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Treatment of Helicobacter pylori with potassium competitive acid blockers:A systematic review and meta-analysis

World Journal of gastroenterology 2024年第9期30卷 1213-1223页

作者： Joseph Edwin Kanu Jonathan Soldera post graduate program at acute medicine and gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND Helicobacter pylori(***)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric *** *** is crucial for treating and preventing these *** conventional proton pump inhibitor(PPI)-based triple therapy is effective,there’s growing interest in longer acid suppression *** competitive acid blocker(P-CAB)triple and dual therapy are new regimens for *** *** used in Asian populations,vonoprazan(VPZ)has been recently Food and Drug Administration-approved for *** *** To assess the efficacy of regimens containing P-CABs in eradicating *** *** This study,following PRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"Potassium-Competitive Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of P-CABs-based treatment to classical PPIs in eradicating *** were *** criteria included case reports,case series,unpublished trials,or conference *** variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and *** eradication method were gathered by two independent ***-analysis was performed in R software,and forest plots were *** A total of 256 references were initially retrieved through the search ***,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing P-CAB triple therapy to PPI triple *** intention-to-treat analysis involved 8049 patients,with 4471 in the P-CAB intervention g

关键词： Helicobacter pylori infection Potassium competitive acid blockers Proton pump inhibitors Vonoprazan Amoxicillin

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Insights into skullcap herb-induced liver injury

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World Journal of Hepatology 2024年第2期16卷 120-122页

作者： Jonathan Soldera post graduate program at acute medicine and gastroenterology University of South WalesCardiff CF371DLUnited Kingdom

This editorial addresses the growing concern of herb-induced liver injury(HILI),focusing on a unique case of Skullcap-induced HILI *** editorial underscore the significant mortality rate linked to Skullcap-induced HILI,emphasizing the importance of vigilant monitoring and *** herbal supplement usage rises,collaboration among clinicians and researchers is crucial to comprehend and address the complexities of HILI,particularly those involving Skullcap.

关键词： Herb-induced liver injury Drug induced liver injury Dietary supplements Herbal hepatotoxicity Liver transplantation

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Anemia in cirrhosis:An underestimated entity

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World Journal of Clinical Cases 2022年第3期10卷 777-789页

作者： Manish Manrai Saurabh Dawra Rajan Kapoor Sharad Srivastava Anupam Singh Department of Internal medicine Armed Forces Medical CollegePune 411040India Department of medicine and gastroenterology Command HospitalPune 411040India Department of medicine Command HospitalKolkata 70027India Department of gastroenterology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

Anemia in a patient with cirrhosis is a clinically pertinent but often overlooked clinical *** guidelines highlight the algorithmic approach of managing a patient of cirrhosis presenting with acute variceal hemorrhage but day-to-day management in hospital and out-patient raises multiple dilemmas:Whether anemia is a disease complication or a part of the disease spectrum?Should iron,folic acid,and vitamin B complex supplementation and nutritional advice,suffice in those who can perform tasks of daily living but have persistently low *** does one investigate and manage anemia due to multifactorial etiologies in the same patient:acute or chronic blood loss because of portal hypertension and bone marrow aplasia secondary to hepatitis B or C viremia?To add to the clinician’s woes the prevalence of anemia increases with increasing disease *** thus aim to critically analyze the various pathophysiological mechanisms complicating anemia in a patient with cirrhosis with an emphasis on the diagnostic flowchart in such patients and proposed management protocols thereafter.

关键词： Anemia Cirrhosis Iron deficiency anemia Macrocytic anemia Normocytic anemia

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Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis

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World Journal of gastroenterology 2014年第28期20卷 9458-9467页

作者： Bruno César da Silva Andre Castro Lyra Raquel Rocha Genoile Oliveira Santana post-graduate program in medicine and Health Federal University of Bahia gastroenterology Department of the University Hospital Professor Edgard Santos Federal University of Bahia Gastro-Hepatology Service of Hospital S?o Rafael Department of Sciences of Nutrition School of NutritionFederal University of Bahia

Ulcerative colitis(UC)is a chronic disease characterized by diffuse inflammation of the mucosa of the colon and *** hallmark clinical symptom of UC is bloody *** clinical course is marked by exacerbations and remissions,which may occur spontaneously or in response to treatment changes or intercurrent *** is most commonly diagnosed in late adolescence or early adulthood,but it can occur at any *** incidence of UC has increased worldwide over recent decades,especially in developing *** contrast,during this period,therapeutic advances have improved the life expectancy of patients,and there has been a decrease in the mortality rate over *** is important to emphasize that there is considerable variability in the phenotypic presentation of *** this context,certain clinical and demographic characteristics are useful in identifying patients who tend to have more severe evolution of the disease and a poor *** this group of patients,better clinical surveillance and more intensive therapy may change the natural course of the *** aim of this article was to review the epidemiology and demographic characteristics of UC and the factors that may be associated with its clinical prognosis.

