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Global variation in skin injures and skincare practices in extremely preterm infants

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World Journal of pediatrics 2023年第2期19卷 139-157页

作者： Pranav Jani Umesh Mishra Julia Buchmayer Rajesh Maheshwari Daphne D’Çruz Karen Walker Duygu Gözen Krista Lowe Audrey Wright James Marceau Mihaela Culcer Archana Priyadarshi Adrienne Kirby James EMoore Ju Lee Oei Vibhuti Shah Umesh Vaidya Abdelmoneim Khashana Sunit Godambe Fook Choe Cheah Wen-Hao Zhou Xiao-Jing Hu Muneerah Satardien Faculty of Medicine and Health The University of SydneySydneyNSWAustralia Department of neonatology Westmead HospitalWestmeadNSW2145Australia Comprehensive Center for pediatrics Department of Pediatrics and Adolescent MedicineDivision of NeonatologyPediatric Intensive Care and NeuropediatricsMedical University of ViennaViennaAustria Department of Newborn Care Royal Prince Alfred HospitalCamperdownNSWAustralia Council of International Neonatal Nurses BostonMAUSA The George Institute for Global Health SydneyNSWAustralia Sydney Institute for Women Children and Their FamiliesSydneyNSWAustralia pediatric Nursing Department Florence Nightingale Faculty of Nursingİstanbul University-CerrahpaşaIstanbulTurkey The National Health and Medical Research Council Clinical Trials Centre University of SydneySydneyNSWAustralia Connecticut Children’s Division of Neonatal-Perinatal Medicine Connecticut Children’s Medical CenterHartfordCTUSA UCONN School of Medicine FarmingtonCTUSA The Royal Hospital for Women RandwickNSWAustralia School of Women’s and Children’s Health University of New South WalesRandwickNSWAustralia Department of Paediatrics and Institute of Health Policy Management and EvaluationMount Sinai HospitalTorontoCanada Department of pediatrics King Edward Memorial HospitalPuneIndia pediatrics Suez Canal UniversityIsmailiaEgypt Divisional Director for Clinical Governance Women’sChildren’s and Clinical SupportImperial College Healthcare NHS TrustLondonUK Department of pediatrics Faculty of MedicineUniversiti KebangsaanBangiMalaysia Hospital Canselor Tuanku Muhriz Jalan Yaacob LatifBandar Tun RazakKuala LumpurMalaysia Department of neonatology and Vice President Children’s Hospital of Fudan UniversityShanghaiChina Vice Director of Nursing Department Children’s Hospital of Fudan UniversityShanghaiChina Department of Paediatrics and Child Health Tygerberg HospitalCape TownSouth Africa University of Stellenbosch Cape TownSouth Africa

Background Globally,are skincare practices and skin injuries in extremely preterm infants comparable?This study describes skin injuries,variation in skincare practices and investigates any association between *** A web-based survey was conducted between February 2019 and August *** skin injuries and describing skincare practices in extremely preterm infants were the main *** association between skin injuries and skincare practices was established using binary multivariable logistic regression adjusted for *** Responses from 848 neonatal intensive care units,representing all geographic regions and income status groups were *** dermatitis(331/840,39%)and medical adhesive-related skin injuries(319/838,38%)were the most common *** a local skincare guideline reduced skin injuries[medical adhesive-related injuries:adjusted odds ratios(aOR)=0.63,95%confidence interval(CI)=0.45–0.88;perineal injuries:aOR=0.66,95%CI=0.45–0.96;local skin infections:OR=0.41,95%CI=0.26–0.65;chemical burns:OR=0.46,95%CI=0.26–0.83;thermal burns:OR=0.51,95%CI=0.27–0.96].Performing skin assessments at least every four hours reduced skin injuries(abrasion:aOR=0.48,95%CI=0.33–0.67;pressure:aOR=0.51,95%CI=0.34–0.78;diaper dermatitis:aOR=0.71,95%CI=0.51–0.99;perineal:aOR=0.52,95%CI=0.36–0.75).Regional and resource settings-based variations in skin injuries and skincare practices were *** Skin injuries were common in extremely preterm *** in practice and improved surveillance appears to reduce the occurrence of these *** evidence regarding optimal practices is needed to reduce skin injuries and minimize practice variations.

