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Antioxidant activity of curcumine as protector on methylmercury inducedpancreas damage in mice

Journal of Chinese Pharmaceutical Sciences 2017年第3期26卷 196-201页

作者： Sri Agus Sudjarwo Koerniasari Eraiko Giftania Wardani Sudjarwo Koerniasari Department of Pharmacology Faculty of Veterinary Medicine Airlangga University Surabaya 60115 Indonesia Department of Conservative Dentistry Faculty of Dentistry Airlangga University Surabaya 60115 Indonesia Faculty of Pharmacy Hang Tuah University Surabaya 60115 Indonesia Study Program of Environmental health Polytechnic of Health Surabaya 60115 Indonesia

Curcumin has been reported to have a strong antioxidant activity. In recent years, use of antioxidant in reducing heavy metal toxicities has been increased worldwide. In this study, we investigated the protective effects of curcumin on methylmercury-induced pancreas damage in mice. Briefly, 50 male mice were divided into five groups as follows: negative control(mice were given daily with aquadest); positive control(mice were orally given 2 mg/kg BW methylmercury daily for 35 d); and the treatment groups(mice were orally adminstered with curcumin 100 mg; 200 mg; 400 mg/kg BW daily for 35 d, and from 5th day, animals were given 2 mg/kg BW methylmercury daily 1 h after curcumin administration for 30 d). On day 35, levels of glucose, insulin, MDA, SOD and GPx were measured. Pancreas also was fixed in 10% neutral buffered formalin solution for histopathological examination. The results revealed that methylmercury toxicity induced a significant increase in the levels of glucose and MDA. Moreover, a significant decrease in insulin, SOD and GPx levels was observed, and pancreas tissues showed degeneration and necrotic changes in the islets of Langerhans. Treatment with curcumin(400 mg/kg BW but not 200 mg/kg BW and 100 mg/kg BW) significantly(P<0.05) decreased glucose and MDA levels in pancreas in mercury-induced mice. Treatment with curcumin 400 mg/kg BW also significantly increased insulin, SOD and GPx levels and reversed the histopathological damage in methylmercury-induced mice. Taken together, curcumin could be a potent natural herbal product, which had pancreas protective effect against methylmercury-induced pancreas damage in mice.

关键词： Curcumin Methylmercury Glucose Insulin MDA SOD GPx

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Development of an empowerment model for burnout syndrome and quality of nursing work life in Indonesia

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International Journal of Nursing Sciences 2018年第4期5卷 390-395页

作者： Nursalam Nursalam Rizeki Dwi Fibriansari Slamet Riyadi Yuwono Muhammad Hadi Ferry Efendi Angeline Bushy Faculty of Nursing Universitas AirlanggaSurabayaIndonesia polytechnic of health of surabaya Ministry of HealthIndonesia Faculty of Nursing Universitas Muhammadiyah JakartaIndonesia College of Nursing University of Central FloridaUSA

Objectives:This study aimed to develop an empowerment model for burnout syndrome and quality of nursing work life(QNWL).Methods:This study adopted a mixed-method cross-sectional *** variables included structural empowerment,psychological empowerment,burnout syndrome and *** population consisted of nurses who have civil servant status in one of the regional hospitals in *** participants were recruited using multi-stage sampling measures with 134 *** were collected using questionnaires,which were then analysed using partial least squares.A focus group discussion was conducted with nurses,chief nurses and the hospital management to identify strategic issues and compile ***:Structural empowerment influenced psychological empowerment(path coefficient=0.440;t=6.222)and QNWL(path coefficient=0.345;t=4.789).Psychological empowerment influenced burnout syndrome(path coefficient=-0.371;t=4.303),and burnout syndrome influenced QNWL(path coefficient=-0.320;t=5.102).Structural empowerment increased QNWL by 39.7%.Conclusion:The development of a structural empowerment model by using the indicators of resources,support and information directly influenced the psychological empowerment of the sample of *** an indicator of meaning,psychological empowerment decreased burnout *** turn,burnout syndrome,as the indicator of personal achievement,could affect the *** empowerment directly influenced the QNWL,particularly within the workplace *** studies must be conducted to analyse the effects of empowerment,leadership styles and customer satisfaction.

