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Photonics Research 2024年第5期12卷 921-931页

作者： YISI DONG WENWEN LI JiNRAN ZHANG WENRUI LUo HAIJIN FU XU XING PENGCHENG HU YONGKANG DONG JIUBIN TAN Center of Ultra-precision Optoelectronic Instrument Harbin Institute of TechnologyHarbin 150080China Key laboratory of Ultra-precision Intelligent Instrumentation(Harbin Institute of Technology) Ministry of Industry and Information TechnologyHarbin 150080China National Key laboratory of Science and Technology on Tunable laser Harbin Institute of TechnologyHarbin 150001China

As the key of embedded displacement measurement,a fiber-optic micro-probe laser interferometer(FMI)is of great interest in developing high-end equipment as well as precision ***,conventional phasegenerated carrier(PGC)approaches are for low-speed scenes and local error analysis,usually neglecting the global precision analysis and dynamic effect of system parameters under high-speed measurement,thus hindering their broad *** present a high-speed PGC demodulation model and method to achieve subnanometer displacement measurement precision in *** model includes a global equivalent resolution analysis and revelation of the demodulation error *** this model,the failure issues regarding the PGC demodulation method under high speed and large range are ***,an ultra-precision PGC demodulation algorithm based on the combination of static and dynamic delay adaptive regulation is proposed to enable high-speed and large-range displacement *** this paper,the proposed model and algorithm are validated through simulation and experimental *** results demonstrate a displacement resolution of 0.1 nm with a standard deviation of less than 0.5 nm when measuring at a high velocity of 1.5 m/s—nearly a tenfold increase of the latest study.

关键词： interferometer fiber displacement

A continuous-wave Nd:YVO_(4)-KGW intracavity Raman laser with over 34% diode-to-Stokes optical efficiency

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High Power laser Science and Engineering 2024年第2期12卷 62-68页

作者： Quan Sheng Jingni Geng Tianchang Liu Shijie Fu Wei Shi Jianquan Yao Institute of laser and Optoelectronics School of Precision Instrument and Optoelectronics EngineeringTianjin UniversityTianjinChina Key laboratory of Optoelectronic Information Technology(Ministry of Education) Tianjin UniversityTianjinChina

We demonstrate a continuous-wave(CW)Nd:YVO_(4)-potassium gadolinium tungstate(KGW)intracavity Raman laser with a diode-to-Stokes optical efficiency of 34.2%.By optimizing the cavity arrangement and reducing the cavity losses,8.47 W Stokes output at 1177 nm was obtained under an incident 878.6 nm diode pump power of 24.8 *** influence of cavity losses on the power and efficiency of the CW Raman laser,as well as the potential for further optimization,was investigated based on the numerical *** observation of thermally-induced output rollover was well explained by the calculation of the thermal lensing and cavity stability,indicating that the end-face curvature played an important role when the end-face of the crystal was highly reflective coated to make the cavity.A 10.9 W Stokes output under 40.9 W incident pump was also demonstrated with a cavity arrangement less sensitive to the end-face curvature,which is the highest output power of CW intracavity Raman lasers reported.

关键词： continuous wave intracavity Raman laser KGW crystal thermal lens

High-repetition-rate and high-power efficient picosecond thin-disk regenerative amplifier

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High Power laser Science and Engineering 2024年第2期12卷 16-23页

作者： Sizhi Xu Yubo Gao Xing Liu Yewang Chen Deqin Ouyang Junqing Zhao Minqiu Liu Xu Wu Chunyu Guo Cangtao Zhou Qitao Lue Shuangchen Ruan Key laboratory of Advanced Optical precision Manufacturing Technology of Guangdong Higher Education Institutes Sino-German College of Intelligent ManufacturingShenzhen Technology UniversityShenzhenChina Han’s laser Technology Industry Group Co. Ltd.ShenzhenChina Shenzhen Key laboratory of laser Engineering College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenChina Shenzhen Key laboratory of Ultraintense laser and Advanced Material Technology College of Engineering PhysicsShenzhen Technology UniversityShenzhenChina

