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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 213-216页

作者： Jian Cheng De-Fei Hong Cheng-Wu Zhang Xiao-Ming Fan Zu-Yan Luo Wei-Feng Yao Li-Ming Jin General Surgery Cancer CenterDepartment of Hepatobiliary&Pancreatic Surgery and Minimally Invasive SurgeryZhejiang Provincial People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310014China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020China

To the Editor: Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) promotes the future liver remnant(FLR) rapid proliferation in the short term, which in turn provides an opportunity for... 详细信息

关键词： hepatocellular liver microwave

Experimental and numerical investigations on acoustic damping of monoclinic crystalline wideband sound absorbing structures

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Journal of Central South University 2024年第6期31卷 1931-1944页

作者： XIE Su-chao HE Lei YAN Hong-yu ZHANG Feng-yi HE Guan-di WANG Jia-cheng Key Laboratory of Traffic Safety on Track Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangsha 410075China Joint International Research Laboratory of Key Technology for Rail Traffic Safety Changsha 410075China National&Local Joint Engineering Research center of Safety Technology for Rail Vehicle Changsha 410075China

In order to overcome the limitations of traditional microperforated plate with narrow sound absorption bandwidth and a single structure,two multi-cavity composite sound-absorbing materials were designed based on the shape of monoclinic crystals:uniaxial oblique structure(UOS)and biaxial oblique structure(BOS).Through finite element simulation and experimental research,the theoretical models of UOS and BOS were verified,and their sound absorption mechanisms were *** the same time,the influence of multi-cavity composites on sound absorption performance was analyzed based on the theoretical model,and the influence of structural parameters on sound absorption performance was *** research results show that,in the range of 100-2000 Hz,UOS has three sound absorption peaks and BOS has five sound absorption *** frequency range of the half-absorption bandwidth(α>0.5)of UOS and BOS increases by 242% and 229%,*** with traditional microperforated sound-absorbing structures,the series and parallel hybrid methods significantly increase the sound-absorbing bandwidth of the sound-absorbing *** research has guiding significance for noise control and has broad application prospects in the fields of transportation,construction,and mechanical design.

关键词： monoclinic crystal microperforated plate acoustic metamaterials inclined cavity sound absorption

Activation Effect of Hydrochemical Energy in Regenerative Agriculture on Nutrients of Arsenic Sandstone

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Asian Agricultural Research 2021年第2期13卷 41-42,46页

作者： Tingting MENG Dan WU Shaanxi provincial Land Engineering Construction Group Co. Ltd.Institute of Land Engineering and TechnologyShaanxi Provincial Land Engineering Construction Group Co.Ltd.Key Laboratory of Degraded and Unused Land Consolidation EngineeringMinistry of Natural ResourcesShaanxi Provincial Land Consolidation Engineering Technology Research CenterXi an 710075China

[Objectives]To study the activation effect of hydrochemical energy in regenerative agriculture on the nutrients of arsenic sandstone.[Methods]Starting from common environmental factors,moisture,it studied the mechanism of the release and activation of N,P,K nutrient elements in arsenic sandstone under different dry and wet environments.[Results]Water played a positive role in activating soil *** the conditions of long-term dryness and alternating dry and wet conditions,the content of total nitrogen,available phosphorus and available potassium coexisted in the 210 d of culture and the element absorption and release,but the overall trend was increasing;under long-term flooding conditions,the content of total nitrogen and available potassium showed an overall increasing trend during the 210 d of culture,but the content of available phosphorus decreased.[Conclusions]Water plays a positive effect on activating soil *** research results are expected to provide a certain reference for the application research of water in regenerative agriculture.

关键词： Water Arsenic sandstone Regenerative agriculture Total nitrogen Available phosphorus Available potassium Nutrient activation

Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via theβ2 adrenergic pathway suppression

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Natural Products and Bioprospecting 2023年第1期13卷 14-29页

作者： Xinxin Li Runlu Shi Lingchen Yan Weiwei Chu Ruishuang Sun Binkai Zheng Shuai Wang Hui Tan Xusheng Wang Ying Gao School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Department of Anesthesiology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233004China center for Child Care and Mental health Shenzhen Children’s Hospital Affiliated to Shantou University Medical CollegeShenzhen 518026China Institute of Biopharmaceutical and health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Plastic and Reconstructive Surgery Guangdong Second Provincial General HospitalGuangzhou 510317China The Yonghe Medical Beauty Clinic Department Guangzhou 510630China Department of Anesthesiology The First People’s Hospital of FoshanFoshan 528000China

