Economic evaluation of cervical cancer screening strategies in urban China

作     者：Li Ma Yuying Wang Xiaohong Gao Yi Dai Yu Zhang Zhaojing Wang Xiaoxia Wang Limin Wang Jing Jiang Xinhua Jing Chunxia Yang Fanghui Zhao Jinghe Lang Youlin Qiao 

作者机构：Department of EpidemiologySchool of Public HealthDalian Medical UniversityDalian 116044China Department of Obstetrics and GynecologyPeking Union Medical College HospitalChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100730China Department of Obstetrics and GynecologyWafangdian Maternal and Child Health Care HospitalDalian 116300China Department of Epidemiology and BiostatisticsWest China School of Public HealthSichuan UniversityChengdu 610041China Department of EpidemiologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2019年第31卷第6期

页      面：974-983页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Health Commission of the People’s Republic of China (formerly the Health and Family Planning Commission) of China (No. 201502004) 

主　　题：Cervical cancer Markov model economic evaluation 

摘      要：Objective:This study evaluated the feasibility of different cervical cancer screening strategies in urban ***:A Markov model was constructed to simulate a hypothetical cohort of 100,000 females aged 30-59 years in a 20-year *** strategies included liquid-based cytology(LBC)every three years,human papillomavirus(HPV)DNA testing every three and five years,respectively,and a combination of HPV DNA testing and LBC(HPV+LBC)every three and five years,*** outcomes included cumulative incidence over 20 years,cumulative risk of cervical cancer,costs,life year saved(LYS),quality-adjusted life years(QALYs)and *** cost-effectiveness ratios(CERs),incremental cost-effectiveness ratios(ICERs),costutility ratios(CURs),and benefit-cost ratios(BCRs)were used as outcomes in the health economic evaluation *** sensitivity analyses were performed to examine the stability of the ***:The cumulative incidence of the five screening strategies ranged from 833.02 to 1,158.07 cases per100,000 *** DNA testing was most effective in reducing the cumulative risk of cervical cancer,saving life years and QALYs and gaining *** CERs of HPV DNA testing every three and five years,and LBC every three years were considered to be very cost-effective if they were below China s GDP per *** CERs of HPV+LBC were considered to be cost-effective if they were below three times GDP per *** incremental cost-effectiveness analysis showed that HPV DNA testing every three and five years,LBC every three years and HPV+LBC every five years were dominant ***:The findings of this study indicated that HPV DNA testing every five years or LBC every three years should be recommended in urban China.