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Economic evaluation of cervical cancer screening strategies in urban China

Chinese Journal of Cancer Research 2019年第6期31卷 974-983页

作者： Li Ma Yuying Wang Xiaohong Gao Yi Dai Yu Zhang Zhaojing Wang Xiaoxia Wang Limin Wang Jing Jiang Xinhua Jing Chunxia Yang Fanghui Zhao Jinghe Lang Youlin Qiao Department of Epidemiology School of Public HealthDalian Medical UniversityDalian 116044China Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100730China Department of Obstetrics and Gynecology Wafangdian Maternal and Child Health Care HospitalDalian 116300China Department of Epidemiology and Biostatistics West China School of Public HealthSichuan UniversityChengdu 610041China Department of Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:This study evaluated the feasibility of different cervical cancer screening strategies in urban ***:A Markov model was constructed to simulate a hypothetical cohort of 100,000 females aged 30-59 years in a 20-year *** strategies included liquid-based cytology(LBC)every three years,human papillomavirus(HPV)DNA testing every three and five years,respectively,and a combination of HPV DNA testing and LBC(HPV+LBC)every three and five years,*** outcomes included cumulative incidence over 20 years,cumulative risk of cervical cancer,costs,life year saved(LYS),quality-adjusted life years(QALYs)and *** cost-effectiveness ratios(CERs),incremental cost-effectiveness ratios(ICERs),costutility ratios(CURs),and benefit-cost ratios(BCRs)were used as outcomes in the health economic evaluation *** sensitivity analyses were performed to examine the stability of the ***:The cumulative incidence of the five screening strategies ranged from 833.02 to 1,158.07 cases per100,000 *** DNA testing was most effective in reducing the cumulative risk of cervical cancer,saving life years and QALYs and gaining *** CERs of HPV DNA testing every three and five years,and LBC every three years were considered to be very cost-effective if they were below China's GDP per *** CERs of HPV+LBC were considered to be cost-effective if they were below three times GDP per *** incremental cost-effectiveness analysis showed that HPV DNA testing every three and five years,LBC every three years and HPV+LBC every five years were dominant ***:The findings of this study indicated that HPV DNA testing every five years or LBC every three years should be recommended in urban China.

关键词： Cervical cancer Markov model economic evaluation

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Potential application of graphene nanoplatelets as a high temperature lubricant for hot rolling

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Friction 2022年第11期10卷 1810-1823页

作者： Long WANG Anh Kiet TIEU Ming MA Jiaqing LI Guojuan HAI Hongtao ZHU State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710021China School of Mechanical MaterialsMechatronic and Biomedical EngineeringFaculty of Engineering and Information SciencesUniversity of WollongongNorthfields AvenueWollongongNSW 2522Australia State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China School of Materials Science and Engineering Shaanxi University of Science and TechnologyXi’an 710021China

Graphene has been shown to be a promising solid lubricant to reduce friction and wear of the sliding counterparts,and currently is reported to only function below 600℃.In this study,its potential as a lubricant above 600℃ was studied using a ball-on-disc tribo-meter and a rolling *** results suggest that a reduction up to 50%can be obtained with graphene nanoplatelets(GnP)under lubricated conditions between 600 and 700℃ when compared with dry *** this friction reduction can last more than 3 *** 800 and 900℃,the friction reduction is stable for 70 and 40 s,respectively,which indicates that GnP can potentially provide an effective lubrication for hot metal forming *** rolling experiments on steel strips indicate that GnP reduces the rolling force by 11%,7.4%,and 6.9%at 795,890,and 960℃,*** friction reductions are attributed to the easily sheared GnP between the rubbing interfaces.A temperature higher than 600℃ will lead to the gasification of the residual graphene on the strip surface,which is believed to reduce the black contamination from traditional graphite lubricant.

