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Psychophysiological Effects of Sideritis and Bacopa Extract and Three Combinations Thereof—A Quantitative EEG Study in Subjects Suffering from Mild Cognitive Impairment (MCI)

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Advances in Alzheimer's Disease 2016年第1期5卷 1-22页

作者： Wilfried Dimpfel Leonie Schombert Andreas Biller Justus-Liebig-University Giessen Giessen Germany Neuro Code AG Wetzlar Germany Dr. Loges gmbh Winsen Germany

Mild cognitive impairment (MCI) is regarded as a transitional stage during the development of Alzheimer’s disease. Diagnosis of MCI can be obtained by the questionnaire “DemTect” in German speaking countries. Quantitative assessment has been successfully performed using psychometric testing concomitantly with quantitative EEG recording. The present investigation aimed at the possible treatment of MCI with two botanicals, namely extracts from Sideritis scardica (500 mg) or Bacopa monnieri (320 mg) and three combinations thereof using this method in order to find a new treatment. The performance of the d2-test, an arithmetic calculation test (CPT) and a memory-test revealed better performance for the d2-test only in the presence of Sideritis extract or the combinations with Bacopa extract. Quantitative EEG assessment during the different experimental conditions showed massive differences between both extracts. Whereas Sideritis extract and its combination with a low amount of Bacopa extract (160 mg) induced increases of spectral power in fronto-temporal brain areas, Bacopa and the combination of Sideritis with high amounts of Bacopa extract produced attenuation of all waves except for delta in fronto-temporal brain areas. These differences were also documented by quantitative EEG maps in comparison to Placebo. A different action of both extracts was confirmed by discriminant analysis, where Sideritis extract and its combination with low Bacopa grouped together quite at distance to Bacopa and the combination of Sideritis with high Bacopa. A combination of Sideritis extract with a low amount of Bacopa should be tested with daily repetitive dosing for at least 4 weeks as a consequence.

关键词： DemTect Cognition Psychometry EEG Source density Mild Cognitive Impairment (MCI) Alzheimer’s Disease CATEEM Sideritis Bacopa

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Magnetic Moment Tensor Potentials for collinear spin-polarized materials reproduce different magnetic states of bcc Fe

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npj Computational Materials 2022年第1期8卷 107-112页

作者： Ivan Novikov Blazej Grabowski Fritz Körmann Alexander Shapeev Skolkovo Institute of Science and Technology Skolkovo Innovation CenterNobel St.3Moscow143026Russia Institute for Materials Science University of StuttgartPfaffenwaldring 5570569StuttgartGermany Computational Materials Design Max-Planck-Institut für Eisenforschung GmbHD-40237DüsseldorfGermany Materials Science and Engineering Delft University of Technology2628 CDDelftThe Netherlands

We present the magnetic Moment Tensor Potentials(mMTPs),a class of machine-learning interatomic potentials,accurately reproducing both vibrational and magnetic degrees of freedom as provided,e.g.,from first-principles *** accuracy is achieved by a two-step minimization scheme that coarse-grains the atomic and the spin *** performance of the mMTPs is demonstrated for the prototype magnetic system bcc iron,with applications to phonon calculations for different magnetic states,and molecular-dynamics simulations with fluctuating magnetic moments.

关键词： magnetic fluctuating states

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Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

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Light(Science & Applications) 2021年第1期10卷 71-85页

作者： Elisabet A.Rank Ryan Sentosa Danielle J.Harper Matthias Salas Anna Gaugutz Dana Seyringer Stefan Nevlacsil Alejandro Maese-Novo Moritz Eggeling Paul Muellner Rainer Hainberger Martin Sagmeister Jochen Kraft Rainer ALeitgeb Wolfgang Drexler Center for Medical Physics and Biomedical Engineering Medical University of ViennaWaehringer Guertel 18-20/4 L1090 ViennaAustria Research Centre for Microtechnology Vorarlberg University of Applied SciencesHochschulstrasse 16850 DornbirnAustria AIT Austrian Institute of Technology gmbh Gieffinggasse 41210 ViennaAustria ams AG Tobelbader Strasse 308141 PremstaettenAustria

In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated *** diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide *** arrayed waveguide grating designs with 256 channels were tested,which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal *** 1 supports a bandwidth of 22nm,with which a sensitivity of up to 91 dB(830μW) and an axial resolution of 10.7 pm was *** 2 supports a bandwidth of 48 nm,with which a sensitivity of 90 dB(480μW) and an axial resolution of 6.5μm was *** silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process,which allows their monolithic co-integration on top of an optoelectronic silicon *** a benchmark for chip-based optical coherence tomography,tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip *** similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.