We present an effective approach to realize a highly efficient,high-power and chirped pulse amplification-free ultrafast ytterbium-doped yttrium aluminum garnet thin-disk regenerative amplifier pumped by a zero-phonon line 969 nm laser *** amplifier delivers an output power exceeding 154 W at a pulse repetition rate of 1 MHz with custom-designed 48 pump *** exceptional thermal management on the thin disk through high-quality bonding,efficient heat dissipation and a fully locked spectrum collectively contributes to achieving a remarkable optical-to-optical efficiency of 61%and a near-diffraction-limit beam quality with an M2 factor of *** the best of our knowledge,this represents the highest conversion efficiency reported in ultrafast thin-disk regenerative ***,the amplifier operates at room temperature and exhibits exceptional stability,with root mean square stability of less than 0.33%.This study significantly represents advances in the field of laser amplification systems,particularly in terms of efficiency and average *** advantageous combination of high efficiency and diffraction limitation positions the thin-disk regenerative amplifier as a promising solution for a wide range of scientific and industrial applications.

关键词： high efficiency high power picosecond laser regenerative amplifier thin-disk laser

Strong field ionization of molecules on the surface of nanosystems

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Chinese Physics B 2024年第4期33卷 25-34页

作者：曲棋文孙烽豪王佳伟高健李辉吴健 State Key laboratory of precision Spectroscopy East China Normal UniversityShanghai 200241China Chongqing Key laboratory of precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China CAS Center for Excellence in Ultra-Intense laser Science Shanghai 201800China

Besides the diverse investigations on the interactions between intense laser fields and molecular systems,extensive research has been recently dedicated to exploring the response of nanosystems excited by well-tailored femtosecond laser *** to the fact that nanostructures hold peculiar effects when illuminated by laser pulses,the underlying mechanisms and the corresponding potential applications can make significant improvements in both fundamental research and development of novel *** this review,we provide a summarization of the strong field ionization occurring on the surface of *** molecules attached to the nanoparticle surface perform as the precursor in the ionization and excitation of the whole nanosystem,the fundamental processes of which are yet to be *** discuss the influence on nanoparticle constituents,geometric shapes and sizes,as well as the specific waveforms of the excitation laser *** intriguing characteristics observed in surface ion emission reflect how enhanced near field affects the localized ionizations and nanoplasma expansions,thereby paving the way for further precision controls on the light-and-matter interactions in the extreme spatial temporal levels.

关键词： nanoparticle femtosecond laser field local field enhancement

Suppressing Wnt signaling of the blood-tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2716-2731页

作者： Yang Tong Pei An Puxian Tang Rui Mu Yuteng Zeng Hang Sun Mei Zhao Ziyan Lv Pan Wang Wanjun Han Chunshan Gui Xuechu Zhen Liang Han Jiangsu Key laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of precision diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid *** inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood-tumor barrier(BTB).BTB activates its Wnt signaling to maintain barrier properties,e.g.,Mfsd2a-mediated BTB low ***,we reported VCAM-1-targeting nano-wogonin(W@V-NPs)as an adjuvant of nano-orlistat(O@V-NPs)to intensify drug delivery and inhibit lipogenesis of brain metastases.W@V-NPs were proven to be able to inactivate BTB Wnt signaling,downregulate BTB Mfsd2a,accelerate BTB vesicular transport,and enhance tumor accumulation of O@*** the ability to specifically kill cancer cells in a lipid-deprived environment with IC_(50) at 48 ng/mL,W@V-NPs plus O@V-NPs inhibited the progression of brain metastases with prolonged survival of model *** combination did not induce brain edema,cognitive impairment,and systemic toxicity in healthy *** Wnt signaling could safely modulate the BTB to improve drug delivery and metabolic therapy against brain metastases.