关键词： Burnout Empowerment Nurses Quality of working life

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Indonesian nurses' perception of disaster management preparedness

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Chinese Journal of Traumatology 2019年第1期22卷 41-46页

作者： Martono Martono Satino Satino Nursalam Nursalam Ferry Efendi Angeline Bushy Nursing Department Health Polytechnic of Surakarta Ministry of Health Indonesia Faculty of Nursing Universitas Airlangga Surabaya Indonesia College of Nursing University of Central Florida USA

Purpose: Using a quantitative approach, this study aims to assess Indonesian nurses' perception of their knowledge, skills, and preparedness regarding disaster management. Methods: This study was a descriptive comparison in design. The research samples are Indonesian nurses working in medical services and educational institutions. The variables of nurses' preparedness to cope with disaster victims were measured using the Disaster Preparedness Evaluation Tool (DPET), which was electronically distributed to all nurses in Indonesia. Data were analyzed using a statistical descriptive one-way Analysis of Variance (ANOVA) and t-test with a significance level of 95%. Results: In total, 1341 Indonesian nurses completed this survey. The average scores of preparedness to cope with disasters, the ability to recover from disaster, and evaluation of disaster victims were 3.13, 2.53, and 2.46, respectively. In general, nurses surveyed in this study are less prepared for disaster management, and do not understand their roles either during the phase of disaster preparedness or in coping with a postdisaster situation. Conclusion: Nurses' preparedness and understanding of their roles in coping with disasters are still low in Indonesia. Therefore, their capacity in preparedness, responses, recovery, and evaluation of disasters needs improvement through continuing education. The efforts needed are significant due to potential disasters in Indonesia.

关键词： Disasters Knowledge Nurses Preparedness

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Antioxidant and anti-caspase 3 effect of chitosan-Pinus merkusii extract nanoparticle against lead acetate-induced testicular toxicity in rat

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Asian pacific Journal of Reproduction 2019年第1期8卷 13-19页

作者： Sri Agus Sudjarwo Chairul Anwar Giftania Wardani Koerniasari Eraiko Koerniasari Department of Pharmacology Faculty of Veterinary MedicineAirlangga UniversitySurabayaIndonesia Department of Histology Faculty of Veterinary MedicineAirlangga UniversitySurabayaIndonesia Department of Pharmacy Biology Faculty of PharmacyHang Tuah UniversitySurabayaIndonesia Department of Conservative Dentistry Faculty of DentistryAirlangga UniversitySurabayaIndonesia Department of Microbiology Study Program of Environmental HealthPolytechnic of HealthSurabayaIndonesia

Objective: To investigate the antioxidant and anti-caspase 3 effect of chitosan-Pinus merkusii extract nanoparticle on lead acetate-induced toxicity in rat testis. Methods: Chitosan-Pinus merkusii nanoparticles were identified by dynamic light scattering and scanning electron microscope. The male rats were divided into control group (rats were given with distilled water);lead acetate group [rats were injected with lead acetate 20 mg/kg body weight (BW) i.p.], and the treatment group (rats were given the chitosan-Pinus merkusii nanoparticle 150 mg;300 mg;600 mg/kg BW orally and were injected with lead acetate 20 mg/kg BW). The testis tissues were collected to evaluate the malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), histological evaluations of testis damage, and the caspase 3 mRNA expression was measured by reverse transcription-polymerase chain reaction. Results: The dynamic light scattering showed that the size of chitosan-Pinus merkusii nanoparticle was (530.2±38.2) nm. The scanning electron microscope images of the chitosan-Pinus merkusii nanoparticles showed an irregular shape, and the morphology surface showed the rough surface. The treatment with lead acetate resulted in significantly increasing MDA level and caspase 3 mRNA expression, and significantly decreasing level of SOD and GPx when compared with control group. The treatment with the chitosan-Pinus merkusii nanoparticle 600 mg/kg BW but not 150 and 300 mg/kg BW significantly decreased the MDA levels, caspase 3 mRNA expression, and also increased level of SOD and GPx when compared with lead acetate group. The lead acetate induced loss of the normal structure of testicular cells and necrosis, whereas treatment with chitosan-Pinus merkusii nanoparticle inhibited testicular cell necrosis. Conclusions: It can be concluded that chitosan-Pinus merkusii nanoparticle protects rat testis from oxidative damage and apoptosis caused by lead acetate, through increasing antioxidant

