Extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them?
作者机构：Programa de Pós-Graduação da Rede Nordeste de Biotecnologia(RENORBIO)Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Graduação em Ciências da Saúde(PPGCS)Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Graduação em Química e Biotecnologia(PPGQB/UFAL)Campus A.C.SimõesAvenida Lourival Melo Motas/nTabuleiro dos MartinsMaceióAL 57072-970Brazil Programa de Pós-Graduação em Nutrição(PPGNU/UFAL)Programa de Pós-Graduação em Ciências Médicas(PPGCM/UFAL)Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2021年第45卷第3期
页 面：461-481页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by grants from the Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq–Brazil)[435704/2018-4] Fundação de AmparoàPesquisa do Estado de Alagoas(FAPEAL)/PPSUS/Ministério da Saúde(MS)[60030-000876/2016]
主 题：Oxidative stress Microbiota Bacterial translocation Ulcerative colitis Crohn disease
摘 要：Inflammatory bowel disease(IBD),which includes Crohn’s disease and ulcerative colitis,has a not yet completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative stress and *** manifestations can occur and affect several organs,including the liver and bile ducts,joints,skin,eyes,and less frequently,the heart,brain,and kidneys,increasing the risk of morbidity and *** repercussions may be associated with the activity or severity of *** present review proposes to report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of extraintestinal manifestations,aiming to contribute to a better understanding of the disease and to focus on the development of individualized preventive and therapeutic strategies.
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