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Highly divergent sympatric lineages of Leptotila verreauxi(Aves:Columbidae)suggest a secondary contact area in the Isthmus of Tehuantepec,Mexico

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Avian Research 2024年第1期15卷 12-21页

作者： Orlando J.Espinosa-Chávez Adolfo G.Navarro-Sigüenza Hernando Rodríguez-Correa Luis A.Sánchez-González Museo de Zoología“Alfonso L.Herrera” Depto.de Biología EvolutivaFacultad de CienciasUniversidad Nacional Autonoma de MexicoApdo.Postal 70-399CP 04510Ciudad de MexicoMexico posgrado en ciencias Biologicas Unidad de PosgradoEdificio D1◦PisoCircuito de PosgradosCiudad UniversitariaUniversidad Nacional Autonoma de MexicoCoyoacanCP 04510CDMXMexico Escuela Nacional de Estudios Superiores Unidad Morelia Universidad Nacional Autonoma de Mexico.Antigua Carretera a Patzcuaro No.8701 Col.Ex Hacienda de San Jose de la HuertaC.P.58190MoreliaMichoacanMexico

Due to a complex geological and biotic history,the Isthmus of Tehuantepec(IT),has been long recognized as a driver for the evolutionary divergence of numerous lowland and highland *** distributed in the lowlands of the American continent,the White-Tipped Dove(Leptotila verreauxi)is a polytypic species with 13 recognized *** of these have been recorded in Mexico,and the distribution of three abuts at the IT,suggesting a contact *** estimate phylogenetic patterns,divergence times and genetic differentiation,we examined two mt DNA(ND2 and COI)and one n DNA(β-fibint 7)*** also used correlative ecological niche models(enM)to assess whether ecological differences across the IT may have acted as a biogeographical *** estimated paleodistributions during the Middle Holocene,last Glacial Maximum and last Interglacial,to evaluate the influence of climate changes on the distribution and demographic *** results showed genetically distinct lineages that diverged approximately 2.5 million years *** and ecological factors may have played a dual role in promoting differentiation,but also in the formation of a secondary contact zone in the southern *** ecological niche comparisons indicated that the ecological niche of sympatric lineages at the IT are not identical,suggesting niches divergence;in addition,environmental niche models across the region indicated no abrupt biogeographic barriers,but the presence of regions with low *** results suggest that genetic differentiation originated by a vicariant event probably related to environmental factors,favored the evolution of different ecological ***,the absence of a biogeographic barrier but the presence of less suitable areas in the contact regions,suggest that secondary contact zones may be also maintained by climatic factors for the eastern group,but also by biotic interactions for the western group.

关键词： Biogeographical boundary Humid and dry forests Isthmus of Tehuantepec Phylogeography Secondary contact

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Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

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Genes & Diseases 2024年第3期11卷 311-323页

作者： David Sanchez-Marin Macrina Beatriz Silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman Alma D.Campos-Parra posgrado en ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

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deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression

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World Journal of Clinical Oncology 2024年第2期15卷 195-207页

作者： Angeles C Tecalco-Cruz Karen H Medina-Abreu enrique Oropeza-Martínez Jesus Zepeda-Cervantes AleidaVázquez-Macías Marina Macías-Silva posgrado en ciencias Genómicas Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Colegio de ciencias y Humanidades Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Instituo de Fisiología Celular Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of *** deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer *** particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γ*** this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in ***,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus *** addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.

关键词： Interferon-gamma IFNGR1 JAK1 Antiviral Anti-tumor Lung adenocarcinoma

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The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain departamento de ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain departamento de enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain departamento de Neurología Hospital Virgen de las NievesGranadaSpain departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain departamento de Antropología Social Universidad de GranadaSpain Unidad enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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Temperature and Concentration Fields in a Generator Integrated to Single Stage Heat Transformer Using Water/Carrol Mixture

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Journal of Thermal Science 2014年第6期23卷 564-571页

作者： E.Gómez-Arias J.Ibarra-Bahena L.Velazquez-Avelar R.J.Romero A.Rodriguez-Martinez M.Montiel-González Centro de Investigación en ingeniería y ciencias Aplicadas Universidad Autónoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaCuernavacaMorelosCP 62209MéXICO Facultad de ciencias químicas e ingeniería Universidad Autónoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaCuernavacaMorelosCP 62209MéXICO posgrado en ingeniería y ciencias Aplicadas Universidad Autónoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaCuernavacaMorelosCP 62209MéXICO

