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Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice

Journal of genetics and Genomics 2022年第4期49卷 364-376页

作者： Jin Wu Yingbo Chen Xue Li Liyuan Ran Xiangdong Liu Xiaoshuang Wang Mingming Zhen Shanshan Shao Li Zeng Chunru Wang Bin Liang Jiajun Zhao Yingjie Wu Shandong Provincial Hospital Shandong Laboratory Animal CenterScience and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250021China Institute for Genome Engineered Animal Models of Human Diseases Dalian Medical UniversityDalianLiaoning 116044China Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructure and NanotechnologyCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Center for Life Sciences School of Life SciencesYunnan UniversityKunmingYunnan 650091China department of Molecular Pathobiology New York University College of DentistryNew York 10010USA

The soaring global prevalence of diabetes makes it urgent to explore new drugs with high efficacy and ***-derived bioactive agents are emerging as one of the most promising candidates for biomedical *** the present study,we investigated the anti-diabetic effects of a functionalized gadofullerene(GF)using obese db/db and non-obese mouse model of type 2 diabete mellitus(MKR)mouse type 2 diabetes mellitus(T2DM)*** both mouse models,the diabetic phenotypes,including hyperglycemia,impaired glucose tolerance,and insulin sensitivity,were ameliorated after two or four weeks of intraperitoneal administration of *** lowered blood glucose levels in a dose-dependent ***,the restored blood glucose levels could persist ten days after withdrawal of GF *** hepatic AKT/GSK3β/FoxO1 pathway is shown to be the main target of GF for rebalancing gluconeogenesis and glycogen synthesis in vivo and in ***,GF treatment significantly reduced weight gain of db/db mice with reduced hepatic fat storage by the inhibition of de novo lipogenesis through m TOR/S6K/SREBP1 *** data provide compelling evidence to support the promising application of GF for the treatment of T2DM.

关键词： Functionalized gadofullerene Type 2 diabetes Glycolipid metabolism AKT De novo lipogenesis

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Culturally tailored DSMES:A new key for South Asian patients with Type 2 Diabetes Mellitus

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Discussion of Clinical Cases 2021年第4期8卷 14-16页

作者： Hongxiu Luo Annah Kuriakose Geethika Thota Naveen Mehrotra Division of Endocrinology Nutritionand MetabolismDepartment of MedicineSaint Peter’s University HospitalNJUSA SKN South Asian Diabetes Center Department of MedicineSaint Peter’s University HospitalNJUSA department of Medicine Saint Peter’s University HospitalNJUSA

South Asians have an exceptionally high risk for developing Type 2 diabetes *** is very challenging for healthcare providers to successfully manage diabetes and control glucose levels at target due to the unique lifestyle of the South Asian *** tailored diabetes self-management education and support(DSMES)can be more effective in guiding South Asian patients with Type 2 *** considerations to address lifestyle modification for South Asians include a diet that typically consists of a high carbohydrate to lipids/proteins ratio,preference for high glucose index fruits,regular intake of traditional sweets or desserts,late afternoon tea break followed by late dinner,lack of vigorous exercise(yoga or walking being the preferred activity),lack of DSMES knowledge and skills,and poor access to culturally appropriate resources for diabetes *** present a 38-year-old male diagnosed with diabetes four years ago who showed poor glucose control before our *** interventions included education on the importance of blood glucose monitoring,exercise,and *** on our experience with this case,we propose the following recommendations for a tailored approach to DSMES for South Asian patients with Type 2 diabetes:make appropriate dietary changes(decrease total daily caloric intake,decrease the percentage of carbohydrates,add low glucose index fruits and vegetables,avoid late afternoon tea breaks,eat dinner before 8 PM);incorporate appropriate daily physical activity;and monitor blood glucose daily for prompt feedback.

