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Anti-voltage-gated potassium channel complex antibody-mediated limbic encephalitis:a case report of a 53-yearold man admitted to intensive care psychiatric unit with psychotic mania

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General Psychiatry 2020年第4期33卷 241-244页

作者： Homayun Shahpesandy Rosemary Mohammed-Ali Ahmed Oladosu Tarik AI-Kubaisy Moses Anene Umesh Sira Ramaiah The Hartsholme Centre Lincolnshire Partnership NHS Foundation TrustLincolnUK Spalding Community Mental Health Team Lincolnshire Partnership NHS Foundation TrustSpaldingUK Early Intervention Psychosis Team Consultant Psychiatrist North Lincolnshire Community Mental HealthRotherham Doncaster NHS Foundation TrustScunthorpeUK Peter Hodgkinson Centre Lincolnshire Partnership NHS Foundation TrustLincolnUK psychiatric Liaison Team Lincolnshire Partnership NHS Foundation TrustLincolnUK

Limbic encephalitis represents a cluster of autoimmune disorders,with inflammation in the medial temporal lobe characterised by subacute onset of neuropsychiatric symptoms such as anxiety,affective symptoms,psychosis,short-term memory impairment as well as faciobrachial and grand mal *** aim to present a case of a 53-year-old man with positive anti-voltage-gated potassium channel(VGKC)complex antibodies who initially presented with symptoms of psychotic *** weeks post-psychiatric symptomatology,he presented with neurological symptoms such as faciobrachial jerking and tonic-clonic *** patient had no previous psychiatric history and was initially treated with psychotropic *** experience emphasises the fact that limbic encephalitis is not easy to identify as most patients initially present with psychiatric symptomatology than neurological ***,immunological and laboratory testing takes a rather long time to determine the *** is more,few psychiatrists consider autoimmune nature of the neuropsychiatric ***,it is important to consider autoimmune encephalitis in patients with new-onset psychosis or mania who also present with neurological symptoms at some stage of their *** indicators of autoimmune encephalitis include neurological symptoms such as facial twitching,seizures,confusion and cognitive decline.

关键词： initially potassium admitted

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Application of virtual reality technology improves the functionality of brain networks in individuals experiencing pain

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World Journal of Clinical Cases 2025年第3期13卷 66-68页

作者： Takahiko Nagamine Department of psychiatric Internal Medicine Sunlight Brain Research CenterHofu 7470066YamaguchiJapan

Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and ***,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)*** has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been *** precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be ***,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain *** salience network is diminished,while the default mode network is ***,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and *** research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.

关键词： Virtual reality Pain Anxiety Salience network Default mode network

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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psychiatric disorders associated with intimate partner violence and sexual violence in Thai women:Aresult from the Thai National Mental Health Survey

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General Psychiatry 2018年第5期31卷 68-75页

作者： Benjaporn Panyayong Nopporn Tantirangsee Rudy R D Bogoian the Thai National Mental Health Survey Team 2013 Somdetchaopraya Institute of Psychiatry Khlong SanThailand Department of Mental Health Songkhla Rajanagarindra Psychiatric HospitalKhlong SanThailand psychiatric Clinic Ann ArborMichiganUSA 不详

Background Intimate partner violence(IPV) and sexual violence(SV) occur commonly and are a violation of basic human rights. There are limited studies to date that examine the impact of IPV, SV and mental health outcomes in *** The objective of the present study was to estimate the prevalence of intimate partner physical violence and IPV in Thai women and the association between these forms of violence and psychiatric *** The present study used data from a national cross-sectional, population-based, household design survey. This study analysed data from 3009 female respondents above the age of 18 who were interviewed in person using the World Mental Health-Composite International Diagnostic Interview V.3.0(WMH-CIDI 3.0). We estimated the lifetime and the 12-month period prevalence of IPV and SV, the lifetime and the past 12-month period correlation of IPV/SV with psychiatric disorders and the OR for psychiatric disorders associated with these types of *** There was only 5.2 % of the weighted sample that reported experiencing some form of violence, including reported rates of intimate partner physical violence of 3.5% and IPV of 2.0%. Women who had experienced IPV have a lifetime prevalence for common psychiatric disorders of 28.9%, for suicidal behaviours of 12.2% and for substance use disorders of 8.8%. Women who had experienced SV have a lifetime diagnoses for common psychiatric disorders of 21.4%, for suicidal behaviours of 16.5% and for substance use disorders of 19.4%. There was a statistically significant association between IPV/SV and being diagnosed with a psychiatric disorder during the past year and also during one's *** The association between IPV/SV and psychiatric disorders is significant; therefore, performing a formal assessment for a history of violence in psychiatric patients is often beneficial in refining the diagnosis and treatment.

