检索结果-南通市图书馆

Anterior mediastinal masses and thymic cysts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第4期13卷 1-7页

作者： ÖnerÖzdemir Department of pediatric allergy and immunology Sakarya Research and Training HospitalSakarya University Medical FacultyAdapazarı54100SakaryaTürkiye

Cystic lesions of the anterior mediastinum in children suggest a well-known group of benign lesions that are comparatively *** cysts(TCs)are mostly positioned in the anterior mediastinum and some patients in the *** TCs classified as congenital intra-thoracic mesothelial cysts are commonly asymptomatic and have slight clinical *** TC,which can mimic another anterior mediastinal cystic tumor and is seen in adults,is more clinically *** is a sporadic mediastinal lesion thought to arise in the course of acquired *** mediastinal cysts represent 3%-6%of all mediastinal tumors and 10%-18%of radiologically reported mediastinal *** TCs are uncommon and it is hard to know their true *** 60%of cases with mediastinal TCs are asymptomatic,and the remainder of patients complains of nonspecific symptoms(e.g.,chest pain,dyspnea,or cough).The literature suggests that most cysts are benign,but an indefinite percentage may have a neoplastic process and result in significant compressive symptoms over *** symptoms of TCs vary depending on the *** addition,frequent symptoms at the appearance of enlarged benign thymic and mediastinal cysts generally contain compressive symptoms(e.g.,respiratory distress,thymic pain,and symptoms related to Horner syndrome,hoarseness,dysphonia,dyspnea,orthopnea,wheezing,and fever).Many TCs have cystic density and a neat border and are simple to diagnose with radiological ***,some TCs are hard to identify before surgery and may be misidentified as thymomas depending on their site and computed tomography *** by thoracotomy,median sternotomy,or video-assisted techniques is essential for conclusive diagnosis,management,and abolition of relapse of anterior mediastinal masses and *** examination may be required after *** the extent of the mass and the preliminary inability to make a definitiv

关键词： Mediastinal mass Thymic cyst Malignant tumor Cysts Thymoma Computer tomography

Congenital anomalies of coronary artery misdiagnosed as coronary dilatations in Kawasaki disease:A clinical predicament

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical pediatrics 2025年第1期14卷 93-100页

作者： Rakesh Kumar Pilania Pallavi L Nadig Suprit Basu Reva Tyagi Abarna Thangaraj Ridhima Aggarwal Munish Arora Arun Sharma Surjit Singh Manphool Singhal pediatric allergy immunology unit Department of PediatricsAdvanced Pediatrics CenterPost Graduate Institute of Medical Education and ResearchChandigarh 160012ChandīgarhIndia Department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and ResearchChandigarh 160012ChandīgarhIndia

BACKGROUND 2D-echocardiography(2DE)has been the primary imaging modality in children with Kawasaki disease(KD)to assess coronary *** To report the presence and implications of incidental congenital coronary artery anomalies that had been misinterpreted as coronary artery abnormalities(CAAs)on *** Records of children diagnosed with KD,who underwent computed tomography coronary angiography(CTCA)at our center between 2013-2023 were *** identified 3 children with congenital coronary artery anomalies in this cohort on *** of CTCA and 2DE were compared in these 3 *** Of the 241 patients with KD who underwent CTCA,3(1.24%)had congenital coronary artery anomalies on CTCA detected *** all 3 patients,baseline 2DE had identified *** was then performed for detailed evaluation as per our unit ***(11-year-boy)amongst the 3 patients had complete KD,while the other two(3.3-year-boy;4-month-girl)had incomplete *** revealed separate origins of left anterior descending artery and left circumflex from left sinus[misinterpreted as dilated left main coronary artery(LCA)on 2DE],single coronary artery(interpreted as dilated LCA on 2DE)and dilated right coronary artery on 2DE in case of anomalous origin of LCA from the main pulmonary *** latter one was subsequently operated *** CTCA is essential for detailed assessment of coronary arteries in children with KD especially in cases where there is suspicion of congenital coronary artery *** solely on 2DE may not be sufficient in such cases,and findings from CTCA can significantly impact therapeutic decision-making.

