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In silico studies of magnesium-based implants: A review of the current stage and challenges

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Journal of Magnesium and Alloys 2022年第11期10卷 2968-2996页

作者： Tamadur Albaraghtheh Regine Willumeit-Römer Berit Zeller-Plumhoff Helmholtz-Zentrum hereon gmbh Institute of Metallic BiomaterialsMax-Planck-Str.1Geesthacht 21502Germany

In silico methods to study biodegradable implants have recently received increasing attention due to their potential in reducing experimental time and cost. An important application case for in silico methods are magnesium(Mg)-based biodegradable implants, as they represent a powerful alternative to traditional materials used for temporary orthopaedic applications. Controlling Mg alloy degradation is critical to designing an implant that supports the bone healing process. To simulate different aspects of this biodegradation process, several mathematical models have been proposed with the ultimate aim of replacing laboratory experiments with computational modeling. In this review, we provide a comprehensive and critical discussion of the published models and their performance with respect to capturing the complexity of the biodegradation process. This complexity is presented initially. Additionally, the present review discusses the different approaches of optimizing and quantifying the different sources of errors and uncertainties within the proposed models.

关键词： Biodegradable implants Degradation In silico Phenomenological approach Physical approach Validation Verification Uncertainty quantification Mg

***-an interactive climate analysis web platform

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International Journal of Digital Earth 2021年第3期14卷 338-356页

作者： Laura Zepner Pierre Karrasch Felix Wiemann Lars Bernard Chair of Geoinformatics Technische Universität DresdenDresdenGermany AED-SICAD gmbh BonnGermany

This article describes the conception and implementation of a web platform which uses special charts and maps for climate monitoring and *** first it gives an overview of related web applications and their advantages and *** is followed by a basic introduction of current technologies and methods for working with climate data,geospatial web services and visualization ***,the implementation based on prior defined requirements is presented and its strengths and limitations are *** application provides several basic charts for climate analysis,as well as a more complex one which uses a standardized visualization concept which is suitable for comparing different local climates(Walter-LiethStandard).The charts are based on different interpolated datasets with global coverage as well as data from the Global Historical Climate Network(GHCN).Overall,the application enables users to generate individual historical climate charts from the beginning of the twentieth century until present day.

关键词： Climate monitoring WalterLieth charts Köppen-Geiger classification user interface design education information visualization

Cell-type specific and non-redundant anti-proliferative effects of shRNA-mediated Galpha12- and Galpha13 knockdown in lung cancer cell lines

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Advances in Bioscience and Biotechnology 2014年第1期5卷 73-80页

作者： Thomas R. H. Büch Marius Grzelinski Olaf Pinkenburg Thomas Gudermann Achim Aigner Rudolf-Boehm-Institute for Pharmacology and Toxicology Uni-versity of Leipzig Leipzig Germany Biochemia Pharmacological Institute/bpc Philipps-University Marburg Marburg Germany Rudolf-Boehm-Institute for Pharmacology and Toxicology University of Leipzig Leipzig Germany Biochemia Pharmacological Institute/bpc Philipps-University Marburg Marburg Germany Rudolf-Boehm-Institute for Pharmacology and Toxicology Uni-versity of Leipzig Leipzig Germany Biochemia Pharmacological Institute/bpc Philipps-University Marburg Marburg Germany present address: Institute for Immunology Philipps-University Marburg Marburg German Rudolf-Boehm-Institute for Pharmacology and Toxicology Uni-versity of Leipzig Leipzig Germany Biochemia Pharmacological Institute/bpc Philipps-University Marburg Marburg Germany present address: Targos Molecular Pathology gmbh Kassel Germany Walther Straub Institute of Pharmacology and Toxicology University of Munich (LMU) Munich Germany Comprehensive Pneumology Center Munich (CPC-M) German Center for Lung Research Munich Germany

In small cell lung cancer cells, various autocrine stimuli lead to the parallel activation of Gq/11 and G12/13 proteins. The contribution of the Gq/11-PLC-β cascade to the mitogenic effects in SCLC cells is well established, but the relevance of G12/13 signaling is less explored. While in prostate and breast cancer, G12/13 activation has been shown previously to promote invasiveness without being involved in cellular proliferation, previous data from our group indicate anti-proliferative effects of G12/13 knockdown in small cell lung cancer (SCLC) cells. To further investigate the role of G12/13-dependent signaling in lung tumor cells, we employed shRNA-mediated targeting of Gα12, Gα13, or both, in SCLC and NSCLC cell lines. Lentiviral expression of shRNAs resulted in specific Gα12 and Gα13 knockdown. Of note, upon single knockdown of one family member, no counter-upregulation of the other one was observed. Interestingly, inhibition of proliferation was cell line dependent. In cell lines where knock-down led to antiproliferation, single knockdown of either Gα12 or Gα13 was sufficient to impair proliferation and double knockdown of Gα12 and Gα13 tended not to further increase anti-proliferative effects. Likewise, when single knockdown was insufficient for an inhibition of proliferation, no effects were observed in double knockdowns. Taken together, these findings indicate that both Gα12 and Gα13 affect cellular proliferation individually and interference with one family member is sufficient for anti-tumor effects.