关键词： Extremely premature infants Injuries Neonatal intensive care unit Skin care Wounds

TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyroptosis and ischemic brain damage

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Neural Regeneration Research 2021年第6期16卷 1037-1043页

作者： Lan-Lan Tan Xiao-Lu Jiang Li-Xiao Xu Gen Li Chen-Xi Feng Xin Ding Bin Sun Zheng-Hong Qin Zu-Bin Zhang Xing Feng Mei Li Department of neonatology Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of pediatrics Research Institute Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Neuropsychiatric Diseases Department of PharmacologyCollege of Pharmaceutical SciencesSoochow UniversitySuzhouJiangsu ProvinceChina

Our previous studies have demonstrated that TP53-induced glycolysis and apoptosis regulator(TIGAR)can protect neurons after cerebral ischemia/***,the role of TIGAR in neonatal hypoxic-ischemic brain damage(HIBD)remains *** the present study,7-day-old Sprague-Dawley rat models of HIBD were established by permanent occlusion of the left common carotid artery followed by 2-hour *** 6 days before induction of HIBD,a lentiviral vector containing short hairpin RNA of either TIGAR or gasdermin D(LV-sh_TIGAR or LV-sh_GSDMD)was injected into the left lateral ventricle and *** aggressively proliferating immortalized(HAPI)microglial cell models of in vitro HIBD were established by 2-hour oxygen/glucose deprivation followed by 24-hour *** days before in vitro HIBD induction,HAPI microglial cells were transfected with LV-sh_TIGAR or LV-sh_*** results showed that TIGAR expression was increased in the neonatal rat cortex after HIBD and in HAPI microglial cells after oxygen/glucose deprivation/*** TIGAR knockdown in rats markedly worsened pyroptosis and brain damage after hypoxia/ischemia in vivo and in *** of exogenous nicotinamide adenine dinucleotide phosphate(NADPH)increased the NADPH level and the glutathione/oxidized glutathione ratio and decreased reactive oxygen species levels in HAPI microglial cells after oxygen/glucose deprivation/***,exogenous NADPH blocked the effects of TIGAR knockdown in neonatal HIBD in vivo and in *** findings show that TIGAR can inhibit microglial pyroptosis and play a protective role in neonatal *** study was approved by the Animal Ethics Committee of Soochow University of China(approval No.2017LW003)in 2017.

关键词： hypoxic-ischemic brain damage in vitro in vivo microglia NADPH pyroptosis ROS TIGAR

Using Fentanyl as An Analgesia for Preterm Infants during Mechanical Ventilation

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Using Fentanyl as An Analgesia for Preterm Infants during Me...

Predictors of poor outcomes in children with tracheoesophageal fistula/oesophageal atresia:an Australian experience

第五届亚洲儿科研究大会

作者： Chun Chen Zhenlang Lin Yaping Shi Jin Lin Department of neonatology Yuying Children’s Hospital Wenzhou Medical College Wenzhou China 325027 Department of neonatology Yuying Children''s HospitalWenzhou Medical CollegeWenzhou China 325027

＜正＞Objective To examine analgesic effect and side effects of fentanyl on preterm infants who were on mechanical ventilation for respiratory distress syndrome（RDS）. Methods Premature infants on mechanical ventilation for RDS were randomly assigned into two groups. The treatment group（n=30） received fentanyl for a total of 48 hours by continuous infusion at 2μg/kg.h for

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World Journal of pediatric Surgery 2021年第2期4卷 1-6页

作者： Nicole Lee Chui Hew Zubin Grover Sanjay Paida Sanchita Gera Rachel Zie Ting Effendy Colin Kikiros Parshotam Gera General Surgery Bunbury HospitalBunburyWestern AustraliaAustralia Gastroenterology Perth Children's HospitalNedlandsWestern AustraliaAustralia neonatology Perth Children's HospitalNedlandsWestern AustraliaAustralia Faculty of Medicine Dentistry and Health SciencesThe University of Western AustraliaPerthWestern AustraliaAustralia Intensive Care unit Caboolture HospitalCabooltureQueenslandAustralia General Surgery Perth Children's HospitalNedlandsWestern AustraliaAustralia

Objective The aim of this study is to characterize long-term morbidities of oesophageal atresia(OA)with or without tracheoesophageal fistula(TOF).Methods Infants born with OA/TOF from 2000 to 2016 in Western Australia were included for *** were categorized into high-risk and low-risk groups based on the presence of one or more perioperative risk factors[low birth weight,vertebraldefects,anal atresia,cardiac defects,TOF,renalanomalies,limb abnormalities(VACTERL),anastomotic leak,long gap OA,and failure to establish oral feeds within the first month]identified by a previous Canadian *** of morbidities in infants with perioperative risk factors was *** Of 102 patients,88(86%)had OA with distal TOF(type C).The most common morbidities in our cohort were anastomotic oesophageal strictures(AS)(n=53,52%),tracheomalacia(n=48,47%),gastroesophageal reflux disease(GORD)(n=42,41%)and recurrent respiratory tract infections(n=40,39%).Presence of GORD(30/59 vs 12/43,p=0.04)and median frequency of AS dilatations(8 vs 3,n=59,p=0.03)were greater in the high-risk *** study further confirmed that inability to be fed orally within the first month was associated with high *** Gastrointestinal and respiratory morbidities remain high in OA/TOF regardless of perioperative risk *** to be fed orally within the first month is a predictor of poor outcomes with high frequency of gastrointestinal and respiratory comorbidities.