关键词： World Mental Health-Composite International Diagnostic Interview V.3.0

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The Correlation between Psychological Resilience and Professional Quality of Life in Saudi psychiatric Nurses:A Cross-Sectional Study

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Psycho-Oncologie 2024年第4期18卷 271-280页

作者： Ahmad M.Rayani Community and psychiatric Mental Health Nursing Department College of NursingKing Saud UniversityRiyadh12371Saudi Arabia

In recent years,significant focus has been placed on resilience,with ongoing studies aiming to identify strategies for reducing the negative effects of job stress and protecting nurses from negative psychosocial ***,as far as this topic is concerned,no research has yet been conducted in the context of Saudi psychiatric *** aim of this research,therefore,is to determine how Saudi Arabian psychiatric nurses’professional quality of life and psychological resilience relate to one *** this aim,a cross-sectional study has been performed in Saudi Arabia incorporating a population of 167(a 66.4%response rate)mental health nurses taken from the largest psychiatric hospital in the capital city *** collection was performed using the popular Arabic version of the Connor–Davidson Resilience and the Arabic version of the Professional Quality of Life *** assess the variables related to both Professional Quality of Life and psychological resilience levels,statistical analyses such as Pearson correlation,ANOVA,t-tests,and linear regression were *** findings show compassion satisfaction and burnout to have a moderate inverse relationship(r=−0.502),while compassion satisfaction(CS)and resilience have a moderate positive correlation(r=0.594).Compared to their morning-shift counterparts,nurses working night shifts reported higher mean scores for resilience(72.70),CS(40.20),burnout(24.52),and compassion fatigue(CF)(28.11).Participants with less than five years’experience in a psychiatric clinic had the highest mean resilience score(72.96).Finally,a positive relationship between resilience and compassion satisfaction(CS)was revealed using linear regression analysis(β=0.536,t=7.080,p=0.000).The study reveals significant differences in the scores assigned to resilience and work-life quality based on educational qualifications,shift-work type,and *** and compassion satisfaction(CS)are found to be significantly correlated,

关键词： Resilience compassion fatigue psychiatric nurse compassion fulfillment professional quality of life burnout

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Triage and Risk Concept: Application Proposal for Pre-Hospital Emergencies in a psychiatric Ambulance in the City of Buenos Aires

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Open Journal of Emergency Medicine 2023年第1期11卷 21-31页

作者： Mazzoglio Y. Nabar Martín Javier Rubén Daniel Algieri Gabriel Schraier Blanca Lopez Sergio Giordano Department of psychiatric Emergencies “Torcuato de Alvear” Psychiatric Emergency Hospital Buenos Aires Argentina

The heterogeneity of clinical presentations in psychiatric emergencies creates difficulties in the response by interdisciplinary Mental Health teams. This is aggravated and difficult when the care is carried out on public roads or the patient’s home, that is, it is a pre-hospital context. Our psychiatric Emergency Hospital, located in the City of Buenos Aires, provides pre-hospital care with a psychiatric ambulance, which is then referred to general hospitals or other health system providers. Not all effectors in the network have the same resources and, at the time of the emergency, the reasons for consultation such as the patient’s clinic are heterogeneous and require the greatest effectiveness in the intervention that is taken. The triage system is a resource that allows the systematization of approaches against the multiplicity of reasons for consultation and presentation of mental pathologies in the emergency room, in addition to providing greater effectiveness in interventions, homogeneity for the health system and consensus among the health effectors. Framed in the Mental Health Law, and especially in the concept of risk, a triage proposal was designed for pre-hospital interventions by the psychiatric ambulance dependent on Hospital Alvear and under current legal regulations with the aim of homogenizing care and referrals with the highest rate of effectiveness to provide quality interdisciplinary medicine.