关键词： KEYWORDS Galpha12 Galpha13 G12/13 Lung Cancer SCLC NSCLC Gene Knockdown

Predictions of the P1 approximation for radiative heat transfer in heterogeneous granular media

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Particuology 2023年第11期82卷 25-47页

作者： Jelena Macak Christoph Goniva Stefan Radl DCS Computing gmbh 4020LinzAustria Graz University of Technology Institute of Process and Particle Engineering8010GrazAustria

The P1 approximation is a computationally efficient model for thermal ***,we present a P1 formulation in the context of the combined computational fluid dynamics and discrete element method(CFD-DEM),including closures for dependent scattering and *** available analytical and semi-analytical solutions,we find agreement for steady-state and transient quantities in sizedisperse *** flux is identified as the most sensitive quantity to predict,displaying unphysical spatial *** oscillations are due to a temperature slip at the locations of abrupt change in solid *** propose two techniques that mitigate this effect:smoothing of the radiative properties,and ***,using up to a million times enlarged particles,we demonstrate practically limitless compatibility with ***,we compare predictions made with our code to experimental data for a pebble bed under vacuum conditions,and in presence of *** find that a carefully calibrated simulation can replicate trends observed in experiments,with relative temperature error of less than 10%.

关键词： CFD-DEM Thermal radiation Coarse-graining P1 Pebble bed nuclear reactor

Comparison of Protein Expression Profiles of Novel Halomonas smyrnensisAAD6Tand Halomonas salinaDSMZ 5928T

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Natural Science 2014年第9期6卷 628-640页

作者： Aydan Salman Dilgimen Kazim Yalcin Arga Volker A. Erdmann Brigitte Wittmann-Liebold Aziz Akin Denizci Dilek Kazan Bioengineering Department Faculty of Engineering Marmara University (Goztepe Campus) Istanbul Turkey Bioengineering Department Faculty of Engineering Marmara University (Goztepe Campus) Istanbul Turkey Institute for Chemistry/Biochemistry Freie University Berlin Germany present address: Department of Biochemistry & Molecular Biology University of Calgary Calgary Canada Institute for Chemistry/Biochemistry Freie University Berlin Germany The Scientific and Technological Research Council of Turkey (TUBITAK) Marmara Research Center (MAM) Genetic Engineering and Biotechnology Institute Gebze Turkey Wita gmbh Berlin Germany

In this work, the protein pattern of novel Halomonas smyrnensis AAD6T was compared to that of Halomonas salina DSMZ5928T, which is the closest species on the basis of 16S rRNA sequence, to understand how AAD6T differs from type strains. Using high resolution NEPHEGE technique, the whole cell protein composition patterns of both Halomonas salina DSMZ5928T and H. smyrnensis AAD6T were mapped. The expressed proteins of the two microorganisms were mostly located at the acidic side of the gels, at molecular weight values of 60 to 17 kDa, and at isoelectric points 3.8 to 6.0, where they share a significant number of common protein spots. Identification and characterization of protein spots via whole genome sequencing data indicated that these two microorganisms used similar pathways, especially TCA cycle, for their survival;in other words, for their energy requirements. On the other hand, the protein expression differences in AAD6T and H. salina DSMZ 5928T showed that they prefer different metabolic pathways for lipid biosynthesis and in adaptation to extreme environments. Thus, we suggested that phylogenetic dissimilarities between these microorganisms could be related to the protein expression differences;in other words, metabolic flux differences in AAD6T and H. salina DSMZ 5928T. This is the first study to explain the dissimilarities of phenotypic characters and DNA-DNA hybridization between type strain and novel strain AAD6T by using protein expression differences.

