检索结果-南通市图书馆

Adipose tissue,systematic inflammation,and neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第1期18卷 38-46页

作者： Ana paula de A.Boleti pedro Henrique de o.Cardoso Breno emanuel F.Frihling patrícia souza e silva Luiz Filipe R.Nde Moraes Ludovico Migliolo s-Inova Biotech Programa de Pós-Graduação em BiotecnologiaUniversidade Católica Dom BoscoCampo GrandeMSBrazil programa de pós-graduação em Biologia Celular e Molecular Programa de Pós-Graduação em BioquímicaUniversidade Federal do Rio Grande do NorteNatalBrazil

obesity is associated with several diseases,including mental *** tissue is distributed around the internal organs,acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the *** nutritional intake results in hypertrophy and proliferation of adipocytes,leading to local hypoxia in adipose tissue and changes in these adipokine *** leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammatory *** presence of high levels of free fatty acids and inflammatory molecules interfere with intracellular insulin signaling,which can generate a neuroinflammatory *** this review,we provide an up-to-date discussion of how excessive obesity can lead to possible cognitive *** also address the idea that obesity-associated systemic inflammation leads to neuroinflammation in the brain,particularly the hypothalamus and hippocampus,and that this is partially responsible for these negative cognitive *** addition,we discuss some clinical models and animal studies for obesity and clarify the mechanism of action of anti-obesity drugs in the central nervous system.

关键词： adiposity anti-obesity drugs hypothalamic inflammation metabolic disease neurodegenerative disease neuroinflammation

Coffee protection against the development of hepatocellular carcinoma: review article

在线全文

学校读者我要写书评

暂无评论

Hepatoma Research 2020年第2期6卷 33-38页

作者： Kellyane s.D.Carvalho Helma p.Cotrim programa de pós-graduação em medicina e saúde Faculdade de Medicina-Universidade Federal da BahiaBahia 40110-060Brazil

Coffee, a popular drink around the world, is composed of a complex mix of biologically active molecules, including caffeine, chlorogenic acid, and diterpenes. These compounds have antioxidant, anti-inflammatory, antifibrotic, and anticarcinogenic properties, which may explain observational data showing that coffee drinkers have lower rates of chronic liver disease, including cirrhosis and hepatocellular carcinoma (HCC). Recent studies have also shown that coffee consumption may also increase patient survival before and after liver transplantation. The mechanism by which coffee consumption protects against HCC is not clear;however, its relevant role has been demonstrated. This literature review article focuses on the role of coffee consumption in protecting against the development of HCC. Methodology: scientific articles indexed through pubMed, including Medline, scielo, and Lilacs, published in english were used as search methods. The terms used in english were: "hepatocellular carcinoma" or "Liver cancer" or "HCC" and "coffee". According to the study design or review article, cross-sectional, longitudinal, or descriptive investigations were included, showing site and year of publication until 2019.

关键词： Hepatocellular carcinoma coffee consumption protection liver cancer

Remarks on the application of two-dimensional shape factors under severe wear conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Friction 2016年第1期4卷 65-71页

作者： Giuseppe pINTAUde Mario CoseGLIo programa de pós-gradua(a)(a)o em engenharia Mec(a)nica e de Materiais UTFPR Curitiba PR Brazil University of Birmingham Birmingham UK

The use of two-dimensional shape parameters to characterize abrasive particles is a potential approach to express their angularity. Nevertheless, in sliding abrasion, especially in pin abrasion testing, these descriptors could not be suitable for characterizing severe wear of engineering materials such as steels and cast irons. This work compares the applicability of two-dimensional shape parameters in describing severe wear of metals in recent pin abrasion tests with cases where they could have been correlated with the wear rates. Considering these aspects, this work puts in evidence the importance of clogging occurrence and the coated paper structure for a carefully application of shape parameters. In addition, it is proposed a possible relation between the shape parameters and one of the components of the abrasion factor.

