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Correlation of periodontal inflamed surface area with glycated hemoglobin,interleukin-6 and lipoprotein(a)in type 2 diabetes with retinopathy

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World Journal of Diabetes 2024年第4期15卷 686-696页

作者： Nusreen Jamal Thazhe Poyil Rosamma Joseph Vadakkekuttical Chandni Radhakrishnan department of periodontics Government Dental College(Affiliated to Kerala University of Health Sciences)Calicut 673008KeralaIndia department of Medicine Government Medical College(Affiliated to Kerala University of Health Sciences)Calicut 673008KeralaIndia

BACKGROUND The two-way relationship between periodontitis and type 2 diabetes mellitus(T2DM)is well *** hyperglycemia contributes to increased periodontal destruction and severe periodontitis,accentuating diabetic *** inflammatory link exists between diabetic retinopathy(DR)and periodontitis,but the studies regarding this association and the role of lipoprotein(a)[Lp(a)]and interleukin-6(IL-6)in these conditions are scarce in the *** To determine the correlation of periodontal inflamed surface area(PISA)with glycated Hb(HbA1c),serum IL-6 and Lp(a)in T2DM subjects with *** This cross-sectional study comprised 40 T2DM subjects with DR and 40 T2DM subjects without *** subjects were assessed for periodontal parameters[bleeding on probing(BOP),probing pocket depth,clinical attachment loss(CAL),oral hygiene index-simplified,plaque index(PI)and PISA],and systemic parameters[HbA1c,fasting plasma glucose and postprandial plasma glucose,fasting lipid profile,serum IL-6 and serum Lp(a)].RESULTS The proportion of periodontitis in T2DM with and without DR was 47.5%and 27.5%*** of periodontitis,CAL,PISA,IL-6 and Lp(a)were higher in T2DM with DR group compared to T2DM without DR *** difference was observed in the mean percentage of sites with BOP between T2DM with DR(69%)and T2DM without DR(41%),but there was no significant difference in PI(P>0.05).HbA1c was positively correlated with CAL(r=0.351,P=0.001),and PISA(r=0.393,P≤0.001)in study subjects.A positive correlation was found between PISA and IL-6(r=0.651,P<0.0001);PISA and Lp(a)(r=0.59,P<0.001);CAL and IL-6(r=0.527,P<0.0001)and CAL and Lp(a)(r=0.631,P<0.001)among study *** Despite both groups having poor glycemic control and comparable plaque scores,the periodontal parameters were higher in DR as compared to T2DM without *** a bidirectional link exists between periodontitis and DM,the presence of DR may have contr

关键词： Type 2 diabetes mellitus Periodontitis Periodontal inflamed surface Area Glycated Hb Diabetic retinopathy

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Beyond dentistry:could prevention and screening for neurodegenerative diseases start in the dental office?

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Neural Regeneration Research 2024年第1期19卷 156-157页

作者： Francesca R.Buccellato Daniela Galimberti Gianluca M.Tartaglia department of Biomedical Surgical and Dental SciencesUniversity of MilanMilanItalyFondazione IRCCS Ca’GrandaOspedale Maggiore PoliclinicoMilanItaly

The differential diagnosis of neurodegenerative diseases is complex and relies on clinical assessment,biomarker levels in cerebrospinal fluid,neuroimaging and neuropsychological *** efforts of the scientific community are focused on two aspects:a)the discovery of minimally invasive biomarkers;b)the discovery of early biomarkers that can predict the progression to clinical disease in the presymptomatic stage of a *** the impact of the number of patients affected by chronic neurodegenerative diseases on public health expenditures,early diagnosis seems to be a primary need of our society.

