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XBP1S,a BMP2-inducible transcription factor,Accelerates Endochondral Bone Growth by activating GEP Growth Factor

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XBP1S,a BMP2-inducible transcription factor,Accelerates Endo...

A Quantitative Phosphoproteome Analysis of cGMP-Dependent Cellular Responses in Arabidopsis thaliana

中国遗传学会第九次全国会员代表大会暨学术研讨会

作者： Feng-Jin Guo Peng Zhang Xiaofeng Han Rong Jiang Meiling Li Fei Xia Department of Cell Biology and Genetics Core Facility of Development BiologyChongqing Medical University Laboratory of Stem Cells and Tissue Engineering Chongqing Medical University

We reported earlier that transcription factor XBPIS binds to RUNX2 and enhances chondrocyte hypertrophy through functions as a cofactor of *** we report that XBP 1S is a key downstream molecule of BMP2,and it is required for BMP2-mediated chondrocyte ***1S is upregulated during chondrocyte differentiation and demonstrates the temporal and spatial expression pattern during skeletal ***1S stimulates chondrocyte differentiation from mesenchymal stem cells in vitro and endochondral ossification ex *** also show that XBP1S activates granulin-epithelin precursor(GEP) growth factor and endogenous GEP is required for XBP1S-stimulated chondrocyte hypertrophy,mineralization,and endochondral bone formation. In addition,XBP1S acts as a new GEP regulator and increases GEP-stimulated endochondral bone formation:(1) overexpression of XBP1S stimulates chondrogenesis in vitro and chondrocyte hypertrophy,mineralization,and endochondral bone growth ex vivo;(2) XBP1S is a downstream molecule of BMP2 and is required for BMP2 stimulation of chondrogenesis;(3) XBP1S increases GEP expression in chondrogenesis and enhances chondrogenesis through GEP;(4) XBP1S accelerates the chondroinductive activity of GEP. Collectively,these findings demonstrate that XBP1S,a BMP2-inducible transcription factor, positively regulates endochondral bone formation by activating GEP chondrogenic growth *** reveals a novel critical role of XBP 1S in chondrocyte differentiation and the molecular events both in vivo and in vitro.

关键词： X-box binding protein 1 spliced(XBP1S) chondrogenesis GEP BMP2 unfolded protein response

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Molecular Plant 2016年第4期9卷 621-623页

作者： Claudius Marondedze Arnoud J. Groen Ludivine Thomas Kathryn S. Lilley Chris Gehring Division of Biological and Environmental Sciences and Engineering 4700 King Abdullah University of Science and Technology Thuwal 23955-6900 Kingdom of Saudi Arabia Department of Biochemistry Cambridge Centre for Proteomics Cambridge Systems Biology Centre University of Cambridge Tennis Court Road Cambridge CB2 1QR UK Bioscience core Laboratory Division of Biological and Environmental Sciences and Engineering 4700 King Abdullah University of Science and Technology Thuwal 23955-6900 Kingdom of Saudi Arabia

Dear Editor,The second messenger cyclic nucleotide 3＇,5＇-cyclic guanosine monophosphate （cGMP） is increasingly recognized as a key signaling molecule that mediates many physiological and developmental processes in... 详细信息

关键词： cGMP 蛋白质组分磷酸化拟南芥反应细胞环磷酸鸟苷环核苷酸

IRE1α dissociates with BiP and inhibits ER stressmediated apoptosis in cartilage development

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IRE1α dissociates with BiP and inhibits ER stressmediated a...

Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance

中国遗传学会第九次全国会员代表大会暨学术研讨会

作者： Xiaofeng Han Jinghua Zhou Peng Zhang Rong Jiang Feng-Jin Guo Department of Cell Biology and Genetics Core Facility of Development BiologyChongqing Medical University Laboratory of Stem Cells and Tissue Engineering Chongqing Medical University

Bone morphogenetic protein 2 is known to activate unfolded protein response signaling molecules,including XBP1S,BiP and IREIα.Endoplasmic Reticulum stress is induced in chondrogenesis and activates IRE lαsignal pathway,which is associated with ER stress-mediated ***,the influence on IRElαt and BiP in BMP2-induced chondrocyte differentiation have not yet been elucidated,the molecular mechanism remains unexplored. In this study,we demonstrate that IRE1αinteracts with BiP in unstressed cells and dissociates from BiP in the course of cartilage *** of ER stress-responsive proteins (XBPIS,IRE1α,BiP) was also observed in differentiating ***αinhibition ER stress-mediated apoptosis lies in the process of chondrocyte ***, knockdown of IRE1αexpression by way of the RNAi approach accelerates ER stress-mediated apoptosis in ehondrocyte differentiation induced by BMP2,as revealed by enhanced expression of cleaved caspase3,CHOP and p-JNK1;and this IRE1αinhibition effect on ER stress-mediated apoptosis is required for BiP in chondrogenesis. Collectively,the ER stress sensors were activated during apoptosis in cartilage development, suggesting that selective activation of ER stress signaling was sufficient for induction of apoptosis These findings reveal a novel critical role of IRElαin ER stress-mediated apoptosis and the molecular mechanisms *** results suggest that activation of p-JNKl,caspase3 and CHOP were detected in developing chondrocytes and that specific ER stress signaling leads to naturally occurring apoptosis during cartilage development.