关键词： graphene high temperature lubricant hot rolling tribology properties

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Scale effects of eroded sediment transport in Wujiang River Basin, Guizhou Province, China

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Journal of Groundwater Science and Engineering 2017年第2期5卷 182-192页

作者： WANG Yao HOU Li-sheng CAI Yun-long Development Research center of China Geological Survey Beijing 100037 China China Geological Survey Beijing 100037 China center for Land Study College of Urban and Environmental Sciences Peking University Beijing 100871 China

In recent years, research on spatial scale and scale transformation of eroded sediment transport has become a forefront field in current soil erosion research, but there are very few studies on the scale effect problem in Karst regions of China. Here we quantitatively extracted five main factors influencing soil erosion, namely rainfall erosivity, soil erodibility, vegetative cover and management, soil and water conservation, and slope length and steepness. Regression relations were built between these factors and also the sediment transport modulus and drainage area, so as to initially analyze and discuss scale effects on sediment transport in the Wujiang River Basin(WRB). The size and extent of soil erosion influencing factors in the WRB were gauged from: Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation Model(ASTER GDEM), precipitation data, land use, soil type and Normalized Difference Vegetation Index(NDVI) data from Global Inventory Modeling and Mapping Studies(GIMMS) or Advanced Very High Resolution Radiometer(AVHRR), and observed data from hydrometric stations. We find that scaling effects exist between the sediment transport modulus and the drainage area. Scaling effects are expressed after logarithmic transformation by a quadratic function regression relationship where the sediment transport modulus increases before decreasing, alongside changes in the drainage area. Among the five factors influencing soil erosion, slope length and steepness increases first and then decreases, alongside changes in the drainage area, and are the main factors determining the relationship between sediment transport modulus and drainage area. To eliminate the influence of scale effects on our results, we mapped the sediment yield modulus of the entire WRB, adopting a 1 000 km^2 standard area with a smaller fitting error for all sub-basins, and using the common Kriging interpolation method.

关键词： Sediment transport modulus Scale effect Soil erosion Wujiang River Basin

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Vascular Smooth Muscle Cell Development and Cardiovascular Malformations

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Cardiology Discovery 2021年第4期1卷 259-268页

作者： Lihua Qi Wei Kong Yi Fu Department of Human Anatomy Histology and EmbryologySchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Key Laboratory of Molecular Cardiovascular Science Ministry of EducationBeijing 100191China Beijing Key Laboratory of Cardiovascular Receptors Research Beijing 100191China

Vascular smooth muscle cells(VSMCs)have diverse biological functions that include maintaining the vascular structure and recruiting progenitors to form the embryonic vascular *** evidence suggests that the VSMCs are not just derived from the mesoderm,as previously thought,but have diverse developmental *** tracing analysis indicates that VSMCs have at least 7 different origins,thereby giving it the characteristic of a mosaic *** crucial role of the diverse origins of the VSMCs has been recognized in relation to blood vessel function and diseases such as *** VSMC distribution in cardiovascular development and whether and how their heterogeneous origins contribute to the overall cardiovascular development continue to be topics of ***,we review the current state of research,mainly focusing on the role of VSMCs in cardiovascular *** emphasize the following biological pathways:(1)normal course of development of VSMCs and their diverse origins in relation to cardiovascular development,(2)signaling regulation of progenitor cell development and differentiation into VSMCs,and(3)abnormal development of vascular smooth muscle and the associated cardiovascular malformations.

关键词： Vascular smooth muscle Development Diverse progenitor Signaling pathway Cardiovascular malformation

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Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population

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Chinese Medical Journal 2010年第22期123卷 3173-3177页