关键词： Psychiatry Ambulance Emergencies Triage

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Psychotropic Medication Refusal:Reasons and Patients’Perception at a Secure Forensic psychiatric Treatment Centre

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Journal of Forensic Science and Medicine 2016年第1期2卷 12-17页

作者： Olajide O Adelugba Mansfield Mela Inam U Haq Regional psychiatric Center University of SaskatchewanSaskatoonSaskatchewanCanada Department of Psychiatry University of SaskatchewanSaskatoonSaskatchewanCanada

Poor adherence to prescribed medication regimens can undermine the effectiveness of *** study was conducted to determine the demographic profile of forensic psychiatric inpatients refusing medications and to identify the reasons for *** were collected through interviews using a questionnaire including Drug Attitude Inventory‑*** refusal was more common among Aboriginals(68%,n=34)than Caucasians(32%,n=16)and was highest among the patients 21–30 years of age(44%,n=22).Antisocial personality disorder and substance use disorder featured prominently among patients refusing *** main reasons for medication refusal were inconvenience(34%,n=17)followed by side effects(22%,n=11),ineffective medication(20%,n=10),illness‑related(16%,n=8),and no reasons(8%,n=6).Antipsychotic medications topped the list of the major classes of medications refused followed by Antidepressants and Mood Stabilizers.

关键词： Forensic medication nonadherence psychiatry refusal

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Changes in neurotransmitter levels,brain structural characteristics,and their correlation with PANSS scores in patients with firstepisode schizophrenia

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World Journal of Clinical Cases 2023年第22期11卷 5215-5223页

作者： Xian-Jia Xu Tang-Long Liu Liang He Ben Pu The Fifth Ward Ningbo Psychiatric HospitalNingbo 315000Zhejiang ProvinceChina Department of Science and Education Ningbo Psychiatric HospitalNingbo 315000Zhejiang ProvinceChina The Sixteenth Ward Ningbo Psychiatric HospitalNingbo 315000Zhejiang ProvinceChina The Twelfth Ward Ningbo Psychiatric HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND In patients with schizophrenia,the brain structure and neurotransmitter levels change,which may be related to the occurrence and progression of this *** To explore the relationships between changes in neurotransmitters,brain structural characteristics,and the scores of the Positive and Negative Symptom Scale(PANSS)in patients with first-episode *** The case group comprised 97 patients with schizophrenia,who were evaluated using the Canadian Neurological Scale and confirmed by laboratory tests at Ningbo Mental Hospital from January 2020 to July *** control group comprised 100 healthy *** all participants,brain structural characteristics were explored by measuring brain dopamine(DA),glutamic acid(Glu),and gamma-aminobutyric acid(GABA)levels,with magnetic resonance *** case group was divided into negative and positive symptom subgroups using PANSS scores for hierarchical *** correlation analysis was used to analyze the correlations between neurotransmitters,brain structural character istics,and PANSS *** Patients in the case group had higher levels of DA and lower levels of Glu and GABA,greater vertical and horizontal distances between the corpus callosum and the inferior part of the fornix and larger ventricle area than patients in the control group(P<0.05).Patients with positive schizophrenia symptoms had significantly higher levels of DA,Glu,and GABA than those with negative symptoms(P<0.05).In patients with positive schizophrenia symptoms,PANSS score was significantly positively correlated with DA,vertical and horizontal distances between the corpus callosum and the infrafornix,and ventricular area,and was significantly negatively correlated with Glu and GABA(P<0.05).In patients with negative schizophrenia symptoms,PANSS score was significantly positively correlated with DA,vertical distance between the corpus callosum and the infrafornix,horizontal distance between the corpus cal

关键词： Brain structural characteristics Negative symptoms Neurotransmitters positive symptoms Schizophrenia

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A case report of FTD with acute manifestation of psychiatric symptoms and comorbidity of Neuroleptic malignant syndrome

A case report of FTD with acute manifestation of psychiatric...

