A novel traditional Chinese medicine combination for radiation
A novel traditional Chinese medicine combination for radiation作者机构：Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and UniversitiesGansu University of Chinese MedicineLanzhou 730000China School of Radiation Medicine and ProtectionMedical College of Soochow UniversitySuzhou 215123China Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsSuzhou 215123China College of Pharmaceutical SciencesSoochow UniversitySuzhou 215123China Department of PathologyThe Second Affiliated HospitalMedical College of Soochow UniversitySuzhou 215123China
出 版 物：《Radiation Medicine and Protection》 (放射医学与防护（英文）)
年 卷 期：2024年第5卷第1期
页 面：37-42页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the National Natural Science Foundation of China(82192883,82103786) the National Key R&D Program of China(2022YFA1104300) the National Space Science Center(YYWT-0801-EXP-12) the Postdoctoral Science Foundation of Jiangsu Province(7112851420),China
主 题：Radiation protection Acute radiation syndrome Chinese medicine Drug-containing serum
摘 要：Objective:To formulate an efficacious radioprotective combination of Chinese medicines with minimal ***:Aqueous and alcoholic extracts from 38 traditional Chinese herbs were *** produce drugcontaining sera,rats received six doses of each extract via oral gavage at 12-h ***,human lung epithelial BEAS-2B cells were cultured in these drug-containing *** cell viability was assessed after different doses of irradiation to identify the radioprotective effects of Chinese herbal *** efficacy of a selected Chinese herbal extract combination was further confirmed through cell viability analysis via in vitro colony formation and survival rate assessments in C57BL/6 mice ***:Extracts from Angelicae Sinensis Radix(ASR;two extracts),Citri Reticulatae Pericarpium(CRP),Platycladi Cacumen(PC),Schisandrae chinensis Fructus(SF),Scutellariae Radix(SR),and Glycyrrhizae Radix et Rhizome(GRR)demonstrated radioprotective *** combination of the seven Chinese herbal extracts notably increased the survival and viability of the BEAS-2B cells exposed to varying doses of ***,the group of mice receiving Chinese medicine combination and irradiation exhibited prolonged survival after exposure to 6.5 Gy Xrays with a median survival of(14=2)d compared to(11=2)d in the irradiated group without the herbal ***,the Chinese medicine combination group displayed a significantly higher 28 d survival rate(30%)compared to the irradiation-only group(16.6%,P0.05).Conclusion:The novel combination of Chinese herbal extracts from ASR,CRP,PC,SF,SR,and GRR has the potential for radiation protection applications.
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