关键词： analysis. fir defects

Reading impairment after neonatal hypoglycemia with parietotemporo-occipital injury without cortical blindness:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3899-3906页

作者： Naoko Kurahashi Shunsuke Ogaya Yuki Maki Norie Nonobe Sumire Kumai Yosuke Hosokawa Chikako Ogawa Keitaro Yamada Koichi Maruyama Kiyokuni Miura Miho Nakamura Department of pediatric Neurology Central HospitalAichi Developmental Disability CenterKasugai 480-0392AichiJapan Department of pediatrics Nagoya University Graduate School of MedicineNagoya 466-8560AichiJapan Division of neonatology Center for Maternal-Neonatal Care Nagoya University HospitalNagoya 466-8560AichiJapan Department of pediatrics Tokyo Metropolitan Fuchu Medical Center for the DisabledFuchu 183-0042TokyoJapan Department of Functioning and Disability Institute for Developmental ResearchAichi Developmental Disability CenterKasugai 480-0392AichiJapan Okazaki Medical Center for Child Development Okazaki 444-0011AichiJapan

BACKGROUND Perinatal brain injury may lead to later neurodevelopmental disorders,whose outcomes may vary due to neuroplasticity in young *** neuroimaging studies have shown that the left parietotemporal area(which includes the left inferior parietal lobe)is associated with phonological awareness and decoding skills,which are essential skills for reading acquisition in ***,the literature on the effect of perinatal cerebral injury on the development of phonological awareness or decoding ability in childhood is *** SUMMARY We report the case of an 8-year-old boy who presented with reading difficulty following a perinatal injury in the parieto-temporal-occipital *** patient was born at term and was treated for hypoglycemia and seizures during the neonatal ***-weighted brain magnetic resonance imaging on postnatal day 4 revealed cortical and subcortical hyperintensities in the parieto-temporo-occipital *** the age of 8 years,physical examination was unremarkable,aside from mild *** occipital lobe injury,the patient had adequate visual acuity,normal eye movement,and no visual field ***-scale intelligence quotient and verbal comprehension index on Wechsler Intelligence Scale for Children-Fourth Edition were 75 and 90,*** assessment revealed adequate recognition of Japanese Hiragana ***,he had significantly slower reading speed in the Hiragana reading test than control *** phonological awareness test revealed significant errors(standard deviation+2.7)in the mora reversal *** Patients with perinatal brain injuries in the parietotemporal area require attention and may benefit from additional reading instructions.

关键词： Brain diseases Hypoglycemia Dyslexia Long-term care Education Case report

Proteinuria in Children Living with HIV on Highly Active Antiretroviral Therapy (Haart)

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Open Journal of pediatrics 2020年第2期10卷 255-262页

作者： Lucie Charlotte Ollandzobo Ikobo Roland Bienvenu Ossibi Ibara Neli Yvette Ngakengni Laren Babomi Gaston Ekouya Bowassa Linda Tchidjo Ngamo Steve Vassili Missambou Mandilou Sabrina Nadia Bouithy Evrard Romaric Nika Jean Robert Mabiala Babela Faculty of Health Sciences Marien Ngouabi University of Brazzaville Brazzaville Republic of Congo pediatric Services Brazzaville University Hospital Brazzaville Republic of Congo Infectious Diseases Service Brazzaville University Hospital Brazzaville Republic of Congo Department of neonatology Brazzaville University Hospital Brazzaville Republic of Congo Department of Internal Medicine and Cardiology Talangai Hospital Brazzaville Republic of Congo