关键词： Ulcerative colitis Incidence Prevalence Risk factors Predictive factors

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Palliative care for end-stage liver disease and acute on chronic liver failure:A systematic review

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World Journal of Methodology 2024年第4期14卷 131-148页

作者： Vakaola I Pulotu Mafi Jonathan Soldera post-graduate program Acute MedicineUniversity of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND End stage liver disease(ESLD)represents a growing health concern characterized by elevated morbidity and mortality,particularly among individual ineligible for liver *** demand for palliative care(PC)is pronounced in patients grappling with ESLD and acute on chronic liver failure(ACLF).Unfortunately,the historical underutilization of PC in ESLD patients,despite their substantial needs and those of their family caregivers,underscores the imperative of seamlessly integrating PC principles into routine healthcare practices across the entire disease *** To comprehensively investigate the evidence surrounding the benefits of incorporating PC into the comprehensive care plan for individuals confronting ESLD and/or *** A systematic search in the Medline(PubMed)database was performed using a predetermined search command,encompassing studies published in English without any restrictions on the publication ***,the retrieved studies were manually *** descriptive analyses were employed to summarize the *** The search strategies yielded 721 *** the final analysis,32 fulllength references met the inclusion criteria and were consequently incorporated into the *** data extraction from these 32 studies was undertaken,leading to the execution of a comprehensive narrative systematic *** review found that PC provides significant benefits,reducing symptom burden,depressive symptoms,readmission rates,and hospital ***,barriers like the appeal of transplants and misconceptions about PC hinder optimal *** PC early,upon the diagnosis of ESLD and ACLF,regardless of transplant eligibility and availability,improves the quality of life for these *** Despite the substantial suffering and poor prognosis associated with ESLD and ACLF,where liver transplantation stands as the only curative treatment,albeit largely inaccessible,PC services h

关键词： End stage liver disease acute on chronic liver failure Palliative care Liver transplantation Quality of life

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Controversies in the management of acute pancreatitis:An update

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World Journal of Clinical Cases 2023年第12期11卷 2582-2603页

作者： Manish Manrai Saurabh Dawra Anupam K Singh Daya Krishna Jha Rakesh Kochhar Department of Internal medicine Armed Forces Medical CollegePune 411040India Department of medicine and gastroenterology Command HospitalPune 411040India Department of gastroenterology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of gastroenterology Army Hospital(Research and Referral)New Delhi 11010India

This review summarized the current controversies in the management of acute pancreatitis(AP).The controversies in management range from issues involving fluid resuscitation,nutrition,the role of antibiotics and antifungals,which analgesic to use,role of anticoagulation and intervention for complications in *** interventions vary from percutaneous drainage,endoscopy or *** research and emerging data are helping to formulate better *** available evidence favors crystalloids,although the choice and type of fluid resuscitation is an area of dynamic *** nutrition aspect does not have controversy as of now as early enteral feeding is preferred most often than *** empirical use of antibiotics and antifungals are gray zones,and more data is needed for conclusive *** choice of analgesic is being studied,and the recommendations are still *** position of using anticoagulation is still awaiting *** role of intervention is well established,although the modality is constantly changing and favoring endoscopy or percutaneous drainage rather than *** is evident that more multicenter randomized controlled trials are required for establishing the standard of care in these crucial management issues of AP to improve the morbidity and mortality worldwide.

关键词： acute pancreatitis Fluid resuscitation Antibiotics Analgesia Anti coagulation Intervention

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Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution

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World Journal of gastroenterology 2011年第33期17卷 3802-3809页

作者： Tomohisa Takagi Yuji Naito Kazuhiko Uchiyama Toshimitsu Okuda Katsura Mizushima Takahiro Suzuki Osamu Handa Takeshi Ishikawa Nobuaki Yagi Satoshi Kokura Hiroshi Ichikawa Toshikazu Yoshikawa Department of Molecular gastroenterology and Hepatology Graduate School of Medical ScienceKyoto Prefectural University of Medicine6028566 KyotoJapan

AIM:To investigate the efficacy of rebamipide in a rat model of colitis and restitution of intestinal epithelial cells in ***:acute colitis was induced with trinitrobenzene sulfonic acid(TNBS)in male Wistar *** received intrarectal rebamipide treatment daily starting on day 7 and were sacrificed on day 14 after TNBS *** distal colon was removed to evaluate the various parameters of ***,wound healing assays were used to determine the enhanced restitution of rat intestinal epithelial(RIE)cells treated with ***:Intracolonic administration of rebamipide accelerated TNBSinduced ulcer *** in the wet weight of the colon after TNBS administration were significantly inhibited by *** wound assay revealed that rebamipide enhanced the migration of RIE cells through phosphorylation of extracellular signalregulated kinase(ERK)and activation of Rho ***:Rebamipide enema healed intestinal injury by enhancing restitution of RIE cells,via ERK *** might be a novel therapeutic approach for inflammatory bowel disease.

关键词： Rebamipide Experimental colitis Intestinal epithelial cells Extracellular signalregulated kinase Rho kinase

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COVID-19 and the liver:Are footprints still there?