The generator is the starter device of single stage heat transformer(SSHT) and its characteristics have main effects on the overall efficiency of this kind of absorption *** article reports a study of the generation of steam and changes in the concentration of the working solution(Water/Carrol mixture) into a plate heat exchanger as a function of its horizontal and vertical position by gravity *** is considered the analysis of six experimental tests;two were evaluated in a plate heat exchanger in a horizontal position and four in a vertical position(90 degree inclination).The generation of steam and increased concentration of the working solution are more sensitive to the vertical position of exchanger than in horizontal *** results of numerical-experimental analysis indicates that a heat exchanger in horizontal position,the steam generation and the change in the concentration of the working solution occurring in the middle of the plate(or at greater distance depending to the thermodynamic conditions) and instantly in vertical position(at the input of the plate).

关键词： Single stage heat transformer Plate heat exchanger Numerical modeling Temperature and concentration field Water/Carrol mixture

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Microbial oxidation of refractory gold sulfide concentrate by a native consortium

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Transactions of Nonferrous Metals Society of China 2017年第5期27卷 1143-1149页

作者： N. MARCHEVSKY M. M. BARROSO quIROGA A. GIAVenO E. DONATI Centro de Investigación y desarrollo en Fermentaciones Industriales (CINdeFI CCT LA PLATA-CONICETUNLP) Facultad de Ciencias Exactas Universidad Nacional de La Plata Calle 50 N° 227 1900 La Plata Argentina departamento de Minería Facultad de Ciencias Físico-Matemáticas y Naturales Universidad Nacional de San Luis Chacabuco 917 5700 San Luis Argentina Instituto de Investigación y desarrollo en ingeniería de Procesos Biotecnología y energías Alternativas (PROBIen CONICET-UNCo) Departamento de Química Facultad de Ingeniería Universidad Nacional del Comahue Buenos Aires 1400 8300 Neuquén Argentina

A defined mesophilic consortium including an iron oxidizing bacterium and a sulfur oxidizing bacterium was constructed to evaluate its ability for bioleaching a flotation concentrate from Andacollo mine in Neuquén,*** were performed in shake flasks with a pulp density of10%(w/v),using a basal salt medium containing ferrous iron at *** leaching solutions were analyzed for pH,redox potential(using specifics electrodes),ferrous iron(by UV-Vis spectrophotometry)and metal concentrations(by atomic absorption spectroscopy).The results showed that the consortium was able to reduce the refractory behavior of the concentrate,allowing91.6%of gold recovery;at the same time,high dissolution of copper and zinc was *** dissolutions followed a shrinking core kinetic *** to this model,the copper solubilization was controlled by diffusion through a product layer(mainly jarosite),while zinc dissolution did not show a defined control *** designed consortium,composed of bacterial strains with specific physiological abilities,could be useful not only to optimize gold recovery but also to decrease the leachates metallic charge,which would be an environmental advantage.

关键词： biooxidation refractory gold concentrate native consortium kinetic analysis

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A Novel and Functional Artificial Bruch’s Membrane Made of Poly (ε-Caprolactone)/Gelatin for Retinal Pigment Epithelium Restoration

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Advances in Bioscience and Biotechnology 2024年第8期15卷 443-461页

作者： López Edith Silva-Bermudez Phaedra Gonzalez-Salinas Roberto Velasquillo Cristina Torres-Romero Abigail López-Colomé Ana María Pérez Armando Gina Prado-Prone Edgar Ramos-Martínez Iván Ramos-Martínez quiroz-Mercado Hugo Hernández-Zimbrón Luis Fernando Instituto de Fisiologa Celular Universidad Nacional Autnoma de Mxico Ciudad de Mxico City Mxico Unidad de ingeniería de Tejidos Terapia Celular y Medicina Regenerativa Instituto Nacional de Rehabilitación Luis Guiller-mo Ibarra Ibarra Ciudad de México México departamento de Investigacin Asociacin Para Evitar la Ceguera Ciudad de Mxico Mxico Subdireccin de Investigacin Tecnolgica Instituto Nacional de Rehabilitacin Luis Guillermo Ibarra Ibarra Ciudad de Mxico Mxico departamento de Biologa Celular y Tisular Facultad de Medicina Universidad Nacional Autnoma de Mxico Ciudad de Mxico Mxico Escuela de ciencias Universidad Autnoma Benito Jurez de Oaxaca Oaxaca Mxico departamento de Medicina y Zootecnia de Cerdos Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional utnoma de Mxico Mxico laboratorio de Investigacion Interdisciplinaria rea de Optometria Escuela Nacional de Estudios Superiores Unidad Len Universidad Nacional Autnoma de Mxico Len Guanajuato Mxico laboratorio Nacional de ptica de la Visin-Centro de Investigaciones en ptica Len Guanajuato Mxico

