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Modified approach of regenerative treatment for distal intrabony defect beneath non-keratinized mucosa at terminal molar:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3575-3581页

作者： Jian-Ru Liu Yan Huang Xiang-Ying Ouyang Wen-Yi Liu Ying Xie Department of periodontology Peking University School and Hospital of StomatologyBeijing 100081China

BACKGROUND Intrabony defects beneath non-keratinized mucosa are frequently observed at the distal site of terminal ***,the application of regenerative treatment using the modified wedge-flap technique is considered impractical for these specific dental *** SUMMARY This article proposes a modified surgical procedure aimed at exposing the distal intrabony defect by making a vertical incision in the keratinized buccal *** primary objective is to maintain gingival flap stability,thereby facilitating periodontal *** described technique was successfully employed in a case involving the left mandibular second molar,which presented with an intrabony defect without keratinized gingiva at the distal *** this case,an incision was made on the disto-buccal gingival tissue,creating a tunnel-like separation of the distal non-keratinized soft tissue to expose the intrabony ***,bone grafting and guided tissue regeneration surgeries were performed,resulting in satisfactory bone fill at 9 mo *** This technique offers a regenerative opportunity for the intrabony defects beneath non-keratinized mucosa and is recommended for further research.

关键词： Non-keratinized mucosa Regenerative therapy Vertical incision Tunnel-like separation Case report

Myeloid sarcoma with maxillary gingival swell

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World Journal of Clinical Cases 2024年第19期12卷 3985-3994页

作者： Shu-Han Li Cai-Xiu Yang Xiao-Ming Xing Xiang-Ru Gao Zhao-Yu Lu Qiu-Xia Ji Department of periodontology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of periodontology School of Stomatology of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pathology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND Myeloid sarcoma(MS),also referred to as granulocytic sarcoma or chloroma,is a rare type of extramedullary malignant *** comprises primitive granulocytic precursor cells that play a key role in the early stages of white blood cell ***,the occurrence of this tumor in the gingiva is *** SUMMARY The present study reported the case of MS with gingival swelling in the maxillary region,with aleukemic presentation in a 32-year-old male *** two courses of chemotherapy,computed tomography of the region demonstrated complete clearance of the *** the 12-month follow-up appointment,the patient was in a stable condition with the absence of *** etiology,clinical features,diagnosis,and relevant treatment of MS are discussed in the present *** Diagnosis of MS may be confirmed following histological and immunohistochemical examinations.

关键词： Acute myeloid leukemia Biopsy Gingival Myeloid sarcoma Immunohistochemistry Case report

Metabolic memory:mechanisms and diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1086-1114页

作者： Hao Dong Yuezhang Sun Lulingxiao Nie Aimin Cui Pengfei Zhao Wai Keung Leung Qi Wang State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduChina Department of Prosthodontics West China Hospital of StomatologySichuan UniversityChengduChina periodontology and Implant Dentistry Division Faculty of DentistryThe University of Hong KongHong KongChina

Metabolic diseases and their complications impose health and economic burdens *** from past experimental studies and clinical trials suggests our body may have the ability to remember the past metabolic environment,such as hyperglycemia or hyperlipidemia,thus leading to chronic inflammatory disorders and other diseases even after the elimination of these metabolic *** long-term effects of that aberrant metabolism on the body have been summarized as metabolic memory and are found to assume a crucial role in states of health and *** molecular mechanisms collectively participate in metabolic memory management,resulting in different cellular alterations as well as tissue and organ dysfunctions,culminating in disease progression and even affecting *** elucidation and expansion of the concept of metabolic memory provides more comprehensive insight into pathogenic mechanisms underlying metabolic diseases and complications and promises to be a new target in disease detection and ***,we retrace the history of relevant research on metabolic memory and summarize its salient *** provide a detailed discussion of the mechanisms by which metabolic memory may be involved in disease development at molecular,cellular,and organ levels,with emphasis on the impact of epigenetic ***,we present some of the pivotal findings arguing in favor of targeting metabolic memory to develop therapeutic strategies for metabolic diseases and provide the latest reflections on the consequences of metabolic memory as well as their implications for human health and diseases.

