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food Science and Human Wellness 2024年第1期13卷 115-123页

作者： Yue Yu Haibin Zhu Mingyue Shen Qiang Yu Yi Chen Shiru Mo Jianhua Xie State Key Laboratory of food Science and technology Nanchang UniversityNanchang 330047China International Institute of food Innovation Nanchang UniversityNanchang 330200China

The biological activity of plant polysaccharides can be enhanced by sulfated *** this study,the immunomodulatory effect of sulfated Cyclocarya paliurus polysaccharides(SCP3)on macrophages RAW264.7 and its potential molecular mechanism were *** showed that SCP3 at 25-100μg/m L increased viability and improved phagocytosis of RAW264.7 ***,SCP3 could activate mitogen-activated protein kinase(MAPK)and nuclear factor kappa B(NF-κB)signaling pathways,which increased the phosphorylation of Erk1/2,JNK,p38 and NF-κB p65,promoting secretion of cytokines tumor necrosis factorα(TNF-α),interleukin 6(IL-6)and nitric oxide(NO)as well as the production of reactive oxygen species(ROS).In addition,Toll-like receptor 4(TLR4)receptor inhibitors were able to block the production of NO and TNF-αby SCP3-stimulated *** on Western blot analysis and validation using specific inhibitors against MAPK and NF-κB signaling pathways,the results demonstrated that SCP3 induced macrophages activation and enhanced TNF-αand NO production via TLR4-mediated MAPK and NF-κB *** summary,SCP3 has significant immunomodulatory *** underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production,which in turn activates the downstream MAPK/NF-κB signaling pathway and then increases the secretion levels of cytokines and NO.

关键词： Cyclocarya paliurus Sulfated polysaccharides Macrophages Immunomodulatory Mechanism

Valorization of wheat bran arabinoxylan: A review on nutritional and materials perspectives

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Grain & Oil Science and technology 2024年第3期7卷 196-208页

作者： Muhammad Bilal Dandan Li Chong Xie Runqiang Yang Zhenxin Gu Dong Jiang Xueming Xu Pei Wang College of food Science and technology Whole Grain Food Engineering Research Center Nanjing Agricultural University The Sanya Institute of Nanjing Agricultural University National Technique Innovation Center for Regional Wheat Production/Key Laboratory of Crop Physiology Ecology and Management Ministry of Agriculture/National Engineering and Technology Center for Information Agriculture Nanjing Agricultural University Key Laboratory of food Science and technology School of Food Science and Technology Jiangnan University

Wheat bran, a principal byproduct of flour milling, stands as an abundant source of dietary fiber, yet its economic potential remains under-exploited in current forage applications. Arabinoxylan(AX), constituting the core of dietary fiber, emerges as a versatile compound with multifaceted functionalities. Its nutritional significance,coupled with its role in cereal food processing, has prompted a surge of studies focusing on the valorization of wheat bran AX. Moreover, the hydrolyzed derivative, arabinoxylan oligosaccharides(AXOS), demonstrates prebiotic and antioxidant properties, offering potential avenues to mitigate the risk of chronic diseases. This review summarizes current knowledge on the valorization of wheat bran AX in terms of the processing and nutritional properties of AX. Moreover, multiple novel applications of AX in the materials area, including biodegradable food packaging films, delivery of bioactive substances as nanoparticles, and the manufacture of food emulsifiers, are also highlighted to extend the utilization of AX. This review underscores the immense potential of wheat bran AX, advocating for its exploitation not only as a nutritional asset but also as a primary ingredient in advanced materials. The synthesis of nutritional and materials perspectives accentuates the multifaceted utility of wheat bran AX, thereby paving the way for sustainable valorization pathways. By unraveling the latent potential within AX, this paper advocates for the holistic and sustainable utilization of wheat bran in diverse, value-added applications.

