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World Journal of Gastrointestinal oncology 2016年第4期8卷 358-365页

作者： Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry department of radiation oncology Winship Cancer Institute Emory University School of Medicine department of radiation oncology Memorial Sloan Kettering Cancer Center department of radiation oncology the Medial College of Wisconsin Division of Surgical oncology Department of Surgery Emory University School of Medicine

Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies.

关键词： Chromodomain-helicase-DNA binding protein 5 Chromodomain-helicase-DNA binding protein 7 Mixed lineage kinase domain-like protein Pancreatic adenocarcinoma Biomarker

Advances of stereotactic body radiotherapy in pancreatic cancer

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Chinese Journal of Cancer Research 2015年第4期27卷 349-357页

作者： Qichun Wei Wei Yu Lauren M.Rosati Joseph M.Herman department of radiation oncology the Second Affiliated Hospital Zhejiang University School of Medicine department of radiation oncology & Molecular radiation Sciences Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine

Pancreatic cancer（PCA） is one of the most aggressive tumors with few effective treatment modalities. It is the 4th and 7th leading cause of cancer death in the United States and China, respectively. At the time of diagnosis, only 20% of cases present with a resectable tumor, and about 40% with a locally advanced tumor that is considered unresectable. Even resected patients still have a poor prognosis, with an incidence of local recurrence ranging from 20% to 60%. It is also reported that up to 30% of PCA patients die from locally obstructive disease with few or no distant metastases. These findings have highlighted the importance of local radiation therapy in the treatment of PCA. As the role of conventional chemoradiotherapy remains controversial, the dawn of the pancreas stereotactic body radiation therapy（SBRT） era represents a potential paradigm shift in the management of PCA. SBRT delivers a higher biological effective dose to the tumor with sharp dose escalation in a shorter treatment time course. Pancreas SBRT is a novel therapeutic option to achieve local tumor control with minimal toxicity. Herein, we review the advancement of SBRT for PCA patients with different stages of pancreatic adenocarcinoma.

关键词： Stereotactic body radiation therapy(SBRT) pancreatic cancer(PCA)

Pressure induced superconducting dome in LaNiGa_(2)

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 161-166页

作者： Yanan Zhang Dajun Su Zhaoyang Shan Yunshu Shi Rui Li Jinyu Wu Zihan Yang Kaixin Ye Fei Zhang Yanchun Li Xiaodong Li Chao Cao Valentin Taufour Lin Jiao Michael Smidman Huiqiu Yuan Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China department of Physics and Astronomy University of CaliforniaDavis 95616USA Beijing Synchrotron radiation Facility Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Silicon and Advanced Semiconductor Materials Zhejiang UniversityHangzhou 310058China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

LaNiGa_(2)is a time-reversal symmetry breaking superconductor with symmetry protected band crossings,making it an ideal platform for investigating the interplay between unconventional superconductivity and electronic structure *** we present a transport study of LaNiGa_(2)under *** application of pressure to LaNiGa_(2)induces a significant enhancement of the superconducting transition temperature Tcat a pressure of 7 *** contrast,powder X-ray diffraction(XRD)results show no evidence of structural phase transitions up to 26.3 ***,the ratio of band diffusivity shows a sudden increase at around 7 GPa,suggesting possible pressure-induced changes in the electronic structure that are closely linked to the evolution of superconductivity.

关键词： high pressure superconductivity time-reversal breaking

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Hodgkin's lymphoma involving extranodal sites:potential association with HIV infection and the implications for clinical management

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Chinese Journal of Cancer 2013年第2期32卷 102-102,F0003页

作者： Swaroop Revannasiddaiah Sridhar Papaiah Susheela Priyanka Thakur Madhup Rastogi department of radiation Therapy & oncology HCG Bangalore Institute of Oncology department of radiation Therapy & oncology Regional Cancer CenterIndira Gandhi Medical College

