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Flexible interdigitated layered framework with multiple accessible active sites for high-performance CH_(3)I capture

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Science China Chemistry 2024年第5期67卷 1569-1577页

作者： Bo Tai Baoyu Li Linwei He Zhonglin Ma Shujing Lin Mingxing Zhang Junchang Chen Fuqi Wu Long Chen Xing Dai Fuyin Ma Zhifang Chai Shuao Wang State Key Laboratory of Radiation Medicine and protection School for Radiological and interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China

The development of adsorbent materials for effective capture of radioactive iodomethane(CH_(3)I) from the off-gas of used nuclear fuel reprocessing, remains a significant and challenging line of research because currently state-of-art adsorbents still suffer from low binding affinity with CH_(3)I. Here, we proposed a brand-new adsorption topological structure by developing a 2D interdigitated layered framework, named SCU-20, featuring slide-like channel with multiple active sites for CH_(3)I capture. The responsive rotating-adaptive aperture of SCU-20 enables the optimal utilization of all active sites within the pore for highly selective recognition and capture of CH_(3)I. A record-breaking CH_(3)I uptake capacity of 1.84 g/g was achieved under static sorption conditions with saturated CH_(3)I vapor. Both experimental and theoretical findings demonstrated that the exceptional uptake of SCU-20 towards CH_(3)I can be attributed to the confined physical electrostatic adsorption of F sites, coupled with the chemical nitrogen methylation reaction with uncoordinated N atoms of pyrazine. Moreover, dynamic CH_(3)I uptake capacity potentially allows for the capture of CH_(3)I in simulated real-world off gas reprocessing conditions. This study highlights the potential of SCU-20 as a promising candidate for efficient capture of iodine species and contributes to the development of effective solutions for radioactive iodine remediation.

关键词： 2D interdigitated layered framework iodomethane dual-sites electrostatic interaction physisorption and chemisorption

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Flexible interdigitated layered framework with multiple accessible active sites for high-performance CHI capture

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Science China Chemistry 2024年

作者： Bo Tai Baoyu Li Linwei He Zhonglin Ma Shujing Lin Mingxing Zhang Junchang Chen Fuqi Wu Long Chen Xing Dai Fuyin Ma Zhifang Chai Shuao Wang State Key Laboratory of Radiation Medicine and protection School for Radiological and interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University

The development of adsorbent materials for effective capture of radioactive iodomethane(CH3I) from the off-gas of used nuclear fuel reprocessing, remains a significant and challenging line of research because currently state-of-art adsorbents still suffer from low binding affinity with CH3I. Here, we proposed a brand-new adsorption topological structure by developing a 2D interdigitated layered framework, named SCU-20, featuring slide-like channel with multiple active sites for CH3I capture. The responsive rotating-adaptive aperture of SCU-20 enables the optimal utilization of all active sites within the pore for highly selective recognition and capture of CH3I. A record-breaking CH3I uptake capacity of 1.84 g/g was achieved under static sorption conditions with saturated CH3I vapor. Both experimental and theoretical findings demonstrated that the exceptional uptake of SCU-20 towards CH3I can be attributed to the confined physical electrostatic adsorption of F sites, coupled with the chemical nitrogen methylation reaction with uncoordinated N atoms of pyrazine. Moreover, dynamic CH3I uptake capacity potentially allows for the capture of CH3I in simulated real-world off gas reprocessing conditions. This study highlights the potential of SCU-20 as a promising candidate for efficient capture of iodine species and contributes to the development of effective solutions for radioactive iodine remediation.

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A pH-responsive nanoparticle delivery system containing dihydralazine and doxorubicin-based prodrug for enhancing antitumor efficacy

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Aggregate 2024年第1期5卷 436-450页

作者： Lianxue Zhang Jianxiang Huang Damiano Buratto Panli Han Zaixing Yang Ruhong Zhou Institute of Quantitative Biology Shanghai Institute for Advanced StudyCollege of Life SciencesZhejiang UniversityHangzhouChina State Key Laboratory of Radiation Medicine and protection School for Radiological and Interdisciplinary Sciences(RAD-X)Soochow UniversitySuzhouChina Cancer Center Zhejiang UniversityHangzhouChina Department of Chemistry Columbia UniversityNew YorkNew YorkUSA

