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Factors associated with self-rated mental health in mothers of children and adolescents with autism spectrum disorder

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2024年第11期25卷 1020-1030页

作者： Yanan ZHAO Huiyun FAN Rong ZHANG Xiaoying ZHENG School of Public health Peking UniversityBeijing100191China Faculty of health and Wellness City University of MacaoMacao999078China institute of Population Research Peking UniversityBeijing100871China Neuroscience Research institute Peking UniversityBeijing100191China Department of Neurobiology School of Basic Medical SciencesPeking UniversityBeijing100191China Key laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionBeijing100191China Autism Research Center Peking University Health Science CentreBeijing100191China School of Population Medicine and Public health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing100730China

The rising demand for child care is putting a strain on parents of children with autism spectrum disorder(ASD),particularly the *** study investigated Chinese mothers of children with ASD and examined the factors associated with maternal mental *** online national survey was completed by the parents of 5077 ASD children and adolescents aged 0–17 years.A total of 28.0%of the mothers reported poor mental health *** with children aged 10–13 years had a lower chance of having poor mental health status than mothers with children aged 0–2 years(odds ratio(OR)0.63,95%confidence interval(CI)0.43–0.91).Mothers of children with high-functioning autism were less likely to have poor mental health status than those of children with low-functioning autism(OR 0.76,95%CI 0.62–0.94).Having children with comorbidities was related with a higher risk of poor mental status(OR 1.56,95%CI 1.35–1.81),as were having conflicts with other family members(OR 1.44,95%CI 1.22–1.70)and providing full-time care(OR 1.22,CI 1.06–1.41).A higher-than-average family income was associated with lower risk of having poor mental health status(OR 0.70,95%CI 0.58–0.82).Factors related to the children and family,and providing full-time care,have a significant effect on mothers’mental health *** obstacles to work and social interaction,as well as tackling the financial burden of raising an ASD child,may help improve the well-being of mothers.

关键词： Autism spectrum disorder(ASD) Mother Mental health status Influencing factor

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Pediatric body mass index trajectories and the risk of hypertension among adolescents in China:a retrospective cohort study

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World Journal of Pediatrics 2023年第1期19卷 76-86页

作者： Wen-Xin Ge Di Han Zi-Yao Ding Li-Ping Yi Zhuo-Qiao Yang Xin-Nan Wang Yue Xiao Fei Liang Bo Hai Hui-Ling Lv Hui Shen Hai-Bing Yang Jie-Yun Yin Jia Hu Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases School of Public HealthMedical College of Soochow University199 Renai RoadSuzhou 215123China Suzhou Center for Disease Prevention and Control 72 Sanxiang RoadSuzhou 215004China institute of child and adolescent health School of Public HealthPeking UniversityBeijingChina Department of Epidemiology School of Public HealthKey Laboratory of Public Health SafetyMinistry of EducationFudan UniversityShanghaiChina State Key Laboratory of Reproductive Medicine School of Public HealthNanjing Medical UniversityNanjingChina Suzhou institute of Advanced Study in Public health Gusu SchoolNanjing Medical UniversitySuzhouChina

Background The impact of pediatric body mass index(BMI)trajectories on the risk of adolescent hypertension(HTN)determined by three separate visits remains *** longitudinal study aims to identify potential pediatric sex-specific BMI trajectories and to assess their associations with HTN and HTN *** Based on the health Promotion Program for children and adolescents(HPPCA)in Suzhou,China,a total of 24,426 participants who had initial normal blood pressure(BP)and had at least four BMI measurements during 2012-2020 were *** was defined as simultaneously having three separate visits of elevated BP in *** class growth models were used to explore sex-specific BMI trajectories,whose associations with HTN and HTN subtypes were further examined by logistic *** The incidence of HTN determined through three separate visits was 3.34%.Four trajectories were identified for both sexes:low BMI increasing,medium BMI increasing,high BMI increasing,and highest BMI *** to the medium BMI increasing group,the odds ratio(95%confidential interval)for developing adolescent HTN of the low,high,and highest BMI increasing groups among boys were 0.54(0.39,0.75),1.90(1.44,2.51),and 2.89(1.90,4.39),respectively;and the corresponding values for girls were 0.66(0.48,0.90),2.30(1.72,3.09),and 4.71(3.06,7.26).Similar gradually elevated associations between different trajectories with isolated systolic hypertension,systolic and diastolic hypertension were *** Current results emphasized the adverse effects of stable high BMI on HTN and the benefits of maintaining normal weight throughout childhood.