作者： SU Yin ZHAO Yi LIU Xu GUO Jian-ping JIANG Quan LIU Xiang-yuan ZHANG Feng-chun ZHENG Yi LI Xiao-xia SONG Hui HUANG Ci-bo HUANG Yan-hong WANG Tian PAN Si-si LI Chun LIU Xia ZHU Lei ZHANG Chun-fang LI Zhan-guo Department of Rheumatology & Immunology/Clinical Immunology center Peking University People's Hospital Beijing 100044 China Department of Clinical Epidemiology Peking University People's Hospital Beijing 100044 China Department of Rheumatology & Immunology Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China Department of Rheumatology & Immunology Peking University Third Hospital Beijing 100191 China Department of Rheumatology & Immunology Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100730 China Department of Rheumatology & Immunology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Department of Rheumatology & Immunology Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Rheumatology & Immunoiogy Beijing Jishuitan Hospital Beijing 100035 China Department of Rheumatology & Immunology Beijing Hospital Beijing 100730 China Department of Rheumatology & Immunology Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Background Recent studies have identified signal transducer and activator of transcription 4 （STAT4） as a susceptibility gene for systemic lupus erythematosus （SLE） in different populations. In order to examine whether the allele distribution of the single nucleotide polymorphism （SNP） in gene STAT4 rs7574865 in patients with SLE is different from those of healthy controls in Chinese Northern Han population, we investigated whether the variants of STAT4 rs7574865 were associated with any specific clinical features of SLE. Methods We genotyped SNPs in STAT4 rs7574865 in 252 patients with SLE and 497 healthy controls. All subjects were from the Northern part of Chinese Han population. The genotypes in rs7574865 were determined by polymerase chain reaction （PCR） and consequence direct sequencing of PCR products in the DNA samples. Results There was a significant difference in distribution of the SNPs in rs7574865 between the SLE patients and healthy controls. Compared with healthy controls, there was a significant correlation between TT genotypes in rs7574865 and the risk of SLE when GG genotype was used as a reference genotype after adjusting for gender and age. The frequency of T allele in the SLE patients was strongly significantly higher than that of healthy controls. Furthermore, there was a significant difference in the distribution of SNP in rs7574865 between male and female SLE patients, when compared with healthy controls. The frequency of T allele in rs7574865 in male patients was significantly higher than that of male healthy controls or female patients. There was no significant correlation between the frequencies of T allele in STAT4 rs7574865 and the clinical features of SLE. Conclusions The SNP rs7574865 in STAT4 is strongly associated with risk of SLE in the Chinese Northern Hart population. The TT genotype and T allele in STAT4 rs7574869 are susceptibility factors for SLE, especially for male SLE patients.

关键词： STAT4 systemic lupus erythematosus genetic association single-nucleoticle polymorphisms

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Insight into cellular dedifferentiation in regenerative medicine

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Science China(life sciences) 2020年第2期63卷 301-304页

作者： Tian Hu Bin Yao Sha Huang Xiaobing Fu Wound Healing and Cell Biology Laboratory Institute of Basic Medical SciencesGeneral Hospital of PLABeijing 100853China Key Laboratory of Tissue Repair and Regeneration of PLA Beijing Key Research Laboratory of Skin InjuryRepair and Regenerationthe Fourth Medical Center of General Hospital of PLABeijing 100048China MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineUniversity of OxfordJohn Radcliffe HospitalOxford OX39DUUK The Shenzhen Key Laboratory of Health sciences and Technology Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China tsinghua-Berkeley Shenzhen Institute(TBSI) Tsinghua UniversityShenzhen 518055China

The wonderful capacity of regeneration observed in some lower animals has been a focus of researchers for more than a ***,decoding this regenerative potential and its governing mechanisms has been *** are key questions that warrant investigation:how is regeneration elicited,initiated,and controlled;what are the cellular factors involved in regeneration and the processes that they undergo;does proliferation or differentiation come first;how is latestage regenerative patterning regulated;and how is tissue memory or positional identity maintained,as well as how repair and regeneration are balanced(Poss,2010).Some of these questions have been answered through in vivo studies,while others have remained unanswered.

