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汞污染渔业的恢复

AMBIO－人类环境杂志 2007年第1期36卷 31-41页

作者： John Munthe R. A. （Drew） Bodaly Brian A. Branfireun Charles T. Driscoll Cynthia C. Gilmour Reed Harris Milena Horvat Marc Lucotte Olaf Malm 林宝法（译） IVL Swedish Environmental Research Institute PO BOX5302SE 400 14 GothenburgSweden Penobscot River Mercury Study（Maine） 115 Oystercatcher Place．Salt Spring IslandB．C．Canado V8K2W5 Department of Geography University of Torontoat Mississauga3359 Mississauga Road NorthMississaugaOntarioCanada L5L 1C6 Department of Civil and Environmental Engineering 151 Link HallSyracuse UniversitySyracuse．NY14244USA Smithsonian Environmental Research centre．P．O．BOX28 647 Contees Wharf RoadEdgewater．Maryland21037 Tetra Tech Inc． 180 Forestwood DriveOakvilleOntarioCanadaL6J4E6 Department of Environmental Sciences Jose Stefan Institute．Jamova 39．SI-1000 LjubljanaSlovenia Universite du Quebe ca Montreal．GEOTOP C．P．8888SUC．Centre-VilleMontrealQuebecH3C3P8Canada Lab．Radioisotopes EPF．Inst．Biofisica CCF．Universidade Federal do Rio de Janeiro 21941-900 Rio de JaneiroBrazil 不详

本文中,我们综合了有关生态系统无机汞(Hg)载荷变化与鱼体内甲基汞(MeHg)浓度之间联系的现有信息。尽管人们普遍假定水生生态系统汞载荷的增加导致鱼体内甲基汞浓度的增加,验证这一假定的定量数据尚很有限。这里,我们研究了源于一系列... 详细信息

本文中,我们综合了有关生态系统无机汞(Hg)载荷变化与鱼体内甲基汞(MeHg)浓度之间联系的现有信息。尽管人们普遍假定水生生态系统汞载荷的增加导致鱼体内甲基汞浓度的增加,验证这一假定的定量数据尚很有限。这里,我们研究了源于一系列出处的现有证据:关于被工业排放物污染的生态系统的研究;关于鱼类甲基汞对大气载荷的响应的观测资料;跨越空间和环境梯度的研究以及实验操作。本文概述了目前对从汞载荷到鱼体甲基汞的运输和转化所涉及的主要过程的了解情况。还结合影响与鱼体内甲基汞响应的时机和大小有关的汞循环和生物积累的其他因素探讨了汞载荷的作用。所得出的主要结论是,汞载荷的变化(增加或减少)将引起鱼体内甲基汞的反应,这种反应的时间和大小将根据生态系统特有的变量和所添加的汞的形态而变化。

关键词：汞污染水生生态系统载荷变化渔业甲基汞工业排放物观测资料实验操作

Plant regeneration in the new era:from molecular mechanisms to biotechnology applications

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Science China(Life Sciences) 2024年第7期67卷 1338-1367页

作者： Chunli Chen Yuxin Hu Momoko Ikeuchi Yuling Jiao Kalika Prasad Ying Hua Su Jun Xiao Lin Xu Weibing Yang Zhong Zhao Wenkun Zhou Yun Zhou Jian Gao Jia-Wei Wang National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of Sciences(CAS)China National Botanical GardenBeijing 100093China Division of Biological Sciences Graduate School of Science and TechnologyNara Institute of Science and TechnologyNara 630-0192Japan State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Center for Quantitative BiologyAcademy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Indian Institute of Science Education and Research Pune 411008IndiaThiruvananthapuram 695551India State Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai’an 271018China Sino-German Joint Research Center on Agricultural Biology Shandong Agricultural UniversityTai’an 271018China Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology(IGDB)CASBeijing 100101China CAS-JIC centre of Excellence for Plant and Microbial Science(CEPAMS) IGDBCASBeijing 100101China National Key Laboratory of Plant Molecular Genetics CEMPSInstitute of Plant Physiology and Ecology(SIPPE)CASShanghai 200032China CEPAMS SIPPECASShanghai 200032China Hefei National Laboratory for Physical Sciences at the Microscale CEMPSSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China Department of Botany and Plant Pathology and Center for Plant Biology Purdue UniversityWest Lafayette 47907USA School of Life Science and Technology Shang