Objective: To determine the prevalence of proteinuria in children living with HIV (CLHIV) and identify associated factors. Patients and methods: This was a cross-sectional, descriptive and analytical study carried out from April to August 2017 in the HIV care centres in Brazzaville and Pointe-Noire. The study included CLHIV with dipstick urinalysis test “Combur10 Test® M”. Results: Thirty seven CLHIV on HAART presented a proteinuria, 21.8%. Children were male gender in 21 cases (56.8%) and female gender in 16 cases (43.2%). Mean age was 10.9 ± 3.9 years. The children were infected with type 1 virus in 35 cases (94.6%), vertical transmission in all the cases (100%). Children were living with HIV for about 2 to 4 years of average n = 18 (48.6%) and they were WHO clinical stage 2 in 18 cases (48.6%). 13 children (35%) had CD4 level 3. All CLHIV (100%) were on HAART thus 20 (37.7%) on the combination of zidovudine (AZT), lamivudine (3TC) and nevirapine (NVP). This combination AZT, 3TC, NVP was a protective factor regarding the occurrence of proteinuria (OR: 0.43;IC (95%). Conclusion: Proteinuria

Perinatal morbidity and early neonatal mortality in twin pregnancies

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 78-89页

作者： Corinna Peter Paul Wenzlaff Jan Kruempelmann Gerhard Alzen Eva Bueltmann Susanne E. Gruessner Center for Quality Assurance and Management in Health Care Hannover Germany Department for Trauma and Orthopaedic Surgery Insurance Accident and Prevention Clinic Frankfurt am Main Germany Department of Obstetrics and Gynaecology Justus-Liebig University of Giessen Giessen Germany&Department of Obstetrics Gynaecology and Reproductive Medicine Hannover Medical School Hannover Germany Department of pediatric Pulmonology Allergology and Neonatology Hannover Medical School Hannover Germany Department of pediatric Radiology University of Giessen Giessen Germany Institute of Diagnostic and Interventional Neuroradiology Hannover Medical School Hannover Germany

Purpose: The purpose of this study was to investigate the impact of maternal, fetal and obstetric parameters in twin pregnancies due to chorionicity, perinatal morbidity and early neonatal mortality. Methods: Early neonatal outcome parameters were retrospectively analysed in 240 twin pregnancies (51 monochorionic [MC], 189 dichorionic [DC] twins) over a 7.5 years period. Beside chorionicity, we focused on risk factors affecting perinatal morbidity and early neonatal outcome in the overall study cohort and subgroups 1) late preterm and 2) pregnancies conceived by artificial fertilization (IVF/ICSI). Mixed effects logistic regression models were used for multivariate risk analyses. Results: MC vs DC pregnancies showed significantly lower birth weights (p 25% and amniotic inflammation (amniotic infection syndrome [AIS]). A gestational age >36 completed weeks was accompanied by a decrease of early neonatal complications

关键词： Twins Chorionicity Obstetric Outcome Perinatal Morbidity Early Neonatal Outcome

欧洲新生儿呼吸窘迫综合征防治指南-2010版

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中华儿科杂志 2011年第1期49卷 27-33页

作者： Sweet DG Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 袁琳(翻译) 陈超(审校) Regional Neonatal unit Royal Maternity HospitalBelfast UK Dipartimento di Neonatologia Ospedale Universitario di Ancona Universita Politecnica delle Marche Ancona Department of neonatology Rigshospitalet and University of Copenhagen Copenhagen Denmark Department of pediatrics institute of Clinical Medicine Oulu UniversityHospital University of Oulu Oulu Finland Department of pediatrics Marmara University Medical Faculty Istanbul Turkey Division of neonatology Department of Obstetrics and Gynecology General Faculty Hospital and 1st Faculty of MedicineCharles University Prague Czech Republic Department of pediatric Research Rikshospitalet Medical Center Faculty of MedicineUniversity of Oslo Oslo Norway Service de Neonatologie Hopital de la Conception Assistance Publique-I-Iopitauxde Marseille Marseille France Department of pediatrics University Children's Hospital Wtirzburg Germany Department of Child Health Queen's University Belfast and RoyalMaternity Hospital Belfast UK 不详

呼吸窘迫综合征（RDS）是由于肺表面活性物质（PS）缺乏及肺结构发育不成熟所致，多见于早产儿，自然病程为生后当时或很快发病，并在生后2d内进行性恶化，如不及时治疗，因进行性缺氧和呼吸衰竭而死亡，存活者，在生后2—4d病情开始改... 详细信息

呼吸窘迫综合征（RDS）是由于肺表面活性物质（PS）缺乏及肺结构发育不成熟所致，多见于早产儿，自然病程为生后当时或很快发病，并在生后2d内进行性恶化，如不及时治疗，因进行性缺氧和呼吸衰竭而死亡，存活者，在生后2—4d病情开始改善。胎龄越小，RDS发生率越高，2006年EuroNeoStat的数据显示：胎龄23～25周的早产儿RDS发生率为91％，