关键词： Endoplasmic reticulum stress Apoptosis UPR IRE1α BiP cartilage development

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Science Bulletin 2019年第16期64卷 1132-1135页

作者： Jun Cao Hong Jiang Ran Zhang Amr.R.Ghanam Honghai Xia Yuting Zhu Zhen Yang Xiaoyuan Song Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research CenterSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Department of Emergency Surgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China core facility Center for Life Sciences School of Life SciencesUniversity of Science and Technology of ChinaHefei 230026China

Cancer stem cells (CSCs) are largely responsible for the formation of tumor heterogeneity and tumor’s resistance to traditional treatments such as chemotherapy due to its self-renew capability and multi-lineage differentiation potential (1)However, it remains elusive how the CSCs maintain their stemness, thus restricting the development of therapeutic treatments specifically targeting the CSCs.

关键词： HCC Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance CYP

Fundamentals and comprehensive insights on pulsed laser synthesis of advanced materials for diverse photo-and electrocatalytic applications

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Light(Science & Applications) 2022年第9期11卷 2018-2064页

作者： Jayaraman Theerthagiri K Karuppasamy Seung Jun Lee R.Shwetharani Hyun-Seok Kim S.K Khadheer Pasha Muthupandian Ashokkumar Myong Yong Choi core-facility Center for Photochemistry&Nanomaterials Department of ChemistryResearch Institute of Natural SciencesGyeongsang National UniversityJinju 52828Republic of Korea Division of Electronics and Electrical Engineering Dongguk University-SeoulSeoul 04620Republic of Korea Centre for Nano and Material Sciences Jain UniversityJain Global CampusKanakapuraBangalore 562112 KarnatakaIndia Department of Physics Vellore Institute of Technology(Amaravati Campus)Amaravati522501 GunturAndhra PradeshIndia School of Chemistry University of MelbourneParkville CampusMelbourneVIC 3010Australia

The global energy crisis is increasing the demand for innovative materials with high purity and functionality for the development of clean energy production and *** development of novel photo-and electrocatalysts significantly depends on synthetic techniques that facilitate the production of tailored advanced *** emerging use of pulsed laser in liquid synthesis has attracted immense interest as an effective synthetic technology with several advantages over conventional chemical and physical synthetic routes,including the fine-tuning of size,composition,surface,and crystalline structures,and defect densities and is associated with the catalytic,electronic,thermal,optical,and mechanical properties of the produced ***,we present an overview of the fundamental understanding and importance of the pulsed laser process,namely various roles and mechanisms involved in the production of various types of nanomaterials,such as metal nanoparticles,oxides,non-oxides,and carbon-based *** mainly cover the advancement of photo-and electrocatalytic nanomaterials via pulsed laser-assisted technologies with detailed mechanistic insights and structural optimization along with effective catalytic performances in various energy and environmental remediation ***,the future directions and challenges of pulsed laser techniques are briefly *** review can exert practical guidance for the future design and fabrication of innovative pulsed laser-induced nanomaterials with fascinating properties for advanced catalysis applications.

关键词： insight synthesis comprehensive

Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153

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Bone Research 2022年第4期10卷 799-815页

作者： Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler Department of Internal Medicine 3–Rheumatology and Immunology Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum ErlangenErlangenGermany Deutsches Zentrum für Immuntherapie Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum ErlangenErlangenGermany Department of Rheumatology Xiangya HospitalCentral South UniversityChangshaHunanChina core facility Hohenheim University of HohenheimStuttgartGermany Graduate Institute of Anatomy and Cell biology National Taiwan University College of MedicineTaipeiTaiwan

Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone *** inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target *** O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically *** demonstrate that dynamic changes in O-GlcNAcylation are required for *** O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast *** the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell ***αfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory *** pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental *** of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits *** findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption.