关键词： Chitosan-Pinus merkusii nanoparticle Lead acetate Antioxidant Caspase 3

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The effect of calcination temperature on the capacitive properties of WO3-based electrochemical capacitors synthesized via a sol-gel method

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Frontiers of Materials Science 2013年第4期7卷 370-378页

作者： Diah SUSANTI Rizky Narendra Dwi WIBAWA Lucky TANANTA Hariyati PURWANINGSIH Rindang FAJARIN George Endri KUSUMA Materials and Metallurgical Engineering Department Faculty of Industrial Technology nstitut Teknologi Sepuluh Nopember (ITS) Kampus ITS Keputih Sukolilo Surabaya 60111 Indonesia Mechanical Engineering Department Surabaya State Shipbuilding Polytechnic Kampus PPNS Jalan Teknik Kimia ITS Surabaya 60111 Indonesia

Electrochemical capacitor （EC） is a promising energy storage device which can be hybridized with other energy conversion or energy storage devices. One type of ECs is pseudocapacitor made of metal oxides. WO3 is an inexpensive semiconductor metal oxide which has many applications. However the application of WO3 as an EC material was rarely reported. Therefore in this research EC was prepared from WO3 nanomaterial synthesized by a sol-gel process. The WO3 gel was spin-coated on graphite substrates and calcined at various temperatures of 300~C, 400℃, 500℃ and 600℃ for 1 h. Cyclic voltammetry （CV） measurements were used to observe the capacitive property of the WO3 samples. SEM, XRD, FTIR and Brunauer-Emmett-Teller （BET） analyses were used to characterize the material structures. WO3 calcined at 400~C was proved to have the highest capacitance of 233.63 Fo g^-1 （1869 mFo cm-2） at a scan rate of 2 mVo s-1 in 1 mol/L H2SO4 between potentials -0.4 and 0.4 V vs. SCE. Moreover it also showed the most symmetric CV curves as the indication of a good EC. Hence WO3 calcined at 400℃ is a potential candidate for EC material of pseudocapacitor type.

关键词： electrochemical capacitor (EC) WO3 nanomaterial sol-gel process calcination

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Comparison of the morphology and structure of W03 nanomaterials synthesized by a sol-gel method followed by calcination^or hydrothermal treatment

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Frontiers of Chemical Science and Engineering 2012年第4期6卷 371-380页

作者： Diah Susanti Stefanus Haryo N Hasnan Nisfu Eko Prasetio Nugroho Hariyati Purwaningsih GeorgeEndri Kusuma Shao-Ju Shih Materials and Metallurgical Engineering Department Faculty of Industrial Technology Sepuluh Nopember Institute of Technology (ITS) Surabaya 60111 Indonesia Mechanical Engineering Department Surabaya State Shipbuilding Polytechnic Surabaya 60111 Indonesia Materials Science and Engineering Department Taiwan Tech (NTUST) Taipei 106 China

Tungsten （VI） oxide （WO3） nanomaterials were synthesized by a sol-gel method using WC16 and C2HsOH as precursors followed by calcination or hydrothermal treatment. X-Ray diffraction （XRD）, scanning electron microscopy （SEM） and high resolution transmission electron microscopy （HRTEM） equipped with energy dispersive X-ray spectroscopy （EDX） were used to characterize the structure and morphology of the materials. There were significant differences between the WO3 materials that were calcinated and those that were subjected to a hydrothermal process. The XRD results revealed that calcination temperatures of 300℃and 400℃ gave hexagonal structures and temperatures of 500℃ and 600℃ gave monoclinic structures. The SEM images showed that an increase in calcination temperature led to a decrease in the WO3 powder particle size. The TEM analysis showed that several nanoparticles agglomerated to form bigger clusters. The hydrothermal process produced hexagonal structures for holding times of 12, 16, and 20 h and monoclinic structures for a holding time of 24 h. The SEM results showed transparent rectangular panicles which according to the TEM results originated from the aggregation of several nanotubes.