Purpose: The primary aim of this paper is to design, create, and improve functional and artificial Bruch’s membranes (BM) using bioengineering techniques, which can be applied in the treatment of maculopathies by supporting the growth and maintenance of retinal pigment epithelium (RPE) cells, thereby potentially enabling subretinal implantation in patients. Methods: We fabricated by electrospinning ultrathin 3D nanofibrous membranes from Polycaprolactone (PCL), and different concentrations of gelatin (5%, 15% and 30%). ARPE-19 cells were seeded onto these artificial membranes. MTT assays were performed in order to evaluate ARPE-19 cell viability and cytotoxicity. IF assays were realized to observe the ARPE-19 cells onto each membrane. Ultrastructure of the modified Bruch’s membrane and ARPE-19 morphology after 25 days of culture were studied with transmission and scanning electron microscopy. To evaluate expression changes in markers of ARPE-19 (RPE65 and ZO-1) qRT-PCR assays were realized. Data from three independent experiments were pooled and expressed as the mean SD. A confidence level of P 0.05 was considered to be statistically significant. Results ARPE-19 cells grew on PCL/Gelatin membranes mainly in PCL/30% gelatin combination, which had not cytotoxic effect. RPE65/cytokeratin-18/ and actin-positive ARPE-19 cells formed a correctly orientated monolayer of polygonal cells with morphological polarity. The apical cell surfaces exhibited abundant protruding microfolds. Moreover, zones of polygonal border look as if ARPE-19 cells fused among, suggesting the presence of tight junctions. The expression of RPE65 and ZO-1 was unchanged. Conclusions: PCL/30% Gelatine membranes may imitate the natural BM to such extent that they support RPE-cells and exhibited RPE-like morphology. The engineering of a human RPE monolayer with these artificial BM, emulating the in vivo retina, arouse their potential subretinal implantation in patients with wet age-related macular degene

关键词： Artificial Bruch’s Membrane Electrospinning ARPE-19 Cells Age-Related Macular degeneration

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Biocomposites Based on Thermoplastic Starch and Granite Sand quarry Waste

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Journal of Renewable Materials 2019年第4期7卷 393-402页

作者： María G.Passaretti Mario D.Ninago Cecilia I.Paulo Horacio A.Petit Edgardo F.Irassarc Daniel A.Vega Marcelo A.Villar Olivia V.López Planta Piloto de ingeniería química PLAPIQUI(UNS-CONICET)Camino"La Carrindanga"Km 7Bahía Blanca8000Buenos AiresArgentina departamento de ingeniería química Universidad Nacional del Sur(UNS)Bahía Blanca8000Buenos AiresArgentina Facultad de ciencias Aplicadas a la Industria(FCAI) Universidad Nacional de Cuyo(UNCuyo)Bernardo de Irigoyen 375San Rafael5600MendozaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Godoy Cruz 2290Ciudad Autónoma de Buenos AiresC1425FQBBuenos AiresArgentina Facultad de ingeniería Universidad Nacional del Centro de la Provincia de Buenos Aires(UNCPBA).Centro de Investigaciones en Física e IngenieríaCIFICEN(UNCPBA-CICPBA-CONICET)7400OlavarríaArgentina Instituto de Física del Sur IFISUR(UNS-CONICET)Bahía Blanca8000Argentina

Granite stone is a by-product of the rock crushing *** industrial waste in powder form that causes health problems and environmental *** particles fraction can be used as a partial replacement of sand in concrete *** this work,an alternative exploitation of this waste fraction is *** sand(GS)with particles mean size of ~1μm was employed as thermoplastic starch(TPS)filler at different *** were obtained by melt-mixing and thermo-compression,achieving translucent and easy to handle films.A good GS dispersion within the matrix was evidenced by *** presence induced a shift of starch’s melting point to higher values and a better thermal *** UV absorption capacity was increased ~90% by GS *** increment in TPS Young’s modulus and maximum tensile stress of 5 and 3 times,respectively was observed by adding 5%w/w GS.