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2018年浙江省老年精神障碍学术年会

作者： Wu yuejing Chen yaopian Sun lin Tao jing Li xia Xiao shifu The geriatric psychiatric department of Shanghai Mental Health Center the psychiatric department of Zhejiang Hospital

Frontotemporal dementia(FTD) is the third most common dementia for individuals 65 years and older,and is the second most common form for individuals 65 years and *** affects brain regions implicated in motivation,personality,social cognition,attention,executive functioning and *** clinic subtypes of FTD,like behavioral variant FTD(bvFTD),and variants of primary progressive aphasia(PPA) which contain the semantic variant of primary progressive aphasia(svPPA) and nonfluent variant of primary progressive aphasia(nfvPPA),are currently characterized by different clinic manifestation of specific cognitive,behavioral and socio-emotional deficits,and associated with different focal neurodegeneration in the frontal and anterior temporal *** companied with complicated presentation of neuropsychiatric symptoms,the clinic had high risk of misdiagnosis and increased difficulty in treatment.A 66 years old male patient who had an acute manifestation of aggressive behavior for 2 months,had delusions of persecution and refused food and medicine for 1 week,was sent to our inpatient *** patient had a three-year history of memory impairment(like forget his daughter’ s call),executive function deficits(like don’ t know how to conduct his laptop),and changing of character(from temperate to aggressive and bold).He got 21 in MMSE and 18 in MoCA for the first time in Oct,2014,and the MRI scan indicated "encephalatrophy".Obtaining a clinic diagnosis of "dementia" in neurology outpatient,he was prescribed with donepezil for the next *** symptoms of disinhibited behavior and memory decline *** followed up in the neurology outpatient in 2015 and got 15 in MMSE and 8 in MoCA,the treatment was replaced by memantine(maximum 10 mg/day).In Feb 2016,the patient had a seizure attack for 1-2 minutes which positive electroencephalogram *** he had been cured with combination of gabapentin(300 mg,Tid) since then,he still had similar seizure a

关键词： Frontotemporal dementia neuroleptic malignant syndrome epilepsy donepezil

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Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第3期12卷 163-173页

作者： Massimo GIUSTI Giulia MELLE Monica FENOCCHIO Lorenzo MORTARA Francesca CECOLI Valeria CAORSI Diego FERONE Francesco MINUTO Elda RASORE Department of Endocrine and Medical Sciences University of Genoa Department of psychiatric Sciences University of Genoa

Differentiated thyroid carcinoma(DTC) generally has a favorable *** disease,treatments,stress,and comorbidity can compromise health-related quality of life(QoL) and indirectly weigh upon the outcome. From 2004 to 2008,we evaluated QoL longitudinally in 128 DTC *** scheduled examinations,subjects were asked to undergo a semi-structured psychiatric interview and five rated *** same examination was conducted in 219 subjects after surgery for benign thyroid *** scores represent a better *** and control subjects were similar in terms of age,male/female ratio,concomitant psychopharmacological treatments,and frequency of psychiatric *** DTC subjects,Billewicz scale(BS) scores showed an increasing trend over time,especially among *** ad hoc thyroid questionnaire(TQ) scores were similar in both groups and did not change over time,but at the end of the study ad hoc TQ and BS were significantly *** hoc TQ scores were also related to age on entry to the *** both male and female DTC subjects,Hamilton's tests for anxiety(HAM-A) ,but not for depression(HAM-D),showed an improving *** the end of the study,HAM-A and HAM-D scores were comparable to those of the control ***-A and HAM-D were both positively correlated with the stage of cancer and the time between diagnosis and *** HAM-D correlated with age on entry to the *** symptom questionnaire(KSQ) item scores were higher in DTC subjects than in *** change over time in the items including anxiety,somatization,depression,and hostility was *** and hostility were more significantly reduced in DTC females than in DTC *** scores were significantly lower in DTC subjects than in controls at the end of the *** and depression were significantly related to staging on diagnosis and age on entry to the *** study confirms a wide variation of illness perception in DTC subjects

关键词： Thyroid cancer Outcome Psycholoqical evaluation Qualitv of life Loneitudinal study

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