关键词： Wheat bran Arabinoxylan Nutrition Biodegradable films Nanoparticles food emulsifiers

Effect of sodium starch octenyl succinate-based Pickering emulsion on the physicochemical properties of hairtail myofibrillar protein gel subjected to multiple freeze-thaw cycles

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food Science and Human Wellness 2024年第2期13卷 1018-1028页

作者： Huinan Wang Jiaxin Zhang Xinran Liu Jinxiang Wang Xuepeng Li Jianrong Li Key Laboratory of food Nutrition and Safety Ministry of EducationCollege of Food Science and EngineeringTianjin University of Science and TechnologyTianjin 300457China College of food Science and technology Bohai UniversityNational R&D Branch Center of Surimi and Surimi Products ProcessingJinzhou 121013China

A Pickering emulsion based on sodium starch octenyl succinate(SSOS)was prepared and its effects on the physicochemical properties of hairtail myofibrillar protein gels(MPGs)subjected to multiple freeze-thaw(F-T)cycles were *** whiteness,water-holding capacity,storage modulus(G')and texture properties of the MPGs were significantly improved by adding 1%-2%Pickering emulsion(P<0.05).Meanwhile,Raman spectral analysis demonstrated that Pickering emulsion promoted the transformation of secondary structure,enhanced hydrogen bonds and hydrophobic interactions,and promoted the transition of disulfide bond conformation from g-g-g to g-g-t and *** an emulsion concentration of 2%,theα-helix content decreased by 10.37%,while theβ-sheet content increased by 7.94%,compared to the *** F-T cycles,the structure of the MPGs was destroyed,with an increase in hardness and a decrease in whiteness and water-holding capacity,however,the quality degradation of MPGs was reduced with 1%-2%Pickering *** findings demonstrated that SSOS-Pickering emulsions,as potential fat substitutes,can enhance the gel properties and the F-T stability of MPGs.

关键词： Pickering emulsion Myofibrillar protein Gel properties Freeze-thaw stability Intermolecular interactions

Research advance of Bacillus velezensis:bioinformatics,characteristics,and applications

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food Science and Human Wellness 2024年第4期13卷 1756-1766页

作者： Ting Su Biao Shen Xingjuan Hu Yue Teng Peifang Weng Zufang Wu Lianliang Liu State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Key Laboratory of Animal Protein Deep Processing Technology of ZhejiangZhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and NutritionSchool of Food and Pharmaceutical SciencesNingbo UniversityNingbo 315000China Zhoushan Customs District Zhoushan 316100China

Bacillus velezensis is a Gram-positive and spore-forming *** has potent antimicrobial properties that can be used to promote plant growth and as a pesticide by inhibiting *** has the capability to generate a diverse range of enzymes that have potential applications in various fields,such as enzyme production,fermented food,degradation of pollutants,and *** addition,*** is a promising *** possesses high bile-salt tolerance characteristics and has a high success rate of colonization in the intestinal ***,the strain can also regulate gut microbiota constitute by increasing the number of beneficial microorganisms and decreasing the number of ***,based on its special properties,including high-yield protease production and high salt-tolerance,*** shows potential for use in marine protein fermentation,opening up new avenues for the development of novel food products and bioactive *** addition,*** can shorten the fermentation time as well as improve the nutritional value and flavor of fermented *** safety of *** for food production was *** review provides valuable insights into the potential uses and benefits of ***,particularly in the context of fermented foods.

关键词： Bacillus velezensis Bioinformatics Properties Fermentation Bioactive peptides

Long-term Consumption of Highland Barley Tea Promotes Healthy Aging of Skeletal Muscle

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food Science and Human Wellness 2024年

作者： Li Yan Chenzhipeng Nie Qingwei Zheng Mingcong Fan Waleed AL-Ansi Haifeng Qian Li Wang State Key Laboratory of food Science and technology， School of food Science and technology， Jiangnan University

Highland barley tea (HBT) is made from roasted barley seeds and is abundant in β-glucan， amino acids， minerals， phenolics， and other natural active ingredients. These natural compounds found in whole grains have been shown to slow aging and positively affect skeletal muscle function. As a result， studying the effects of HBT on the skeletal muscle health of the elderly population is critical from a scientific and societal standpoint for improving their health status and reducing the medical burden on society. The antioxidant activity and the content of natural active substances were used as indicators to screen the optimal process of HBT brewing. The effects of long-term HBT consumption on aging in mice were investigated by using HBT as a substitute for drinking water in naturally aging mice for a 5-month intervention. Afterward， various factors were measured， such as basic physiological indices， inflammation， plasma metabolites， skeletal muscle function， and exercise capacity， to evaluate the effects of HBT on aging in mice. Long-term consumption of HBT reduced body and spleen weight， increased body weight percentage of skeletal muscle， and reduced plasma inflammation levels in aging mice. Metabolomic results showed increased plasma levels of the mitochondrial marker short-chain acylcarnitine and some amino acids. Additionally， there was a decrease in bile and long-chain acylcarnitine. The level of fibrosis in the gastrocnemius muscle of aging mice was suppressed， and the percentage of type I muscle fibers was increased， improving the endurance of the mice. Thus， long-term consumption of HBT may reduce body weight and increase skeletal muscle mitochondrial activity and exercise capacity in aging mice by reducing inflammation levels and alleviating mitochondrial damage.

