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Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics

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Protein & Cell 2024年第7期15卷 530-546页

作者： Tao Chen Yiliang Xu Xiaocui Xu Jianzhang Wang Zhiruo Qiu Yayuan Yu Xiaohong Jiang Wanqi Shao Dandan Bai Mingzhu Wang Shuyan Mei Tao Cheng Li Wu Shaorong Gao Xuan Che Department of Obstetrics and Gynecology Affiliated Women and Children Hospital of Jiaxing UniversityJiaxing 314000China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Key Laboratory of Animal Bioengineering and Disease Prevention of Shandong Province College of Animal Science and TechnologyShandong Agricultural UniversityTaian 271018China Women’s Hospital School of MedicineZhejiang UniversityHangzhou 310013China postgraduate training base Alliance of Wenzhou Medical University Wenzhou Medical UniversityWenzhou 325035China Jiaxing University Master Degree Cultivation Base Zhejiang Chinese Medical UniversityHangzhou 310053China Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal-Fetal Medicine and Gynecologic OncologyClinical and Translational Research CenterShanghai First Maternity and Infant HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Adenomyosis is a poorly understood gynecological disorder lacking effective *** persists regarding“invagination”and“metaplasia”*** endometrial-myometrial junction(EMJ)connects the endometrium and myometrium and is important for diagnosing and classifying adenomyosis,but its in-depth study is just *** single-cell RNA sequencing and spatial profiling,we mapped transcriptional alterations across eutopic endometrium,lesions,and *** lesions,we identified unique epithelial(LGR5+)and invasive stromal(PKIB+)subpopulations,along with WFDC1+progenitor cells,supporting a complex interplay between“invagination”and“metaplasia”theories of ***,we observed endothelial cell heterogeneity and abnormal angiogenic signaling involving vascular endothelial growth factor and angiopoietin ***-cell communication differed markedly between ectopic and eutopic endometrium,with aberrant signaling in lesions involving pleiotrophin,TWEAK,and WNT *** study reveals unique stem cell-like and invasive cell subpopulations within adenomyosis lesions identified,dysfunctional signaling,and EMJ abnormalities critical to developing precise diagnostic and therapeutic strategies.

关键词： adenomyosis single-cell RNA sequencing spatial transcriptomics endometrial-myometrial junction progenitor cells

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Effect of solidification mode on microstructure evolution and properties of magnesium alloy with long-period stacking ordered phase

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Journal of Iron and Steel Research(International) 2024年第5期31卷 1127-1138页

作者： Hao Li Hong-mei Chen Xu Zhang Qian-hao Zang Jing Zhang Di Feng Yan-xin Qiao Yu-hang Guo school of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100JiangsuChina school of Metallurgy and Materials Engineering Jiangsu University of Science and TechnologySuzhou215600JiangsuChina

The solidification methods of electromagnetic stirring(EMS)and non-electromagnetic stirring were employed to prepare Mg–6Gd–3Y–xZn–0.6Zr(x=1,1.5,2,3)*** evolution of alloy microstructures and the changes in properties were analyzed for different Zn *** has been observed that in alloys without electromagnetic stirring,as the Zn content increases,the alloy structure gradually *** primary second phase transitions from Mg5RE phase to long-period stacking ordered(LPSO)phase,resulting in improved hardness and *** alloys subjected to electromagnetic stirring,there is a relatively higher content of the second phase,primarily consisting of LPSO *** applying electromagnetic stirring,the quantity and the type of LPSO phase in the alloy *** alloy structure becomes more uniform with electromagnetic stirring,resulting in increased hardness and reduced hardness gradients within the *** mechanical properties of alloys with electromagnetic stirring are superior to those without electromagnetic stirring.

