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Comparative in-vitro analysis of different brands of paracetamol tablets available in Nepal

Journal of Coastal Life Medicine 2016年第8期4卷 645-648页

作者： Ganesh Man Singh Thakuri Kailash Kumar Yadav Rahul Rana Chhetri Department of Pharmaceutical Chemistry Doon(PG)Paramedical College and Hospital DehradunHemavati Nandan Bahuguna Garhwal UniversityPauri GarhwalUttarakhandIndia Department of Microbiology Tribhuwan UniversityKathmanduNepal Department of pharmacy Pokhara UniversityPokharaKaskiNepal

Objective:To examine the physico-chemical parameters of commercially available local and multinational brands of paracetamol tablets in ***:Different five paracetamol brands were explored by testing various parameters according to standard *** studied parameters included weight variation,friability,disintegration,dissolution and *** limits of the official test were referenced from official guidelines of Indian Pharmacopoeia(IP)and British Pharmacopoeia(BP).All brands were tested according to their pharmacopoeial claim and methods for these tests were successfully conducted to find out their *** methods were economic and ***:Requirements of weight variation and friability value were complied by all *** minutes of disintegration time were also complied by all the brands according to the BP/IP recommendation for uncoated *** brands showed not less than 80%drug release in 45 min as per BP and not less than 85%in 30 min as per *** of each brand was found to be within the range of 95%-105%.The present findings suggested that about every paracetamol brand which was accessible in Nepali market encountering the IP/BP ***:Although the physico-chemical examinations such as weight variation,friability,disintegration,dissolution and assay were detected varying brand wise,but were found interior to defined *** an over-the-counter drug,the consumption of paracetamol is too ***,it is important for each brand to be genuine,good manufactured and well ***,additional exploration over the quality of paracetamol is compulsory for safe human consumption.

关键词： Acetaminophen Comparative study In-vitro analysis Paracetamol Physico-chemical test Quality control parameters

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Hiding on jagged karst pinnacles:A new microendemic genus and species of a limestone-dwelling agamid lizard(Squamata:Agamidae:Draconinae)from Khammouan Province,Laos

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Zoological Research 2023年第6期44卷 1039-1051页

作者： Saly Sitthivong Peter Brakels Santi Xayyasith Nathanaël Maury Sabira Idiiatullina Parinya Pawangkhanant Kai Wang Tan Van Nguyen Nikolay A.Poyarkov Faculty of Forestry National University of LaosVientiane 01170Lao PDR IUCN Laos PDR Vientiane 01160Lao PDR Faculty of Environmental Sciences National University of LaosVientiane 01170Lao PDR Chelonian Conservation Center Laos World Encyclopedia of HerpetofaunaVientiane 01000Lao PDR Department of Vertebrate Zoology Biological FacultyLomonosov Moscow State UniversityMoscow 119234Russia Rabbit in the Moon Foundation(RIM) SuanphuengRatchaburi 70180Thailand State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar Institute for Research and Training in Medicine Biology and PharmacyDuy Tan UniversityDa Nang 550000Vietnam college of Medicine&pharmacy Duy Tan UniversityDa Nang 550000Vietnam Joint Russian-Vietnamese Tropical Research and Technological Center Nghia DoCau GiayHanoi 122000Vietnam

We describe a unique new species and genus of agamid lizard from the karstic massifs of Khammouan Province,central *** carsticola *** *** an elusive medium-sized lizard(maximum snout-vent length101 mm)specifically adapted to life on limestone rocks and *** assess the phylogenetic position of the new genus amongst other agamids,we generated DNA sequences from two mitochondrial gene fragments(16S rRNA and ND2)and three nuclear loci(BDNF,RAG1 and c-mos),with a final alignment comprising 7418 base pairs for 64 agamid *** analyses unambiguously place the new genus in the mainland Asia subfamily Draconinae,where it forms a clade sister to the genus Diploderma from East Asia and the northern part of Southeast ***,the new genus is distinguished from all other genera in Draconinae by possessing a notably swollen tail base with enlarged scales on its dorsal and ventral *** work provides further evidence that limestone regions of Indochina represent unique“arks of biodiversity”and harbor numerous relict *** date,Laodracon carsticola *** *** known from only two adult male specimens and its distribution seems to be restricted to a narrow limestone massif on the border of Khammouan and Bolikhamxai provinces of *** studies are required to understand its life history,distribution,and conservation status.