关键词： waveguide arrayed optical

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LUREC^(TM)工艺———高浓度SO_2冶炼烟气处理的新途径

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硫磷设计与粉体工程 2006年第1期 27-35页

作者： Karl H．Daum 郝锐（译） Outokumpu Technology gmbh 德国不详

许多成本研究证明,从冶炼烟气中回收硫以及减少SO_2排放到大气是降低硫酸生产成本最可行的方案,随着先进的硫酸工艺出现,这一点显得尤其明显。采用富氧空气的现代硫化矿火法冶炼工艺操作,导致冶炼烟气中的SO_2浓度很高,这是冶炼烟气处... 详细信息

许多成本研究证明,从冶炼烟气中回收硫以及减少SO_2排放到大气是降低硫酸生产成本最可行的方案,随着先进的硫酸工艺出现,这一点显得尤其明显。采用富氧空气的现代硫化矿火法冶炼工艺操作,导致冶炼烟气中的SO_2浓度很高,这是冶炼烟气处理中显著节约的一个前提条件。从不同处理方案的技术边界条件及经济角度论述了高浓度SO_2烟气处理技术的现状,着重阐述了OUTOKUMPU-LURGI METALLURGIE开发的一套新工艺,对此类高浓度烟气进行更有利的处理,同时避免通常存在的以过多的空气稀释。该项新的LURECTM工艺对新装置和冶炼厂扩建项目都很有吸引力。

关键词：冶炼烟气硫酸生产高浓度SO2 LUREC^TM工艺介绍

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Optimised Pattern Recognition for Robotic Weldment Geometry Measuring

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Journal of Mechanics Engineering and Automation 2012年第11期2卷 688-693页

作者： Guido Hoffmeier Maria Plyusnina Bernd Kuhlenkoetter Jobst Bickendorf Institute for Production Systems Faculty of Mechanical Engineering Technische Universitaet Dortmund Dortmund 44227Germany Autocam lnformationstechnik gmbh Dortmund 44229 Germany

Today, automated robot welding of components with low tolerances in series production is state-of-the-art. But turning to small batch production particularly of parts with high tolerances, engineering and construction of automated solutions is just at the beginning of providing economic efficiency. While weld seam tracking is well established for the described problem, geometric recognition of weldments is not yet solved satisfactorily. This paper will present an optimisation approach of a laser sensor guided and programmed robot welding system which was developed within the project ROPROF at the TU Dortmund. With this development, a working prototype of a robot weld system was built by a steel construction company as well as additional demonstration software showing the potential and transferability of adjusted geometric location of weldments for industrial applications.

关键词： Geometry measuring welding process control welding start point search seam finding error correction.

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Novel approach for real-time monitoring of carrier-based DPIs delivery process via pulmonary route based on modular modified Sympatec HELOS

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1331-1346页

作者： Xuejuan Zhang Yingtong Cui Ruifeng Liang Guanlin Wang Xiao Yue Ziyu Zhao Zhengwei Huang Ying Huang Jianfang Geng Xin Pan Chuanbin Wu School of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhou 510006China Institute for Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Pharmaceutical Science Jinan UniversityGuangzhou 510006China Department of Pharmacology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Sympatec gmbh Suzhou Rep.Office Suzhou 215123China

