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检索条件"机构=Pharmacology and Toxicology Unit"
1901 条 记 录,以下是1-10 订阅
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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation
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Neural Regeneration Research 2025年 第8期20卷 2325-2336页
作者: Yafan Bai Hui Ma Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of pharmacology and toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina
Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Allium cepa root tip assay in assessment of toxicity of magnesium oxide nanoparticles and microparticles
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Journal of Environmental Sciences 2018年 第4期30卷 125-137页
作者: Bhanuramya Mangalampalli Naresh Dumala Paramjit Grover toxicology unit Pharmacology and Toxicology Division CSIR-Indian Institute of Chemical Technology Academy of Scientific and Innovative Research CSIR-Indian Institute of Chemical Technology
Allium cepa bioassay had been used from decades for the assessment of toxicants and their harmful effects on environment as well as human health. Magnesium oxide(MgO) particles are being utilized in different fields... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Quantification of flupirtine maleate polymorphs using X-ray powder diffraction
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Chinese Chemical Letters 2016年 第11期27卷 1666-1672页
作者: Yu-Mei Zhao Zhi-Bing Zheng Song Li Laboratory of Computer-Aided Drug Design & Discovery Beijing Institute of Pharmacology and Toxicology Laboratory of Structure Identification Beijing Institute of Pharmacology and Toxicology State Key Laboratory of toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology
Flupirtine maleate, a pharmaceutical compound for treating psychotic disease in clinics, has seven polymorphs. Form A, with better crystal stability and bioavailability, has been widely used as the pharmaceutical crys... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Design and synthesis of cyclic acylguanidines as BACE1 inhibitors
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Chinese Chemical Letters 2015年 第10期26卷 1327-1330页
作者: Jia-Kuo Liu Wei Gu Xiao-Rui Cheng Jun-Ping Cheng Wen-Xia Zhou Ai-Hua Nie Beijing Institute of pharmacology and toxicology
Based on the lead compound 1 reported in literature, a series of novel BACE1 inhibitors were designed and synthesized, among which compound 11 exhibited a 14-fold improvement in potency over the lead compound 1. This ... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Polymorphisms of the oxidant enzymes glutathione S-transferase and glutathione reductase and their association with resistance of Plasmodium falciparum isolates to antimalarial drugs
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Asian Pacific Journal of Tropical Medicine 2010年 第9期3卷 673-677页
作者: Raewadee Wisedpanichkij Wanna Chaicharoenkul Poonuch Mahamad Prapichaya Prompradit Kesara Na-Bangchang pharmacology and toxicology unit Graduate Program in Biomedical SciencesThammasat UniversityThailand
Objective:To investigate the association between amplification of the two regulatory genes controlling glutathione(GSH) levels,glutathione reductase(PfGR) and glutathione S-transferase (PfGST) genes and sensitivity of... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant
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Military Medical Research 2019年 第1期6卷 78-88页
作者: Xiao-rui Zhang Wen-xia Zhou Yong-xiang Zhang State Key Laboratory of toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology
AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase(SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical counte... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Effect of thienorphine on intestinal transit and isolated guinea-pig ileum contraction
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World Journal of Gastroenterology 2013年 第9期19卷 1444-1450页
作者: Pei-Lan Zhou Yu-Lei Li Ling-Di Yan Zheng Yong Gang Yu Hua-Jin Dong Hui Yan Rui-Bin Su Ze-Hui Gong Beijing Institute of pharmacology and toxicology
AIM: To evaluate the effect of thienorphine on small intestinal transit in vivo and on guinea-pig ileum (GPI) contraction in vitro . METHODS: The effects of thienorphine on intestinal transit were examined in mice and... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis
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World Journal of Gastroenterology 2018年 第5期24卷 549-572页
作者: Aya El Khodiry Menna Afify Hend M El Tayebi Genetic pharmacology Research Group Clinical Pharmacy Unit department of Pharmacology and toxicology faculty of Pharmacy and biotechnology German University in Cairo
Hepatocellular carcinoma(HCC) is one of the most common and aggressive cancers worldwide. HCC is the fifth common malignancy in the world and the second leading cause of cancer death in Asia. Long non-coding RNAs(lncR... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions
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Neural Regeneration Research 2025年 第1期20卷 191-192页
作者: Narek Manukjan Daniel Fulton Zubair Ahmed WMatthijs Blankesteijn Sébastien Foulquier Department of pharmacology and toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands
As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying va... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Anti-epitope antibody, a novel site-directed antibody against human acetylcholinesterase
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Acta Pharmacologica Sinica 2004年 第4期25卷 33-37页
作者: Xing-mei ZHANG, GangLIU, Man-ji SUN2 Institute of pharmacology and toxicology, Academyof MilitaryMedical Sciences, Beijing 100850, China Institute of pharmacology and toxicology Academy of Military Medical Sciences
AIM: To construct synthetic antigens using the epitope of human brain acetylcholinesterase (hbAChE) for induc- tion and detection of the specific antibody against the epitope, and to analyse the immunogenicity of the ... 详细信息
来源: 同方期刊数据库 同方期刊数据库 评论