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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Multi‑omics integration identifies regulatory factors underlying bovine subclinical mastitis

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Journal of Animal Science and Biotechnology 2024年第3期15卷 987-1007页

作者： Mengqi Wang Naisu Yang Mario Laterriere David Gagne Faith Omonijo Eveline M.Ibeagha‑Awemu Agriculture and Agri‑Food Canada Sherbrooke Research and Development CentreSherbrookeQCCanada Department of Animal Science Universite LavalQuebec CityQCCanada quebec research and development centre Agriculture and Agri-Food CanadaQuebec CityQCCanada

Background Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy ***-omics approaches enable the comprehensive investigation of the complex interactions between mul-tiple layers of information to provide a more holistic view of disease ***,this study investigated the genomic and epigenomic signatures and the possible regulatory mechanisms underlying subclinical mastitis by integrating RNA sequencing data(mRNA and lncRNA),small RNA sequencing data(miRNA)and DNA methylation sequencing data of milk somatic cells from 10 healthy cows and 20 cows with naturally occurring subclinical mastitis caused by Staphylococcus aureus or Staphylococcus *** Functional investigation of the data sets through gene set analysis uncovered 3458 biological process GO terms and 170 KEGG pathways with altered activities during subclinical mastitis,provided further insights into subclin-ical mastitis and revealed the involvement of multi-omics signatures in the altered immune responses and impaired mammary gland productivity during subclinical *** abundant genomic and epigenomic signatures with sig-nificant alterations related to subclinical mastitis were observed,including 30,846,2552,1276 and 57 differential methylation haplotype blocks(dMHBs),differentially expressed genes(DEGs),lncRNAs(DELs)and miRNAs(DEMs),***,5 factors presenting the principal variation of differential multi-omics signatures were *** important roles of Factor 1(DEG,DEM and DEL)and Factor 2(dMHB and DEM),in the regulation of immune defense and impaired mammary gland functions during subclinical mastitis were *** of the omics within Factors 1 and 2 explained about 20%of the source of variation in subclinical ***,networks of impor-tant functional gene sets with the involvement of multi-omics signatures were demonstrated,which contributed to a comprehensive view of the possible regu

关键词： Candidate discriminant multi-omics signature Gene Long non-coding RNA Methylation haplotype block MicroRNA Multi-omics integration Natural killer cell mediated cytotoxicity pathway Staphylococcus aureus infection pathway

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Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis

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Journal of Animal Science and Biotechnology 2023年第2期14卷 593-613页

作者： Mengqi Wang Nathalie Bissonnette Mario Laterriere Pier‑Luc Dudemaine David Gagne Jean‑Philippe Roy Xin Zhao Marc‑Andre Sirard Eveline M.Ibeagha‑Awemu Sherbrooke research and development centre Agriculture and Agri-Food CanadaSherbrookeQuebecCanada Department of Animal Science Laval UniversityQuebecQuebecCanada quebec research and development centre Agriculture and Agri-Food CanadaQuebecQuebecCanada Department of Clinical Sciences Universite de MontrealSt‑HyacintheQuebecCanada Department of Animal Science McGill UniversitySte‑Anne‑De‑BellevueQuebecCanada.

Background:Mastitis caused by different pathogens including Streptococcus uberis(***)is responsible for huge economic losses to the dairy *** order to investigate the potential genetic and epigenetic regulatory mecha‑nisms of subclinical mastitis due to ***,the DNA methylome(whole genome DNA methylation sequencing)and transcriptome(RNA sequencing)of milk somatic cells from cows with naturally occurring *** subclinical mastitis and healthy control cows(n=3/group)were ***:Globally,the DNA methylation levels of CpG sites were low in the promoters and first exons but high in inner exons and *** DNA methylation levels at the promoter,first exon and first intron regions were nega‑tively correlated with the expression level of genes at a whole‑genome‑wide *** general,DNA methylation level was lower in ***‑positive group(SUG)than in the control group(CTG).A total of 174,342 differentially methylated cytosines(DMCs)(FDR<0.05)were identified between SUG and CTG,including 132,237,7412 and 34,693 DMCs in the context of CpG,CHG and CHH(H=A or T or C),***,101,612 methylation haplotype blocks(MHBs)were identified,including 451 MHBs that were significantly different(dMHB)between the two groups.A total of 2130 differentially expressed(DE)genes(1378 with up‑regulated and 752 with down‑regulated expression)were found in *** of methylome and transcriptome data with MethGET program revealed 1623 genes with signifi‑cant changes in their methylation levels and/or gene expression changes(MetGDE genes,MethGET P‑value<0.001).Functional enrichment of genes harboring≥15 DMCs,DE genes and MetGDE genes suggest significant involvement of DNA methylation changes in the regulation of the host immune response to *** infection,especially cytokine ***,discriminant correlation analysis with DIABLO method identified 26 candidate biomarkers,including 6 DE genes,15 CpG‑DMCs and 5 dMHBs that discrimina