关键词： Body mass index children Hypertension Pediatric Trajectories

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Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018

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China CDC weekly 2022年第29期4卷 640-645页

作者： Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang institute of Reproductive and child health/Key Laboratory of Reproductive health National Health Commission of the People’s Republic of ChinaPeking UniversityBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Information and Statistics Beijing Center for Disease Prevention and ControlBeijingChina Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning B

Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging *** prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by *** is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was *** overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in *** are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control.

关键词： Metabolic prevention smoke

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Epidemiological characteristics of childhood obesity in eastern China, 2017-2019

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World Journal of Pediatrics 2019年第4期15卷 412-414页

作者： Xi-Yan Zhang Wen-Yi Yang Jie Yang Yan Wang Yao Xiang Liu-Wei Gao Feng-Yun Zhang Yong-Lin Zhou Department of child and adolescent health Promotion Jiangsu Provincial Center for Disease Control and PreventionNo.172 Jiangsu RoadNanjing 210009China Public health Research institute of Jiangsu Province NanjingChina School of Public health Southeast UniversityNanjingChina

childhood obesity has becoming an increasing concern in many countries including China [1-3].Located in the eastern China,Jiangsu Province is one of the developed regions in China and is also facing this problem.

关键词： childhood obesity Epidemiology Jiangsu province Risk factors

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Effectiveness of resilience-promoting interventions in adolescents with diabetes mellitus:a systematic review and meta-analysis

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World Journal of Pediatrics 2023年第4期19卷 323-339页

作者： Yi Wu Yi-Yun Zhang Ya-Ting Zhang Hui-Jing Zhang Tian-Xue Long Qi Zhang Jing Huang Ming-Zi Li peking university health Science Center 38 Huayuan RoadHaidian DistrictBeijing100191China School of Nursing Peking UniversityBeijingChina peking university health Science Centre for Evidence-Based Nursing A Joanna Briggs Institute Affiliated GroupBeijingChina School of Nursing Jilin UniversityChangchunChina

Background This study aimed to analyze the efficacy of resilience-promoting interventions among adolescents and youth aged 10-24 years with any type of *** A systematic literature search was performed using the PubMed,Web of Science,Embase,Cochrane Library,CINAHL,and PsycINFO databases from inception to May 25,*** Cochrane risk of bias tool(version 2)was used to assess the quality of the included studies.A meta-analysis was performed to calculate the pooled effects of resilience-promoting *** Nineteen articles were included covering an overall sample of 2048 adolescents with *** analyzing the effectiveness of resilience-promoting interventions,hemoglobin A1c(HbA1c)at six months[mean difference=-0.47,95%confidence interval(CI)=-0.83 to-0.12,P=0.009]after the intervention was ***,long-term(≥12 months)improvement in HbA1c was not *** addition,comparing the control group,there were significant differences in the effect size for stress[standardized mean difference(SMD)=-0.87,95%CI=-1.25 to-0.48,Padolescent diabetes management to improve HbA1c,stress,self-efficacy,and quality of *** resilience-promoting components into diabetes education and re-enforcing these contents every six months are recommended for implementation in clinical practice.

关键词： adolescents Diabetes mellitus Intervention Meta-analysis Resilience

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Cesarean delivery on maternal request and childhood intelligence： a cohort study

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Chinese Medical Journal 2011年第23期124卷 3982-3987页

作者： LI Hong-tian YE Rong-wei PEI Li-jun REN Ai-guo ZHENG Xiao-ying LIU Jian-meng institute of Reproductive and child health/Ministry of health Key Laboratory of Reproductive health Peking University Health Science Center Beijng 100191 China

Background Cesarean section births have been steadily increasing over the past decade and have become an epidemic in China. Cesarean delivery on maternal request is a major contributor to this upward trend, and there has been of much concern about its impact on maternal and child health. Most of mothers believe that cesarean delivery on maternal request can improve the child＇s intelligence, but direct evidence is sparse. In this cohort study, we aimed to directly assess the impact of cesarean delivery on maternal request on childhood intelligence. Methods Intelligence quotient （IQ） of 4144 preschool children from 21 cities/counties of Zhejiang and Jiangsu province whose mothers were registered in a population-based perinatal surveillance program during 1993-1996 was assessed with Chinese Wechsler Young children Scale of Intelligence （C-WYCSI） in 2000. The outcomes were full-scale IQ, verbal IQ, and performance IQ of C-WYCSI. Mode of delivery and covariates were obtained from the surveillance program. We estimated unadjusted and adjusted effects of cesarean delivery on maternal request and assisted vaginal delivery on IQ scores compared with spontaneous vaginal delivery using regression analysis. Results The mean full-scale, verbal, and performance IQ for all children was 99.3_＋16.1,93.6_＋17.7, and 105.3_＋14.3. In crude analysis, cesarean delivery on maternal request versus spontaneous vaginal delivery was associated with an increase of 3.9 （95% confidence interval, 0.6 to 7.2） points in full-scale IQ, 4.8 （1.2 to 8.4） points in verbal IQ, and 2.4 （-0.6 to 5.3） points in performance IQ. After adjusting for maternal education, occupation, and IQ, the advantage was reduced to 1.6 （-1.3 to 4.5）, 2.3 （-0.8 to 5.5）, and 0.6 （-2.0 to 3.3） points for full-scale, verbal, and performance IQ, respectively. Assisted vaginal delivery versus spontaneous vaginal delivery was not associated with IQ scores in any analysis. Conclusion Neither cesarean delivery on maternal request nor