关键词： Lipogenesis Brain metastases Blood-tumor barrier Wnt signaling Drug delivery Fatty acid synthase Nanoparticles Combination therapy

Observation of transition from superfluorescence to polariton condensation in CsPbBr3 quantum dots film

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Light(Science & Applications) 2024年第2期13卷 316-324页

作者： Danqun Mao Linqi Chen Zheng Sun Min Zhang Zhe-Yu Shi Yongsheng Hu Long Zhang Jian Wu Hongxing Dong Wei Xie Hongxing Xu State Key laboratory of precision Spectroscopy East China Normal UniversityShanghai 200241China Key laboratory of Materials for High-Power laser Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences201800 ShanghaiChina Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanShanxi 030006China Chongqing Key laboratory of precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China CAS Center for Excellence in Ultraintense laser Science Shanghai 201800China School of Physics and Technology Center for Nanoscience and NanotechnologyWuhan UniversityWuhan 430072China

The superfluorescence effect has received extensive attention due to the many-body physics of quantum correlation in dipole gas and the optical applications of ultrafast bright radiation field based on the cooperative quantum ***,we demonstrate not only to observe the superfluorescence effect but also to control the cooperative state of the excitons ensemble by externally applying a regulatory dimension of coupling light fields.A new quasi-particle called cooperative exciton-polariton is revealed in a light-matter hybrid structure of a perovskite quantum dot thin film spin-coated on a Distributed Bragg *** the nonlinear threshold,polaritonic condensation occurs at a nonzero momentum state on the lower polariton branch owning to the vital role of the synchronized *** phase transition from superfluorescence to polariton condensation exhibits typical signatures of a decrease of the linewidth,an increase of the macroscopic coherence as well as an accelerated radiation decay *** findings are promising for opening new potential applications for super-brightness and unconventional coherent light sources and could enable the exploitation of cooperative effects for quantum optics.

关键词： quantum condensation polar

Spatial light modulation for femtosecond laser manufacturing:Current developments and challenges

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Science China(Technological Sciences) 2024年第1期67卷 60-72页

作者： ZANG Xue LIU ZiTing XU YiShi WANG Yi WANG Qing LI ZhenZe WANG Lei State Key laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China State Key laboratory of precision Measurement and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China

Since the invention of lasers,spatial-light-modulated laser processing has become a powerful tool for various *** enables multidimensional and dynamic modulation of the laser beam,which significantly improves the processing efficiency,accuracy,and flexibility,and presents wider prospects over traditional mechanical technologies for machining three-dimensional,hard,brittle,or transparent *** this review,we introduce:(1)The role of spatial light modulation technology in the development of femtosecond laser manufacturing;(2)the structured light generated by spatial light modulation and its generation methods;and(3)representative applications of spatial-light-modulated femtosecond laser manufacturing,including aberration correction,parallel processing,focal field engineering,and polarization ***,we summarize the present challenges in the field and possible future research.

关键词： femtosecond laser manufacturing spatial light modulation structured light aberration correction parallel processing focal field engineering polarization control

MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 594-604页

作者： Yanjin WANG Yifei CHEN Fuji YANG Xiaolong YU Ying CHU Jing ZHOU Yongmin YAN Jianbo XI Department of laboratory Medicine Wujin Hospital Affiliated with Jiangsu UniversityJiangsu UniversityChangzhou 213017China Department of laboratory Medicine School of MedicineJiangsu UniversityZhenjiang 212013China Changzhou Key laboratory of Molecular diagnostics and precision Cancer Medicine Wujin Clinical College of Xuzhou Medical UniversityChangzhou 213017China