关键词： Discriminant biomarkers Gene expression Genome‑wide DNA methylation pattern Immune processes and pathways Methylation haplotype block Milk somatic cell Streptococcus uberis Subclinical mastitis

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Effects of Sr^(2+) substitution on the structural, dielectric, and piezoelectric properties of PZT-PMN ceramics

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International Journal of Minerals,Metallurgy and Materials 2014年第2期21卷 175-180页

作者： Arvind Kumar S.K. Mishra research and Technology development centre Sharda University

This study described the structural, dielectric, and piezoelectric behavior of Pb1-xSrx[（Zr0.52Ti0.48）0.95（Mn1/3Nb2/3）0.05]O3 ceramics （PSZT-PMN, x=0, 0.025, 0.050, and 0.075）, prepared by a semi-wet route. X-ray diffraction, dielectric, and piezoelectric investigations were carried out to analyze the crystal structure. The relative dielectric constant and dielectric loss were both calculated as the functions of temperature. The room-temperature dielectric constant reaches a maximum for a Sr2＋-modified PZT-PMN ceramic with an x value of 0.050, which corresponds to the morphotropic phase boundary （MPB）. Raman spectroscopy studies also confirm the existence of this MPB for x=0.050. The piezoelectric strain coefficients （d33） value shows a maximum response for this composition. In addition, the phase transition temperature decreases significantly when the Sr2＋concentration increases in the PZT-PMN ceramics.

关键词： ceramic materials strontium substitution structural properties dielectric properties piezoelectricity

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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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Accuracy of genomic selection in biparental populations of flax(Linum usitatissimum L.)

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The Crop Journal 2016年第4期4卷 290-303页

作者： Frank M.You Helen M.Booker Scott D.Duguid Gaofeng Jia Sylvie Cloutier Morden research and development centre Agriculture and Agri-Food Canada Crop development centre Department of Plant Sciences University of Saskatchewan Ottawa research and development centre Agriculture and Agri-Food Canada

Flax is an important economic crop for seed oil and stem fiber. Phenotyping of traits such as seed yield, seed quality, stem fiber yield, and quality characteristics is expensive and time consuming. Genomic selection(GS) refers to a breeding approach aimed at selecting preferred individuals based on genomic estimated breeding values predicted by a statistical model based on the relationship between phenotypes and genome-wide genetic markers. We evaluated the prediction accuracy of GS(rMP) and the efficiency of GS relative to phenotypic selection(RE) for three GS models: ridge regression best linear unbiased prediction(RR-BLUP),Bayesian LASSO(BL), and Bayesian ridge regression(BRR), for seed yield, oil content, iodine value, linoleic, and linolenic acid content with a full and a common set of genome-wide simple sequence repeat markers in each of three biparental populations. The three GS models generated similar rMPand RE, while BRR displayed a higher coefficient of determination(R^2)of the fitted models than did RR-BLUP or BL. The mean rMPand RE varied for traits with different heritabilities and was affected by the genetic variation of the traits in the *** for seed yield generated a mean RE of 1.52 across populations and marker sets, a value significantly superior to that for direct phenotypic selection. Our empirical results provide the first validation of GS in flax and demonstrate that GS could increase genetic gain per unit time for linseed breeding. Further studies for selection of training populations and markers are warranted.

关键词： Genomic selection SSR Flax Linseed Seed yield Fatty acid composition

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Evaluating the impact of auxiliary fan practices on localised subsurface ventilation

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International Journal of Mining Science and Technology 2019年第6期29卷 933-941页

作者： David J.de Villiers Marc J.Mathews Philip Maré Marius Kleingeld Deon Arndt centre for research and Continued Engineering development North-West University

Mines are continually expanding in size and depth,leading to an increased reliance on localised subsurface ventilation *** use of underground auxiliary fans is a favoured method to increase and control airflow in working ***,the effectiveness of auxiliary fans in this regard is not *** paper evaluated the performance of these underground fan systems in four different South African deeplevel gold mines.A total auxiliary fan system efficiency of 5%was found across six systems,with the average fan efficiency of 33 fans at 38%.The results showed that these fans deviate significantly from their design operating ***,there are significant shortcomings in current underground fan *** detailed investigations led to the conclusion that the assemblage of underground auxiliary fan systems results in significant energy ***,maintaining good underground fan practice such as optimal fan selection,ducting design and maintenance is crucial for the efficacy of a mine ventilation network.