关键词： Rare earth magnesium alloy LPSO phase Electromagnetic stirring Casting Property

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Risk factors and outcomes of peptic ulcer bleed in a Pakistani population:A single-center observational study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 1-9页

作者： Nazish Butt Muhammad Tayyab Usmani Nimrah Mehak Saba Mughal Fakhar Ali Qazi-Arisar Ghulam Mohiuddin Gulzar Khan Department of Gastroenterology Jinnah Postgraduate Medical CentreKarachi 75505SindhPakistan National Institute of Liver&GI Diseases Dow University of Health SciencesKarachi 75330SindhPakistan school of Public Health Dow University of Health SciencesKarachi 75330SindhPakistan

BACKGROUND Peptic ulcer disease(PUD)remains a significant healthcare burden,contributing to morbidity and mortality *** advancements in therapies,its prevalence persists,particularly in regions with widespread nonsteroidal antiinflammatory drugs(NSAIDs)use and Helicobacter pylori *** To comprehensively analyse the risk factors and outcomes of PUD-related upper gastrointestinal(GI)bleeding in Pakistani *** This retrospective cohort study included 142 patients with peptic ulcer bleeding who underwent upper GI endoscopy from January to December *** on demographics,symptoms,length of stay,mortality,re-bleed,and Forrest classification was *** The mean age of patients was 53 years,and the majority was men(68.3%).Hematemesis(82.4%)and epigastric pain(75.4%)were the most common presenting *** patients(73.2%)were discharged within five *** mortality rates at one week and one month were 10.6%and 14.8%,***-bleed within 24 h and seven days occurred in 14.1%and 18.3%of patients,*** ulcers were Forrest class(FC)Ⅲ(72.5%).Antiplatelet use was associated with higher mortality at 7 and 30 d,while alternative medications were linked to higher 24-hour re-bleed *** use was associated with more FCⅢ***-bleed at 24 h and 7 d was strongly associated with one-week or one-month *** Antiplatelet use and rebleeding increase the risk of early mortality in PUD-related upper GI bleeding,while alternative medicines are associated with early rebleeding.

关键词： Non variceal bleed Mortality Re-bleed Forrest classification Antiplatelets Alternative medicines

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Configuration Synthesis and Grasping Performance Analysis of Multi-Loop Coupling Capture Mechanism for Launch and Recovery of Torpedo-Shaped Autonomous Underwater Vehicle

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China Ocean Engineering 2024年第3期38卷 453-466页

作者： ZHANG Guo-xing XIA Xin-lu GUO Jin-wei school of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Research of capture mechanisms with strong capture adaptability and stable grasp is important to solve the problem of launch and recovery of torpedo-shaped autonomous underwater vehicles(AUVs).A multi-loop coupling capture mechanism with strong adaptability and high retraction rate has been proposed for the launch and recovery of torpedo-shaped AUVs with different morphological ***,the principle of capturing motion retraction is described based on the appearance characteristics of torpedo-shaped AUVs,and the configuration synthesis of the capture mechanism is carried out using the method of constrained chain ***,the screw theory is employed to analyze the degree of freedom(DoF)of the capture ***,the 3D model of the capture mechanism is established,and the kinematics and dynamics simulations are carried *** with the capture orientation requirements of the capture mechanism,the statics and vibration characteristics analyses are carried ***,considering the capture process and the underwater working environment,the motion characteristics and hydraulics characteristics of the capture mechanism are ***,a principle prototype is developed and the torpedo-shaped AUVs capture experiment is *** work provides technical reserves for the research and development of AUV capture special equipment.

关键词： capture mechanism torpedo-shaped AUVs configuration synthesis launch and recovery grasping performance analysis

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generalized Inverses and Units in a Unitary Ring

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1000-1014页

作者： Yu Kun ZHOU Jian Long CHEN school of Mathematics Southeast UniversityNanjing 210096P.R.China

Let R be a unitary ring and a,b∈R with ab=*** find the 2/3 property of Drazin invertibility:if any two of a,b and a+b are Drazin invertible,then so is the third ***,we combine the 2/3 property of Drazin invertibility to characterize the existence of generalized inverses by means of *** applications,the need for two invertible morphisms used by You and Chen to characterize the group invertibility of a sum of morphisms is reduced to that for one invertible morphism,and the existence and expression of the inverse along a product of two regular elements are obtained,which generalizes the main result of Mary and Patricio(2016)about the group inverse of a product.