关键词： Culturally South Asian Lifestyle Diabetes Self-management Exercise DSMES Diet

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Genomic analysis,trajectory tracking,and field surveys reveal sources and long-distance dispersal routes of wheat stripe rust pathogen in China

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Plant Communications 2023年第4期4卷 174-188页

作者： Yuxiang Li Jichen Dai Taixue Zhang Baotong Wang Siyue Zhang Conghao Wang Jiguang Zhang Qiang Yao Mingju Li Chengyun Li Yuelin Peng Shiqin Cao Gangming Zhan Fei Tao Haifeng Gao Weili Huang Xiaojun Feng Yingwen Bai Zhuoma Qucuo Hongsheng Shang Chong Huang Wancai Liu Jiasui Zhan Xiangming Xu Xianming Chen Zhensheng Kang Xiaoping Hu State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest A&F UniversityTaicheng Road 3YanglingShaanxiChina KeyLaboratory of Agricultural Integrated PestManagement Qinghai ProvinceAcademyof Agriculture and ForestryScienceQinghai UniversityXiningQinghaiChina Yunnan Key Laboratory of Green Prevention and Control of Agricultural Transboundary Pests Agricultural Environment and Resource InstituteYunnan Academy of Agricultural SciencesKunmingYunnanChina State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan Yunnan Agricultural UniversityKunmingYunnanChina department of Plant Pathology Tibet Agricultural and Animal Husbandry CollegeLinzhiTibetChina Wheat Research Institute Gansu Academy of Agricultural SciencesLanzhouGansuChina Biocontrol Engineering Laboratory of Crop Diseases and Pests of Gansu Province College of Plant ProtectionGansu Agricultural UniversityLanzhouGansuChina Institute of Plant Protection Xinjiang Academy of Agricultural SciencesUrumqiXinjiangChina Xi’an Huang’s Bio-technology Company Ltd Xi’anShaanxiChina Shaanxi Plant Protection Extension Station Xi’anShaanxiChina Baoji Plant Protection Extension Station BaojiShaanxiChina National Agricultural Technology Extension and Service Center Ministry of AgricultureBeijingChina department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesUppsalaSweden Pest&Pathogen Ecology NIAB EMREast MallingWest MallingKentUK Agricultural Research Service United States Department of Agriculture and Department of Plant PathologyWashington State UniversityPullmanWAUSA

Identifying sources of phytopathogen inoculum and determining their contributions to disease outbreaks are essential for predicting disease development and establishing control *** striiformis ***(Pst),the causal agent of wheat stripe rust,is an airborne fungal pathogen with rapid virulence variation that threatens wheat production through its long-distance *** of wide variation in geographic features,climatic conditions,and wheat production systems,Pst sources and related dispersal routes in China are largely *** the present study,we performed genomic analyses of 154 Pst isolates from all major wheat-growing regions in China to determine Pst population structure and *** trajectory tracking,historical migration studies,genetic introgression analyses,and field surveys,we investigated Pst sources and their contributions to wheat stripe rust *** identified Longnan,the Himalayan region,and the Guizhou Plateau,which contain the highest population genetic diversities,as the Pst sources in *** from Longnan disseminates mainly to eastern Liupan Mountain,the Sichuan Basin,and eastern Qinghai;that from the Himalayan region spreads mainly to the Sichuan Basin and eastern Qinghai;and that from the Guizhou Plateau migrates mainly to the Sichuan Basin and the Central *** findings improve our current understanding of wheat stripe rust epidemics in China and emphasize the need for managing stripe rust on a national scale.

关键词： Puccinia striiformis f.sp.tritici stripe rust disease epidemics population genetics genome sequencing

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Integrated Open Source Design for Architecture in High-Density Housing Practice

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Journal of Civil Engineering and Architecture 2015年第9期9卷 1085-1098页

作者： Yan Gao Xin Guo Tiantian Lo Qiang Chang department of Architecture University of Hong Kong Hong Kong 999077 China College of Architecture and Urban Planning Shenzhen University Shenzhen 518053 China School of Architecture Chinese University ofHong Kong Hong Kong 999077 China International Research Centre of Computational Design Tsinghua Architectural Design & Research Institute Beijing 100084China

High-density housing can be interpreted as collections of individual units, which inevitably results in the dilemma between the global standardization designed by architects and local customization implemented by users. However, it is impossible to reflect the users＇ various needs in the conceptual design stage for high-density housing because of the economic, industrial and time constrains. In response to this challenge, this research paper outlines a different high-density housing design approach that can adopt users＇ individual customization in the conceptual design stage during the housing design practice. Hence, the design process would be an open-ended evolutionary and transparent process rather than deterministic executions as we have now in most high-density cities, such as Hong Kong. In order to overcome the deficiency in addressing future uncertainties of different users and address the issues of one-off developments without iterating users＇ feedback in the housing practice, this essay proposes IOSDA （integrated open source design for architecture） for the design practice of high-density housing, through collective data and parametric connectivity between users and architects. IOSDA reflects a different design attitude towards the future, i.e., to shift from architects＇ heroic prediction of the future to collective engagement of the present with more robust capacities for new possibilities.