An explicit illustration of pulmonary delivery processes(PDPs)was a prerequisite for the formulation design and optimization of carrier-based ***,the current evaluation approaches for DPIs could not provide precise investigation of each PDP separately,or the approaches merely used a simplified and idealized *** the present study,a novel modular modified Sympatec HELOS Real-time monitoring;Modular modification;Carrier;Air flow rate;Mechanism of drug delivery(MMSH)was developed to fully investigate the mechanism of each PDP separately in *** inhaler device,artificial throat and pre-separator were separately integrated with a Sympatec *** dispersion and fluidization,transportation,detachment and deposition processes of pulmonary delivery for model DPIs were explored under different flow ***,time-sliced measurements were used to monitor the PDPs in *** Next Generation Impactor(NGI)was applied to determine the aerosolization performance of the model *** release profiles of the drug particles,drug aggregations and carriers were obtained by MMSH in *** PDP of the DPIs was analyzed in ***,a positive correlation was established between the total release amount of drug particles and the fine particle fraction(FPF)values(R^2=0.9898).The innovative MMSH was successfully developed and was capable of illustrating the PDPs and the mechanism of carrier-based DPIs,providing a theoretical basis for the design and optimization of carrier-based DPIs.

关键词： Dry powder inhalation Pulmonary delivery process

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Strong-yet-ductile Ti−Zr alloys through high concentration of oxygen strengthening

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Transactions of Nonferrous Metals Society of China 2020年第9期30卷 2449-2458页

作者： Yong LIU Han-chun TANG Qian-li HUANG Da-peng ZHAO Jun-yang HE Yuan-kui CAO Min SONG Bin LIU Si-hui OUYANG State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China College of Biology Hunan UniversityChangsha 410082China Max-Planck-Institut für Eisenforschung gmbh Düsseldorf 40237Germany

Ti−Zr alloys(oxygen content 0.42−0.54 wt.%)were prepared via powder metallurgy and hot *** results indicate that the Ti−Zr alloys exhibit Zr-rich and Zr-lean areas with the sameα-phase structure,and the Zr-rich area shows a slightly higher oxygen content and a much finer grain *** Ti−Zr alloys present a good combination of high strength(σs=700−900 MPa)and total elongation(>20%),and solid solution strengthening of oxygen plays a major *** does not influence much the oxygen-induced brittleness due to its high structural similarity to ***,the high value of 0.54 wt.%is still within the critical oxygen content for the ductile-to-brittle transition of Ti and does not degrade the ductility.

关键词： oxygen Ti−Zr alloys ductility powder metallurgy

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Experimentally validated atomistic simulation of the effect of relevant grinding parameters on work piece topography,internal stresses,and microstructure

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Friction 2022年第4期10卷 608-629页

作者： S.J.EDER P.G.GRÜTZMACHER T.SPENGER H.HECKES H.ROJACZ A.NEVOSAD F.HAAS AC2T research gmbh Viktor-Kaplan-Straße 2/CWiener Neustadt 2700Austria Institute of Engineering Design and Product Development TU WienLehárgasse 6-Objekt 7Vienna 1060Austria Institute of Production Engineering Graz University of TechnologyKopernikusgasse 24/IGraz 8010Austria Tyrolit-Schleifmittelwerke Swarovski K.G. Swarovskistraße 33Schwaz 6130Austria

In this work,we present a fully atomistic approach to modeling a finishing process with the goal to shed light on aspects of work piece development on the microscopic scale,which are difficult or even impossible to observe in experiments,but highly relevant for the resulting material *** a large-scale simulative parametric study,we varied four of the most relevant grinding parameters:The work piece material,the abrasive shape,the temperature,and the infeed *** order to validate our model,we compared the normalized surface roughness,the power spectral densities,the steady-state contact stresses,and the microstructure with proportionally scaled macroscopic experimental *** the grain sizes vary by a factor of more than 1,000 between experiment and simulation,the characteristic process parameters were reasonably reproduced,to some extent even allowing predictions of surface quality degradation due to tool *** the experimentally validated model,we studied time-resolved stress profiles within the ferrite/steel work piece as well as maps of the microstructural changes occurring in the near-surface *** found that blunt abrasives combined with elevated temperatures have the greatest and most complex impact on near-surface microstructure and stresses,as multiple processes are in mutual competition here.

