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Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min Li Jiazhi Chen Zhuyong Wang Huantao Wen Ming Zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

Characteristics and Risk Factors for pediatric Sepsis

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Current Medical Science 2024年第3期44卷 648-656页

作者： Yong-bing ZHU Tong-lin LIU Qi DAI Shu-fan LIU Peng XIONG Hao HUANG Yi YUAN Tian-nan ZHANG Yu CHEN Department of pediatric Intensive Care unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Sepsis is considered a major cause of health loss in children and had high mortality and ***,there is no reliable model for predicting the prognosis of pediatric patients with *** study aimed to analyze the clinical characteristics of sepsis in children and assess the risk factors associated with poor prognosis in pediatric sepsis patients to identify timely interventions and improve their *** This study analyzed the clinical indicators and laboratory results of septic patients hospitalized in the pediatric Intensive Care unit of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,China,from January 1,2019,to December 31,*** factors for sepsis were identified by logistic regression *** A total of 355 children with sepsis were enrolled,with 333 children(93.8%)in the good prognosis group,and 22 children(6.2%)in the poor prognosis *** them,there were 255 patients(71.8%)in the sepsis group,and 100 patients(28.2%)in the severe sepsis *** length of hospital stay in the poor prognosis group was longer than that in the good prognosis group(P0.05),and the platelet(PLT),albumin(ALB),and hemoglobin(Hb)levels were lower in the poor prognosis group(P<0.01).The IL-8 levels in the severe sepsis group were higher than those in the sepsis group(P<0.05).Multiple logistic regression analysis suggested that lower Hb levels,ALB levels,peak PLT counts,and higher IL-1βlevels were independent risk factors for poor prognosis in children with *** Lower Hb,ALB,and PLT counts and elevated IL-1βare independent risk factors for poor prognosis in children with sepsis.

关键词： pediatric sepsis inflammation severity prognosis risk factors

Anterior mediastinal masses and thymic cysts

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World Journal of Clinical Cases 2025年第4期13卷 1-7页

作者： ÖnerÖzdemir Department of pediatric Allergy and Immunology Sakarya Research and Training HospitalSakarya University Medical FacultyAdapazarı54100SakaryaTürkiye

Cystic lesions of the anterior mediastinum in children suggest a well-known group of benign lesions that are comparatively *** cysts(TCs)are mostly positioned in the anterior mediastinum and some patients in the *** TCs classified as congenital intra-thoracic mesothelial cysts are commonly asymptomatic and have slight clinical *** TC,which can mimic another anterior mediastinal cystic tumor and is seen in adults,is more clinically *** is a sporadic mediastinal lesion thought to arise in the course of acquired *** mediastinal cysts represent 3%-6%of all mediastinal tumors and 10%-18%of radiologically reported mediastinal *** TCs are uncommon and it is hard to know their true *** 60%of cases with mediastinal TCs are asymptomatic,and the remainder of patients complains of nonspecific symptoms(e.g.,chest pain,dyspnea,or cough).The literature suggests that most cysts are benign,but an indefinite percentage may have a neoplastic process and result in significant compressive symptoms over *** symptoms of TCs vary depending on the *** addition,frequent symptoms at the appearance of enlarged benign thymic and mediastinal cysts generally contain compressive symptoms(e.g.,respiratory distress,thymic pain,and symptoms related to Horner syndrome,hoarseness,dysphonia,dyspnea,orthopnea,wheezing,and fever).Many TCs have cystic density and a neat border and are simple to diagnose with radiological ***,some TCs are hard to identify before surgery and may be misidentified as thymomas depending on their site and computed tomography *** by thoracotomy,median sternotomy,or video-assisted techniques is essential for conclusive diagnosis,management,and abolition of relapse of anterior mediastinal masses and *** examination may be required after *** the extent of the mass and the preliminary inability to make a definitiv

关键词： Mediastinal mass Thymic cyst Malignant tumor Cysts Thymoma Computer tomography

Thrombosis prophylaxis in pediatric liver transplantation: A systematic review

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World Journal of Hepatology 2018年第10期10卷 752-760页

作者： Mirco Nacoti Giulia Maria Ruggeri Giovanna Colombo Ezio Bonanomi Federico Lussana Department of Anesthesia and Intensive Care Pediatric Intensive Care Unit Papa Giovanni Ⅹ Hospital Hematology and Bone Marrow Transplant unit Papa Giovanni Ⅹ Hospital