关键词： wear particle shape sliding abrasion coated papers

extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIoCeLL 2021年第3期45卷 461-481页

作者： AMYLLY saNUeLLY DA pAZ MARTINs saMARA BoMFIM GoMes CAMpos MARÍLIA oLIVeIRA FoNseCA GoULART FABIANA ANDRÉA MoURA programa de pós-graduação da Rede Nordeste de Biotecnologia(ReNoRBIo) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil programa de pós-graduação em Ciências da saúde(ppGCs) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil programa de pós-graduação em Química e Biotecnologia(ppGQB/UFAL) Campus A.C.SimõesAvenida Lourival Melo Motas/nTabuleiro dos MartinsMaceióAL 57072-970Brazil programa de pós-graduação em Nutrição(ppGNU/UFAL) Programa de Pós-Graduação em Ciências Médicas(PPGCM/UFAL)Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil

Inflammatory bowel disease(IBD),which includes Crohn’s disease and ulcerative colitis,has a not yet completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative stress and *** manifestations can occur and affect several organs,including the liver and bile ducts,joints,skin,eyes,and less frequently,the heart,brain,and kidneys,increasing the risk of morbidity and *** repercussions may be associated with the activity or severity of *** present review proposes to report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of extraintestinal manifestations,aiming to contribute to a better understanding of the disease and to focus on the development of individualized preventive and therapeutic strategies.

关键词： oxidative stress Microbiota Bacterial translocation Ulcerative colitis Crohn disease

Curcumin in inflammatory bowel diseases:Cellular targets and molecular mechanisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIoCeLL 2023年第11期47卷 2547-2566页

作者： AMYLLY saNUeLLY DA pAZ MARTINs MARLA de CeRQUeIRA ALVes oRLANDo RoBeRTo pIMeNTeL de ARAÚJo FABIANA oLIVeIRA Dos saNTos CAMATARI MARÍLIA oLIVeIRA FoNseCA GoULART FABIANA ANDRÉA MoURA Rede Nordeste de Biotecnologia(ReNoRBIo) Instituto de química e BiotecnologiaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil programa de pós-graduação em Nutrição(ppGNUT) Faculdade de Nutrição(FANUT)Universidade Federal de Alagoas(UFAL)Maceió57072-900Brasil programa de pós-graduação em Química e Biotecnologia(ppGQB) Instituto de química e BiotecnologiaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil Colegiado de Nutrição Universidade de Pernambuco(UPE)Campus PetrolinaPernambuco56328-900Brasil programa de pós-graduação em Ciências da saúde(ppGCs) Instituto de Ciências da SaúdeUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil programa de pós-graduação em Ciências Médicas(ppGCM) Faculdade de MedicinaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil

Curcumin,a natural product,has exhibited promising effects in both animal models and clinical trials,interacting with a multitude of factors linked to Inflammatory Bowel Disease(IBD).These factors encompass cytokines,oxidative stress-associated enzymes,and modulation of the intestinal ***,curcumin has demonstrated therapeutic potential in animal models of colitis,wherein it exerts a negative regulatory influence on pivotal signaling pathways such as pI3/Akt,JAK/sTAT,andβ-***,it inhibits the expression of proinflammatory enzymes and co-stimulatory molecules(including RANKL,ICAM-1,CD205,CD256,TLR4,among others),while curbing immune cell chemotaxis,thereby attenuating the characteristic neutrophil infiltration observed in *** facet of curcumin’s action involves its modulation of the intestinal ***,the microbiota itself contributes to beneficial biotrans formations of curcumin,thereby enhancing its effectiveness in IBD *** a clinical front,curcumin has demonstrated the ability to induce clinical and/or endoscopic remission without any reported toxic ***,curcumin warrants consideration as an adjunctive therapy in IBD *** clinical investigations should concentrate on meticulously evaluating curcumin’s impact on these precise therapeutic targets.

关键词： Curcuminoids polyphenols CDAI scores Ulcerative colitis Antioxidant

short-and long-term effects of an extreme case of autotomy:does“tail”loss and subsequent constipation decrease the locomotor performance of male and female scorpions?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2022年第5期17卷 672-688页

作者： solimary GARCÍA-HeRNÁNdeZ Glauco MACHADo programa de pós-graduação em ecologia Instituto de BiociênciasUniversidade de São PauloSão PauloBrazil LAGe do departamento de ecologia Instituto de BiociênciasUniversidade de São PauloSão PauloBrazil