关键词： Biodiversity Endemism Indochina Karstic landscape Laodracon carsticola Phylogeny Southeast Asia Taxonomy

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Experimentally unsupervised deconvolution for light-sheet microscopy with propagation-invariant beams

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Light(Science & Applications) 2022年第11期11卷 2790-2804页

作者： Philip Wijesinghe Stella Corsetti Darren J.X.Chow Shuzo Sakata Kylie R.Dunning Kishan Dholakia SUPA School of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsFife KY169SSUK Robinson Research Institute Adelaide Medical SchoolThe University of AdelaideAdelaideSAAustralia Australian Research Council Centre of Excellence for Nanoscale BioPhotonics The University of AdelaideAdelaideSAAustralia Institute for Photonics and Advanced Sensing The University of AdelaideAdelaideSAAustralia Strathclyde Institute of pharmacy and Biomedical Sciences University of StrathclydeGlasgow G4 OREUK School of Biological Sciences The University of AdelaideAdelaideSAAustralia Department of Physics College of ScienceYonsei UniversitySeoul 03722South Korea

Deconvolution is a challenging inverse problem,particularly in techniques that employ complex engineered pointspread functions,such as microscopy with propagation-invariant ***,we present a deep-learning method for deconvolution that,in lieu of end-to-end training with ground truths,is trained using known physics of the imaging ***,we train a generative adversarial network with images generated with the known point-spread function of the system,and combine this with unpaired experimental data that preserve perceptual *** method rapidly and robustly deconvolves and super-resolves microscopy images,demonstrating a two-fold improvement in image contrast to conventional deconvolution *** contrast to common end-to-end networks that often require 1000-10,000s paired images,our method is experimentally unsupervised and can be trained solely on a few hundred regions of *** demonstrate its performance on light-sheet microscopy with propagation-invariant Airy beams in oocytes,preimplantation embryos and excised brain tissue,as well as illustrate its utility for Bessel-beam *** method aims to democratise learned methods for deconvolution,as it does not require data acquisition outwith the conventional imaging protocol.

关键词： invariant propagation implantation

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Effect of Roucongrong(Herba Cistanches Deserticolae) decoction on the substantia nigra through Wnt/β-catenin signaling pathway in rats with Parkinson's disease induced by 6-hydroxydopamine hydrochloride

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Journal of Traditional Chinese Medicine 2021年第5期41卷 762-770页

作者： XU Qian QIN Wei WU Fangzhen LIN Yao HONG Liting CHEN Dan HU Xuefeng CAI Jing Fujian Key Laboratory of Developmental and Neural Biology College of Life ScienceFujian Normal UniversityFuzhou 350117China college of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122China Department of Rheumatology and Endocrinology The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityFuzhou 350003China Institute of pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China

OBJECTIVE:To investigate the effect of Roucongrong(Herba Cistanches Deserticolae)decoction on the substantia nigra in rats with Parkinson’s disease(PD)induced by 6-hydroxydopamine hydrochloride(6-OHDA).To further determine whether the Wnt/β-catenin signaling pathway is involved in the ***:A rat model of PD was established by intracranial injection of ***,three concentrations of Roucongrong(Herba Cistanches Deserticolae)decoction were prepared and administered to rats by gavage therapy for 14 *** changes were measured in PD *** vivo tyrosine hydroxylase(TH)levels in the substantia nigra were examined by ***,gene and protein expression levels of members of the Wnt/β-catenin signaling pathway were examined by Western blotting and polymerase chain ***,a Wnt/β-catenin inhibitor was used to investigate the mechanism of action in 1-methyl-4-phenylpyridinium(MPP+)-treated MES23.5 cells in ***:Roucongrong(Herba Cistanches Deserticolae)decoction improved performance in the stride and gait adjustment tests in PD *** also increased TH in the substantia nigra and altered the expression of genes and proteins in the Wnt/β-catenin signaling ***/β-catenin inhibitor reduced the effect of Roucongrong(Herba Cistanches Deserticolae)decoction in MPP+-treated MES23.5 ***:Roucongrong(Herba Cistanches Deserticolae)decoction may promote neuronal survival in PD in vivo and in vitro by increasing TH content in the substantia nigra and by activating the Wnt/β-catenin signaling pathway.