关键词： maintained initiated challenging

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Monocyte activation and cardiovascular disease in HIV infection

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Cellular & Molecular Immunology 2017年第12期14卷 960-962页

作者： Hua Liang Zhe Xie Tao Shen State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChina CDCCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina Department of Microbiology and center of Infectious Diseases School of Basic Medical SciencesPeking UniversityBeijingChina

Antiretroviral therapy(ART)has increased the lifespan of HIVinfected individuals,which is now approaching that of the general ***,cardiovascular disease(CVD),including myocardial infarction,stroke,heart failure,and arrhythmia,is still a main cause of mortality in HIVpositive *** risk of CVD in people living with HIV is about 1.5–2-fold higher than that in the general population.1 Even in those successfully treated with ART,the incidence of CVD is still higher than that in uninfected individuals.2 Thus,in addition to the traditional risk factors associated with CVD,other factors(such as ART per se,inflammation,and immune activation caused by HIV infection)may be involved in CVD development.

关键词： cardiovascular mortality inflammation

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Probiotic mixture VSL#3 prevents ulcerative colitis-associated carcinogenesis in mice and cells by regulating the inflammatory and Wnt/β-catenin pathway

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Chinese Medical Journal 2022年第19期135卷 2357-2359页

作者： Wenbin Li Yanan Wang Chunsaier Wang Hongying Wang Yiming Ma Hong Yang Xinhua Zhao Xiaomin Hu John Y.Kao Jiaming Qian Chung Owyang Jingnan Li Department of Gastroenterology Key Laboratory of Gut Microbiota Translational Medicine ResearchPeking Union Medical Cllege HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100730China Department of Gastroenterology Bejing HospitalNational Center of GerontologyInstitute of Geriatic MedicineChinese Academy of Medical ScienceBejing 100730China National Cancer center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China Department of Central Laboratory Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CllegeBejing 100730China Department of Internal Medicine Division of GastroenterologyUniversity of Michigan Health SystemAnn ArborMIUSA.

To the Editor:Increasing attention is being paid to preventing ulcerative colitis(UC)-associated *** intestinal microbiota plays an important role in maintaining the intestinal barrier and immune *** mixture VSL#3,that was bought from Sigma-Tau pharmaceuticals(De Simone Formulation)in May 2015,is a mixture of Lactobacillus casei,***,***,*** ***,Bifidobacterium longum,***,*** and Streptococcus salivarius andcontains 4.5 billion live bacterialcolonies.i Previous studies have shown that VSL#3 can help induce and maintain UC *** effects of probiotics on UC-associated carcinogenesis are difficult to observe clinically;therefore,mouse models are often used to study this *** studies have shown that azoxymethane(AOM)combined with dextran sulfate sodium(DSS)can quickly induce a UC-associated carcinogenesis model.

关键词： carcinogenesis function. mixture

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Annual variations of black carbon over the Yangtze River Delta from 2015 to 2018

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Journal of Environmental sciences 2020年第10期32卷 72-84页

作者： Yue Tan Honglei Wang Shuangshuang Shi Lijuan Shen Chen Zhang Bin Zhu Song Guo zhijun Wu Ziyi Song Yan Yin Ankang Liu Collaborative Innouation center on Forecast and Evaluation of Meteorological Disasters Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological AdmiristrationNanjing Uniuersity of information Science & TechnologyNanjing 210044China State Key Joint Laboratory of Enuironment Simulation and Pollution Control(peking university)College of Enuironmental sciences and Engineering Peking UniuersityBeijing 100871China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100o29China

In this study,the black carbon (BC) measurements in the atmosphere of Nanjing,China were continuously conducted from 2015 to 2018 using a Model AE-33 *** combining dataset of PM_(2.5),PM_(10),CO,NO_2,SO_2,O_3 and meteorological parameters,the temporal variations and the source apportionment of BC were given in this *** results showed that the PM_(2.5) mass concentrations decreased in Nanjing,with an average annual rate of variation of 6.50μg/(m^3·year).Differently,the annual average concentrations of BC increased with an average annual variation rate of 214.71 ng/(m^3·year).The seasonal variations showed the pattern of BC mass concentrations in winter>autumn>spring>*** diurnal variations of BC mass concentrations showed a double-peak in all four *** first peak occurred at approximately 7:00 in spring,summer and autumn and around 8:00 in *** second peak took place after 18:*** average AAE (absorption ?ngstr?m exponent) was 1.26 with a maximum of 1.35 during wintertime and the lowest(1.12) during *** addition,the AAE was smaller in the daytime than that at night,with a minimum occurring between 13:00 and 14:*** and visibility show a good power-function relationship at different humidity *** average values of the visibility thresholds of the BC mass concentrations in spring,summer,autumn and winter were 1.326,5.522,1.340 and 0.708μg/m^3,*** greater the relative humidity,the smaller the visibility threshold for the BC mass concentrations was.