AIM To review current literature of thrombosis prophylaxis in pediatric liver transplantation(PLT) as thrombosis remains a critical *** Studies were identified by electronic search of MEDLINE, EMBASE and Cochrane Library(CENTRAL) databases until March 2018. The search was supplemented by manually reviewing the references of included studies and the references of the main published systematic reviews on thrombosis and PLT. We excluded from this review case report, small case series, commentaries, conference abstracts, papers which describing less than 10 pediatric liver transplants/year and articles published before 1990. Two reviewers performed study selection independently, with disagreements solved through discussion and by the opinion of a third reviewer when *** Nine retrospective studies were included in this review. The overall quality of studies was poor. A pooled analysis of results from studies was not possible due to the retrospective design and heterogeneity of included studies. We found an incidence of portal vein thrombosis(PVT) ranging from 2% to 10% in pediatric living donorliver transplantation(LDLT) and from 4% to 33% in pediatric deceased donor liver transplantation(DDLT). Hepatic artery thrombosis(HAT) was observed mostly in mixed LDLT and DDLT pediatric population with an incidence ranging from 0% to 29%. In most of the studies Doppler ultrasonography was used as a first line diagnostic screening for thrombosis. Four different surgical techniques for portal vein anastomosis were reported with similar efficacy in terms of PVT reduction. Reduced size liver transplant was associated with a low risk of both PVT(incidence 4%) and HAT(incidence 0%, P < 0.05). Similarly, aortic arterial anastomosis without graft interposition and microsurgical hepatic arterial reconstruction were associated with a significant reduced HAT incidence(6% and 0%, respectively). According to our inclusion and exclusion criteria, we did not find

关键词： pediatric liver transplantation Prophylaxis Hepatic artery thrombosis Surgical technique Portal vein thrombosis

Gastric transposition as a valid surgical option for esophageal replacement in pediatric patients:experience from three Italian medical centers

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Gastroenterology Report 2017年第1期5卷 47-51,I0002页

作者： Rossella Angotti Francesco Molinaro Carmine Noviello Giovanni Cobellis Ascanio Martino Carmine Del Rossi Adrian Bianchi Mario Messina Division of pediatric Surgery Department of MedicineSurgical and Neurological SciencesUniversity of SienaSienaItaly pediatric Surgery unit Academic Salesi Children HospitalMarche Polytechnic UniversityAnconaItaly Department of pediatric Surgery University of ParmaParmaItaly Neonatal and Paediatric Reconstructive Surgery Royal Manchester Children’s HospitalManchesterUK

Background:Esophageal replacement in children is an option that is confined to very few situations including long-gap esophageal atresia and esophageal strictures unresponsive to other therapies(peptic or caustic ingestion).The purpose of our work was to describe the experience of gastric transposition in three Italian ***:This is a retrospective *** data were extrapolated from a prospective *** included all patients who had undergone gastric transposition in the last 15 ***:In the 15-year period,eight infants and children(3 males and 5 females)underwent gastric transposition for esophageal *** patients had long-gap esophageal atresia,and two had caustic esophageal *** were no deaths in the *** patients had an early postoperative complication:two had a self-limited salivary fistula at three weeks,and one(a patient with jejunostomy)had a jejunal perforation treated *** late complication,anastomotic stricture,was recorded that required two endoscopic *** median follow-up was 60 months(range:18–144 months).At final clinical follow-up,six patients had no eating problems,and two patients had some difficulties with eating(jejunostomy in situ),but they underwent logopedic therapy with improved *** patients had an increase in body weight and height ***:Our small study reports the clinical experience of three Italian centers in which gastric transposition was performed with excellent results,both in terms of surgical technique(simplicity,reproducibility,complication rate)and clinical follow-up(good oral feeding of young patients,normal social life and regular growth curves).

关键词： gastric transposition children esophageal atresia caustic ingestion

Should pediatric idiopathic hypercalciuria be treated with hypocalciuric agents?

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World Journal of Nephrology 2021年第4期10卷 47-58页

作者： Maria Goretti Moreira Guimarães Penido Marcelo de Sousa Tavares pediatric Nephrology unit Nephrology Center of Santa Casa de Belo HorizonteBelo Horizonte 30150320Minas GeraisBrazil Federal University of Minas Gerais Faculty of MedicineDepartment of PediatricsPediatric Nephrology UnitBelo Horizonte 30130100Minas GeraisBrazil

BACKGROUND Hypercalciuria is the most common metabolic risk factor for calcium urolithiasis and is associated with bone loss in adult *** bone mineral density(BMD)was already described in idiopathic hypercalciuria(IH)children,but the precise mechanisms of bone loss or inadequate bone mass gain remain ***-long hypercalciuria might be considered a risk to change bone structure and determine low bone mass throughout *** peak of bone mass should occur without interferences.A beneficial effect of citrate formulations and thiazides on bone mass in adult and pediatric patients with IH have been *** To evaluate whether pharmacological therapy has a beneficial effect on bone mass in children and adolescents with *** This retrospective cohort study evaluated 40 hypercalciuric children nonresponsive to lifestyle and diet *** a 2-mo run-in period of citrate formulation(Kcitrate)usage,the first bone densitometry(DXA)was *** patients with sustained hypercalciuria,a thiazide diuretic was *** second DXA was performed after 12 *** densitometry was performed by DXA at lumbar spine(L2-L4).A 24-h urine(calcium,citrate,creatinine)and blood samples(urea,creatinine,uric acid,calcium,phosphorus,magnesium,chloride,hemoglobin)were *** data included age,gender,weight,height and body mass *** Forty IH children;median age 10.5 year and median time follow-up 6.0 year were *** patients were treated with Kcitrate(G1)and 31 with Kcitrate+thiazide(G2).There were no differences in age,gender,body mass index z-score and biochemical parameters between G1 and *** were no increases in total cholesterol,kalemia and *** decreased in both groups after *** spine BMD z-score increased after thiazide treatment in *** was no improvement in *** Results point to a beneficial effect of thiazide on lumbar spine BMD z-score in children with *** studies ar