Norepinephrine(NA),a stress hormone,can accelerate hair graying by binding toβ2 adrenergic receptors(β_(2)AR)on melanocyte stem cells(McSCs).From this,NA-β_(2)AR axis could be a potential target for preventing the stress ***,identifying selective blockers forβ_(2)AR has been a key ***,in this study,advanced computer-aided drug design(CADD)techniques were harnessed to screen natural molecules,leading to the discovery of rhynchophylline as a promising *** exhibited strong and stable binding within the active site ofβ_(2)AR,as verified by molecular docking and dynamic simulation *** administered to cells,rhyncho-phylline effectively inhibited NA-β_(2)AR *** intervention resulted in a significant reduction of hair graying in a stress-induced mouse model,from 28.5%to 8.2%.To gain a deeper understanding of the underlying mechanisms,transcriptome sequencing was employed,which revealed that NA might disrupt melanogenesis by affecting intracellular calcium balance and promoting cell ***,rhynchophylline acted as a potent inhibitor of these downstream *** conclusion,the study demonstrated that rhynchophylline has the potential to mitigate the negative impact of NA on melanogenesis by targetingβ_(2)AR,thus offering a promising solution for preventing stress-induced hair graying.

关键词： Natural product Rhynchophylline Stress Hair graying β2 adrenergic signaling

Efficacy of Guhong injection versus Butylphthalide injection for mild ischemic stroke: A multicenter controlled study

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World Journal of Clinical Cases 2022年第21期10卷 7265-7274页

作者： Wei-Wei Zhang Jiang Xin Guang-Yu Zhang Qi-Jin Zhai Hua-Min Zhang Cheng-Si Wu Department of Neurology The Seventh Medical Center of PLA General HospitalBeijing 100039China Department of Neurology Liaoning Provincial People’s HospitalShenyang Liaoning Provincial People's HospitalShenyang 110016Liaoning ProvinceChina Department of Neurology Cangzhou City People’s HospitalCangzhou 061000Hebei ProvinceChina Department of Neurology Huai’an Second People’s HospitalHuai’an 223002Jiangsu ProvinceChina Department of Neurology Ganyu People’s Hospital of LianyungangGanyu 222100Jiangsu ProvinceChina Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Most studies on Guhong injection have involved a single center with a small sample size,and the level of clinical evidence is *** To assess the safety and efficacy of Guhong injection for mild ischemic stroke(IS).METHODS A total of 399 IS patients treated at six hospitals from August 2018 to August 2019 were retrospectively *** patients were given Guhong injection(experimental group)or Butylphthalide injection(control group).Changes in National Institutes of health Stroke Scale(NIHSS)and modified Rankin Scale(mRS)scores were observed before treatment and at 1,2,and 3 wk after treatment in each *** efficacy and safety of Guhong injection for IS were *** medications taken by the patients were confounding factors for efficacy *** factors were controlled by propensity score matching,and the results were further analyzed based on the *** The marked response rates at three follow-up visits were 64.64%,74.7%,and 66.7%in the experimental group,and 48.26%,45.4%,and 22.2%in the control *** marked response rates increased significantly in the experimental group compared with the control group(P0.05)and 64.0%and 47.7%in the control group(P<0.05)at the first

关键词： Guhong injection Ischemic stroke Propensity score matching National Institutes of health Stroke Scale

The relationship between HBV lamivudine resistance and HBV genotypes or basic core promoter mutations

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Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 85-89页

作者： Dong-Yao Zhou Lian-Ying Lin Hong Wang Jian-Sheng Huang the Department of Clinical Laboratory Medicine, Guangdong provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China Molecular Biology Diagnostic center, First Military Medical University, Guangzhou 510515, China Department of Clinical Laboratory Medicine Guangdong Provincial Hospital of Traditional Chinese Medicine (TCM) Guangzhou 510120 China. zhoudongyao@***

OBJECTIVE: To investigate the relationship between HBV Iamivudine resistance and HBV genotypes or basic core promoter (BCP) mutations. METHODS: The common coated probes were synthesized according to the conserved regions of the preC gene of hepatitis B virus (HBV). Different colorized probes were chosen from the sequences of different genotypes of HBV (A to F), BCP and YMDD wild types and mutants, respectively. HBV DNA levels, HBV genotypes, BCP and YMDD resistants were analyzed by PCR microplate hybridization ELISA at the zero and 6th month after the patients were treated with lamivudine. RESULTS: HBV genotyping results showed that HBV types B, C, D accounted for about 30%, 36% and 23% patients respectively. Thirteen BCP mutations (type B in 1 patient, type C in 8 and type D in 4) were found before treatment with lamivudine. HBV DNA levels were lower than 100 pg/ml in 2 patients anti higher than 100 pg/ml in 11. 9.4% of the HBV patients (5/43; type C in 3 and type D in 2) showed YMDD resistants and 4 BCP mutations at the same time. CONCLUSION: Oral treatment of lamivudine decreases the level of serum HBV DNA. The appearance of HBV YMDD resistants is related to certain HBV genotypes, and most of them are BCP mutations.