关键词： diagnosis diseases prevention

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Exploring dielectric phenomena in sulflower-like nanostructures via Monte Carlo technique

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Communications in Theoretical Physics 2024年第4期76卷 188-198页

作者： N Saber Z Fadil Hussein Sabbah A Mhirech B Kabouchi L Bahmad Chaitany Jayprakash Raorane Siva Sankar Sana Hassan Fouad Mohamed Hashem Laboratory of Condensed Matter and Interdisciplinary sciences(LaMCScI) Research Unit Labelled CNRSTURL-CNRST-17.Faculty of SciencesPO Box 1014Mohammed Ⅴ University in RabatMorocco College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait School of Chemical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea Applied Medical Science department Community CollegeKing Saud UniversityPO Box 11433Riyadh Saudi Arabia department of dental Health College of Applied Medical SciencesKing Saud UniversityPO Box 12372RiyadhSaudi Arabia

This research focuses on the electric behavior of a mixed ferrielectric sulflower-like *** structure includes a core with spin S_(i)^(Z)-1 atoms and a shell with spin σ_(j)^(Z)-5/2 *** Blume–Capel model and the Monte Carlo technique(MCt)with the Metropolis algorithm are *** are established for absolute zero,investigating stable spin configurations correlated with various physical *** MCt method explores phase transition behavior and electric hysteresis cycles under different physical parameters.

关键词： sulfower-like nanostructure dielectric characteristics Monte Carlo technique phase transition phase diagrams electric hysteresis

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Knowledge and the Attitude on the Use of Mouthwash among Two Selected Senior High Schools in Kumasi

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Open Journal of Stomatology 2024年第5期14卷 218-234页

作者： Ama Agyeibea Amuasi Kwame A. Koranteng Joseph Abu-Sakyi The department Child Oral Health & Orthodontics School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The department of community Dentistry School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

BACKGROUND: The route of most systemic diseases begins in the oral cavity. Oral health knowledge of mouthwashes and their uses is indispensable for the general population and especially adolescents. The use of mouthwash by adolescents can be a beneficial adjunct to their oral hygiene routine, providing additional protection against dental diseases and promoting fresher breath. Overuse or misuse of mouthwash, particularly those containing alcohol or other potentially irritating ingredients, may lead to adverse effects such as oral mucosal irritation, dry mouth, or alteration of the oral microbiome. OBJECTIVES: To determine the knowledge, attitude, and use of mouthwash among senior high school students in Kumasi. METHODOLOGY: 120 students responded to a standard questionnaire by a convenient sample technique. The Statistical Package for Social sciences (SPSS) 22.0 and MS Excel were used for data management and analysis. The results of the study were presented using tables, bar charts, and pie chart. RESULTS: The ages of the respondents ranged from 14 to 20 years. Out of the 120 participants, 71 students that represent 59.2% of the total, used mouthwash. Majority of the participants (63%) utilized a mouthwash after brushing their teeth. 49% of the participants reported using mouthwash to address halitosis, 37% used it to combat periodontal disease, and 10% used it for relief from a sore throat. CONCLUSION: In general, most of the participants who use mouthwash had excellent knowledge and a positive attitude toward the use of mouthwash.

关键词： Oral Cavity Mouthwash Plaque Biofilm Gingivitis Convenient Sampling

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The Oral Health Status of Person with Special Needs in Kumasi

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Open Journal of Stomatology 2024年第1期14卷 14-31页

作者： Ama Agyeibea Amuasi Alexander Oti-Acheampong Victoria N. A. Boadu Lord J. J. Gowans The department Child Oral Health & Orthodontics School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The department of Oral & Maxillofacial sciences School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The department of community Dentistry School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

Background: The most prevalent non-communicable disease worldwide is oral health-related disease, with dental caries and periodontal conditions being common. Oral health status significantly impacts overall health and quality of life. Barriers to dental care affect children with special needs. This study evaluates the oral health status and treatment requirements of people with special needs. Methodology: This descriptive cross-sectional study in Kumasi, Ghana examined oral health status among people, 121 children with special needs over two months, in June-July 2022. dental caries, periodontal changes, malocclusion, and trauma were assessed. The data was analyzed using SPSS 20.0. Results: The oral health status among people with special needs in this study was generally moderate, with a range from very good to very poor. The prevalence of dental caries was 37%, with a mean DMFT score of 2.82. Periodontal health showed unsatisfactory indicators such as mobile teeth, poor gingival health, high plaque scores, and the presence of halitosis. Conclusion: This descriptive study aimed to provide baseline data on the oral health status of special needs students in Kumasi, addressing the lack of knowledge in this area. It highlighted the importance of dental care in maintaining good oral health and overall well-being in individuals with special needs. Coordinated efforts by dental professionals are needed to provide dental health education and preventive interventions for these children.

