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Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

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Nano-Micro Letters 2024年第3期16卷 254-302页

作者： Hyeonseok Kim Bruno Rigo Gabriella Wong Yoon Jae Lee Woon‑Hong Yeo IEN Center for Wearable Intelligent Systems and Healthcare Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker H.petit institute for Bioengineering and biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health *** considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human *** addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and *** wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease ***,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

关键词： Implantable electronics Biomedical systems Batteryless devices Wireless electronics Physiological signal monitoring

Parallel droplet microfluidics for high throughput cell encapsulation and synthetic microgel generation

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Microsystems & Nanoengineering 2018年第1期4卷 525-533页

作者： Devon M.Headen JoséR.García Andrés J.García Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA petit institute for Bioengineering and biosciences Georgia Institute of TechnologyAtlantaGA 30332USA

Cells can be microencapsulated in synthetic hydrogel microspheres(microgels)using droplet microfluidics,but microfluidic devices with a single droplet generating geometry have limited throughput,especially as microgel diameter *** we demonstrate microencapsulation of human mesenchymal stem cells(hMSCs)in small(o100μm diameter)microgels utilizing parallel droplet generators on a two-layer elastomer device,which has 600% increased throughput ***-nozzle *** of microgel diameters were compared between products of parallel ***-nozzle configurations for two square nozzle widths,35 and 100μ*** produced on parallel nozzles were equivalent to those produced on single nozzles,with substantially the same *** of hMSCs was compared for parallel nozzle devices of each *** five micrometer wide nozzle devices could be operated at twice the cell concentration of 100μm wide nozzle devices but produced more empty microgels than predicted by a Poisson *** micrometer wide nozzle devices produced microgels as predicted by a Poisson *** of microgels did not increase with the addition of cells for either nozzle *** encapsulated on 35μm wide nozzle devices had reduced viability(~70%)and a corresponding decrease in vascular endothelial growth factor(VEGF)secretion compared to hMSCs cultured on tissue culture(TC)*** hMSCs using 100μm wide nozzle devices mitigated loss of viability and function,as measured by VEGF secretion.

关键词： droplets microencapsulation microgel multilayer parallel

Mechanosensing via Immunereceptors

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医用生物力学 2019年第A1期34卷 9-9页

作者： Cheng Zhu Wei Chen Jizhong Lou William Rittase Kaitao Li Coulter Department of Biomedical Engineering Woodruff School of Mechanical Engineering petit institute forbioengineering and biosciences Georgia Institute of TechnologyAtlantaGeorgia30332USA Department of Neurobiology Institute of Neuroscienceand Department of Cardiology of the Second Affiliated HospitalZhejiang UniversitySchool of MedicineHangzhou310058China Key Laboratory of RNA Biology CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China

The immune response is orchestrated by a variety of immune cells,the function of which then is determined by the collective signals from different *** studies have highlighted the presence of mechanical force on these receptor-ligand pairs and its important role in regulating antigen recognition/discrimination and *** this perspective,we use the T cell receptor as an example to review the current understanding of the mechanosensing properties of *** discuss the types of forces that immunoreceptors may encounter,the effects on ligand recognition,conformational changes and mechanosensing mechanisms,as well as the consequences in downstream signal transduction and function.

关键词： Mechanosensing Immunereceptors

Soft wearable flexible bioelectronics integrated with an anklefoot exoskeleton for estimation of metabolic costs and physical effort

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npj Flexible Electronics 2023年第1期7卷 535-544页

作者： Jihoon Kim Prakyath Kantharaju Hoon Yi Michael Jacobson Hyungkeun Jeong Hojoong Kim Jinwoo Lee Jared Matthews Nathan Zavanelli Hyeonseok Kim Heejin Jeong Myunghee Kim Woon-Hong Yeo IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Department of Mechanical and Industrial Engineering the University of Illinois at ChicagoChicagoIL 60607USA Department of Mechanical Roboticsand Energy EngineeringDongguk UniversitySeoulRepublic of Korea Human Systems Engineering The Polytechnic SchoolIra A.Fulton Schools of EngineeringArizona State UniversityMesaAZ 85212USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA

Activities and physical effort have been commonly estimated using a metabolic rate through indirect calorimetry to capture breath *** physical effort represents the work hardness used to optimize wearable robotic ***,personalization and rapid optimization of the effort are *** respirometry is the gold standard for estimating metabolic costs,this method requires a heavy,bulky,and rigid system,limiting the system’s field ***,this paper reports a soft,flexible bioelectronic system that integrates a wearable ankle-foot exoskeleton,used to estimate metabolic costs and physical effort,demonstrating the potential for real-time wearable robot adjustments based on *** from a set of activities,including walking,running,and squatting with the biopatch and exoskeleton,determines the relationship between metabolic costs and heart rate variability root mean square of successive differences(HRV-RMSSD)(R=−0.758).Collectively,the exoskeleton-integrated wearable system shows potential to develop a field-deployable exoskeleton platform that can measure wireless real-time physiological signals.

关键词： skeleton wear estimation

Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

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npj Flexible Electronics 2023年第1期7卷 119-130页

作者： Kiho Kim In Sik Min Tae Hee Kim Do Hyeon Kim Seungwon Hwang Kyowon Kang Kyubeen Kim Sangun Park Jongmin Lee Young Uk Cho Jung Woo Lee Woon-Hong Yeo Young Min Song Youngmee Jung Ki Jun Yu Functional Bio-integrated Electronics and Energy Management Lab School of Electrical and Electronic EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Fusion Research and Collaboration Biomedical Research InstituteSeoul National University HospitalSeoul 03080Republic of Korea School of Electrical Engineering and Computer Science(EECS) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea PA1 Foundry BusinessSamsung Electronics1 Samsungjeonja-roHwaseong-siGyeonggi-doRepublic of Korea R&D Center DNA Lab PharmaresearchSeongnam 13486Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 136-705Republic of Korea School of Materials Science and Engineering Energy Materials for Soft Electronics LaboratoryPusan National UniversityBusan 46241Republic of Korea IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Photodynamic therapy(PDT)is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues,exhibit fewer side effects,and lack pain during *** PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive *** implantable PDT systems,however,are not able to perform multiple functions simultaneously,such as modulating light intensity,measuring,and transmitting tumor-related data,resulting in the complexity of cancer ***,we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in *** system exploits micro inorganic light-emitting diodes(μ-LED)that emit light with a wavelength of 624 nm,designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity ofμ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation(2–3 weeks).The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments,ray-tracing simulation results,and a tumor xenograft mouse model in *** all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.

关键词： optoelectronic enable battery