关键词： Children Adolescent Hypercalciuria Bone mineral density Thiazides Citrate

2018 Chinese pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents

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Science Bulletin 2018年第23期63卷 1558-1564页

作者： Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu Department of pediatric Cardiovasoloy Children's Medical CenterThe Second Xiangya HospitalCentral South UniversityChangsha 410071China Department of pediatrics Peking University First HospitalBeijing 100034China Department of pediatric Cardiology Children's Hospital of Fudan UniversityShanghai 201102China Department of pediatric Cardiology Shanghai Children's HospitalShanghai 207102China of pediatrics the 2nd Hospital of Lanzhou UniversityLanzhou 730020China Department of pediatric Cardiology Capital Institute of PediatricsBezjing 100020China Department of pediatrics Jilin University First HospitalChangchun 130021China Chinese pediatric Cardiology Society Chinese Pediatric Society(CPCS)Chinese Medical Association(CMA)China Committee on pediatric Syncope Pediatricians BranchChinese Medical Doctor Association(CMDA)China pediatric Cardiology Society Beijing Pediatric SocietyBeijing Medical Association(BMA)China Committee on pediatric Cardiology Chinese College of Cardiovascular PhysiciansChinese Medical Doctor Association(CMDA)China

Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department *** syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the pediatric Cardiology Society, Chinese pediatric Society, Chinese Medical Association(CMA)/Committee on pediatric Syncope, pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/pediatric Cardiology Society, Beijing pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up.

关键词： CPCS Children Adolescent syncope

Innovations in pediatric and Congenital Cardiac Surgery

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Congenital Heart Disease 2022年第1期17卷 1-3页

作者： Vladimiro Vida pediatric and Congenital Cardiac Surgery unit Department of CardiacThoracic and Vascular Sciences and Public HealthUniversity of PaduaPaduaItaly

Cardiac surgery is one of the youngest surgical *** a century ago the heart and great vessels were not surgically approachable,and any pathology affecting these structures that needed surgery inevitably led to a poor prognosis[1].The turning point came with the introduction of modern anesthesia and,above all,with the invention of extracorporeal cardiopulmonary circulation.

关键词： Surgery anesthesia Cardiac

Assessment of left-ventricular diastolic function in pediatric intensive-care patients:a review of parameters and indications compared with those for adults

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World Journal of pediatrics 2021年第1期17卷 21-30页

作者： Morgan Recher Astrid Botte Jerome Soquet Jean-Benoit Baudelet François Godart Stephane Leteurtre ULR 2694-METRICS:évaluation des Technologies de santéet des Pratiques Médicales Univ.LilleCHU Lille59000 LilleFrance Réanimation et Surveillance Continue Pédiatriques Hopital Jeanne de FlandreCHU de Lille59037 Lille CedexFrance pediatric and Neonatal Intensive Care unit CHU Bordeaux33076 BordeauxFrance Cardiac Surgery unit CHU Lille59000 LilleFrance Congenital and pediatric Cardiology unit CHU Lille59000 LilleFrance

Background The incidence of diastolic heart failure has increased over *** evaluation of left-ventricular diastolic func-tion is complex,ongoing,and remains poorly performed in pediatric intensive-care *** study aimed to review the literature and to provide an update on the evaluation of left-ventricular diastolic function in adults and children in intensive *** sources We searched data from PubMed/***-two studies were *** pragmatic questions were identified:(1)What is the physiopathology of diastolic dysfunction?(2)Which tools are required to evaluate diastolic func-tion?(3)What are the echocardiographic criteria needed to evaluate diastolic function?(4)When should diastolic function be evaluated in pediatric intensive care?Results Early diastole allows characterization of relaxation,whereas compliance assessments and filling pressures are evalu-ated during late *** evolution of diastolic function differs between adults and *** in adults,decreased compliance occurs at the same time as delayed relaxation in *** function can be evaluated by Doppler *** echocardiographic criteria for ventricular relaxation include the E wave,E/A wave ratio,and isovolumic relaxation *** compliance can be assessed by the E/e'wave ratio,atrial volume,and Ap wave duration during pulmonary vein *** adult intensive-care patients,the E/e'ratio can be used as an index of tolerance for volume expan-sion in septic patients and to adjust the inotropic *** Clinical studies would allow some of these parameters to be validated for use in children in intensive care.

关键词： Diastole Echocardiography Heart failure Intensive-care unit pediatric