Plants or tissues can be regenerated through various *** animal regeneration,cell totipotency and pluripotency are the molecular basis of plant *** systematic studies on Arabidopsis thaliana gradually unravel the fundamental mechanisms and principles underlying plant ***,plant hormones,cell division,epigenetic remodeling,and transcription factors play crucial roles in reprogramming somatic cells and reestablishing meristematic *** research on basal non-vascular plants and monocot crops has revealed that plant regeneration differs among species,with various plant species using distinct mechanisms and displaying significant differences in regenerative *** multi-omics studies at the single-cell level,tracking plant regeneration processes in real-time,and deciphering the natural variation in regenerative capacity will ultimately help understand the essence of plant regeneration,improve crop regeneration efficiency,and contribute to future crop design.

关键词： apical meristem model species regeneration phytohormone plant cell reprogramming somatic embryogenesis

Dual-channel quantum meta-hologram for display

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Advanced Photonics Nexus 2024年第1期3卷 86-92页

作者： Yubin Fan Hong Liang Yuhan Wang Shufan Chen Fangxing Lai Mu Ku Chen Shumin Xiao Jensen Li Din Ping Tsai City University of Hong Kong Department of Electrical EngineeringHong KongChina City University of Hong Kong Centre for BiosystemsNeuroscienceand NanotechnologyHong KongChina City University of Hong Kong The State Key Laboratory of Terahertz and Millimeter WavesHong KongChina The Hong Kong University of Science and Technology Department of PhysicsHong KongChina The Hong Kong University of Science and Technology IAS Center for Quantum TechnologiesHong KongChina Harbin Institute of Technology(Shenzhen) Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information SystemGuangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsShenzhenChina Pengcheng Laboratory ShenzhenChina

Quantum technologies rely on creating and manipulating entangled sources,which are essential for quantum information,communication,and *** integrating quantum technologies and all-dielectric metasurfaces,the performance of miniature display devices can be enhanced to a higher *** display technology,such as virtual reality display,has achieved original commercial success,and was initially applied to immersive games and interactive *** the consumer market has quickly adopted this technology,several areas remain for improvement,including concerns around bulkiness,dual-channel display,and noise ***,we experimentally realize a quantum meta-hologram concept demonstration of a miniature *** fabricate an ultracompact meta-hologram based on 1μm thick titanium dioxide(TiO_(2)).The meta-hologram can be remotely switched with heralding technique and is robust against noise with the quantum entangled *** platform can alter the miniature display channel by manipulating heralding photons’polarization,removing speckles and multiple reflective light noise,improving imaging contrast,and potentially decreasing device *** contrast increases from 0.36 dB under speckle noise influences to 6.8 dB in quantum correlation *** approach has the potential to miniaturize quantum displays and quantum communication devices.

关键词： quantum meta-hologram display metasurface dual channel

Activity and Selectivity of Bimetallic Catalysts Based on SBA-15 for Nitrate Reduction in Water

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Materials Sciences and applications 2023年第2期14卷 78-93页