关键词： Open source architecture high density urban transformation plug-in infrastructure smart BIM iterative design parametric crowd network thinking.

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Biosensors for Environmental Analysis:Novel strategies towards Monitoring and Remediation

Biosensors for Environmental Analysis:Novel strategies towar...

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2007中国科协年会

作者： Sunil Bhand Klas Risveden Bengt Danielsson department of Chemistry Birla Institute of Technology and Science-Pilani Goa CampusGoa 403726 India.Fax.:0091 832 2557030/33 Pure and Applied Biochemistry Chemical Center Lund University Box 124SE22100 Lund Sweden

The biosensors for the analysis of organophosphates OPs and carbamates have been developed using enzyme *** analysis has been addressed using the immunoarrays for organochlorines *** a nanobiosensor for the detection of ultra sensitive analysis of organophosphates based on enzyme inhibition has been *** the real environmental samples,both the inorganic and organic contaminants are present *** a discriminative detection strategy was developed for quantitation of both metals and pesticides from the sample *** developments on environmental analysis mostly address use of functionalized nanomaterials such a iron-oxide nanoparticles (FeNP),Titanium dioxide TiO,carbonnanotubes CNTs and nanosilicates. Miniaturized biosensors have been tested for the simultaneous measurement of OCs and OPs using the functionalized nanomaterials coupled to thermal and optical biosensor *** such hyphenated systems,atrazine,simazine paraoxon,and carbofuran have been measured from the given sample *** has also been made to integrate these smart materials into removal/degradation of *** recent results on in-situ monitoring for inhibition measurements using biosensors will be presented.

关键词： pesticides biosensors thermistor nanoparticles

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儿童和成人肺毛细血管的血管瘤:1新病例报道以及文献回顾

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 43-44页

作者： Bartyik K. Bede O. Tiszlavicz L. 王一飞 department of Paediatri cs Albert Szent-Gyorgyi Med. P. University of Szeged 14-15 Koranyi fasor 6720 Szeged Hungary

Pulmonary capillary haemangiomatosis (PCH) in childhood is a rarity, character ised by the uncontrolled proliferation of pulmonary microvessels which may invad e pulmonary, bronchial and vascular structures, resulting in diffuse alveolar ha emorrhage, manifesting clinically in haemoptysis, dyspnoea and symptoms of pulmo nary hypertension (PH). A 14-year-old boy with some particular features (peric ardial effusion and thrombocytopenia) is presented and 14 paediatric/adolescent cases from the literature are surveyed. The diagnostic problems and difficulties are discussed, including the importance of imaging (high-resolution CT) and hi stopathological studies, with the aim of providing a clear-cut distinction of P CH from other conditions such as primary PH (PPH). The literature data can be re garded as ambiguous: both similarities and relatively sharp distinctions between PCH and PPH are to be found. New developments in the field of genetics are also discussed. The early coexistence of PCH and other (vascular) disorders and asso ciations, involving focal or diffuse, disseminated forms is summarised briefly. Conclusion: The diagnosis of this progressive disorder may lead to effective the rapy. Treatment possibilities include the rapidly evolving field of anti-angiogenic therapy, but at present lung transp lantation is universally accepted as the final definitive treatment for pulmonar y capillary haemangiomatosis.

关键词：文献回顾肺毛细血管血管瘤新病例弥漫性肺泡出血肺动脉高压抗血管生成治疗血管结构血管疾病异常增殖

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母亲妊娠期间的因素能否影响到出生后10年内子女的哮喘表现型

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世界核心医学期刊文摘（儿科学分册） 2005年第9期1卷 54-55页

作者： Kurukulaaratchy R.J. Waterhouse L. Matthews S.M. ArshadS.H. 李开 department of Respiratory Medicine University Hospital of North Staffordshire Newcastle Road Stoke-on-Trent ST4 6QG United Kingdom