关键词： diseases metabolism alterations

A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface

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International Journal of Oral Science 2024年第2期16卷 225-237页

作者： William Macalester Asme Boussahel Rafael O.Moreno-Tortolero Mark R.Shannon Nicola West Darryl Hill Adam Perriman School of Cellular and Molecular Medicine Biomedical Sciences BuildingUniversity of BristolUniversity WalkBristolUnited Kingdom Bristol Centre for Functional Nanomaterials HH Wills Physics LaboratoryUniversity of BristolTyndall AvenueBristolUnited Kingdom Centre for Protolife Research School of ChemistryUniversity of BristolCantocks CloseBristolUnited Kingdom periodontology Bristol Dental SchoolUniversity of BristolLower Maudlin StreetBristolUnited Kingdom Max Planck-Bristol Centre for Minimal Biology School of ChemistryUniversity of BristolBristolUnited Kingdom

Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral ***,the oral cavity presents a unique and challenging environment for in vivo bone tissue engineering,exhibiting both hard and soft periodontal tissue as well as acting as key biocenosis for many distinct microbial communities that interact with both the external environment and internal body systems,which will impact on cell fate and subsequent treatment ***,we design and bioprint a facile 3D in vitro model of a human dentine interface to probe the effect of the dentine surface on human mesenchymal stem cells(hMSCs)encapsulated in a microporous hydrogel *** demonstrate that the dentine substrate induces osteogenic differentiation of encapsulated hMSCs,and that both dentine andβ-tricalcium phosphate substrates stimulate extracellular matrix production and maturation at the gel-media interface,which is distal to the gel-substrate *** findings demonstrate the potential for long-range effects on stem cells by mineralized surfaces during bone tissue engineering and provide a framework for the rapid development of 3D dentine-bone interface models.

关键词： interface den surface

Monkeypox: A Viral Zoonotic Disease of Rising Global Concern

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Infectious Diseases & Immunity 2024年第3期4卷 121-131页

作者： Sukumaran Ani Betsy Joseph Mary Thomas Vishnupriya K.Sweety Nandita Suresh Tumos Waltimo Department of Dentistry Oral Health InstituteHamad Medical CorporationPost Box 3050DohaQatar College of Dental Medicine Qatar UniversityPost Box 2713DohaQatar Department of periodontology Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennai 600077India Department of Oral and Maxillofacial Diseases Helsinki University and University HospitalHelsinki 00014Finland Pushpagiri Institute of Medical Sciences and Research Centre MedicityPerumthuruthyTiruvallaKerala 689101India Clinic for Oral Health and Medicine University Center for Dental Medicine Basel UZBUniversity of Basel4058 BaselSwitzerland.

Monkeypox(mpox)is a rare viral zoonotic disease,endemic to Central and West Africa,caused by the monkeypox virus,an orthopoxvirus similar to the variola virus(smallpox).Although sporadic travel-associated cases have historically occurred outside Africa,in May 2022,mpox began spreading globally in multiple nonendemic countries across several *** 2024,there has been an increase in globally reported confirmed cases of mpox and deaths from mpox,making it a public health emergency of international *** reasons for the unusual global spread are under investigation but likely relate to increased travel and waning population immunity to *** now appears to be mainly through close,intimate contact,especially among men who have sex with *** is usually a self-limited *** limited approved antiviral treatments are available,such as tecovirimat,which the European Medicines Agency approved in January 2022 for the treatment of mpox,their widespread availability and effectiveness in the current outbreak remain to be *** health control measures include surveillance,case identification/isolation,contact tracing,and targeted vaccination of contacts at high risk of ***,challenges remain in curtailing the current unprecedented *** knowledge gaps include animal reservoir(s)responsible for initial spillover events,viral mutations that may enhance transmissibility,optimal diagnostics for noninvasive specimens,effective antiviral therapies,next-generation vaccines providing longer-term immunity,and building global capacity for outbreak *** review summarizes the current literature on mpox virology,epidemiology,pathogenesis,clinical manifestations,diagnostics,treatment,prevention,and public health control *** investigation and research are needed to better understand mpox’s evolving epidemiology,pathogenicity,transmissibility,and ecology to guide strategies for containin