The efficacy of nanoparticle(NP)-based drug delivery technology is hampered by aberrant tumor stromal microenvironments(TSMs)that hinder NP ***,the promotion of NP permeation into deep tumor sites via the regulation of tumor microenvironments is of critical ***,we propose a potential solution using a dihydralazine(HDZ)-loaded nanoparticle drug delivery system containing a pH-responsive,cyclic RGD peptide-modified prodrug based on doxorubicin(cRGD-Dex-DOX).With a combined experimental and theoretical approach,we find that the designed NP system can recognize the acid tumor environments and precisely release the encapsulated HDZ into tumor *** can notably downregulate the expression levels of hypoxia-inducible factor 1α(HIF1α),α-smooth muscle actin,and fibronectin through the dilation of tumor blood *** changes in the TSMs enhance the enrichment and penetration of NPs and also unexpectedly promote the infiltration of activated T cells into tumors,suggesting that such a system may offer an effective“multifunctional therapy”through both improving the chemotherapeutic effect and enhancing the immune response to *** vivo experiments on 4T1 breast cancer bearing mice indeed validate that this therapy has the most outstanding antitumor effects over all the other tested control regimens,with the lowest side effects as well.

关键词： antitumor dihydralazine drug delivery system tumor stromal microenvironment vasculature

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Efficient and selective H_(2)O_(2)production through uranyl-assisted photocatalytic oxygen reduction reaction process in a uranium-organic framework

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Science China Chemistry 2024年第7期67卷 2274-2281页

作者： Jianxin Song Chao Liang Baoyu Li Xuemin Wang Min Lei Lisha Jiang Zhenyu Li Yugang Zhang Jian Xie Zuju Ma Xing Dai Yanlong Wang Shuao Wang Wei Liu School of Environmental and Materials Engineering Yantai UniversityYantai 264005China State Key Laboratory of Radiation Medicine and protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China School of Life and Environmental Sciences Shaoxing UniversityShaoxing 312000China School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049China

Harnessing solar energy by photocatalytically converting oxygen and water into high-value-added H_(2)O_(2)is a promising way of alleviating both environmental and energy *** is worth noting that suppressing detrimental side reactions,such as the generation of·O_(2)^(-),is a critical approach to enhancing H_(2)O_(2)***,a 2-fold interpenetrating 3D uranium-organic framework(YTU-W-1)was developed and introduced for photocatalytic H_(2)O_(2)*** material demonstrates a different photocatalytic mechanism when employing uranyl as an initiator,as compared with the conventional semiconductor photocatalytic pathway involving photo-generated charge *** from the strong hydrogen abstraction effect of the U≡O·and the direct one-step oxygen reduction pathway,YTU-W-1 exhibits enhanced photocatalytic performance for H_(2)O_(2)production with yield efficiency of 221μmol h^(-1)g^(-1).Furthermore,YTU-W-1 displays a high H_(2)O_(2)selectivity of 68%,confirmed by rotating ring-disk electrode(RRDE)*** were used to elucidate the critical role of uranyl in the photocatalytic oxygen reduction reaction for H_(2)O_(2)*** research introduces an innovative approach to photo-driven H_(2)O_(2)production,underscoring the potential for heterogeneous catalysts to engage in photocatalytic reactions independently of photogenerated charge carriers.

关键词： uranyl metal-organic frameworks oxygen reduction reaction photocatalytic H_(2)O_(2)synthesis

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Fluorescent Nile blue-functionalized poly(N-isopropylacrylamide)microgels responsive to temperature and polyamines

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SmartMat 2024年第2期5卷 156-168页

作者： Qiming Shen Changhao Fang Liang Hu Michael J.Serpe Department of Chemistry University of AlbertaEdmontonAlbertaCanada State Key Laboratory of Radiation Medicine and protection Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutionsand School for Radiological and Interdisciplinary Sciences(RAD-X)Soochow UniversitySuzhouChina

Fluorescent poly(N-isopropylacrylamide-co-Nile blue)(pNIPAm-co-NB)microgels were synthesized that exhibited fluorescence intensity changes in a water temperature-dependent *** is well known to exhibit fluorescence intensity that depends on the hydrophobicity of the environment,while pNIPAm-based microgels are well known to transition from swollen(hydrophilic)to collapsed(relatively hydrophobic)at temperatures greater than 32℃;hence,we attribute the above behavior to the hydrophobicity changes of the microgels with increasing *** phenomenon is ultimately due to NB dimers(relatively quenched fluorescence)being broken in the hydrophobic environment of the microgels leading to relatively enhanced *** went on to show that the introduction of cucurbit[7]uril(CB[7])into the pNIPAm-co-NB microgels enhanced their fluorescence allowing them to be used for polyamine(e.g.,spermine[SPM])***,CB[7]forms a host–guest interaction with NB in the microgels,which prevents NB dimerization and enhances their *** SPM is present,it forms a host–guest complex that is favored over the CB[7]-NB host–guest interaction,which frees the NB for dimerization and leads to fluorescence *** a result,we could generate an SPM sensor capable of SPM detection down to~0.5µmol/L in complicated matrixes such as serum and urine.