We commend Li et al.[1]for their article "Clinical characteristics of the patients with Hodgkin’s lymphoma involving extranodal sites" (published in the Chinese Journal of Cancer in July 2012). We agree that in comparison with extranodal non-Hodgkin’s lymphoma(NHL), the incidence of extranodal Hodgkin’s lymphoma(HL) is much rarer and thus described much

关键词：淋巴瘤艾滋病毒感染临床管理部位金关联临床特点发病率

Erianin inhibits the proliferation of lung cancer cells by suppressing mTOR activation and disrupting pyrimidine metabolism

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Cancer Biology & Medicine 2025年第02期 144-165页

作者： Lili Yan Yanfen Liu Yufei Huang Xiaoyu Sun Haiyang Jiang Jie Gu Jing Xia Xueni Sun Xinbing Sui School of Pharmacy and department of Medical oncology The Affiliated Hospital of Hangzhou Normal University Hangzhou Normal University department of Gastrointestinal & Pancreatic Surgery Key Laboratory of Gastroenterology of Zhejiang Province Zhejiang Provincial People's Hospital Affiliated People's Hospital Hangzhou Medical College

Objective: Erianin has potential anticancer activities, especially against lung cancer. The specific mechanisms underlying the anticancer effects, including the molecular targets and signaling pathways in lung cancer, remain poorly understood and necessitate further ***: Lung cancer cell viability was evaluated using the CCK-8 assay. Flow cytometry was used to examine the effects of erianin on apoptosis and cell cycle progression. m RNA sequencing and metabolomics analysis were utilized to explore erianin-induced biological changes. Potential targets were identified and validated through molecular docking and Western blot analysis. The roles of mammalian target of rapamycin(m TOR) and carbamoyl-phosphate synthetase/aspartate transcarbamylase/dihydroorotase(CAD) in erianin-induced growth inhibition were studied using gene overexpression/knockdown techniques with uridine and aspartate supplementation confirming pyrimidine metabolism involvement. Additionally, lung cancer-bearing nude mouse models were established to evaluate the anti-lung cancer effects of erianin in ***: Erianin significantly inhibits the proliferation of lung cancer cells, induces apoptosis, and causes G2/M phase cell cycle arrest. Integrative analysis of m RNA sequencing and metabolomics data demonstrated that erianin disrupts pyrimidine metabolism in lung cancer cells. Notably, uridine supplementation mitigated the inhibitory effects of erianin, establishing a connection between pyrimidine metabolism and anticancer activity. Network pharmacology analyses identified m TOR as a key target of erianin. Erianin inhibited m TOR phosphorylation, thereby blocking downstream effectors(S6K and CAD), which are essential regulators of pyrimidine ***: Erianin is a promising therapeutic candidate for lung cancer. Erianin likely inhibits lung cancer cell growth by disrupting pyrimidine metabolism by suppressing m TOR activation.

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Neo-adjuvant radiotherapy in rectal cancer

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World Journal of Gastroenterology 2013年第46期19卷 8489-8501页

作者： Bengt Glimelius department of Radiology Oncology and Radiation Science Uppsala University

In rectal cancer treatment,attention has focused on the local primary tumour and the regional tumour cell deposits to diminish the risk of a loco-regional *** large randomized trials have also shown that combinations of surgery,radiotherapy and chemotherapy have markedly reduced the risk of a locoregional recurrence,but this has not yet had any major influence on overall *** best results have been achieved when the radiotherapy has been given *** radiotherapy improves loco-regional control even when surgery has been optimized to improve lateral clearance,i.e.,when a total mesorectal excision has been *** relative reduction is then 50%-70%.The value of radiotherapy has not been tested in combination with more extensive surgery including lateral lymph node clearance,as practised in some Asian *** details about how the radiotherapy is performed are still open for discussion,and practice varies between countries.A highly fractionated radiation schedule(5 Gy×5),proven efficacious in many trials,has gained much popularity in some countries,whereas a conventionally fractionated regimen(1.8-2.0 Gy×25-28),often combined with chemotherapy,is used in other *** additional therapy adds morbidity to the morbidity that surgery causes,and should therefore be administered only when the risk of loco-regional recurrence is sufficiently *** best integration of the weakest modality,to date the drugs(conventional cytotoxics and biologicals)is not known.A new generation of trials exploring the best sequence of treatments is ***,there is a great need to develop predictors of response,so that treatment can be further individualized and not solely based upon clinical factors and anatomic imaging.