关键词： Coronary artery abnormalities Congenital coronary artery anomalies Computed tomography coronary angiography Kawasaki disease 2-dimensional echocardiography

Genetics on early onset inflammatory bowel disease:An update

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2020年第1期7卷 93-106页

作者： Johnson Nameirakpam Rashmi Rikhi Sanjay Singh Rawat Jyoti Sharma Deepti Suri pediatric allergy and immunology unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Inflammatory bowel disease(IBD)is more common in adults than in *** of IBD before 17 years of age is referred as pediatric onset IBD and is further categorized as very early onset IBD(VEO-IBD)for children who are diagnosed before 6 years of age,infantile IBD who had the disease before 2 years of age and neonatal onset IBD for children less than 28 days of *** presenting with early onset disease may have a monogenic *** and awareness of the clinical manifestations facilitates early evaluation and *** generation sequencing is helpful in making the genetic *** of childhood IBD is difficult;targeted therapies and hematopoietic stem cell transplantation form the *** this review we aim to summarize the genetic defects associated with IBD *** describe genetic location and functions of various genetic defect associated with VEO-IBD with their key clinical *** also provide clinical clues to suspect these conditions and approaches to the diagnosis of these disorders and suitable treatment options.

关键词： Il-10 signalling defect IPEX Next generation sequencing Targeted therapy Very early onset inflammatory bowel disease

Role of immunotherapy in the treatment of allergic asthma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2014年第12期2卷 859-865页

作者： Ayfer Yukselen Seval Guneser Kendirli Clinic of pediatric allergy and immunology Gaziantep Children Hospital Sehitkamil 27310 Gaziantep Turkey Division of pediatric allergy and immunology Cukurova University Faculty of Medicine Balcali 01150 Adana Turkey

Allergen-specific immunotherapy(SIT) induces clinical and immunological tolerance as defined by persistence of clinical benefit and associated long-term immunological parameters after cessation of treatment. Although the efficacy of SIT has been shown in terms of reducing symptoms, medication consumption and ameliorating quality of life in both allergic rhinitis and asthma, there has long been some controversies about effectiveness of SIT in the treatment of allergic asthma. The type of allergen, the dose and protocol of immunotherapy, patient selection criteria, the severity and control of asthma, all are significant contributors to the power of efficacy in allergic asthma. The initiation of SIT in allergic asthma should be considered in case of coexisting of other allergic diseases such as allergic rhinitis, unacceptable adverse effects of medications, patient's preference to avoid long-term pharmacotherapy. Steroid sparing effect of SIT in allergic asthma is also an important benefit particularly in patients who have to use these drugs in high doses for a long-time. Symptomatic asthma is a risk factor for systemic reactions and asthma should be controlled at the time of administration of SIT. Both subcutaneous immunotherapy(SCIT) and sublingual immunotherapy(SLIT) have been found to be effective in patients with allergic asthma. Although the safety profile of SLIT seems to be better than SCIT, the results of some studies and meta-analyses suggest that the efficacy of SCIT may appear better and earlier than SLIT in children with allergic asthma.

关键词： Asthma Efficacy Safety Subcutaneous immunotherapy Sublingual immunotherapy

Regulation of JAK/STAT signal pathway by miR-21 in the pathogenesis of juvenile idiopathic arthritis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of pediatrics 2020年第5期16卷 502-513页

作者： Hong-Wei Li Hua-Song Zeng Department of pediatric allergy immunology and Rheumatology Guangzhou Women and Children Medical CenterGuangzhou 510623China Department of pediatric allergy Immunology and RheumatologyGuangzhou Women and Children's Medical CenterGuangzhou Medical University9 Jinsui RoadGuangzhou 510175China