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World Journal of gastroenterology 2023年第4期29卷 656-669页

作者： Tarana Gupta Hemant Sharma Department of medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

The coronavirus disease 2019(COVID-19)hit the entire world as a global pandemic and soon became the most important concern for all patients with chronic *** early trend in higher mortality in patients with acute respiratory distress attracted all researchers to closely monitor patients for the involvement of other *** soon became apparent that patients with chronic liver diseases are at increased risk of mortality given their cirrhosis-associated immune ***,liver function abnormalities were noted in patients with severe *** cytokine storm,direct viral infection,drugs and reactivation of viral infections were causes of deranged liver ***,we discuss the relation between COVID-19 and chronic liver disease,specifically cirrhosis,hepatitis B,hepatitis C,and non-alcoholic fatty liver disease(NAFLD),as well as the liver manifestations of *** metabolic syndrome,obesity,diabetes mellitus and NAFLD were found to worsen outcome in different studies reported *** cirrhosis should be considered a risk factor for death and severe ***,COVID-19 related cholangiopathy has also been reported with changes of secondary sclerosing *** long-term persistence of viral antigens in gut epithelia raises concern regarding the future risk of autoimmune liver diseases.

关键词： COVID-19 Chronic liver disease Cirrhosis Liver injury Transaminases Non-alcoholic fatty liver disease post-acute COVID-19 syndrome

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Genetic risk factors associated with NAFLD

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Hepatoma Research 2020年第12期6卷 42-51页

作者： Dong Yun Kim Jun Yong Park Department of medicine Yonsei University Graduate School of MedicineSeoul 03722Korea Department of medicine Physician-Scientist ProgramYonsei University Graduate School of MedicineSeoul 03722Korea Division of gastroenterology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Korea Yonsei Liver Center Severance HospitalSeoul 03722Korea

Non-alcoholic fatty liver disease(NAFLD)is estimated to affect 25%of the worldwide population,and is the leading cause of chronic liver disease in developed *** research on NAFLD has included heritability studies,candidate gene studies,familial aggregation studies,and genome-wide association studies(GWAS).Next-generation sequencing approaches,such as whole-genome sequencing and whole-exon sequencing,are emerging as the post-GWAS era of genetic ***,GWAS remains more practical for elucidating the genetic factors related to NAFLD,which is affected by thousands of common genetic variants and does not follow Mendelian *** the present review,we summarize the current knowledge regarding five GWAS-identified genetic loci that are associated with *** also discuss the relationships between NAFLD-predisposing polymorphisms and cardiovascular disease,and potential applications for these identified genetic loci.

关键词： Genome-wide association study non-alcoholic fatty liver disease PNPLA3 TM6SF2 GCKR MBOAT7 HSD17B13

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Herb-induced liver injury: Systematic review and meta-analysis

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World Journal of Clinical Cases 2021年第20期9卷 5490-5513页

作者： Vinícius Remus Ballotin Lucas Goldmann Bigarella Ajacio Bandeira de Mello Brandão Raul Angelo Balbinot Silvana Sartori Balbinot Jonathan Soldera School of medicine Universidade de Caxias do SulCaxias do Sul 95070-560RSBrazil post-graduate program in medicine Division of HepatologyUniversidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre90050-110RSBrazil Department of Clinical gastroenterology Universidade de Caxias do SulCaxias do Sul 95070-560RSBrazil

BACKGROUND The use of herbal supplements and alternative medicines has been increasing in the last *** popular belief that the consumption of natural products is harmless,herbs might cause injury to various organs,particularly to the liver,which is responsible for their metabolism in the form of herb-induced liver injury(HILI).AIM To identify herbal products associated with HILI and describe the type of lesion associated with each *** Studies were retrieved using Medical Subject Headings Descriptors combined with Boolean *** were run on the electronic databases Scopus,Web of Science,MEDLINE,BIREME,LILACS,Cochrane Library for Systematic Reviews,SciELO,Embase,and *** were restricted to English,Spanish,and *** was no date of publication *** reference lists of the studies retrieved were searched *** access causality,the Maria and Victorino System of Causality Assessment in Drug Induced Liver Injury was *** descriptive analysis were used to summarize the *** The search strategy retrieved 5918 *** the final analysis,446 references were included,with a total of 936 cases *** found 79 types of herbs or herbal compounds related to ***-Shou-Wu,Green tea extract,Herbalife,kava kava,Greater celandine,multiple herbs,germander,hydroxycut,skullcap,kratom,Gynura segetum,garcinia cambogia,ma huang,chaparral,senna,and aloe vera were the most common supplements with HILI *** of these patients had complete clinical recovery(82.8%).However,liver transplantation was necessary for 6.6%of these ***,chronic liver disease and death were observed in 1.5%and 10.4%of the cases,*** HILI is normally associated with a good prognosis,once the implied product is ***,it is paramount to raise awareness in the medical and non-medical community of the risks of the indiscriminate use of herbal products.

关键词： Herb-induced liver injury Drug induced liver injury Dietary supplements Herbal hepatotoxicity Liver transplantation

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