Liver fibrosis is a significant health burden,marked by the consistent deposition of ***,the currently available treatment approaches for this condition are far from *** oxidase-like protein 2(LOXL2)secreted by hepatic stellate cells(HSCs)is a crucial player in the cross-linking of matrix collagen and is a significant target for treating liver *** stem cell-derived small extracellular vesicles(MSC-sEVs)have been proposed as a potential treatment option for chronic liver *** studies have found that MSC-sEV can be used for microRNA delivery into target cells or *** is currently unclear whether microRNA-4465(miR-4465)can target LOXL2 and inhibit HSC ***,it is uncertain whether MSC-sEV can be utilized as a gene therapy vector to carry miR-4465 and effectively inhibit the progression of liver *** study explored the effect of miR-4465-modified MSC-sEV(MSC-sEVmiR-4465)on LOXL2 expression and liver fibrosis *** results showed that miR-4465 can bind specifically to the promoter of the LOXL2 gene in ***,MSC-sEVmiR-4465 inhibited HSC activation and collagen expression by downregulating LOXL2 expression in ***-sEVmiR-4465 injection could reduce HSC activation and collagen deposition in the CCl4-induced mouse ***-sEVmiR-4465 mediating via LOXL2 also hindered the migration and invasion of HepG2 *** conclusion,we found that MSC-sEV can deliver miR-4465 into HSC to alleviate liver fibrosis via altering LOXL2,which might provide a promising therapeutic strategy for liver diseases.

关键词： Mesenchymal stem cell(MSC) Small extracellular vesicle(sEV) MicroRNA-4465(miR-4465) Hepatic stellate cell(HSC) Liver fibrosis

Triboelectric‘electrostatic tweezers'for manipulating droplets on lubricated slippery surfaces prepared by femtosecond laser processing

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International Journal of Extreme Manufacturing 2024年第3期6卷 411-426页

作者： Jiale Yong Xinlei Li Youdi Hu Yubin Peng Zilong Cheng Tianyu Xu Chaowei Wang Dong Wu CAS Key laboratory of Mechanical Behavior and Design of Materials Department of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China

The use of‘Electrostatic tweezers'is a promising tool for droplet manipulation,but it faces many limitations in manipulating droplets on superhydrophobic ***,we achieve noncontact and multifunctional droplet manipulation on Nepenthes-inspired lubricated slippery surfaces via triboelectric electrostatic tweezers(TETs).The TET manipulation of droplets on a slippery surface has many advantages over electrostatic droplet manipulation on a superhydrophobic *** electrostatic field induces the redistribution of the charges inside the neutral droplet,which causes the triboelectric charged rod to drive the droplet to move forward under the electrostatic *** or negatively charged droplets can also be driven by TET based on electrostatic attraction and *** enables us to manipulate droplets under diverse conditions,including anti-gravity climb,suspended droplets,corrosive liquids,low-surface-tension liquids(*** with a surface tension of 22.3 mN·m^(-1)),different droplet volumes(from 100 nl to 0.5 ml),passing through narrow slits,sliding over damaged areas,on various solid substrates,and even droplets in an enclosed *** droplet-related applications,such as motion guidance,motion switching,droplet-based microreactions,surface cleaning,surface defogging,liquid sorting,and cell labeling,can be easily achieved with TETs.

关键词： triboelectric electrostatic tweezer droplet manipulation slippery surface superhydrophobic surface femtosecond laser

A Yb optical clock with a lattice power enhancement cavity

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Chinese Physics B 2024年第3期33卷 70-74页

作者：王春云姚远师浩森于洪浮马龙生蒋燕义 State Key laboratory of precision Spectroscopy East China Normal UniversityShanghai 200062China

We construct a power enhancement cavity to form an optical lattice in an ytterbium optical *** is demonstrated that the intra-cavity lattice power can be increased by about 45 times,and the trap depth can be as large as 1400Er when laser light with a power of only 0.6 W incident to the lattice *** high trap depths are the key to accurate evaluation of the lattice-induced light shift with an uncertainty down to~1×*** probing the ytterbium atoms trapped in the power-enhanced optical lattice,we obtain a 4.3 Hz-linewidth Rabi spectrum,which is then used to feedback to the clock laser for the close loop operation of the optical lattice *** evaluate the density shift of the Yb optical lattice clock based on interleaving measurements,which is-0.46(62)*** result is smaller compared to the density shift of our first Yb optical clock without lattice power enhancement cavity mainly due to a larger lattice diameter of 344μm.

关键词： optical atomic clock optical lattice optical cavity Stark shift