In many taxa,individuals voluntarily detach a body part as a form to increase their chances of escaping *** defense mechanism,known as autotomy,has several consequences,such as changes in locomotor performance that may affectﬁ*** of the genus Ananteris autotomize the“tail”,which in fact corresponds to the last abdominal *** autotomy,individuals lose nearly 25%of their body mass and the last portion of the digestive tract,including the anus,which prevents defecation and leads to constipation,because regeneration does not ***,we experimentally investigated the short-and long-term effects of tail loss on the locomotor performance of Ananteris *** a short-term experiment,the maximum running speed(MRs)of males and females did not change after ***,the relative mass of the lost tail did not affect the change in MRs after *** a long-term experiment,autotomy had a negative effect on the MRs of males,but not of *** over-fed individuals suffered from severe constipation but were not slower than autotomized normally fed *** conclusion,tail loss has no immediate effect on the locomotor performance of *** long-term decrease in the locomotor performance of autotomized males may impair mate ***,because death by constipation takes several months,males have a long time toﬁnd mates and ***,the prolonged period between autotomy and death by constipation is crucial for understanding the evolution of one of the most extreme cases of autotomy in nature.

关键词： ﬁtness costs maximum running speed sex differences tail loss weight loss

Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第5期16卷 805-812页

作者： Viviane Rostirola elsner Lucieli Trevizol Isadora de Leon Marcos da silva ThaynáWeiss Milena Braga Daniela pochmann Amanda stolzenberg Blembeel Caroline Dani elenice Boggio Curso de Fisioterapia do Centro Universitário Metodista-IpA Porto AlegreRSBrasil programa de pós-graduação em Biociências e Reabilitação do Centro Universitário Metodista-IpA Porto AlegreRSBrasil programa de pós-graduação em Ciências Biológicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil

A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of ***,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these *** exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different ***,little is reported on this in post-stroke *** purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(Fes)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke *** this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(eXe alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(eXe+Fes group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and *** intervention,higher Berg Balance scale scores were obtained in the eXe+Fes group than in the eXe alone *** was no significant difference in the Timed Up and Go test results post-intervention between eXe alone and eXe+Fes *** intervention,a better cognitive performance was found in both groups compared with before the *** intervention,the Timed Up and Go test scores were higher in the eXe+Fes group than in the eXe alone *** addition,the intervention induced lower levels of lipid *** intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the eXe+Fes group,compared with the

关键词： cognition epigenetic exercise functional electrical stimulation functional mobility oxidative stress stroke WalkAide

Bird habitat preferences drive hemoparasite infection in the Neotropical region

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2021年第5期16卷 755-768页

作者： Gabriel Massaccesi de LA ToRRe Karla Magalhães CAMpIÃo Biological Interactions Departamento de ZoologiaUniversidade Federal do ParanáCuritibaBrazil programa de pós-graduação em ecologia e Conservação Universidade Federal do ParanáCuritibaBrazil

The role that the environment plays in vector-borne parasite infection is one of the central factors for understanding disease *** assessed how Neotropical bird foraging strata and habitat preferences determine infection by parasites of the genera Haemoproteus,plasmodium,Leucocytozoon,and Trypanosoma and filarioids,and tested for phylogenetic signal in these host-parasite *** performed extensive searches of the scientific literature and created a database of hemoparasite *** collected data on host body mass,foraging strata,habitat preference,and migratory status,and tested if host ecological traits predict each hemoparasite occurrence and prevalence using a phylogenetic Bayesian *** of plasmodium tend to infect birds from tropical forests while birds from altitudinal environments are likely to be infected by species of *** probability of a bird being infected by filarioid or Trypanosoma is higher in lowland *** species that occur in anthropic environments and dry habitats of tropical latitudes are more susceptible to infection by species of *** foraging strata is also influential and bird species that forage in the mid-high and canopy strata are more prone to infection by species of Haemoproteus and *** also identified phylogenetic signal for host-parasite associations with the probability of infection of Neotropical birds by any hemoparasite being more similar among more closely related *** provided a useful framework to identify environments that correlate with hemoparasite infection,which is also helpful for detecting areas with potential suitability for hemoparasite infection due to land conversion and climate change.

关键词： habitat use haemosporidians host-parasite interaction migratory birds prevalence

Molecular approaches for spinal cord injury treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第1期18卷 23-30页

作者： Fernanda Martins de Almeida suelen Adriani Marques Anne Caroline Rodrigues dos santos Caio Andrade prins Fellipe soares dos santos Cardoso Luiza dos santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez Laboratório de Neurodegeneração e Reparo Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the spinal cord result in permanent disabilities that limit daily life *** main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic *** decades of research,there is still no efficient treatment for spinal cord *** strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord *** these,molecular compounds are currently being used for neurological recovery,with promising *** molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes growth factors molecular therapy neurotrophic factors purines spinal cord injury