关键词： Special Needs Oral Health dental Caries Periodontal Diseases Malocclusion

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Role of dental plaque,saliva and periodontal disease in Helicobacter pylori infection

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World Journal of Gastroenterology 2014年第19期20卷 5639-5653页

作者： Pradeep S Anand Kavitha P Kamath Sukumaran Anil department of periodontics People’s College of Dental Sciences and Research CentreBhopalMadhya Pradesh 462037India department of Oral Pathology People’s Dental AcademyBhopalMadhya Pradesh 462037India department of periodontics and community Dentistry College of DentistryKing Saud UniversityRiyadh 11545Saudi Arabia

Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections in humans. Although H. pylori may be detected in the stomach of approximately half of the world’s population, the mechanisms of transmission of the microorganism from individual to individual are not yet clear. Transmission of H. pylori could occur through iatrogenic, fecal-oral, and oral-oral routes, and through food and water. The microorganism may be transmitted orally and has been detected in dental plaque and saliva. However, the role of the oral cavity in the transmission and recurrence of H. pylori infection has been the subject of debate. A large number of studies investigating the role of oral hygiene and periodontal disease in H. pylori infection have varied significantly in terms of their methodology and sample population, resulting in a wide variation in the reported results. Nevertheless, recent studies have not only shown that the microorganism can be detected fairly consistently from the oral cavity but also demonstrated that the chances of recurrence of H. pylori infection is more likely among patients who harbor the organism in the oral cavity. Furthermore, initial results from clinical trials have shown that H. pylori-positive dyspeptic patients may benefit from periodontal therapy. This paper attempts to review the current body of evidence regarding the role of dental plaque, saliva, and periodontal disease in H. pylori infection.

关键词： Helicobacter pylori dental plaque Saliva Oral cavity Periodontitis Periodontal therapy

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Non-surgical management of dens invaginatus type IIIB in maxillary lateral incisor with three root canals and 6-year follow-up:A case report and review of literature

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World Journal of Clinical Cases 2022年第33期10卷 12240-12256页

作者： Suraj Arora Gurdeep Singh Gill Shahabe Abullais Saquib Priyanka Saluja Suheel M Baba Shafait Ullah Khateeb Anshad M Abdulla Shashit Shetty Bavabeedu Ahmed Babiker Mohamed Ali Mohamed Fadul A Elagib department of Restorative dental sciences College of DentistryKing Khalid UniversityAbha 61421Saudi Arabia department of Conservative Dentistry and Endodontics JCD Dental CollegeSirsa 125055India department of periodontics and community dental sciences King Khalid UniversityAbha 61421Saudi Arabia department of Pediatric Dentistry and Orthodontic sciences King Khalid UniversityAbha 61421Saudi Arabia

BACKGROUND The presence of dens invaginatus(DI)complicates treatment of any tooth,from diagnosis to access cavity and biomechanical preparation and *** of successful non-surgical management of DI type IIIB in maxillary lateral incisor are ***,we report such a case,with three root canals and a long *** SUMMARY A 13-year-old female patient presented with mild pain in the maxillary right lateral incisor(#7)for 10-15 *** examination,the tooth was slightly rotated,with slight tenderness on percussion and grade I mobility but with no caries,pockets or restorations and non-vital pulp(via vitality tests).Radiographic examination revealed unusual configuration of the tooth’s root canals,with an enamel-lined invagination extending to the apex,suggesting the possibility of DI Oehler’s type IIIB and a periapical *** the access cavity lingually revealed one distinct buccal orifice and two distinct palatal orifices;under higher magnification of a dental operating microscope(DOM),the mesio palatal and disto-palatal orifices were observed as connected by a C-shaped *** root canals were prepared with hand K-files following a step-back technique,and obturated using a combination technique of lateral condensation and vertical *** the 6-year follow-up,the patient was asymptomatic,and the periapical radiography displayed significant healing around the apical end of the *** Proper knowledge of unusual root canal anatomy is required in treating *** methods of root canal treatment can successfully resolve such complex cases,facilitated by DOM and cone-beam computed tomography.