关键词： Black carbon(BC) Absorptionngstrm exponent(AAE) Meteorological elements Temporal characteristics

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Boosting wheat functional genomics via an indexed EMS mutant library of KN9204

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Plant Communications 2023年第4期4卷 58-76页

作者： Dongzhi Wang Yongpeng Li Haojie Wang Yongxin Xu Yiman Yang Yuxin Zhou Zhongxu Chen Yuqing Zhou Lixuan Gui Yi Guo Chunjiang Zhou Wenqiang Tang Shuzhi Zheng Lei Wang Xiulin Guo Yingjun Zhang Fa Cui Xuelei Lin Yuling Jiao Yuehui He Junming Li Fei He Xigang Liu Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Ministry of Education Key Laboratory of Molecular and Cellular Biology Hebei Key Laboratory of Molecular and Cellular BiologyCollege of Life SciencesHebei Normal UniversityHebei Collaboration Innovation Center for Cell SignalingShijiazhuang 050024China center for Agricultural Resources Research Institute of Genetics and Development BiologyChinese Academy of SciencesShijiazhuang 050022China university of Chinese Academy of sciences Beijing 100049China Department of life Science TcuniIncChengdu 610000China State Key Laboratory of Protein and Plant Gene Research Peking-Tsinghua Center for Life SciencesSchool of Life SciencesCenter for Quantitative BiologyPeking UniversityBeijing 100871China State Key Laboratory of Protein and Plant Gene Research School of Advanced Agricultural SciencesPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Plant Genetic Engineering center of Hebei Province Institute of Biotechnology and Food ScienceHebei Academy of Agriculture and Forestry SciencesShijiazhuang 050051China Institute ofCereal and OilCrops Hebei Academy of Agriculture and Forestry SciencesLaboratory of CropGenetics andBreeding ofHebeiShijiazhuang 050035China Key Laboratory of Molecular Module-Based Breeding of High Yield and Abiotic Resistant Plants in Universities of Shandong College of AgricultureLudong UniversityYantai 264025China Centre of Excellence for Plant and Microbial Science(CEPAMS) JIC-CASBeijing 100101China

A better understanding of wheat functional genomics can improve targeted breeding for better agronomic traits and environmental ***,the lack of gene-indexed mutants and the low transformation efficiency of wheat limit in-depth gene functional studies and genetic manipulation for *** this study,we created a library for KN9204,a popular wheat variety in northern China,with a reference genome,transcriptome,and epigenome of different tissues,using ethyl methyl sulfonate(EMS)*** library contains a vast developmental diversity of critical tissues and transition *** capture sequencing of 2090 mutant lines using KN9204 genome-designed probes revealed that 98.79%of coding genes had mutations,and each line had an average of 1383 EMS-type *** identified new allelic variations for crucial agronomic trait-related genes such as Rht-D1,Q,TaTB1,and *** tested 100 lines with severemutations in 80 NAC transcription factors(TFs)under drought and salinity stress and identified 13 lines with altered *** analysis of three lines using transcriptome and chromatin accessibility data revealed hundreds of direct NAC targets with altered transcription patterns under salt or drought stress,including SNAC1,DREB2B,CML16,and ZFP182,factors known to respond to abiotic ***,we have generated and indexed a KN9204 EMS mutant library that can facilitate functional genomics research and offer resources for genetic manipulation of wheat.

关键词： wheat exome capture sequencing EMS mutagenesis functional genomics

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