关键词： cucurbituril fluorescence pNIPAm-co-NB microgel spermine detection thermoresponsive

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Furin Enzyme-Responsive siRNA Delivery System for Efficient Anti-Hypoxia-Assisted Cancer Photodynamic Therapy

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CCS Chemistry 2024年第4期6卷 999-1010页

作者： Shuyue Ye Yali Feng Yuqi Zhang Jing Fang Anna Wang Chaoxiang Cui Jinfeng Zhu Liangsheng Guo Guohua Fan Haibin Shi State Key Laboratory of Radiation Medicine and protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123 Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004 Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow UniversitySuzhou 215004

RNA interfering therapy has emerged as a promising therapeutic modality to treat *** specific and efficient delivery of RNA into a tumor is crucial for achieving effective cancer gene therapy but remains a huge ***,we report a novel furin-responsive small interfering RNA(siRNA)delivery vehicle with multiple functions for colorectal tumor treatment.A peptide-based siRNA delivery vehicle RVRR-P18-Gd,consisting of furin enzyme-specific peptide substrate Arg-Val-Arg-Arg(RVRR)with positive charge for siRNA binding,a Gd(III)chelated 1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acid(DOTA)(DOTA-Gd)for magnetic resonance imaging,and purpurin 18 as photosensitizer for photodynamic therapy(PDT),was rationally designed and *** advantage of the cationic amphiphilic feature,RVRR-P18-Gd molecules spontaneously self-assembled with negatively charged Hif-1αsiRNA into stable nanoparticles via attractive electrostatic interaction,which effectively prevented siRNA degradation by nucleases,prolonged the circulation half-life,and enhanced tumor ***,the specific release of Hif-1αsiRNA mediated by endogenous furin significantly downregulated Hif-1αexpression in colorectal cancer cells,resulting in enhanced therapeutic susceptibility,and with the PDT effect,effectively suppressed HCT116 tumor growth in living *** work highlights a powerful and universal approach to precisely deliver siRNA to targeted tumors for efficient synergistic therapy.

关键词： self-assembly RNA interfering enzymeresponsive delivery anti-hypoxia photodynamic therapy

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A novel traditional Chinese medicine combination for radiation

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Radiation Medicine and protection 2024年第1期5卷 37-42页

作者： Ming Shang Yicheng Ke Jiangyun Liu Zhifei Cao Liying Zhang Wenyang Zhang Weiwei Pei Guangming Zhou Yongqi Liu Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine research in Gansu Colleges and Universities Gansu University of Chinese MedicineLanzhou 730000China School of Radiation Medicine and protection Medical College of Soochow UniversitySuzhou 215123China Collaborative Innovation Center of radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Department of Pathology The Second Affiliated HospitalMedical College of Soochow UniversitySuzhou 215123China

Objective:To formulate an efficacious radioprotective combination of Chinese medicines with minimal ***:Aqueous and alcoholic extracts from 38 traditional Chinese herbs were *** produce drugcontaining sera,rats received six doses of each extract via oral gavage at 12-h ***,human lung epithelial BEAS-2B cells were cultured in these drug-containing *** cell viability was assessed after different doses of irradiation to identify the radioprotective effects of Chinese herbal *** efficacy of a selected Chinese herbal extract combination was further confirmed through cell viability analysis via in vitro colony formation and survival rate assessments in C57BL/6 mice ***:Extracts from Angelicae Sinensis Radix(ASR;two extracts),Citri Reticulatae Pericarpium(CRP),Platycladi Cacumen(PC),Schisandrae chinensis Fructus(SF),Scutellariae Radix(SR),and Glycyrrhizae Radix et Rhizome(GRR)demonstrated radioprotective *** combination of the seven Chinese herbal extracts notably increased the survival and viability of the BEAS-2B cells exposed to varying doses of ***,the group of mice receiving Chinese medicine combination and irradiation exhibited prolonged survival after exposure to 6.5 Gy Xrays with a median survival of(14=2)d compared to(11=2)d in the irradiated group without the herbal ***,the Chinese medicine combination group displayed a significantly higher 28 d survival rate(30%)compared to the irradiation-only group(16.6%,Pprotection applications.