作者： Mouhamad Rachini Mira Jaafar Nabil Tabaja Sami Tlais Rasha Hamdan Fatima Al Ali Ola Haidar Ali Jaber Mohammad Kassem Eugene Bychkov Lucette Tidahy Renaud Cousin Dorothée Dewaele Tayssir Hamieh Joumana Toufaily Laboratory of Materials Catalysis Environment and Analytical Methods (MCEMA) EDST FS Lebanese University Hariri Campus Hadath Lebanon Université du Littoral Cô te d’Opale (ULCO) LPCA EA 4493 F-59140 Dunkerque France Laboratory of Applied Studies for Sustainable Development and Renewable Energy (LEADDER) EDST Lebanese University Hariri Campus Hadath Lebanon College of Engineering and Technology American University of the Middle East Kuwait Kuwait Department of Chemistry American University of Beirut Riad El-Solh Beirut Lebanon Laboratoire de Recherche et Développement des Médicaments et des Produits Naturels RDMPN Faculty of Pharmacy Lebanese University Hariri Campus Hadath Lebanon Université du Littoral Cô te d’Opale UCEIV Unité de Chimie Environnementale et Interactions sur le Vivant EA 4492 SFR Condorcet FR CNRS 3417 Dunkerque France centre Commun de Mesures Université du Littoral C&ocircte d’Opale Dunkerque France Faculty of Science and Engineering Maastricht University Maastricht The Netherlands

Nitrate from the application of nitrogen-based fertilizers in intensive agriculture is a notorious waste product, though it lacks cost-effective solutions for its removal from potential drinking water resources. Catalytic reduction appears to be a promising technique for converting nitrates to benign nitrogen gas. Mesoporous silica SBA-15 is a frequently used catalyst support that has large surface areas and highly ordered nanopores. In this work, mesoporous silica SBA-15 bimetallic catalysts for nitrate reduction were investigated. The catalyst was optimized for the selection of promoter metal (Sn and Cu), noble metal (Pd and Pt) and loading ratios of these metals at different temperatures and reduction conditions. The catalysts prepared were characterized by FT-IR, N2 physisorption, XRD, SEM, and ICP. All catalysts showed the presence of cylindrical mesoporous channels and uniform pore structures that remained even after metals loading. In the presence of a CO2 buffer, the catalysts 4Pd-1Cu/SBA-15 and 1Pt-1Cu/SBA-15 reduced at 100?C under H2 and 1Pd-1Cu/SBA-15 reduced at 200°C under H2 demonstrated very high nitrate conversion. Furthermore, the forementioned Pd catalysts had higher N2 selectivity (88% - 87%) compared to Pt catalyst (80%). Nitrate conversion by the 4Pd-1Cu/SBA-15 catalyst was significantly decreased to 81% in the absence of CO2.

关键词： Bimetallic Catalyst Heterogeneous Catalyst Nitrate Reduction SBA-15 XRD BET SEM FTIR ICP

applications of MXenes in human-like sensors and actuators

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Nano Research 2023年第4期16卷 5767-5795页

作者： Jinbo Pang Songang Peng Chongyang Hou Xiao Wang Ting Wang Yu Cao Weijia Zhou Ding Sun Kai Wang Mark H.Rümmeli Gianaurelio Cuniberti Hong Liu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongUniversity of JinanJinan 250022China Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany Dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany High-Frequency High-Voltage Device and Integrated Circuits R&D Center Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Microelectronic Devices&Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Shenzhen Key Laboratory of Nanobiomechanics Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353China School of Bioengineering Qilu University of TechnologyShandong Academy of ScienceJinan 250353China Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology(Ministry of Education) Northeast Electric Power UniversityJilin 132012China School of Electrical Engineering Northeast Electric Power UniversityJilin 132012China School of Electrical Engineering Weihai Innovation Research InstituteQingdao UniversityQingdao 266000China School of Electrical and Computer Engineering Jilin Jianzhu UniversityChangchun 130118China Institute for Complex Materials Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key L

Human beings perceive the world through the senses of sight,hearing,smell,taste,touch,space,and *** first five senses are prerequisites for people to *** sensing organs upload information to the nervous systems,including the brain,for interpreting the surrounding ***,the brain sends commands to muscles reflexively to react to stimuli,including light,gas,chemicals,sound,and ***,as an emerging two-dimensional material,has been intensively adopted in the applications of various sensors and *** this review,we update the sensors to mimic five primary senses and actuators for stimulating muscles,which employ MXene-based film,membrane,and composite with other functional ***,a brief introduction is delivered for the structure,properties,and synthesis methods of ***,we feed the readers the recent reports on the MXene-derived image sensors as artificial retinas,gas sensors,chemical biosensors,acoustic devices,and tactile sensors for electronic ***,the actuators of MXene-based composite are ***,future opportunities are given to MXene research based on the requirements of artificial intelligence and humanoid robot,which may induce prospects in accompanying healthcare and biomedical engineering applications.