关键词： Mine ventilation Underground fan assemblage Fan system performance

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Sorption of 2,4-dinitroanisole (DNAN) on lignin

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Journal of Environmental Sciences 2012年第5期24卷 808-813页

作者： Rabih Saad Zorana Radovic-Hrapovic Behzad Ahvazi Sonia Thiboutot Guy Ampleman Jalal Hawari Biotechnology research Institute National Research Council of Canada6100 Royalmount AvenueMontréalQuebecCanada Defense research development Canada Department of National DefenseValcartierQuebecCanada

The present study describes the use of two commercially available lignins,namely,alkali and organosolv lignin,for the removal of2,4-dinitroanisole（DNAN）,a chemical widely used by the military and the dye industry,from *** of DNAN on bothlignins reached equilibrium within 10 hr and followed pseudo second-order kinetics with sorption being faster with alkali than withorganosolv lignin,i.e.k2 10.3 and 0.3 g/（mg·hr）,*** a separate study we investigated sorption of DNAN between 10 and40 C and found that the removal of DNAN by organosolv lignin increased from 0.8 to 7.5 mg/g but reduced slightly from 8.5 to 7.6mg/g in the case of alkali *** isotherms for either alkali or organosolv lignin best fitted Freundlich equation with enthalpyof formation,H0 equaled to 14 or 80 kJ/*** help understand DNAN sorption mechanisms we characterized the two lignins byelemental analysis,BET nitrogen adsorption-desorption and 31P *** in elemental compositions between the two ligninsindicated that alkali lignin should have more sites（O-and S-containing functionalities） for *** BET surface area andcalculated total pore volume of alkali lignin were almost 10 times greater than that of organosolv lignin suggesting that alkali ligninshould provide more sites for sorption.31P NMR showed that organosolv lignin contains more phenolic-OH groups than alkali lignin,i.e.,70% and 45%,*** variations in the type of OH groups between the two lignins might have affected the strength ofH-bonding between DNAN and the type of lignin used.

关键词： sorption DNAN lignin kinetics isotherms.

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Hybrid rice achievements, development and prospect in China

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Journal of Integrative Agriculture 2015年第2期14卷 197-205页

作者： MA Guo-hui YUAN Long-ping China National Hybrid Rice research and development centre

This article reviews the history and progress of hybrid rice development. Hybrid rice research was initiated back in 1964, and commercialized in 1976. Three-line and two-line system hybrid rice were developed in 1974 and 1995, respectively. research on super hybrid rice, which was first launched by Ministry of Agriculture, China in 1996, is discussed, and the great progress of super hybrid rice had been achieved with a new yield record by 15.4 t ha^-1 in the 6.84 ha demonstration location in Xupu, Hunan Province, China in 2014. And the mechanism of heterosis, the techniques of hybrid seed production and the modern field managements in hybrid rice over the past decades are also discussed. Additionally, this article dealt with the intellectual property protection（IPR） and development of hybrid rice seed industry in China. Major factors that constrain hybrid rice development are analyzed and possible solutions to this problems are proposed. Finally, the authors present methods to further increase production yield, and propose an improvement for breeding super high-yielding hybrid rice based on these methods.

关键词： hybrid rice research & development achievement & progress constraint super high yield breeding

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Control strategies for aircraft airframe noise reduction

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Chinese Journal of Aeronautics 2013年第2期26卷 249-260页

作者： Li Yong Wang Xunnian Zhang Dejiu State Key Laboratory of Aerodynamics China Aerodynamics Research & Development Centre

With the development of low-noise aircraft engine, airframe noise now represents a major noise source during the commercial aircraft＇s approach to landing phase. Noise control efforts have therefore been extensively focused on the airframe noise problems in order to further reduce aircraft overall noise. In this review, various control methods explored in the last decades for noise reduction on airframe components including high-lift devices and landing gears are summarized. We introduce recent major achievements in airframe noise reduction with passive control methods such as fairings, deceleration plates, splitter plates, acoustic liners, slat cove cover and side-edge replacements, and then discuss the potential and control mechanism of some promising active flow control strategies for airframe noise reduction, such as plasma technique and air blowing/suction devices. Based on the knowledge gained throughout the extensively noise control testing, a few design concepts on the landing gear, high-lift devices and whole aircraft are provided for advanced aircraft low-noise design. Finally, discussions and suggestions are given for future research on airframe noise reduction.

关键词： Active flow control Airframe noise High-lift devices Landing gear Passive control method

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