关键词： Chemotherapy Chemoradiotherapy Local control Multidisciplinary Organ preservation Radio-therapy Randomized trials Rectal cancer

Clinical features, outcomes and treatment-related pneumonitis in elderly patients with esophageal carcinoma

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World Journal of Gastroenterology 2014年第36期20卷 13185-13190页

作者： Jian He Zhao-Chong Zeng Shi-Ming Shi Ping Yang department of radiation oncology Zhongshan Hospital Fudan University

AIM: To investigate the clinical features and prognoses of elderly patients with esophageal carcinoma and to compare the effects of radiotherapy and rates of treatment-related pneumonitis (TRP) between elderly and non... 详细信息

关键词： Esophageal carcinoma radiation therapy Elderly patients Treatment-related pneumonitis Survival rate

Proton pump inhibitors and all-cause mortality risk among cancer patients

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World Journal of Clinical oncology 2025年第1期16卷 34-42页

作者： Arunkumar Krishnan Carolin Victoria Schneider Declan Walsh department of Supportive oncology Atrium Health Levine CancerCharlotteNC 28204United States department of Medicine Section of Hematology and OncologyWake Forest University School of MedicineWinston-SalemNC 27101United States department of Medicine Ⅲ GastroenterologyMetabolic Diseasesand Intensive CareUniversity Hospital RWTH AachenAachen 52074Germany

BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related *** evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater *** To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize *** This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare *** study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer *** prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)*** primary outcome was all-cause *** patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these *** a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individual

关键词： All-cause mortality Cancer Histamine-2 receptor antagonists Mortality Malignancy Proton pump inhibitors Carcinoma Outcome

Perspectives on the potential application of microRNAs in the diagnosis and treatment of triple-negative breast cancer

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oncology and Translational Medicine 2025年第1期11卷 5-9页

作者： Yeqin Wu Haitao Song Huifang Shi Gangping Wang department of Pathology the Fourth Affiliated Hospital of Zhejiang University School of MedicineInternational School of Medicine Zhejiang UniversityInternational Institutes of Medicine Zhejiang UniversityYiwuChina department of oncology the Rizhao People’s HospitalRizhaoChina Central Laboratory the Rizhao People’s HospitalRizhaoChina

Triple-negative breast cancer(TNBC)is currently the most heterogeneous and aggressive breast cancer *** has a high recurrence rate,poor clinical prospects,and lack of predictive markers and potential treatment *** microRNAs(miRNAs)are involved in various cellular processes in ***,variations in the miRNA levels in TNBC may act as a dependable indicator for predicting the effectiveness and specificity of ***,the application of miRNAs for breast cancer therapy is primarily in the preclinical stage,with a focus on identifying highly specific and sensitive miRNAs that could offer new possibilities for early diagnosis,clinical treat-ment,and prognostic monitoring of TNBC.

关键词： Triple-negative breast cancer miRNA oncomiRs Tumorigenesis Prognosis Chemotherapy resistance

Mass spectrometry-based serum peptide profiling in hepatocellular carcinoma with bone metastasis

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World Journal of Gastroenterology 2014年第11期20卷 3025-3032页

作者： Jian He Zhao-Chong Zeng Zuo-Lin Xiang Ping Yang department of radiation oncology Zhongshan HospitalFudan University

AIM: To investigate the potential of serum peptides as a diagnostic tool for hepatocellular carcinoma (HCC) with bone metastasis.

关键词： Hepatocellular carcinoma Serum Peptides Matrix-assisted laser desorption ionization-time of flight mass spectrometry Tumor biomarker