关键词： osteoclast homeostasis maintained

Global, 30-m resolution continuous fields of tree cover: Landsat-based rescaling of MODIS vegetation continuous fields with lidar-based estimates of error

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International Journal of Digital Earth 2013年第5期6卷 427-448页

作者： Joseph O.Sexton Xiao-Peng Song Min Feng Praveen Noojipady Anupam Anand Chengquan Huang Do-Hyung Kim Kathrine M.Collins Saurabh Channan Charlene DiMiceli John R.Townshend Global Land Cover facility Department of Geographical SciencesUniversity of MarylandCollege ParkMDUSA Department of Geographical Sciences University of MarylandCollege ParkMDUSA

We developed a global,30-m resolution dataset of percent tree cover by rescaling the 250-m MOderate-resolution Imaging Spectroradiometer(MODIS)Vegetation Continuous Fields(VCF)Tree Cover layer using circa-2000 and 2005 Landsat images,incorporating the MODIS Cropland Layer to improve accuracy in agricultural *** Landsat-based estimates maintained consistency with the MODIS VCF in both epochs(RMSE=8.6%in 2000 and 11.9%in 2005),but showed improved accuracy in agricultural areas and increased discrimination of small forest *** lidar measurements,the Landsat-based estimates exhibited accuracy slightly less than that of the MODIS VCF(RMSE=16.8%for MODIS-based vs.17.4%for Landsat-based estimates),but RMSE of Landsat estimates was 3.3 percentage points lower than that of the MODIS data in an agricultural *** Landsat data retained the saturation artifact of the MODIS VCF at greater than or equal to 80%tree cover but showed greater potential for removal of errors through calibration to lidar,with post-calibration RMSE of 9.4%compared to 13.5%in MODIS *** for free download at the Global Land Cover facility(GLCF)website(***),the 30-m resolution GLCF tree cover dataset is the highest-resolution multi=temporal depiction of Earth’s tree cover available to the Earth science community.

关键词： tree cover continuous fields Landsat MODIS lidar

Constructing a highly bioactive tendon-regenerative scaffold by surface modification of tissue-specific stem cell-derived extracellular matrix

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Regenerative Biomaterials 2022年第1期9卷 81-92页

作者： Liang-Ju Ning Jing Cui Shu-Kun He Ruo-Nan Hu Xuan Yao Yi Zhang Wei Ding Yan-Jing Zhang Jing-Cong Luo Ting-Wu Qin Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041P.R.China Department of Orthopedic Surgery Orthopedic Research InstituteWest China HospitalSichuan UniversityChengduSichuan 610041P.R.China core facility West China HospitalSichuan UniversityChengduSichuan 610041P.R.China

Developing highly bioactive scaffold materials to promote stem cell migration,proliferation and tissue-specific differentiation is a crucial requirement in current tissue engineering and regenerative *** previous work has demonstrated that the decellularized tendon slices(DTSs)are able to promote stem cell proliferation and tenogenic differentiation in vitro and show certain pro-regenerative capacity for rotator cuff tendon regeneration in *** this study,we present a strategy to further improve the bioactivity of the DTSs for constructing a novel highly bioactive tendon-regenerative scaffold by surface modification of tendon-specific stem cell-derived extracellular matrix(tECM),which is expected to greatly enhance the capacity of scaffold material in regulating stem cell behavior,including migration,proliferation and tenogenic *** prove that the modification of tECM could change the highly aligned surface topographical cues of the DTSs,retain the surface stiffness of the DTSs and significantly increase the content of multiple ECM components in the *** a result,the tECM-DTSs dramatically enhance the migration,proliferation as well as tenogenic differentiation of rat bone marrow-derived stem cells compared with the ***,this strategy would provide a new way for constructing ECMbased biomaterials with enhanced bioactivity for in situ tendon regeneration applications.

关键词： tendon-regenerative scaffold extracellular matrix bioactive material tissue-specific stem cell

Short communication: genetic variations of SLC2A9 in relation to Parkinson’s disease

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Translational Neurodegeneration 2013年第1期2卷 26-29页

作者： Jianjun Gao Hong Xu Xuemei Huang Honglei Chen Epidemiology Branch National Institute of Environmental Health SciencesResearch Triangle ParkNorth CarolinaUSA Molecular Genetics core facility National Institute of Environmental Health SciencesResearch Triangle ParkNorth CarolinaUSA Department of Neurology Pennsylvania State University-Milton S.Hershey Medical CenterHersheyPennsylvaniaUSA

Background:Epidemiological studies showed that higher plasma urate was associated with lower risk for Parkinson’s disease(PD)and slower disease *** genome-wide association studies(GWAS)consistently showed that several single nucleotide polymorphisms(SNPs)in the solute carrier family 2 member 9 gene(SLC2A9)were associated with plasma urate concentration and the risk of ***:We conducted a case–control study to examine twelve tag SNPs of the SLC2A9 gene in relation to PD among 788 cases and 911 controls of European *** ratios(OR)and 95%confidence intervals(CI)were derived from logistic regression models,adjusting for age,sex,smoking and caffeine ***:These SNPs were all in linkage disequilibrium(R^(2)>0.7).None of them were associated with PD *** women,however,there was a suggestion that the presence of the minor allele of one SNP(rs7442295)was related to a small increase in PD risk[OR(95%CI)=1.48(1.01-2.16)].Conclusion:This study provides little support for genetic variations of SLC2A9 and PD risk.

关键词： SLC2A9 relation linkage