Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+T cell infiltration in mice

作     者：Xiaoqian Meng Linjuan Du Shuo Xu Lujun Zhou Boyan Chen Yulin Li Chumao Chen Huilin Ye Jun Zhang Guocai Tian Xuebing Bai Ting Dong Wenzhen Lin Mengjun Sun Kecong Zhou Yan Liu Wuchang Zhang Shengzhong Duan Xiaoqian Meng;Linjuan Du;Shuo Xu;Lujun Zhou;Boyan Chen;Yulin Li;Chumao Chen;Huilin Ye;Jun Zhang;Guocai Tian;Xuebing Bai;Ting Dong;Wenzhen Lin;Mengjun Sun;Kecong Zhou;Yan Liu;Wuchang Zhang;Shengzhong Duan

作者机构：Department of EndodonticsShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Laboratory of Oral Microbiota and Systemic DiseasesShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Hongqiao International Institute of MedicineShanghai Tongren Hospital/Faculty of Basic MedicineKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghaiChina Department of OrthodonticsShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Department of PeriodontologyShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Stomatology HospitalSchool of StomatologyZhejiang University School of MedicineHangzhouChina 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2024年第16卷第2期

页      面：359-369页

核心收录：

学科分类：1003[医学-口腔医学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：fundings from the National Natural Science Foundation of China(82330015,81991503,81921002,and 82303275) Science and Technology Commission of Shanghai Municipality(23ZR1438300) 

主　　题：hypertension prevention interferon 

摘      要：Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the *** the current study,we showed that experimental periodontitis,which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis,exacerbated hypoxia-induced pulmonary hypertension in ***,periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs,contributing to pulmonary infiltration of interferon gamma positive(IFNγ^(+))T cells and aggravating the progression of pulmonary *** addition,we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving the exacerbation of pulmonary hypertension by periodontitis,and the exacerbation was potently ameliorated by both cervical lymph node excision and IFNγneutralizing *** study suggests a proof of concept that the combined prevention and treatment of periodontitis and pulmonary hypertension are necessary.