Recent advances in metabolic engineering of microorganisms for production of tyrosol and its derivatives

作     者：LIU Yingjie FU Changchun ZHANG Xuepeng GU Bixuan HU Haitao YANG Ruijin LYU Xiaomei 刘英杰;符长春;张学鹏;谷碧璇;胡海涛;杨瑞金;吕小妹

作者机构：School of Food Science and TechnologyJiangnan UniversityWuxi 214122JiangsuChina 

出 版 物：《生物工程学报》 (Chinese Journal of Biotechnology)

年 卷 期：2024年第40卷第8期

页      面：2604-2625页

核心收录：

学科分类：081703[工学-生物化工] 08[工学] 0817[工学-化学工程与技术] 0836[工学-生物工程] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 

基　　金：国家重点研发计划(2022YFF1100300) 国家自然科学基金(22108097) 江苏省重点研发计划(BE2022850) 无锡市太湖创新领军人才项目(1026010241230040) 

主　　题：tyrosol metabolic engineering Escherichia coli Saccharomyces cerevisiae hydroxytyrosol salidroside 

摘      要：Tyrosol is a natural phenolic compound with antioxidant,anti-inflammatory and other biological activities,serving as an important precursor of high-value products such as hydroxytyrosol and ***,the green and efficient biosynthesis of tyrosol and its derivatives has become a research hotspot in recent *** cell factories by metabolic engineering of microorganisms is a potential industrial production way,which has low costs and environmental *** paper introduces the biosynthesis pathway of tyrosol and presents the key regulated nodes in the de novo synthesis of tyrosol in Escherichia coli and Saccharomyces *** addition,this paper reviews the recent advances in metabolic engineering for the production of hydroxytyrosol and *** review can provide a reference for engineering the strains for the high-yield production of tyrosol and its derivatives.