关键词： Cistanche Parkinson disease survival tyrosine 3-monooxygenase Wnt signaling pathway

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Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin

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World Journal of Gastroenterology 2007年第34期13卷 4615-4619页

作者： Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan Li Kin-Wah Chu Peter WC Fung Nagy Habib Farzin Farzaneh Rui-An Xu Molecular Medicine Engineering Research Center of the Ministry of Education Institute of Molecular Medicine Huaqiao University Quanzhou362021 Fujian Province China Department of Medicine Hong Kong University Hong Kong China Department of pharmacy Chicago UniversityUnited States Department of Transplantation Imperial College London United Kingdom Department of Haematological & Molecular Medicine King's College London London SE5 9NUUnited Kingdom

AIM： TO investigate the inhibitory effect of kallistatin （KAL） on angiogenesis and HCT-116 xenograft tumor growth.METHODS： Heterotopic subcutaneous injection of 2 Seven days later, 2 x 1011 injected intratumorally （n tumors were induced by x 106 HCT-11 cells in mice. rAAV-GFP or rAAV-KAL was = 5 for each group）. The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density （MVD） by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining.RESULTS： Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% （171 ＋ 52 mm^3） at d 21 after virus infection compared to the control group （776 ＋ 241 mm^3）. Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL, rAAV-KAL also decreased the proportion of proliferating cells （Ki-67 positive cells） in tumors compared with the control group.CONCLUSION： rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer.

关键词： Kallistatin Adeno-associated virus Angiogenesis inhibitors Colon Neoplasm

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Corrigendum to“The effective transfection of a low dose of negatively charged drug-loaded DNA-nanocarriers into cancer cells via scavenger receptors”[Journal of Pharmaceutical Analysis volume 11(2021)174e182]

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Journal of Pharmaceutical Analysis 2022年第4期12卷 698-700页

作者： Mirza Muhammad Faran Ashraf Baig Chengfei Zhang Muhammad Furqan Akhtar Ammara Saleem Jahanzeb Mudassir Laboratory of Biomedical&Pharmaceutical Engineering of Stem Cells Research Restorative Dental SciencesFaculty of DentistryThe University of Hong KongHong Kong999077PR China State Key Laboratory of Analytical Chemistry for Life Sciences School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023PR China Faculty of pharmacy Bahauddin Zakariya UniversityMultan 60000Pakistan Riphah Institute of Pharmaceutical Sciences Riphah International UniversityLahorePakistan Department of Pharmacology Faculty of Pharmaceutical SciencesGovernment College University FaisalabadFaisalabadPakistan

The authors regret to inform that Figs.4,6,and 7 in the original article were wrongly *** corrected figures appear below:The authors would like to apologize for any inconvenience caused.

关键词： Cor loaded cancer

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Identification of highly efficacious PROTACs targeting BRD4 against acute myeloid leukemia:Design,synthesis,and biological evaluations

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Chinese Chemical Letters 2023年第6期34卷 426-431页

作者： Aiping Chen Yue Zhong Yunxiao Liu Zhancheng Xie Hanyu Wu Wei Shi Wenlong Huang Renxiang Tan Hai Qian college of pharmacy Nanjing University of Chinese MedicineNanjing 210023China Center of Drug Discovery State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease China Pharmaceutical UniversityNanjing 210009China

The abnormal activation of BRD4 accelerates the progression of acute myeloid leukemia(AML),developing more precise therapeutics to intervene BRD4 promise to be an excellent opportunity to avoid current limitations of chemotherapy in ***,a range of small-molecule PROTACs with the privileged 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one scaffold were rationally designed,which harbored different carbon or ethylenedioxy chains to degrade BRD4 mediated by the E3 ubiquitin ligase *** them,the most potential B24 exhibited remarkable BRD4 degradation and excellent anti-proliferative activities in MV4-11 cells,with values of DC_(50)and IC_(50)for 0.75 nmol/L and 0.4 nmol/L,respectively,which were better than the BRD4 inhibitor(+)-***,this compound could time-dependently degrade the target protein in the BRD4-,CRBN-,and proteasome-dependent ***,B24 dramatically decreased the level of proto-oncogene c-Myc,and induced cell apoptosis by arresting the cell cycle in G0/G1 phase,down-regulating Bcl-2 and up-regulating Bax to amplify apoptotic *** proof-of-concept study also highlighted the feasibility of BRD4-based PROTACs as a more powerful strategy against AML.