关键词： WO3 nanomaterial sol-gel method calcina-tion hydrothermal

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印度尼西亚青少年生殖健康促进行为影响因素的结构模型

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International Journal of Nursing Sciences 2017年第4期4卷 367-373页

作者： Siti Nur Kholifah Hilmi Yumni Minarti Tantut Susanto polytechnic of health Sciences of Ministry of health of surabaya SurabayaIndonesia Department of Family and Community health Nursing School of NursingUniversity of JemberJemberIndonesia

目的运用结构方程模式探索印度尼西亚青少年生殖健康的健康促进影响因素,建立结构模型并进行测试。方法采用横断面量性研究方法,调查108名12~16岁青少年。根据基于自我效能的健康促进模型和授权模型自设问卷,调查生殖健康促进行为的相... 详细信息

目的运用结构方程模式探索印度尼西亚青少年生殖健康的健康促进影响因素,建立结构模型并进行测试。方法采用横断面量性研究方法,调查108名12~16岁青少年。根据基于自我效能的健康促进模型和授权模型自设问卷,调查生殖健康促进行为的相关因素素。采用结构方程模型验证变量之间的关系。采用AMOS评估所提出的模型是否适用于所获得的数据。结果该模型数据拟合尚可。自变量之间存在相关关系(P<0.05),包括:个体因素与认知因素(r=0.01)、认知因素和健康促进行为(r=0.09)、情感和健康促进行为(r=0.17)。赋权与健康促进行为之间的关系最为密切(r=0.72)。情感(人际和情境影响)、直接竞争的要求和偏好,以及授权(参与和控制)都与生殖健康行为维持直接相关。同时,青少年的意愿、先前的相关行为、个人因素以及对行动计划的承诺与生殖健康行为维持间接相关。该模型解释了生殖健康行为维持43.9%的变异。结论健康促进模型和授权模型维护有助于确定青少年生殖健康行为维持的相关因素。促进印度尼西亚青少年生殖健康的干预应从儿童-家长-保健专业接触的水平开始,以改善青少年的生殖健康。

关键词：青少年赋能健康促进模式生殖健康自我效验

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WO3 nanomaterials synthesized via a sol-gel method and calcination for use as a CO gas sensor

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Frontiers of Chemical Science and Engineering 2014年第2期8卷 179-187页

作者： Diah SUSANTI A.A. Gede Pradnyana DIPUTRA Lucky TANANTA Hariyati PURWANINGSIH George Endri KUSUMA Chenhao WANG Shaoju SHIH Yingsheng HUANG Department of Materials and Metallurgical Engineering Institut Teknologi Sepuluh Nopember (ITS) Surabaya 60111 Indonesia Department of Mechanical Engineering Surabaya State Shipbuilding Polytechnic Institut Teknologi Sepuluh Nopember (ITS) Surabaya 60111 Indonesia Department of Materials Science and Engineering National Taiwan University of Science and Technology (NTUST) Taipei 10607 Taiwan China Department of Electronic Engineering National Taiwan University of Science and Technology (NTUST) Taipei 10607 Taiwan China

Carbon monoxide is a poisonous and hazardous gas and sensitive sensor devices are needed to prevent humans from being poisoned by this gas. A CO gas sensor has been prepared from WO3 synthesized by a sol-gel method. The sensor chip was prepared by a spin-coating technique which deposited a thin film of WO3 on an alumina substrate. The chip samples were then calcined at 300, 400, 500 or 600 ℃ for 1 h. The sensitivities of the different sensor chips for CO gas were determined by comparing the changes in electrical resistance in the absence and presence of 50 ppm of CO gas at 200 ℃. The WO3 calcined at 500 ℃ had the highest sensitivity. The sensitivity of this sensor was also measured at CO concentrations of 100 ppm and 200 ppm and at operating temperatures of 30 and 100℃. Thermogravimetric analysis of the WO3 calcined at 500 ℃ indicated that this sample had the highest gas adsorption capacity. This preliminary research has shown that WO3 can serve as a CO gas sensor and that is should be further explored and developed.

