosuppression and *** To define if it is necessary reduce immunosuppression drugs during *** The literature search was based on three electronic databases(Pubmed,Scopus,and Web of Science)using selected keywords linked through the"AND"and"OR"Boolean operators to build specific strings for each electronic search *** researchers independently screened the citations,and disagreement was resolved by discussion or through the intervention of a third *** review was conducted and reported according to the PRISMA *** data were narratively synthesized,and,where possible,frequencies,percentages,and ranges were *** The literature search resulted in 147 *** abstracts screening,21 records were selected for full-text *** of these were excluded,leaving six papers considered suitable for *** is still no clear evidence that withdrawing antimetabolites and/or calcineurin inhibitors and/or mammalian target of rapamycin-inhibitors,as opposed to continuing maintenance IS,improves patient survival in kidney transplant recipients with cancer undergoing *** few retrospective studies on small cancer patient cohorts are available in this setting,but without comparison of different immunosuppression *** where immunosuppression therapy was described,patient survival seemed to be correlated only with cancer stage and *** The results of this systematic review do not support the reduction of immunosuppression dose in patients undergoing radiotherapy.
PURPOSE: This study was designed to review experience at our hospital with retained colorectal foreign bodies. METHODS: We reviewed the consultation records at Los Angeles County +University of Southern California Gen...
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PURPOSE: This study was designed to review experience at our hospital with retained colorectal foreign bodies. METHODS: We reviewed the consultation records at Los Angeles County +University of Southern California General Hospital from October 1993 through October 2002. Ninety three cases of transanally introduced, retained foreign bodies were identified in 87 patients. Data collected included patient demographics, extraction method, location, size and type of foreign body, and postextraction course. RESULTS: Of 93 cases reviewed, there were 87 individuals who presented with first time episodes of having a retained colorectal foreign body. For these patients, bedside extraction was successful in 74 percent. Ultimately, 23 patients were taken to the operating room for removal of their foreign body. In total, 17 examinations under anesthesia and 8 laparotomies were performed (2 patients initially underwent an anesthetized examination before laparotomy). In the eight patients who underwent exploratory laparotomy, only one had successful delivery of the foreign object into the rectum for transanal extraction. The remainder required repair of perforated bowel or retrieval of the foreign body via a colotomy. In our review, a majority of cases had objects retained within the rectum; the rest were located in the sigmoid colon. Fifty five percent of patients (6/11) presenting with a foreign body in the sigmoid colon required operative intervention vs. 24 percent of patients (17/70) with objects in their rectum (P = 0.04). CONCLUSIONS: This is the largest single institution series of retained colorectal foreign bodies. Although foreign objects located in the sigmoid colon can be retrieved at the bedside, these cases are more likely to require operative intervention.
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