关键词： Antiviral agents Disease outbreaks Epidemiology Mpox Smallpox vaccine Zoonoses

纳米二氧化硅增强液态金属多功能水凝胶及其在先进应变传感中的应用（英文）

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Science China Materials 2024年

作者：王炳艳刘温霞宋兆萍李国栋于得海刘小娜王慧丽葛少华 State Key Laboratory of Biobased Materials and Green Papermaking Qilu University of Technology Shandong Academy of Science Department of periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration

导电水凝胶由于其优异的性能,在可穿戴电子皮肤中的应用引起了广泛关注.然而,挑战依然存在,包括其灵敏度低、循环稳定性差、对极端条件的耐受性有限.本研究提出了一种新型基于液态金属的导电水凝胶,采用双交联聚丙烯酸（PAA）基质,结合...

导电水凝胶由于其优异的性能,在可穿戴电子皮肤中的应用引起了广泛关注.然而,挑战依然存在,包括其灵敏度低、循环稳定性差、对极端条件的耐受性有限.本研究提出了一种新型基于液态金属的导电水凝胶,采用双交联聚丙烯酸（PAA）基质,结合了“软”配位和“硬”共价交联机制.这种混合交联网络是通过使用瓜尔胶（GG）稳定的镓（Ga）液滴来催化乙烯基二氧化硅纳米粒子（VSNPs）和丙烯酸（AA）的共聚反应而形成的.生成的Ga3+离子与PAA中的羧基相互作用,形成软配位交联,促进了水凝胶的快速凝胶化. VSNPs的加入显著提高了水凝胶的弹性、韧性和低温耐受性,而无需使用甘油.值得注意的是,其固有的可塑性、粘附性和自愈合性能得以保留.作为应变传感材料,该水凝胶具有17.4的高应变系数（GF）、250 ms的响应时间和恢复时间、0.1%的超低检测下限,以及在100%应变下800次循环的出色稳定性.在甘油溶液中短时间（20分钟）的浸泡进一步将其在-18°C下的延伸率提高到2688%,在1325%–1450%应变范围内的GF提高到28.1,工作范围扩大到0–1450%.延长浸泡时间（4小时）还可以改善其保水性和耐高温性能,使该水凝胶成为可持续、高性能可穿戴电子产品的理想传感材料.

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Relationship between Inter Canine Width and Inter Alar Width, Inter Commissural Width, and Inter Canthal Distance: A Pilot Study

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Open Journal of Stomatology 2024年第6期14卷 279-290页

作者： Grevisse Bindele Ndombolo Augustin Mantshumba Milolo Fidele Nyimi Bushabu Em Kalala Kazadi Pierrot Kumpanya Ntumba Jean Marie Kayembe Bukama Elias Lubadi Tshilumba Jean Paul Sekele Isouradi Department of Prosthodontics Teaching Hospital of Kinshasa University Kinshasa Democratic Republic of the Congo National Center of Research in Dental Sciences Kinshasa Democratic Republic of the Congo Department of Oral and Maxillofacial Surgery Teaching Hospital of Kinshasa University Kinshasa Democratic Republic of the Congo Department of periodontology Teaching Hospital of Kinshasa University Kinshasa Democratic Republic of the Congo Department of Operative Dentistry Teaching Hospital of Kinshasa University Kinshasa Democratic Republic of the Congo