关键词： WO3 nanomaterial sol-gel calcinations COgas sensor sensitivity

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Cypermethrin triggers apoptosis, depletes granulosa cells, and induces endometrium thinning in female rats

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Asian pacific Journal of Reproduction 2019年第4期8卷 141-147页

作者： Novita Eka Kusuma Wardani Respatiningrum Respatiningrum Anis Nur Laili Dwi Yuni Nur Hidayati Setyawati Soeharto Hidayat Sujuti Midwifery Master Program Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Midwifery Program Study of Bangkalan Midwifery Department of Health Polytechnic of Ministry of Health SurabayaEast JavaIndonesia Midwifery Program Health Polytechnic of Ministry of Health of TanjungpinangRiau ArchipelagoIndonesia Department of Microbiology Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Department of Pharmacology Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Program of Master of Biomedical Science Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia

Objective: To analyze the effects of subchronic cypermethrin on the ovary and endometrium as well as the involvement of apoptosis in the toxicity of cypermethrin. Methods: A total of 32 female Wistar rats were randomly divided into four groups, with 8 rats in each group. The control group received no treatment, and the other three groups received oral cypermethrin at 10, 15 or 20 mg/kg body weight for 28 days (sub-chronic). The granulosa cells were calculated histopathologically. The apoptotic index was determined by in situ technique. Histopathological examination was performed on the uterus and ovary. Results: There was no significant difference in the number of primary follicular granulosa cells between the treatment groups and the control group (P>0.05). However, the number of secondary and tertiary follicle granulosa cells in the treatment groups was significantly decreased compared to that of the control group (P all<0.05). The apoptotic index of primary follicular granulosa cells increased significantly in the groups treated with cypermethrin compared with the control group (P<0.05). The secondary, tertiary, and endometrial granulosa cell apoptosis index was significantly higher in all treatment groups compared to the control group (P<0.05). The higher the dose of cypermethrin was, the higher the apoptotic index of secondary, tertiary and endometrial granulosa cells was. There was a significant decrease in endometrial thickness in the three treatment groups compared to the control group (P<0.05). Thinning of the endometrial layer was seen in the cypermethrin exposure groups. Conclusions: Exposure to cypermethrin can suppress the number of secondary and tertiary follicular granulosa cells, and trigger thinning of the endometrium through induction of apoptosis.

关键词： Endocrine disruptor Pyrethroid pesticide Uterus Reproduction Apoptosis

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PID-Type Fuzzy Controller for Grid-Supporting Inverter of Battery in Embedded Small Variable Speed Wind Turbine

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Journal of Power and Energy Engineering 2014年第4期2卷 151-160页

作者： Ferdian Ronilaya Hajime Miyauchi Adi Kurniawan Department of Frontier Technology for Energy and Devices Kumamoto University Kumamoto-shi Japan Department of Electrical Power Engineering The State Polytechnic of Malang Malang Indonesia Institut Teknologi Sepuluh Nopember Surabaya Indonesia

Frequency and voltage of embedded variable speed wind turbine (VSWT) driving a permanent magnet synchronous generator (PMSG) is strongly affected by wind speed fluctuations. In practice, power imbalance between supply and demand is also common, especially when VSWT-PMSG is connected to a weak micro grid (MG). If load demand fluctuations become high, isolated MG may be unable to stabilize the frequency and voltage so that battery storage needs to be installed into the MG to adjust energy supply and demand. To allow flexible control of active and reactive power flow from/to battery storage, grid-supporting inverters are used. For a system that contains highly nonlinear components, the use of conventional linear proportional-integral-derivative (PID) controllers may cause system performance deterioration. Additionally, these controllers show slow, oscillating responses, and complex equations are required to obtain optimum responses in other controllers. To cope with these limitations, this paper proposes PID-type fuzzy controller (PIDfc) design to control grid-supporting inverter of battery. To ensure safe battery operating limits, we also propose a new controller scheme called intelligent battery protection (IBP). This IBP is integrated into PIDfc. Several simulation tests are performed to verify the scheme’s effectiveness. The results show that the proposed PIDfc controller exhibits improved performance and acceptable responses, and can be used instead of conventional controllers.

关键词： Battery PID-Type Fuzzy Controller Inverter Permanent Magnet Synchronous Generator (PMSG) Variable Speed Wind Turbine (VSWT)

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