关键词： MXenes sensors actuators gas sensors biosensors tactile sensors sound sensors artificial retina

CsPb(I_(x)Br_(1-x))_(3) solar cells

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Science Bulletin 2019年第20期64卷 1532-1539页

作者： Xue Jia Chuantian Zuo Shuxia Tao Kuan Sun Yixin Zhao Shangfeng Yang Ming Cheng Mingkui Wang Yongbo Yuan Junliang Yang Feng Gao Guichuan Xing Zhanhua Wei Lijun Zhang Hin-Lap Yip Mingzhen Liu Qing Shen Longwei Yin Liyuan Han Shengzhong Liu Lianzhou Wang Jingshan Luo Hairen Tan Zhiwen Jin Liming Ding Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing100190China University of Chinese Academy of Sciences Beijing100049China CSIRO Manufacturing Bag10Clayton SouthVictoria3169Australia Center for Computational Energy Research Department of Applied PhysicsEindhoven University of Technology5600MB EindhovenThe Netherlands MOE Key Laboratory of Low-grade Energy Utilization Technologies and Systems Chongqing UniversityChongqing400044China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China Department of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China Institute for Energy Research Jiangsu UniversityZhenjiang212013China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China School of Physics and Electronics Central South UniversityChangsha410083China Department of Physics Chemistry and BiologyLinkoping UniversitySE-58183 LinkopingSweden Institute of Applied Physics and Materials Engineering University of MacaoMacao999078China College of Materials Science&Engineering Huaqiao UniversityXiamen361021China College of Materials Science and Engineering Jilin UniversityChangchun130012China State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou510640China Center for Applied Chemistry School of Materials and EnergyUniversity of Electronic Science and Technology of ChinaChengdu611731China Faculty of Informatics and Engineering The University of Electro-CommunicationsTokyo182-8585Japan School of Materials Science and Engineering Shandong UniversityJinan250061China State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Normal UniversityXi’an710119China

Owing to its nice performance, low cost, and simple solution-processing, organic-inorganic hybrid perovskite solar cell(PSC) becomes a promising candidate for next-generation high-efficiency solar *** power conversion efficiency(PCE) has boosted from 3.8% to 25.2% over the past ten years. Despite the rapid progress in PCE, the device stability is a key issue that impedes the commercialization of PSCs. Recently, all-inorganic cesium lead halide perovskites have attracted much attention due to their better stability compared with their organic-inorganic counterpart. In this progress report, we summarize the properties of CsPb(IxBr1-x)3 and their applications in solar cells. The current challenges and corresponding solutions are discussed. Finally, we share our perspectives on CsPb(IxBr1-x)3 solar cells and outline possible directions to further improve the device performance.

关键词： Perovskite solar cells Cesium lead halide perovskites Power conversion efficiency Stability

Apple whole genome sequences:recent advances and new prospects

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Horticulture Research 2019年第1期6卷 1247-1270页