关键词： Acute myeloid leukemia BRD4 PROTACs Protein degradation Apoptosis

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Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis

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Molecular Plant 2023年第12期16卷 1867-1870页

作者： Hong Gil Lee Seo Young Jang Eun Yee Jie Seung Hee Choi Ok-Sun Park Soon Hyung Bae Hyun-Soon Kim Suk Weon Kim Geum-Sook Hwang Pil Joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Integrated Metabolomics Research Group Western Seoul CenterKorea Basic Science InstituteSeoul 03759Korea Biological Resource Center Korea Research Institute of Bioscience and BiotechnologyJeongeup56212Korea Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea college of pharmacy Chung-Ang UniversitySeoul 06974Korea

Dear Editor,Plant tissue culture involves callus formation and de novo shoot ***,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-inducing medium(CIM),followed by shoot regeneration on cytokinin-rich shoot-inducing medium(SiM).Callus results from division of pericycle-like cells(Atta et al.,2009;Sugimoto et al.,2010);its cellular identity resembles that of lateral root primordia(Atta et al.,2009;Sugimoto et al.,2010).Callus acquires cellular pluripotency by forming root stem cell niches on CIM(Sugimoto et al.,2010)。

关键词： Adenosine callus

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Bioassay-guided isolation and structural modification of the anti-TB alkenylbenzenediols from Ardisia gigantifolia

Bioassay-guided isolation and structural modification of the...

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中国化学会第十届全国天然有机化学学术会议

作者： Xun Song Yi-Fu Guan Ming-Hua Qiu Nguyen Van Hung D.Doel Soejarto Harry H.S.Fong Scott G.Franzblau Zhen-Dan He Hong-Jie Zhang School of Chinese Medicine Hong Kong Baptist University Department of pharmacy School of Medicine Shenzhen University State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST) Department of Medicinal Chemistry and Pharmacognosy College of Pharmacy University of Illinois at Chicago

Tuberculosis(TB)is a contagious-infectious disease mainly caused by Mycobacterium *** bioassay-guided fractionation of the chloroform extract of the leaves and stems of Ardisia gigantifolia led to the isolation of two alkenyl-1,3-benzenediol compounds,5-(8Z-heptadecenyl)resorcinol(1)1 and 5-(8Z-pentadecenyl)resorcinol(2)*** further synthesized

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Synthesis and biological evaluation of novel bivalent β-carboline-3-carboxylic acid derivatives as potential antiviral agents against porcine reproductive and respiratory syndrome virus

Synthesis and biological evaluation of novel bivalent β-car...

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中国化学会第十二届全国天然有机化学学术会议

作者： Hong-Ling Gu Hui Gao Na Li Ya-Xi Xi Shi-Jun Wang Hao-Ran Wang Jun-Ru Wang Cheng-Bao Wang Shaanxi Key Laboratory of Natural Products & Chemical Biology College of Chemistry and PharmacyNorthwest A&F University Department of Preventive Veterinary Medicine College of Veterinary MedicineNorthwest A&F University State key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences

Porcine reproductive and respiratory syndrome virus(PRRSV) is one of the most prevalent porcine viral pathogen in the ***,there is an urgent need for new antiviral therapies.β-carboline alkaloids are natural and synthetic indole alkaloids,which are of great interest due to their diverse biological ***,we synthesized a series of novel bivalentβ-carboline-3-carboxylic acid derivatives and evaluated the antiviral activity against EGFP-tagged rHP-PRRSV in Marc-145 *** results demonstrated that D2(78%),4 a(68%),and 4 c(76%) displayed a significant antiviral activity against PRRSV at 8 μ*** of virus yields strongly decreased about 2.0,1.7,and 2.1-log after treated with 8 μM of D2,4 a,and 4 *** the quantity of relative EGFP fluorescent reduced about 49%,43%,and 63%,***,the expressions of GP5 and EGFP decreased in a dose-dependent manner.D2,9-o-methylbenzyl-β-carboline-3-carboxylic acid methyl ester;2 c,pentane-1,5-diylbis(9-(2-methylbenzyl)-9 H-pyrido[3,4-b]indole-3-carboxylate;D4,9-o-fluorobenzyl-β-carboline-3-carboxylic acid methyl ester;4 c,pentane-1,5-diylbis(9-(2-fluorobenzyl)-9 H-pyrido[3,4-b]indole-3-carboxylate

关键词： bivalent β-carboline derivatives HP-PRRSV GP5 EGFP

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