关键词： hepatitis B virus genotype mutation lamivudine resistant

Production of ■ in heavy ion collisions

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Chinese Physics C 2023年第5期 7-11页

作者：胡元元张辉 Guangdong provincial Key Laboratory of Nuclear Science Institute of Quantum Matter South China Normal University Guangdong-Hong Kong Joint Laboratory of Quantum Matter Southern Nuclear Science Computing Center South China Normal University

The yields of ■ with its two possible configurations, i.e., the hadronic molecular state and tetraquark state, for Pb-Pb collisions at ■= 5.02 TeV is studied. A volume effect is found from the centrality distribution of ■, which could help to distinguish the inner structure of ■. We also show the rapidity and the transverse momentum distributions of ■ production as well as its elliptic flow coefficient as a function of the transverse momentum.

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Identification and functional analysis of a novel connexin 50 mutation associated with autosome dominant congenital cataract

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Identification and functional analysis of a novel connexin 5...

The overexpression of Rps14 in Lgr5+progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea

2016年浙江省眼科学学术年会

作者：鱼音慧吴梦晗姚克 Eye center Second Affiliated Hospital of Zhejiang University School of Medicine Zhejiang provincial Key Lab of Ophthalmology

Purpose:To identify the mutation responsible for ADCC in a ***:Genomic DNA was extracted from peripheral blood of the family members for direct sequencing of candidate genes to identify the causative mutations.

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来源： cnki会议评论

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再生工程(英文) 2023年第3期4卷 328-336页

作者： Jingru Ai Pei Jiang Jingyuan Huang Hairong Xiao Yanqin Lin Mingchen Dai Yintao Wang Yuan Zhang Mengyao Tian Renjie Chai Shasha Zhang State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Department of Otolaryngology Head and Neck Surgery Affiliated Drum Tower Hospital of Nanjing University Medical SchoolJiangsu Provincial Key Medical Discipline(Laboratory)NanjingChina Research Institute of Otolaryngology NanjingChina Co-Innovation center of Neuroregeneration Nantong UniversityNantong 226001China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijingChina Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijing 100069China

Sensory hair cells(HCs)in the cochlea cannot regenerate spontaneously in adult mammals after being damaged by external or genetic ***,several genes and signaling pathways are reported to induce cochlear HC regeneration at the early neonatal ***14 encodes a ribosomal protein that is involved in the regulation of cell differentiation and proliferation in ***,its roles in the cochlea have not been reported in ***,we specifically overexpressed Rps14 in Lgr5+progenitor cells in the newborn mouse cochlea and found that Rps14 conditional overexpression(cOE)mice had significantly increased the ectopic HCs,including inner and outer *** further explored the source of these ectopic HCs and found no EdU+supporting cells observed in the Rps14 cOE *** lineage tracing results,on the other hand,revealed that Rps14 cOE mice had significantly more tdTomato+HCs in their cochleae than control *** results indicated that regenerated HCs by cOE of Rps14 are most likely derived from inducing the direct trans-differentiation of Lgr5+progenitor cells into ***,real-time qPCR results suggested that the transcription factor genes Atoh1 and Gfi1,which are important in regulating HC differentiation,were upregulated in the cochlear basilar membrane of Rps14 cOE *** summary,this study provides in vivo evidence that,in the postnatal mouse cochlea,Rps14 is a potential gene that can promote the spontaneous trans-differentiation of Lgr5+progenitor cells into *** gene may one day be exploited as a therapeutic target for treating hearing loss.

关键词： Rps14 Lgr5+progenitor cells Ectopic hair cells Regeneration Proliferation Trans-differentiation

Formation and Relative Stabilities of Core-Shelled L12-Phase Nano-structures in Dilute Al–Sc–Er Alloys

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Acta Metallurgica Sinica(English Letters) 2020年第12期33卷 1627-1634页

作者： Chaomin Zhangi Yong Jiang Xiuhua Guo Kexing Song School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023People's Republic of China School of Materials Science and Engineering Central South UniversityChangsha 410083China Henan Province Key Laboratory of Nonferrous Metal Material Science and Processing Technology Luoyang 471023People's Republic of China Collaborative Innovation center of Nonferrous Metals Luoyang 471023Henan ProvinceChina provincial and Ministerial Co-construction of Collaborative Innovation center for Non-ferrous Metal New Materials and Advanced Processing Technology Luoyang 471023Henan ProvincePeople's Republic of China

First-principles thermodynamic calculations were carried out at the interface level for understanding the precipitation of coherent L12-phase nano-structures in dilute Al–Sc–Er *** energetics,relevant to bulk substitution,interface formation,interfacial coherent strain and segregation,were calculated and used to evaluate the nucleation and relative stabilities of various possible L12 *** matrix-dissolved solute Er(or Sc)can substitute Sc(or Er)in L12-Al3Sc(or Al3Er).The inter-substitution between L12-Al3Sc and Al3Er is not energy *** L12-Al3(Er x Sc 1.x)precipitates tend to form the Al3Er-core and Al3Sc-shell structure with a sharp core/shell *** possible formation mechanisms were proposed and *** eff ects of Er/Sc ratio and aging temperature on the relative stabilities of L12-phase nanostructures in Al were also discussed.

关键词： Al–Sc–Er alloy L12 phase Core-shell Interface First-principles