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A visual modeling method for spatiotemporal and multidimensional features in epidemiological analysis:Applied COVID-19 aggregated datasets

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Computational Visual Media 2024年第1期10卷 161-186页

作者： Yu Dong Christy Jie Liang Yi Chen Jie Hua School of Computer Science University of Technology SydneySydneyNSW2007Australia Beijing Key Laboratory of Big Data technology for food Safety Beijing Technology and Business UniversityBeijing100048China

The visual modeling method enables flexible interactions with rich graphical depictions of data and supports the exploration of the complexities of epidemiological ***,most epidemiology visualizations do not support the combined analysis of objective factors that might influence the transmission situation,resulting in a lack of quantitative and qualitative *** address this issue,we developed a portrait-based visual modeling method called+*** method considers the spatiotemporal features of virus transmission patterns and multidimensional features of objective risk factors in communities,enabling portrait-based exploration and comparison in epidemiological *** applied+msRNAer to aggregate COVID-19-related datasets in New South Wales,Australia,combining COVID-19 case number trends,geo-information,intervention events,and expert-supervised risk factors extracted from local government area-based *** perfected the+msRNAer workflow with collaborative views and evaluated its feasibility,effectiveness,and usefulness through one user study and three subject-driven case *** feedback from experts indicates that+msRNAer provides a general understanding for analyzing comprehension that not only compares relationships between cases in time-varying and risk factors through portraits but also supports navigation in fundamental geographical,timeline,and other factor *** adopting interactions,experts discovered functional and practical implications for potential patterns of long-standing community factors regarding the vulnerability faced by the *** confirmed that+msRNAer is expected to deliver visual modeling benefits with spatiotemporal and multidimensional features in other epidemiological analysis scenarios.

关键词： visual modeling epidemiological analysis spatiotemporal multidimensional COVID-19

Inhibitory effect and mechanism of tannic acid against two starch digestive enzymes

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food Quality and Safety 2024年第1期8卷 115-123页

作者：钟毓秀倪德让杨玉波李元一王莉田金虎杨帆叶兴乾 Department of food Science and Nutrition Zhejiang Key Laboratory for Agri-Food ProcessingFuli Institute of Food ScienceZhejiang R&D Centre for Food Technology and EquipmentZhejiang UniversityHangzhouChina Institute of Science and technology Moutai GroupZunyiChina Key Laboratory of Industrial Microbial Resources Development Kweichow Moutai Co.Ltd.RenhuaiChina

Backgrounds:Tannic acid(TA),as a plant-derived phenolic substance,is involved in regulating the activity of starch digestive enzymes,but its underlying mechanism remains *** and Results:In the present study,inhibition rate and inhibition kinetics assays were performed and confrmed that TA had a strong inhibitory effect on bothα-amylase andα-glucosidase with IC50 values of 0.1585 mg/mL and 0.00542 mg/mL,respectively,through a mixed inhibition *** secondary structures of both enzymes were confrmed to be modifed by TA through circular dichroism(CD)*** quenching analysis revealed that the interaction between TA and two enzymes was a static process of pontaneous complex ***,molecular docking revealed that non-covalent bonds were the main interaction forces between TA and both ***:Thus,TA was a promising candidate for the inhibition of starch-digesting enzymes,and the present research provided insight into postprandial glucose regulation through polyphenols.

关键词： Tannic acid α-amylase α-glucosidase inhibition starch digestion.