作者： Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande Department of Horticulture Washington State UniversityPullmanWA 99164USA Computational Biology Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Department of Genomics and Biology of Fruit Crops Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Plant Breeding Wageningen University and ResearchWageningen 6708PBThe Netherlands Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Institut für Biologie und Umweltwissenschaften Carl von Ossietzky Universität26129 OldenburgGermany GQE-Le Moulon Institut National de la Recherche AgronomiqueUniversity of Paris-SudCNRSAgroParisTechUniversitéParis-Saclay91190 Gif-sur-YvetteFrance Institut National de la Recherche Agronomique Institut de Recherche en Horticulture et SemencesUMR 134549071 BeaucouzéFrance Department of Plant Food and Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada The New Zealand Institute for Plant and Food Research Ltd Motueka 7198New Zealand School of Biological Sciences University of AucklandAuckland 1142New Zealand AGAP INRACIRADMontpellier SupAgroUniversity of MontpellierMontpellierFrance Plant Genetic Resources Unit USDA ARSGenevaNY 14456USA Laboratory of Pomology Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan Department of Horticulture Michigan State UniversityEast LansingMI 48824USA The New Zealand Institute for Plant and Food Research Ltd(Plant&Food Research) Palmerston North Research CentrePalmerston North 4474New Zealand College of Horticulture China Agricultural University100193 BeijingChina Agroscope 8820 WädenswilSwitzerland Queensland Alliance of Agriculture and Food Innovation University of QueenslandSt Lucia 4072Australia New Cultivar Innovation Plant and Food ResearchHavelock North 4130New Zealand Agroscope 1260 ChanginsSwitzerland

In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for *** the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued *** gene identities for phenotypes of fundamental and practical interest can today be discovered much more ***-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and ***-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for *** understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild *** WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple *** review includes examples of basic and practical breakthroughs and challenges in using the apple *** for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple.

关键词： breakthrough hundreds frontier

The effects of different travel modes and travel destinations on COVID-19 transmission in global cities

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Science Bulletin 2022年第6期67卷 588-592,M0003页

作者： Rui Zhu Luc Anselin Michael Batty Mei-Po Kwan Min Chen Wei Luo Tao Cheng Che Kang Lim Paolo Santi Cheng Cheng Qiushi Gu Man Sing Wong Kai Zhang Guonian Lü Carlo Ratti Department of Land Surveying and Geo-Informatics the Hong Kong Polytechnic UniversityHong KongChina Key Laboratory of Virtual Geographic Environment(Ministry of Education) Nanjing Normal UniversityNanjing 210023China Senseable City Laboratory Future Urban Mobility IRGSingapore-MIT Alliance for Research and TechnologySingapore 138602Singapore Center for Spatial Data Science Division of the Social SciencesUniversity of ChicagoChicago IL 60637USA School of Geography Science Nanjing Normal UniversityNanjing 210023China centre for Advanced Spatial Analysis Faculty of the Built EnvironmentUniversity College LondonLondon WC1E 6BTUK Department of Geography and Resource Management the Chinese University of Hong KongHong KongChina Institute of Space and Earth Information Science the Chinese University of Hong KongHong KongChina Department of Human Geography and Spatial Planning Utrecht UniversityUtrecht 3584 CSNetherlands State Key Laboratory Cultivation Base of Geographical Environment Evolution Nanjing 210023China Department of Geography National University of SingaporeSingapore 117570Singapore SpaceTimeLab Department of CivilEnvironmental and Geomatic EngineeringUniversity College LondonLondon WC1E 6BTUK Department of Clinical Translational Research Singapore General HospitalSingapore 169856Singapore Division of Clinical Immunology and Transfusion Medicine Department of Laboratory MedicineKarolinska InstitutetStockholm 17177Sweden Senseable City Laboratory Department of Urban Studies and PlanningMassachusetts Institute of TechnologyCambridgeMA 02139USA Istituto di Informatica e Telematica del CNR Pisa 56124Italy Department of System Science Institute of High Performance Computing Agency for ScienceTechnology and ResearchSingapore 138632Singapore Department of Tourism Studies School of HumanitiesSoutheast UniversityNanjing 210096China

The international community has made significant efforts to flatten the COVID-19 curve,including predicting transmission[1,2],executing unprecedented global lockdowns and social distancing[3,4],promoting the wearing of facemasks and social distancing measures[5],and isolating confirmed cases and contacts[6].Because of the adverse consequences of these lockdown measures[7],many cities have reopened so they can rebuild their ***,as mobility has gradually returned towards normal,imported cases from unknown sources have disrupted the recovery situation,and cities are continually at high risk of new waves of infection[8,9]since airborne transmission is the dominant transmission route[10].