关键词： Leftπ-regular element stronglyπ-regular element group inverse Drazin inverse inverse along an element

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Multimodal Data-Driven Reinforcement Learning for Operational Decision-Making in Industrial Processes

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 252-254页

作者： Chenliang Liu Yalin Wang Chunhua Yang Weihua Gui the school of Automation Central South UniversityChangsha 410083China IEEE

Dear Editor, This letter proposes a multimodal data-driven reinforcement learning-based method for operational decision-making in industrial processes. Due to the frequent fluctuations of feedstock properties and operating conditions in the industrial processes, existing data-driven methods cannot effectively adjust the operational variables. In addition, multimodal data such as images, audio.

关键词： processes modal adjust

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Recent progress of Pt-based oxygen reduction reaction catalysts for proton exchange membrane fuel cells

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Rare Metals 2024年第6期43卷 2444-2468页

作者： Feng Zhan Kun-Song Hu Jin-Hua Mai Li-Sheng Zhang Zhen-Guo Zhang Huan He Xin-Hua Liu school of Resources Environment and MaterialsGuangxi UniversityNanning530004China school of Transportation Science and Engineering Beihang UniversityBeijing 102206China IDTECH(Suzhou)Co.Ltd Suzhou 215217China Dyson school of Design Engineering Imperial College LondonLondon SW72AZUK

With the increasing consumption of fossil fuels,proton exchange membrane fuel cells(PEMFCs)have attracted considerable attention as green and sustainable energy conversion *** slow kinetics of the cathodic oxygen reduction reaction(ORR)has a major impact on the performance of PEMFCs,and although platinum(Pt)can accelerate the reaction rate of the ORR,the scarcity and high cost of Pt resources still limit the development of ***,the development of low-cost high-performance ORR catalysts is essential for the commercial application and development of *** paper reviews the research progress of researchers on Pt-based ORR catalysts in recent years,including Pt/C catalysts,Pt-based alloy catalysts,Pt-based intermetallic compounds,and Pt-based single-atom catalysts(SACs),with a focus on Pt-based alloy catalysts with different *** described in detail the difficulties and solutions in the research process of various ORR catalysts and explained the principle of their activity enhancement with density functional theory(DFT).In addition,an outlook on the development of Pt-based catalysts is given,and reducing the amount of Pt used and improving the performance of catalysts are the directions to work on in the coming period.

关键词： Pt-based catalysts PEMFCs Pt-based intermetallic compounds Single-atom catalysts

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Partial aging can counter-intuitively couple with sulfidation to improve the reactive durability of zerovalent iron

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 1-11页

作者： Yiwei Liu Kaili Gu Jinhua Zhang Jinxiang Li Jieshu Qian Jinyou Shen Xiaohong Guan Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse School of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China school of Ecological and Environmental Sciences East China Normal UniversityShanghai 200241China

Sulfated zero-valent iron(SZVI)has shown promising applications in wastewater ***,the rapid decline in the reactivity of SZVI with time limits its real *** mediate this problem,partial aging was proposed to improve the reactive durability of *** Cr(VI)as the target contaminant,we found that the aged ZVI(AZVI)gradually lost reactivity as aging time increased from 0.5 to 2 ***-intuitively,the partially aged SZVI(ASZVI)showed greater reactivity than SZVI when exposed to oxygenated water for a period ranging from 0.5 to 14 *** addition,the ASZVI with 0.5 d of aging time(ASZVI-0.5)not only maintained reactivity in successive runs but also increased the Cr(VI)removal capacity from 9.1 mg/g by SZVI to 19.1 mg/g by *** analysis further revealed that the electron transfer from the Fe0 core to the shell was mediated by the conductive FeS and FeS2 in the subshell of ***,the lepidocrocite and magnetite on the surface of ASZVI facilitated Cr(VI)adsorption and subsequent electron transfer for Cr(VI)***,the iron(hydr)oxide shell could retain the conductive FeS and FeS2 in the subshell,allowing ASZVI to reduce Cr(VI)efficiently and *** general,partial aging can enhance the reactive durability of ZVI when coupled with sulfidation and this synergistic effect will be beneficial to the application of SZVI-based technology for wastewater treatment.