关键词： large-scale molecular dynamics surface quality microstructure Revolutions per minute-Synchronous Grinding(RPM-Synchronous Grinding) tool wear

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On the reversibility of the α_(2)/ω_(o) phase transformation in a high Nb containing TiAl alloy during high temperature deformation

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Journal of Materials Science & Technology 2021年第34期93卷 96-102页

作者： Lin Song Fritz Appel Andreas Stark Uwe Lorenz Junyang He Zhanbing He Junpin Lin Tiebang Zhang Florian Pyczak State Key Laboratory of Solidification Processing Northwestern Poly technical University.Xi'an 710072China Institute of Materials Research Helmholtz-Zentrum GeesthachtMax Planck-Str.1Geesthacht 21502Germany Department of Microstructure Physics and Alloys Design Max-Planck-lnsdtut fiir Eisenforschung GmbHDusseldorf 40237Germany State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

The transformations between the phasesα_(2)(Ti_(3)Al)andω_(o)were investigated in a lamellar multiphase titanium aluminide alloy based onγ(TiAl).The paper complements an earlier investigation performed on the same material in which the importance of deformation-induced twin structures for theα_(2)→ω_(o) transformation was *** present study shows that the reverse transformationω_(o)→α_(2) can also occur during high-temperature *** transformation is probably triggered by constraint stresses,which exist between the different constituents due to the crystalline *** combined operation of mechanical twinning of theα_(2) phase and the reversible transformation fully converts theα_(2) lamellae into a mixture ofα_(2) andω_(o).This conversion greatly reduces the mechanical anisotropy existing in formerα_(2) *** the technical use of the alloy,the stability of the converted structure with respect to further annealing was also *** reported processes occur at the nano-meter and sub nano-meter scale,thus,advanced characterization techniques were applied,such as high-resolution transmission electron microscopy(HRTEM)and atom probe tomography(APT).

关键词： TiAl alloys Phase transformation Electron microscopy Microstructure

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Big Data Analytics for Earth Sciences:the EarthServer approach

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International Journal of Digital Earth 2016年第1期9卷 3-29页

作者： Peter Baumann Paolo Mazzetti Joachim Ungar Roberto Barbera Damiano Barboni Alan Beccati Lorenzo Bigagli Enrico Boldrini Riccardo Bruno Antonio Calanducci Piero Campalani Oliver Clements Alex Dumitrua,Mike Grant Pasquale Herzig George Kakaletris John Laxton Panagiota Koltsida Kinga Lipskoch Alireza Rezaei Mahdiraji Simone Mantovani Vlad Merticariu Antonio Messina Dimitar Misev Stefano Natali Stefano Nativi Jelmer Oosthoek Marco Pappalardo James Passmore Angelo Pio Rossi Francesco Rundo Marcus Sen Vittorio Sorbera Don Sullivan Mario Torrisi Leonardo Trovato Maria Grazia Veratelli Sebastian Wagner Large-Scale Scientific Information Systems Jacobs UniversityBremenGermany Rasdaman gmbh BremenGermany CNR-IIA National Research Council of ItalyInstitute of Atmospheric Pollution ResearchFlorenceItaly EOX IT Services gmbh ViennaAustria Consorzio COMETA CataniaItaly Division of Catania Italian National Institute for Nuclear PhysicsCataniaItaly Department of Physics and Astronomy University of CataniaCataniaItaly MEEO S.r.l. FerraraItaly Plymouth Marine Laboratory PlymouthUK Fraunhofer IGD DarmstadtGermany Athena Research and Innovation Center in Information Communication&Knowledge Technologies AthensGreece British Geological Survey EdinburghUK Software Engineering Italia S.r.l. CataniaItaly British Geological Survey KeyworthUK NASA Ames Research Center Moffett FieldCAUSA

Big Data Analytics is an emerging field since massive storage and computing capabilities have been made available by advanced *** and Environmental sciences are likely to benefit from Big Data Analytics techniques supporting the processing of the large number of Earth Observation datasets currently acquired and generated through observations and ***,Earth Science data and applications present specificities in terms of relevance of the geospatial information,wide heterogeneity of data models and formats,and complexity of ***,Big Earth Data Analytics requires specifically tailored techniques and *** EarthServer Big Earth Data Analytics engine offers a solution for coverage-type datasets,built around a high performance array database technology,and the adoption and enhancement of standards for service interaction(OGC WCS and WCPS).The EarthServer solution,led by the collection of requirements from scientific communities and international initiatives,provides a holistic approach that ranges from query languages and scalability up to mobile access and *** result is demonstrated and validated through the development of lighthouse applications in the Marine,Geology,Atmospheric,Planetary and Cryospheric science domains.

关键词： big data Big Data Analytics array databases Earth Sciences interoperability standards

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