关键词：多变量时间序列疫情传播出行方式谷歌公司交通出行病毒传播出行行为大城市

A multifunctional key to open a new window on the path to natural resources-lessons from a study on chemical composition and biological capability of Paeonia mascula *** Turkey

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Food Bioscience 2023年第1期51卷 1301-1316页

作者： Inci Kurt-Celep Gokhan Zengin Engin Celep Stefano Dall’Acqua Stefania Sut Irene Ferrase Gunes Ak Abdullahi Ibrahim Uba Rıdvan Polat Deniz Canlı Ekrem Darendelioglu Muhammad Zakariyyah Aumeeruddy Mohammad Ali Shariati Mohamad Fawzi Mahomoodally Department of Pharmacognosy Faculty of PharmacyYeditepe University34755IstanbulTurkey Department of Biology Science FacultySelcuk UniversityKonya42300Turkey Department of Pharmacognosy Faculty of PharmacyAcıbadem Mehmet Ali Aydınlar University34752IstanbulTurkey Department of Pharmaceutical and Pharmacological Sciences University of PadovaVia Marzolo 535131PadovaItaly Department of Molecular Biology and Genetics Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul34083Turkey Department of Landscape Architecture Faculty of AgricultureBingol University12000BingolTurkey The Unit of Model University Coordination Center Bingol Unviersity12000Bing¨olTurkey Department of Molecular Biology and Genetics Faculty of Art and SciencesBing¨ol UniversityBingolTurkey Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduit80837Mauritius Department of Scientific Research K.G.Razumovsky Moscow State University of Technologies and Management(The First Cossack University)73 Zemlyanoy ValMoscow109004Russian Federation Department of Scientific Research Russian State Agrarian University-Moscow Timiryazev Agricultural Academy49 Timiryazevskaya str.Moscow127550Russian Federation Center for Transdisciplinary Research Department of PharmacologySaveetha Dental CollegeSaveethaInstitute of Medical and Technical ScienceChennai600077India centre of Excellence for Pharmaceutical Sciences(Pharmacen) North-West UniversityPotchefstroom2520South Africa

The genus Paeonia has gained great interest from the scientific community for exploration as a source of bioactive *** current work focused on the chemical characterisation and biological properties of Paeonia mascula *** *** chemical characterisation of the extracts was analysed by LC-DAD-ESI and *** antioxidant,enzyme inhibitory and anticancer properties were evaluated in *** methanol extract was the most effective as antioxidant,metal chelator and was the most effective inhibitor of acetylcholinesterase(AChE)and *** chloroform extract showed highest inhibition of butrylcholinesterase(BChE)and *** acetate extract displayed glucosidase *** most abundant compounds were hexagalloyl glucose,penta galloyl glucose,gallic acid,tetragalloyl glucose,paeoniflorin and the most abundant flavonoid was quercetin-3-O-glucoside.β-sitosterol was the most abundant *** anticancer effect of *** was evaluated by using HELA cells evaluating different *** possible inhibition effect of *** on the reactive oxygen species(ROS)pathway was controlled by performing the advanced glycation end product(AGE).To determine the effect of *** on active molecular pathways in the HELA cancer cell line,the levels of Phospho-NF-Kβp65,AGE receptor RAGE protein,antiapoptotic BCL-2,proapoptotic BAX and P-53 proteins were checked,***-NF-Kβp65,RAGE and BCL-2,which are both ROS inducers and play an active role in cancer prognosis,were found to have decreased levels after the application of *** findings provide a scientific basis for Paeonia mascula,which may serve as a source of naturally occurring bioactive compounds for healthpromoting applications.

关键词： Paeonia Phenolics Antioxidant Enzyme inhibition Anticancer Insilico analysis