关键词：呼吸窘迫综合征肺表面活性物质缺氧呼吸衰竭

Comparison of acute pneumonia caused by SARS-CoV-2 and other respiratory viruses in children:a retrospective multi-center cohort study during COVID-19 outbreak

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Military Medical Research 2021年第4期8卷 468-480页

作者： Guang-Li Ren Xian-Feng Wang Jun Xu Jun Li Qiong Meng Guo-Qiang Xie Bo Huang Wei-Chun Zhu Jing Lin Cheng-He Tang Sheng Ye Zhuo Li Jie Zhu Zhen Tang Ming-Xin Ma Cong Xie Ying-Wen Wu Chen-Xi Liu Fang Yang Yu-Zong Zhou Ying Zheng Shu-Ling Lan Jian-Feng Chen Feng Ye Yu He BenQing Wu Long Chen Si-Mao Fu Cheng-Zhong Zheng Yuan Shi Department of pediatrics General Hospital of Southern Theater Command of PLA111 Liuhua RoadYuexiu DistrictGuangzhou 510010GuangdongChina. Department of pediatrics the Third People’s Hospital of ShenzhenShenzhen 518100GuangdongChina. pediatric Intensive Care unit Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430010China. pediatric Intensive Care unit Maternal and Child Health Hospital of HuangshiHuangshi 435000HubeiChina. Department of pediatrics the Second People’s Hospital of Guangdong ProvinceGuangzhou 510317China. Department of pediatrics the Third Affiliated Hospital of Zunyi Medical University(the First People’s Hospital of Zunyi)Guizhou 563000China. Department of pediatrics the Eighth People’s Hospital of GuangzhouGuangzhou 510440China. Department of pediatrics the First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100HenanChina. pediatric Intensive Care unit the Children’s Hospital Zhejiang University School of MedicineHangzhou 310000China. Department of Emergency/Critical Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China. Department of pediatrics the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260China. Department of Medical information date room General Hospital of Southern Theater Command of PLAGuangzhou 510010China. Department of pediatrics the First Affiliated Hospital of Jinan UniversityGuangzhou 510632China. Department of pediatrics Maternal and Child Health Hospital of YangjiangYangjiang 529500GuangdongChina. Department of pediatrics Shenzhen Hospital Affiliated to the University of Chinese Academy of SciencesShenzhen 518107GuangdongChina. Department of pediatrics Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China. Department of pediatrics Zhujiang Hospital of Southern Medical UniversityGuangzhou 510280China. Department of pediatrics Military Hospital of 74 Group of PLAGuangzhou 510318China. Department of neonatology

Background:Until January 18,2021,coronavirus disease-2019(COVID-19)has infected more than 93 million individuals and has caused a certain degree of *** pneumonia caused by common viruses such as respiratory syncytial virus,rhinovirus,human metapneumovirus,human bocavirus,and parainfluenza viruses have been more common in ***,the incidence of COVID-19 in children was significantly lower than that in *** purpose of this study was to describe the clinical manifestations,treatment and outcomes of COVID-19 in children compared with those of other sources of viral pneumonia diagnosed during the COVID-19 ***:Children with COVID-19 and viral pneumonia admitted to 20 hospitals were enrolled in this retrospective multi-center cohort study.A total of 64 children with COVID-19 were defined as the COVID-19 cohort,of which 40 children who developed pneumonia were defined as the COVID-19 pneumonia *** 284 children with pneumonia caused by other viruses were defined as the viral pneumonia *** epidemiologic,clinical,and laboratory findings were compared by Kolmogorov-Smirnov test,t-test,Mann-Whitney U test and Contingency table *** usage,immunotherapy,blood transfusion,and need for oxygen support were collected as the treatment ***,intensive care needs and symptomatic duration were collected as the outcome ***:Compared with the viral pneumonia cohort,children in the COVID-19 cohort were mostly exposed to family members confirmed to have COVID-19(53/64 vs.23/284),were of older median age(6.3 years vs.3.2 years),and had a higher proportion of ground-glass opacity(GGO)on computed tomography(18/40 vs.0/38,P<0.001).Children in the COVID-19 pneumonia cohort had a lower proportion of severe cases(1/40 vs.38/284,P=0.048),and lower cases with high fever(3/40 vs.167/284,P<0.001),requiring intensive care(1/40 vs.32/284,P<0.047)and with shorter symptomatic duration(median 5d vs.8d,P<0.001).The propor

关键词： Children Severe acute respiratory syndrome Coronavirus disease-2019 Viral pneumonia