The aim of this study was to determine the relationship between inter canine width (ICW) and inter alar width (IAW), inter commissural width (ICoW), and inter canthal distance (ICaD) in Bantu population. Materials and Methods: It was a pilot study included all participants who were aged at least 18 years, without a history of orthodontics treatment from Prosthodontics Department, Faculty of Dental Medicine, University of Kinshasa. The Ethics committee of the National Center of Research for Dental Sciences in DR Congo approved the study protocol (CNRSB 1504.218). The participants medical records were obtained from the interview and dental examination. Nature of the study was explained with participant information sheet, and an informed consent of all participants was obtained. The inclusion criteria were no missing maxillary and mandibular teeth, no diastema, and no anterior restorations, 18 years old before enrollment in the study. The exclusion criteria were inability to meet the above requirements, pregnancy, and refusal to participate in the study. The inter-canine width (ICW), inter alar width (IAW), inter canthal distance (ICaD) and inter-commissural width (ICoW) of each participant were measured with a digital Vernier caliper (Mitutoyo, UK Ltd.,) (0.01 mm) three times and the average value was recorded. The inter canthal distance (ICaD) was measured without applying pressure by bringing the recording parts of the caliper just in contact with the medial angle. The inter alar width (IAW) was marked with a fine marked pencil on the widest outer surface of the alae of the nose on either side or width. Those two points were measured without applying pressure by bringing the recording parts of the caliper just in contact with the outer surface. The participant was told to stop breathing shortly to avoid any change in shape of the nose. The inter-commissural width (ICoW) was determined by measuring the maxillary lip vermilion from commissure to commissure without the

关键词： Relationship Inter-Canine Width Inter Alar Width Inter Canthal Distance Inter Commissural Width

Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+T cell infiltration in mice

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International Journal of Oral Science 2024年第2期16卷 359-369页

作者： Xiaoqian Meng Linjuan Du Shuo Xu Lujun Zhou Boyan Chen Yulin Li Chumao Chen Huilin Ye Jun Zhang Guocai Tian Xuebing Bai Ting Dong Wenzhen Lin Mengjun Sun Kecong Zhou Yan Liu Wuchang Zhang Shengzhong Duan Department of Endodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Laboratory of Oral Microbiota and Systemic Diseases Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Hongqiao International Institute of Medicine Shanghai Tongren Hospital/Faculty of Basic MedicineKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghaiChina Department of Orthodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Department of periodontology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhouChina

Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the *** the current study,we showed that experimental periodontitis,which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis,exacerbated hypoxia-induced pulmonary hypertension in ***,periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs,contributing to pulmonary infiltration of interferon gamma positive(IFNγ^(+))T cells and aggravating the progression of pulmonary *** addition,we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving the exacerbation of pulmonary hypertension by periodontitis,and the exacerbation was potently ameliorated by both cervical lymph node excision and IFNγneutralizing *** study suggests a proof of concept that the combined prevention and treatment of periodontitis and pulmonary hypertension are necessary.

关键词： hypertension prevention interferon

Periodontitis may induce gut microbiota dysbiosis via salivary microbiota

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International Journal of Oral Science 2022年第3期14卷 349-359页

作者： Jun Bao Lili Li Yangheng Zhang Min Wang Faming Chen Shaohua Ge Bin Chen Fuhua Yan Department of periodontology Nanjing Stomatological HospitalMedical School of Nanjing UniversityNo.30 Zhongyang RoadNanjingChina State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases Department of PeriodontologySchool of StomatologyFourth Military Medical UniversityXi’anChina Department of periodontology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinanChina

The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary ***,faecal and salivary samples were collected from periodontally healthy participants(PH group,n=16)and patients with severe periodontitis(SP group,n=21)and analysed by 16S ribosomal RNA *** differences were observed in both the faecal and salivary microbiota between the PH and SP ***,more saliva-sourced microbes were observed in the faecal samples of the SP ***,the remaining salivary microbes were transplanted into C57BL6/J mice(the C-PH group and the C-SP group),and it was found that the composition of the gut microbiota of the C-SP group was significantly different from that of the C-PH group,with Porphyromonadaceae and Fusobacterium being significantly enriched in the C-SP *** the colon,the C-SP group showed significantly reduced crypt depth and zonula occludens-1 *** m RNA expression levels of pro-inflammatory cytokines,chemokines and tight junction proteins were significantly higher in the C-SP *** further investigate whether salivary bacteria could persist in the intestine,the salivary microbiota was stained with carboxyfluorescein diacetate succinimidyl ester and transplanted into *** found that salivary microbes from both the PH group and the SP group could persist in the gut for at least 24 ***,our data demonstrate that periodontitis may induce gut microbiota dysbiosis through the influx of salivary microbes.

关键词： Periodontitis may induce gut microbiota dysbiosis via salivary microbiota