关键词： cesarean delivery on maternal request child intelligence quotient

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Modeling the Prevalence of Asymptomatic COVID-19 Infections in the Chinese Mainland

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The Innovation 2020年第2期1卷 64-68,63页

作者： Xiaoqian Jia Junxi Chen Liangjing Li Na Jia Bahabaike Jiangtulu Tao Xue Le Zhang Zhiwen Li Rongwei Ye Bin Wang institute of Reproductive and child health Peking University/Key Laboratory of Reproductive HealthNational Health Commission of the People's Republic of ChinaBeijing 100191P.R.China Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191P.R.China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071P.R.China These authors contributed equally

Recently,considerable efforts have been focused on intensifying the screening process for asymptomatic COVID-19 cases in the ChineseMainland,especially for up to 10 million citizens living in Wuhan City by nucleic acid ***,a high percentage of domestic asymptomatic cases did not develop into symptomatic ones,which is abnormal and has drawn considerable public ***,we aimed to investigate the prevalence of COVID-19 infections in the Chinese Mainland from a statistical perspective,as it is of referential significance for other *** conservatively assuming a development time lag from pre-symptomatic(i.e.,referring to the infected cases that were screened before the COVID-19 symptom onset)to symptomatic as an incubation time of 5.2 days,our results indicated that 92.5%of those tested in Wuhan City,China,and 95.1%of those tested in the Chinese Mainland should have COVID-19 syndrome onset,which was extremely higher than their corresponding practical percentages of 0.8%and 3.3%,*** propose that a certain false positive rate may exist if large-scale nucleic acid screening tests for asymptomatic cases are conducted in common communities with a low incidence *** adopting relatively high-sensitivity,high-specificity detection kits,we estimated a very low prevalence of COVID-19 infections,ranging from 106 to 104 in both Wuhan City and the Chinese ***,the prevalence rate of asymptomatic infections in China had been at a very low ***,given the lower prevalence of the infection,close examination of the data for false positive results is necessary to minimize social and economic impacts.

关键词： COVID-19 ASYMPTOMATIC INFECTIONS SUBCLINICAL INFECTION BAYES'FORMULA CHINA

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Australian children living with rare diseases:health service use and barriers to accessing care

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World Journal of Pediatrics 2023年第7期19卷 701-709页

作者： Suzy Teutsch Yvonne Zurynski Guy DEslick Marie Deverell John Christodoulou Helen Leonard Troy Dalkeith Sandra LJJohnson Elizabeth JElliott Faculty of Medicine and health Discipline of Child and Adolescent HealthThe University of SydneySydneyNSWAustraliaAustralian Australian Paediatric Surveillance Unit Kids ResearchSydney Children's Hospitals NetworkWestmeadNSWAustralia Australian institute of health Innovation Center for Healthcare Resilience and Implementation Scienceand NHMRC Partnership Centre in Health System SustainabilityMacquarie UniversitySydneyNSWAustraliaFaculty of Medicine and HealthDiscipline of Child and Adolescent HealthThe University of SydneySydneyNSWAustralia Government Department of health Western Australia PerthWAAustralia Murdoch children's Research institute and Victorian Clinical Genetics Services Royal Children's HospitalParkvilleVICAustralia Department of Paediatrics The University of MelbourneParkvilleVICAustralia Telethon Kids institute The University of Western AustraliaNedlandsWAAustralia Genetic Metabolic Disorders Service Sydney Children's Hospitals NetworkWestmeadNSWAustralia