关键词： Thermoplastic starch granite sand melt processing final properties

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Biocompatibility and electrochemical evaluation of ZrO_(2) thin films deposited by reactive magnetron sputtering on MgZnCa alloy

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Journal of Magnesium and Alloys 2021年第6期9卷 2019-2038页

作者： Benjamín Millán-Ramos Daniela Morquecho-Marín Phaedra Silva-Bermudez David Ramírez-Ortega Osmary depablos-Rivera Julieta García-López Mariana Fernández-Lizárraga JoséVictoria-Hernández Dietmar Letzig Argelia Almaguer-Flores Sandra E.Rodil Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico posgrado en Ciencia e ingeniería de Materiales Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Unidad de ingeniería de Tejidos Terapia Celular y Medicina RegenerativaInstituto Nacional de Rehabilitación Luis Guillermo IbarraCDMX 14389Mexico posgrado en ciencias Médicas Odontológicas y de la SaludUniversidad Nacional Autónoma de MéxicoCDMX 04510Mexico Instituto de ciencias Aplicadas y Tecnologia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico posgrado de Doctorado en ciencias en Biomedicina y Biotecnología Molecular Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCDMX 11340Mexico Institute of Material and Process design Helmholtz-Zentrum GeesthachtMax-Planck-Strasse 1Geesthacht 21502Germany Magnesium Innovation Centre MagIC Helmholtz-Zentrum GeesthachtMax-Planck-Strasse 1Geesthacht 21502Germany laboratorio de Biointerfases Facultad de OdontologíaDivisión de Estudios de Posgrado e InvestigaciónUniversidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Biodegradable magnesium alloys are promising candidates for temporary fracture fixation devices in orthopedics;nevertheless,its fast degradation rate at the initial stage after implantation remains as one of the main challenges to be ***_(2)-based coatings to reduce the degradation rate of the Mg-implants are an attractive solution since they show high biocompatibility and *** this work,the degradation,cytotoxicity,and antibacterial performance of ZrO_(2)thin films deposited by magnetron sputtering on a Mg-Zn-Ca alloy was ***-term degradation of ZrO_(2)-coated and uncoated samples was assessed considering electrochemical techniques and H_(2)evolution(gas chromatography).Additionally,long term degradation was assessed by mass-loss *** results showed that a 380 nm ZrO_(2)coating reduces the degradation rate and H_(2)evolution of the alloy during the initial 3 days after immersion but allows the degradation of the bare alloy for the *** ZrO_(2)coating does not compromise the biocompatibility of the alloy and permits better cell adhesion and proliferation of mesenchymal stem cells directly on its surface,in comparison to the bare ***,the ZrO_(2)coating prevents the adhesion and biofilm formation of ***.

关键词： Zirconium dioxide Magnetron sputtering Short-term degradation H_(2)evolution

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Spectrophotometric determination of the formation constants of Calcium(Ⅱ) complexes with 1,2-ethylenediamine,1,3-propanediamine and 1,4-butanediamine in acetonitrile

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Green energy & environment 2017年第1期2卷 51-57页

作者： Jacqueline González González Mónica Nájera-lara Varinia López-Ramírez Juan Antonio Ramírez-Vázquez José J.N.Segoviano-Garfias Programa de Maestría en Biociencias División de Ciencias de la Vida (DICIVA) Universidad de Guanajuato Campus Irapuato-Salamanca Colegio del Nivel Medio Superior de Salamanca(enMS) departamento de ingeniería Bioquímica Instituto Tecnológico Superior de Irapuato (ITESI) departamento de ciencias Ambientales División de Ciencias de la Vida (DICIVA) Universidad de Guanajuato Campus Irapuato-Salamanca

In this work, with the purpose to explore the coordination chemistry of calcium complexes which could work as a partial model of manganese-calcium cluster, a spectrophotometric study to evaluate the stability of the complexes: Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine in acetonitrile, were carried on. By processing the spectrophotometric data with the HypSpec program allows the determination of the formation constants. The logarithmic values of the formation constants obtained for Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine were log β_(110) = 4.69, log β_(110)= 5.25 and log β_(110) = 4.072, respectively.

关键词： Calcium(Ⅱ)complexes Solution equilibria Artificial photosynthesis Absorbance molar Speciation

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