关键词： Zerovalent iron Sulfidation Partial aging Interface reconstruction Electron transfer

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Effect of post heat treatment on microstructure, mechanical property and corrosion behavior of AlSi10Mg alloy fabricated by selective laser melting

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Progress in Natural Science:Materials International 2024年第1期34卷 89-101页

作者： Yang Zheng Zihao Zhao Ruize Xiong Guochun Ren Minghui Yao Wei Liu Libin Zang school of Aeronautics and Astronautics Tiangong University school of Mechanical Engineering Tiangong University 3D Printing Research&Engineering Technology Center AECC Beijing Institute of Aeronautical Materials Tianjin Institute of Aerospace Mechanical and Electrical Equipment

The microstructure, mechanical property and corrosion behavior of the AlSi10Mg alloy fabricated by selective laser melting(SLMed-AlSi10Mg) after different post heat treatment(PHT) of direct aging(DA), solid solution(T4)and solid solution + aging(T6) were investigated. The microstructural characterization revealed that the porosity of the SLMed-AlSi10Mg was increased from 0.41 ± 0.04 % to 3.09 ± 0.11 % with increasing temperature. The Asbuilt and DA-treated samples exhibited a microstructure of α-Al matrix surrounded with continuous Si networks,whereas the T4-treated and T6-treated samples presented a microstructure of α-Al matrix surrounded with discrete Si particles. The microhardness, strength and work hardening rate of the SLMed-AlSi10Mg increased in the order of T4-treated sample < T6-treated sample < As-built sample < DA-treated sample(a reverse order was found for the elongation), which was due to the precipitation of nanoscale Si particles after DA treatment and the softening of α-Al matrix after T4 and T6 treatments. The corrosion resistance of the SLMed-AlSi10Mg was obviously deteriorated after T4 and T6 treatments compared with DA treatment, which was caused by the changes in Si morphology, residual stress and porosity.

关键词： Selective laser melting AlSi10Mg alloy Post heat treatment Microstructure Mechanical property Corrosion behavior

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Antioxidants Enzymes Activities and NO Levels in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis—A Comparative Study

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Journal of Biosciences and Medicines 2024年第2期12卷 50-59页

作者： Natalia Cristina Aparecida Ribeiro e Ribeiro Anderson Martins Tavares Jaslana Hainfellner da Silva João Paulo Lima Daher Salim Kanaan Luciene de Carvalho Cardoso-Weide Laboratory of Neuroplasticity Neurobiology Department Biology Institute Federal Fluminense University Rio de Janeiro Brazil postgraduate Program in Medical Sciences School of Medicine Federal Fluminense University Rio de Janeiro Brazil school of Biology UNIVERSO—Salgado de Oliveira University Rio de Janeiro Brazil Department of Pathology Faculty of Medicine Federal Fluminense University Rio de Janeiro Brazil

It consists of a retrospective study with twenty-two individuals diagnosed with DRC: fourteen HD and eight CAPD, followed up in the dialysis center of Antonio Pedro University Hospital (HUAP) of Fluminense Federal University (UFF), between 2015 and 2017. Fifteen healthy control (HC) subjects were included, without diagnosed CKD. Patients with HIV positive, hepatitis A, B, and C, pregnant, cancer, smokers, alcoholics and those exposed to X-rays in the last 3 months, were excluded. Objectives: As oxidative stress and endothelial dysfunction may be linked to the higher prevalence of CVD in CKD patients, we measured the activities of the antioxidants enzymes: SOD and GPx and total NO levels in the plasma and serum of end-stage CKD patients undergoing dialysis therapy, comparing with the HC group. Methods: Quantification of NO levels was performed by fluorometric kit, while activities of SOD and GPx were determined using kinetic methods. Results: We found higher plasma SOD activity in HD (8.58 U/ml) and CAPD (10.14 U/ml), compared to C (3.73 U/ml) group, while GPx activity was decreased in HD (115.38 nmol/h/ml) and CAPD (122.76 nmol/h/ml) groups compared to HC group (275.83 nmol/h/ml). Total serum NO concentration was decreased in HD (14.09 pmol/μl) and CAPD (10.26 pmol/μl), compared to non-CKD patients (49.65 pmol/μl). Conclusion: Decreased total serum NO and GPx activities may lead to endothelial dysfunction and consequently a higher prevalence of CVD in CKD patients.

关键词： Hemodialysis CAPD SOD GPx NO

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