Background children with rare diseases experience challenges at home and school and frequently require multi-disciplinary *** aimed to determine health service utilization by Australian children with rare diseases and barriers to access-ing *** Parents completed an online survey on health professional and emergency department(ED)presentations,hospi-talization,and barriers to accessing *** barriers to service access included residential location(city,regional,remote)and child health-related functioning,determined using a validated,parent-completed measure-of-function *** Parents of 462 children with over 240 rare diseases completed the *** with the general population,these children were more likely to be hospitalized[odds ratio(OR)=17.25,95%confidence interval(CI)=15.50-19.20]and present to the ED(OR=4.15,95%CI=3.68-4.68)or a family physician(OR=4.14,95%CI=3.72-4.60).child functional impairment was nil/mild(31%),moderate(48%)or severe(22%).Compared to children with nil/mild impair-ment,those with severe impairment were more likely to be hospitalized(OR=13.39,95%CI=7.65-23.44)and present to the ED(OR=11.16,95%CI=6.46-19.27).Most children(75%)lived in major cities,but children from regional(OR=2.78,95%CI=1.72-4.55)and remote areas(OR=9.09,95%CI=3.03-25.00)experienced significantly more barriers to healthcare access than children from major *** included distance to travel,out-of-pocket costs,and lack of specialist medical and other health *** children with rare diseases,especially those with severe functional impairment have an enormous impact on health services,and better integrated multidisciplinary services with patient-centered care are *** must be improved for children living in rural and remote settings.

关键词： Access health functioning health service use Rare diseases

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Attention-deficit/hyperactivity disorder and suicide:A systematic review

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World Journal of Psychiatry 2017年第1期7卷 44-59页

作者： Judit Balazs Agnes Kereszteny Vadaskert child and adolescent Psychiatry Hospital institute of Psychology Eotvos Loránd University School of Ph.D. Studies Semmelweis University

AIM To investigate suicidality and attention-deficit/hyperactivity disorder(ADHD), this paper aims to systematically review the literature as an extension of previous *** We searched five databases(Ovid MEDLINE, Psychinfo, PubM ed, Scopus, Web of Science) with two categories of search terms:(1) suicide; suicidal; suicide behavior; suicide attempt; suicidal thought; and(2) ADHD. RESULTS The search resulted 26 articles. There is a positive association between ADHD and suicidality in both sexes and in all age groups. Comorbid disorders mediate between suicidality and ADHD. CONCLUSION Recognizing ADHD, comorbid conditions and suicidality is important in prevention.

关键词： Attention-deficit/hyperactivity disorder Suicide Systematic review

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Altered microRNA expression profiles of human spermatozoa in normal fertile men of different ages

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Asian Journal of Andrology 2023年第6期25卷 737-744页

作者： Ming-Jia Zhao Yao-Nan Zhang Yong-Ping Zhao Xian-Bing Chen Bao-Sheng Han Ning Ding Yi-Qun Gu Shu-Song Wang Jing Ma Mei-Ling Liu Graduate School of peking Union Medical College Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China National health Commission Key Laboratory of Male Reproductive health National Research Institute for Family PlanningBeijing 100081China Department of Reproduction and Genetics Maternity and Child Health Care HospitalTangshan 063000China Department of Family Planning and Reproductive Medicine Peking University People’s HospitalBeijing 100081China Hebei Key Laboratory of Reproductive Medicine Hebei Institute of Reproductive Health Science and TechnologyShijiazhuang 050071China

MicroRNAs(miRNAs)are mediators of the aging *** purpose of this work was to analyze the miRNA expression profiles of spermatozoa from men of different ages with normal ***-seven donors were divided into three groups by age(Group A,n=8,age:20–30 years;Group B,n=10,age:31–40 years;and Group C,n=9,age:41–55 years)for high-throughput sequencing *** from 65 individuals(22,22,and 21 in Groups A,B,and C,respectively)were used for validation by quantitative real-time polymerase chain reaction(qRT-PCR).A total of 2160 miRNAs were detected:1223 were known,937 were newly discovered and unnamed,of which 191 were expressed in all donors.A total of 7,5,and 17 differentially expressed microRNAs(DEMs)were found in Group A vs B,Group B vs C,and Group A vs C comparisons,***-two miRNAs were statistically correlated with *** miRNAs were identified as age-associated miRNAs,including hsa-miR-127-3p,mmu-miR-5100_L+2R-1,efu-miR-9226_L-2_1ss22GA,cgr-miR-1260_L+1,hsa-miR-652-3p_R+1,pal-miR-9993a-3p_L+2R-1,hsa-miR-7977_1ss6AG,hsa-miR-106b-3p_R-1,hsa-miR-186-5p,PC-3p-59611_111,hsa-miR-93-3p_R+1,and aeca-mir-8986ap5_*** were 9165 target genes of age-associated *** Ontology(GO)analysis of the target genes identified revealed enrichment of protein binding,membrane,cell cycle,and so *** Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis of age-related miRNAs for target genes revealed 139 enriched pathways,such as signaling pathways regulating stem cell pluripotency,metabolic pathways,and the Hippo signaling *** suggests that miRNAs play a key role in male fertility changes with increasing age and provides new evidence for the study of the mechanism of age-related male fertility decline.

关键词： age fertility microRNA spermatozoa

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