关键词： Proteomics Halomonas salina DSMZ 5928T Halomonas smyrnensis AAD6T NEPHGE Technique Genome

Identification of secondary raw materials in mold powders and their melting behavior

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Journal of Iron and Steel Research International 2019年第4期26卷 403-411页

作者： Irmtraud Marschall Nathalie Kolbl Harald Harmuth Christina Atzenhofer KI-MET gmbh 8700 LeobenAustria Department Mineral Resources Engineering Chair of CeramicsMontanuniversitaet Leoben8700 LeobenAustria

Commercial mold powders use a limited number of main mineral constituents,but may differ significantly in chemical *** main mineral raw materials of specimens investigated here are quartz,fluorite and free carbon,as well as wollastonite and *** investigations revealed the use of secondary raw materials like blast furnace slag,fly ash,glass scrap and phosphorous slag as further *** the formation of cuspidine was one major point of interest,the influence of the silica source on its formation was identified.A replacement of wollastonite by blast furnace slag reduced the temperature of the first precipitation of cuspidine by about 100℃;the dissociation of sodium carbonate was lowered by-40℃.The lowest temperature of the first Na2CO3 dissociation could be achieved by using fluorine in combination with blast furnace *** formation from the melt is further decreased if sodium and fluorine are both *** use of glass scrap and phosphorous slag strongly reduced the temperature of first melt formation and enhanced cuspidine formation.

关键词： Mold powder Cuspidine Melting Crystallization behavior

Coupling sensor observation services and web processing services for online geoprocessing in water dam monitoring

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International Journal of Digital Earth 2018年第1期11卷 64-78页

作者： C.Stasch B.Pross B.Gräler C.Malewski C.Förster S.Jirka 52°North gmbh Martin-Luther-King-WegMünsterGermany Wupperverband Untere LichtenplatzerWuppertalGermany

Novel sensor technologies are rapidly *** enable a monitoring and modelling of our environment in a level of detail that was not possible a few years ***,while the raw data produced by these sensors are useful to get a first overview,it usually needs to be post-processed and integrated with other data or models in different *** this paper,we present an approach for integrating several geoprocessing components in the TaMIS water dam monitoring system developed with the Wupperverband,a regional waterbody authority in *** approach relies upon the OGC Web Processing Service and is tightly coupled with Sensor Observation Service instances running at the *** implementing the standardized XML-based interface,lightweight REST APIs have been developed to ease the integration with thin Web clients and other Web-based *** this standards-based approach,new processing facilities can be easily integrated and coupled with different observation data sources.

关键词： Geoprocessing sensor web spatial data infrastructure water monitoring dam monitoring

Visual analytics for event detection: Focusing on fraud

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Visual Informatics 2018年第4期2卷 198-212页

作者： Roger A.Leite Theresia Gschwandtner Silvia Miksch Erich Gstrein Johannes Kuntner Vienna University of Technology Austria sIT Solutions AT Spardat gmbh Austria Erste Group IT International Austria

The detection of anomalous events in huge amounts of data is sought in many *** instance,in the context of financial data,the detection of suspicious events is a prerequisite to identify and prevent attempts to ***,various financial fraud detection approaches have started to exploit Visual Analytics ***,there is no study available giving a systematic outline of the different approaches in this field to understand common strategies but also ***,we present a survey of existing approaches of visual fraud detection in order to classify different tasks and solutions,to identify and to propose further research *** this work,fraud detection solutions are explored through five main domains:banks,the stock market,telecommunication companies,insurance companies,and internal *** selected domains explored in this survey were chosen for sharing similar time-oriented and multivariate data *** this survey,we(1)analyze the current state of the art in this field;(2)define a categorization scheme covering different application domains,visualization methods,interaction techniques,and analytical methods which are used in the context of fraud detection;(3)describe and discuss each approach according to the proposed scheme;and(4)identify challenges and future research topics.

关键词： Visual knowledge discovery Time series data Business and finance visualization Financial fraud detection

Usage Scenarios for Byte-addressable Persistent Memory inHigh-Performance and Data Intensive Computing

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Journal of Computer Science & Technology 2021年第1期36卷 110-122页

作者： Michèle Weiland Bernhard Homölle EPCC The University of EdinburghEdinburgh EH89BTU.K. System Vertrieb Alexander gmbh Paderborn 33106Germany

Byte-addressable persistent memory(B-APM)presents a new opportunity to bridge the performance gap between main memory and *** this paper,we present the usage scenarios for this new technology,based on the capabilities of Intel’s *** outline some of the basic performance characteristics of DCPMM,and explain how it can be configured and used to address the needs of memory and I/O intensive applications in the HPC(high-performance computing)and data intensive *** decision trees are presented to advise on the configuration options for BAPM;their use is illustrated with two *** show that the flexibility of the technology has the potential to be truly disruptive,not only because of the performance improvements it can deliver,but also because it allows systems to cater for wider range of applications on homogeneous hardware.

关键词： byte-addressable data intensive memory intensive persistent