关键词： Radiation protection Acute radiation syndrome Chinese medicine Drug-containing serum

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Two-dimensional-lag complex logistic map with complex parameters and its encryption application

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Chinese Physics B 2024年第5期33卷 324-335页

作者：张芳芳武金波寇磊马凤英吴黎明张雪 School of Information and Automation Engineering Qilu University of Technology (Shandong Academy of Sciences)Jinan 250353China Institute of Oceanographic instrumentation Qilu University of Technology (Shandong Academy of Sciences)Qingdao 266000China

With the rapid development of internet technology,security protection of information has become more and more prominent,especially information *** the great advantages of chaotic encryption,we propose a 2D-lag complex logistic map with complex parameters(2D-LCLMCP)and corresponding encryption ***,we present the model of the 2D-LCLMCP and analyze its chaotic properties and system stability through fixed points,Lyapunov exponent,bifurcation diagram,phase diagram,***,a block cipher algorithm based on the 2D-LCLMCP is proposed,the plaintext data is preprocessed using a pseudorandom sequence generated by the *** on the generalized Feistel cipher structure,a round function F is constructed using dynamic S-box and DNA encoding rules as the core of the block cipher *** generalized Feistel cipher structure consists of two F functions,four XOR operations,and one permutation operation per *** symmetric dynamic round keys that change with the plaintext are generated by the ***,experimental simulation and performance analysis tests are *** results show that the block cipher algorithm has low complexit,good diffusion and a large key *** the block length is 64 bits,only six rounds of encryption are required to provide sufficient security and robustness against cryptographic attacks.

关键词： logistic map block ciphers chaotic system encryption

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增强T/NK细胞抗肿瘤免疫治疗的小结构大方案

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Science Bulletin 2024年第4期69卷 437-440页

作者：王婷婷张浩韩要宝韩孟晓李桢 Center for Molecular Imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and ProtectionSchool for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China

The anti-tumor immunotherapy is primarily reliant on the host’s own immune *** treatment with immunotherapy,the tumor can be inhibited for a longer term potentially or even cured completely because of the systemic immunotherapy *** response can trigger a long-term memory to inhibit the recurrence and malignant progression of tumor.

关键词： inhibited immunotherapy tumor

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Rare earth based MgPm2X4（X=S,Se） spinel chalcogenides for spintronic and thermoelectric applications

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Journal of Rare Earths 2024年第8期42卷 1577-1585页

作者： Tariq M.Al-Daraghmeh Omar Zayed Ghulam M.Mustafa Taharh Zelai Bisma Younas Hind Albalawi S.Bouzgarrou Othman Hakami Q.Mahmood Khaild I.Hussein Department of radiological Sciences College of Applied Medical SciencesKing Khalid University Basic Sciences Department King Abdullah Ⅱ Sch aol of EngineeringPrincess Sumaya University For Technology Department of Physics Division of Science&TechnologyUniversity of Education Department of Physics Faculty of ScienceJazan University Department of Physics The University of Lahore Department of Physics College of SciencesPrincess Nourah bint Abdulrahman University (PNU) Department of Physics College of ScienceQassim University Laboratoire de Microelectronique et instrumentation (UR 03 13-04)Faculté des Sciences de Monastir Department of Chemistry Faculty of ScienceJazan University Basic&Applied Scientific research Center Department of PhysicsCollege of ScienceImam Abdulrahman Bin Faisal University

In current report,the structural,magnetic,and thermoelectric properties of RE doped MgPm2X4（X=S,Se） spinels were *** energy difference in ferromagnetic and antiferromagnetic states reveals the stability of MgPm2（S/Se）4in the ferromagnetic *** co mputation of enthalpy of formation also ascertains thermodynamic stability of crystal ***-dependent band structure and density of states analysis reveal ferromagnetic semiconducting character showing different electronic behavior in both spin *** room temperature ferromagnetism,spin polarization and Curie temperature are estimated from exchange energies *** addition,exchange constants（N0α and N0β）,exchange energy Δx（pd）,crystal ifeld energy,and double exchange mechanism were studied to explore the magnetic ***,the electrical conductivity,thermal conductivity,Seebeck co-efficient,and power factor show effect on electrons spin and their potential for thermoelectric devices.

关键词： Exchange energies Rare earth elements Spintronic applications Thermoelectric effects

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