关键词： Dens invaginatus Maxillary lateral incisor Three root canals Root canal Anatomy Treatment Case report

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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK department of Cardiovascular sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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Saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected patients: a scoping review

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Infectious Diseases of Poverty 2020年第4期9卷 3-9页

作者： Omid Fakheran Mandana Dehghannejad Abbasali Khademi dental research center Department of PeriodonticsDental Research InstituteIsfahan University of Medical sciencesIsfahanIran dental Research Center Dental Research InstituteIsfahan University of Medical sciencesIsfahanIran dental Research Center Department of EndodonticsFaculty of DentistryDental Research InstituteIsfahan University of Medical SciencesIsfahanIran

Background:From the begging months of 2020 a severe acute respiratory syndrome coronavirus(SARS-CoV-2,also called 2019-nCoV)caused a devastating global *** present,the diagnosis of coronavirus disease 2019(COVlD-19)is made through a nasopharyngeal swab based on reverse transcription polymerase chain reaction(RT-PCR)***,some recent studies suggested the possible role of oral fluids and saliva in the detection of *** purpose of this scoping review is evaluating the available evidence regarding the efficacy of saliva as a diagnostic specimen in COVID-19 ***:A systematic literature review of six databases(PubMed,Scopus,The Cochrane Central Register of Controlled Trials[CENTRAL],Science Direct,Web of Science and Google scholar)was carried out without any restrictions on date of publication to identify the reliability of saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected ***:Nine eligible articles were included in this review based on our described *** the included studies are based on clinical surveys among patients with confirmed SARS-CoV-2 *** of studies included in this review,reported that there is no statistically significant difference between nasopharyngeal or sputum specimens and saliva samples regarding viral ***:Despite limitations of this study,the findings of this review suggest that the use of self-collected saliva as a non-invasive specimen has proper accuracy and reliability regarding detection of SARS-CoV-2 based on RT-PCR technique.

关键词： COVID-19 SARS-CoV-2 2019-nCoV Saliva PCR Review

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Microsurgical management of radicular cyst using guided tissue regeneration technique:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1346-1355页

作者： Juan Carlos Gómez Mireles Eugenia Karina Martínez Carrillo Katia Alcalá Barbosa Evangelina Gutiérrez Cortés Javier González Ramos Luis Antonio González Gómez Rubén Alberto Bayardo González Sarah Monserrat Lomelí Martínez periodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of ClinicsCentro Universitario de Los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620Mexico Specialty in Oral Pathology Surgical-Stomatological DepartmentAutonomous University of GuadalajaraZapopan 45129Mexico Independent Researcher Guadalajara 44340Mexico department of Integral Dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico department of Medical and Life sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

BACKGROUND Radicular cyst is a lesion of odontogenic origin that arises from epithelial remains due to periapical periodontitis caused by inflammatory reactions generated at the apex of affected teeth with infected or necrotic *** therapeutic mana gement of radicular cysts is *** is only one case report of enucleation of a radicular cyst managed with microsurgery and apicoectomy,but without the use of the guided tissue regeneration(GTR)technique in the same surgical *** present clinical case describes the management of a radicular cyst with microsurgical approach,performance of an apicoectomy of the tooth associated with the entity,application of GTR technique,use of a resorbable membrane of type I bovine collagen,and bovine *** SUMMARY A 68-year-old patient presented with a radicular cyst from an upper lateral *** microsurgical management used was aimed at enucleating the chemical membrane,performing apicoectomy of the tooth along with careful and precise retrograde filling,and implementing GTR technique using a resorbable collagen membrane and bovine *** diagnosis of radicular cyst was confirmed using histopathological *** patient underwent follow-up evaluations at 10 and 30 d *** 4 months postoperative evaluation,she remained asymptomatic,and radiographs showed significant periapical healing with adequate bone *** These results suggest that microsurgical management using the GTR technique with collagen membrane and xenograft,contributes to bone regeneration.

关键词： Odontogenic cysts Apical periodontal cyst dental root end cyst Case report

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