Aim: Recently, attention has focused on possible early life origins for asthma. We sought to identify whether factors present during pregnancy were associated with development of childhood wheezing phenotypes. Methods: A whole populationbirth cohort (n=1456) on the Isle of Wight, UK, was followed through to age 10 y. Where possible, information regarding environmental exposures and events during pregnancy was obtained from the maternity records (n=1238). Children were seen at ages 1, 2, 4 and 10 y, and wheezing symptoms were used to define wheezing phenotypes in the first decade (n=1034). Results: Risk of early-onset persistent wheeze (onset in the first 4 y, still present at age 10) was increased by environmental tobacco smoke exposure in pregnancy (OR=2.44;95% CI: 1.37-4.34) plus maternal asthma (3.57; 1.84-6.94), but reduced by cat ownership (0.30; 0.13-0.62). Early transient wheeze (onset in the first 4 y, but not present at age 10) was increased by environmental tobacco smoke exposure (1.58; 1.02-2.45),male gender (1.68; 1.09-2.60) and low birthweight (3.65; 1.27-10.52). No environmental factors in pregnancy were associated with lateonset persistent wheeze (onset after age 4 y, still present at 10 y). Conclusion: In addition to genetics, maternal exposures during pregnancy show association with childhood and especially early-life wheezing phenotypes.

关键词：母亲妊娠期表现型出生后出生婴儿早发性环境暴露发病风险早期胚胎发育怀特岛事件信息

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Arteriovenous malformations of the head and neck; new perspectives and the surgical management

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中国口腔颌面外科杂志 2008年第B5期6卷 36-36页

作者： James Y. Suen department of Otolaryngology - Head & Neck Surgery University of Arkansas for Medical Sciences USA

Arteriovenous Malformations (AVMS) are among the most difficult of the vascular malformations to treat. They are considered to be congenital and different from AV fistulas, which are acquired.

关键词：脑动静脉畸形透视技术外科手术血管

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Kuwait's Democratic Experiment: Roots, Reality, Characteristics, Challenges, and the Prospects for the Future

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Asian Journal of Middle Eastern and Islamic Studies 2011年第3期5卷 57-81页

作者： Mohammad Torki Bani SALAMEH Mohammad Kanoush AL-SHARAH department of Political Science Yarmouk University&Al-Zaytoonah University of Jordan

This study aims to shed light on the Kuwaiti democratic experiment by reviewing its historical stages from the establishment of the state,until the present;its most prominent characteristics,the central role of political leadership;major political,economic,social and cultural challenges;proposals to address these challenges and finally predictions in light of local,regional,and international *** study then concludes with an evaluation of this pioneering experience and its potential development and progress.

关键词： Challenges Democratic Experiment Kuwait Gulf Studies

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Health technology assessment in traditional Chinese medicine in China: current status, opportunities, and challenges

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Global Health Journal 2019年第4期3卷 89-93页

作者： Yi Yang Kan Tian Gengliang Bai Xiangyuan Zhu Yong Yang Xiaoyong Yu Lizheng Shi School of Public Health Fudan UniversityNo.130Dong'an RoadShanghai 200032China Key Lab of Health Technology Assessment National Health CommissionNo.138Yi Xue Yuan RoadShanghai 200032China School of Health Economics and Management Nanjing University of Chinese MedicineNo.138Xianlin AvenueNanjingJiangsu 210023China department of Global Policy and Management Tulane University School of Public Health and Tropical Medicine1440 Canal StreetSuite 1900New OrleansLouisiana 70112USA

Objectives:The widespread usage of traditional Chinese medicine(TCM)and the government's emphasis on TCM in China have created a positive macro-environment and great opportunities to develop and strengthen health technology assessment(HTA)in *** the past ten years,a series of policies have been issued by the government to promote the application of HTA and the development of TCM in *** study reviews the concepts and characteristics of TCM,summarizes the current status of HTA in TCM,and analyzes the opportunities and challenges faced by HTA development in TCM with respect to deepening of healthcare ***:Literature review and website searches were used to acquire information regarding the basic theories of TCM and the current status,opportunities,and challenges for HTA in ***:The number of articles on HTA in TCM rose substantially,especially those published in China National Knowledge Infrastructure(CNKI).With the optimistic policy environment and huge market demand for TCM,the development of HTA in TCM is expected to flourish in ***,HTA in TCM also faces numerous challenges such as the absence of a clinical efficacy evaluation system for TCM and insufficient basic research evidence and qualified ***:TCM has unique characteristic that distinguishes it from Western ***,it is important to take all measures to address the existing main challenges and thereby take advantage of the present opportunities to develop and improve HTA in TCM.

关键词： Health technology assessment Traditional Chinese medicine Opportunities Challenges

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