Recent advances in metabolic engineering of microorganisms for production of tyrosol and its derivatives

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生物工程学报 2024年第8期40卷 2604-2625页

作者： LIU Yingjie FU Changchun ZHANG Xuepeng GU Bixuan HU Haitao YANG Ruijin LYU Xiaomei School of food Science and technology Jiangnan UniversityWuxi 214122JiangsuChina

Tyrosol is a natural phenolic compound with antioxidant,anti-inflammatory and other biological activities,serving as an important precursor of high-value products such as hydroxytyrosol and ***,the green and efficient biosynthesis of tyrosol and its derivatives has become a research hotspot in recent *** cell factories by metabolic engineering of microorganisms is a potential industrial production way,which has low costs and environmental *** paper introduces the biosynthesis pathway of tyrosol and presents the key regulated nodes in the de novo synthesis of tyrosol in Escherichia coli and Saccharomyces *** addition,this paper reviews the recent advances in metabolic engineering for the production of hydroxytyrosol and *** review can provide a reference for engineering the strains for the high-yield production of tyrosol and its derivatives.

关键词： tyrosol metabolic engineering Escherichia coli Saccharomyces cerevisiae hydroxytyrosol salidroside

A multi-colloidal gold immunochromatography assay for rapid and simultaneous detection of 13 herbicides

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Nano Research 2024年第9期17卷 8368-8376页

作者： Qianqian Lu Xinxin Xu Aihua Qu Liqiang Liu Yuzhe Li Maozhong Sun Chuanlai Xu Hua Kuang International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and TechnologyJiangnan UniversityWuxi 214122China China National Center for food Safety Risk Assessment Beijing 100021China

Herbicide residues in agricultural products can have adverse effects on the environment and human health,therefore,there is an urgent need to establish a sensitive,rapid,and wide-ranging detection *** this study,haptens of phenylurea herbicides(PUs)and sulfonylurea herbicides(SUs)were analyzed and designed based on computational simulation techniques,and two high-performance broad-spectrum monoclonal antibodies against PUs and SUs were *** this basis,a multi-colloidal gold immunochromatography assay(multi-CGIA)was developed to simultaneously detect 13 herbicides in *** visual limit of detection(vLOD)for PUs including diuron,chlortoluron,neburon,chlorbromuron,and linuron was 1-2μg/*** vLOD for SUs including metsulfuron methyl,ethametsulfuron-methyl,sulfometuron-methyl,tribenuron methyl,cinosulfuron,triasulfuron,chlorimuron-ethyl,and chlorsulfuron was 2-10μg/*** results of real sample determination indicated that the multi-CGIA is accurate,stable,and reliable,and adaptable to on-site preliminary screening of actual samples.

关键词： phenylurea herbicides sulfonylurea herbicides monoclonal antibody immunochromatographic assay wheat

Oral administration of Bacillus coagulans TQ-35 alleviates allergic responses in OVA-sensitive BALB/c mice

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food Science and Human Wellness 2024年第3期13卷 1246-1257页

作者： Yifan Wang Shanjun Chen Chong Wang Yi Zhang Hongliang Zeng Linglin Fu Yanbo Wang food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China College of food Science Fujian Agriculture and Forestry UniversityFuzhou 350002China School of food and Health Beijing Technology and Business UniversityBeijing 100048China

Bacillus coagulans has been extensively studied so far,but there has been a lack of research on its usage in *** this study,we designed to assess the effect of different concentrations of *** on food allergy in a BALB/c mouse model of ovalbumin(OVA)-induced food allergy and its effect on gut *** assessment of symptoms,specific immunoglobulin E(IgE),T-cell differentiation,and related gene expression levels in sensitized mice by assay indicated that high doses of oral *** could alleviate allergic *** with ***,in the high-dose group,significantly reduced IgE and IgG1 levels and modulated the balance of T helper type 1 cell(Th1)and Th2 and the expression of relevant genes in the spleen.16S rRNA analysis showed that probiotics improved the structure of the microbiota,in particular by boosting the percentage of Clostridia,Bacteroides vulgatus and Enterococcus faecium,and by increasing the abundance of microbial species,thereby modulating the immune ***,this study can provide insights into the practical application of *** doses to alleviate OVA allergy.

关键词： Bacillus coagulans TQ-35 food allergy Ovalbumin(OVA) Gut microbiota