Background Overexpression of the components of the Janus kinase/signal transducer and activator of transcription(JAK/STAT)signalling pathway is the key factor of the pathogenic mechanisms underlying systemic juvenile idiopathic arthritis(sJIA).The study aims to investigate the association between miR-21 and the JAK/STAT signal pathway in *** Total RNA was extracted from peripheral blood mononuclear cells(PBMCs)in active JIA *** relative expressions of miR-21,STAT3 and suppressor of cytokine signalling 3 in PBMCs were measured by real-time polymerase chain reaction and their expressions were measured by western blotting and dual-luciferase reported *** arthritis fibroblast-like synovial cell(RASF)was stimulated to become to osteoclasts using macrophage colony-stimulating factor(M-CSF)and factors that can impact on their differentiation ability were identified through the transfection of *** expression of STAT3/p-STAT3 was measured by western blot,and the levels of interleukin(IL)-17A,p65,matrix metalloproteinases(MMP)-3,MMP-4 and receptor activator of nuclear factor-κd3 after the LV3-miR-21 transfection were tested by enzyme-linked immunosorbent ***,the miR-21 targeted STAT3 gene was detected by the dualluciferase reported *** The expression of miR-21 was significantly lower in JIA patients than in healthy control(P<0.05).The level of STAT3 was increased in PBMCs of JIA group compared with control group(P<0.05).Furthermore,the expression levels of miR-21 in sJIA and polyarticular JIA groups were negatively correlated with STAT3(r=-0.5854/r=-0.6134,P<0.05).The expression of STAT3 changed little in PBMCS after the stimulation of IL-6 and not in RASFs with transfection of *** expression of p-STAT3 decreased after the stimulation of IL-6 in RASFs transfected by LV3-miR-21(P<0.05).RASFs were induced into osteoclasts using *** number of osteoclasts as determined by tartrate-resistant acid phospha

关键词： JAK/STAT Juvenile idiopathic arthritis MiR-21 Signal transducer and activator of transcription 3 (STAT3)/p-STAT3

Adipocytokine profile in children with Kawasaki disease at a mean follow-up period of 5.5 years: A study from North India

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical pediatrics 2022年第4期11卷 360-368页

作者： Dibya Lochan Praharaj Amit Rawat Anju Gupta Kanika Arora Rakesh Kumar Pilania Sagar Bhattad Surjit Singh pediatric allergy and immunology unit Advanced Pediatrics CentrePost Graduate Institute of Medical Education and ResearchChandigarh 160012India

BACKGROUND Kawasaki disease(KD)is an acute self-limited vasculitis with a predilection for coronary *** with KD may have altered lipid metabolism and abnormal lipid profiles that may last for prolonged ***,there is a paucity of literature on the role of adipocytokines in *** To estimate the levels of adipocytokines(adiponectin,leptin and resistin)during the convalescent phase of *** Twenty children,who had KD at least three years earlier,were enrolled in this *** addition,20 healthy controls were also *** and laboratory profiles of patients were obtained from hospital *** adiponectin,leptin and resistin levels were estimated by enzyme-linked immunosorbent *** Mean age of the patients in the study group was 10.15±3 years and the male:female ratio was 1.5:*** serum resistin levels in patients with KD(27.77 ng/mL;[IQR:18.66,48.90])were decreased compared to controls(21.20 ng/mL;[IQR:14.80,27.00])(P=0.04).Median serum leptin levels in cases and controls were 1.83 ng/mL;(IQR:1.13,3.80),and 1.10 ng/mL;(IQR:0.41,2.88),respectively(P=0.09).Median serum adiponectin levels were similar in both cases(12.20μg/mL;[IQR:9.76,17.97])and controls(13.95μg/mL;[IQR:11.17,22.58]);(P=0.18).There was no significant difference in all 3 adipocytokines between children with(4/20)and without coronary artery abnormalities(16/20).CONCLUSION Serum resistin levels were significantly elevated in patients with KD during the convalescent phase compared to *** leptin levels appeared to be higher in patients with KD,although the difference was not statistically *** levels were similar in both cases and *** resistin and leptin levels may partially explain lipid perturbations observed during the convalescent phase of KD.

关键词： Adipocytokines Adiponectin Resistin Leptin Lipid metabolism Kawasaki disease Convalescent phase

An unusual cause of an anterior mediastinal mass in a 52-day-old infant with mediastinal tuberculosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of pediatrics 2016年第3期12卷 372-373页

作者： Recep Sancak Mehmet Halil Celiksoy Medical Faculty Department of Pediatric Allergy and ImmunologyOndokuz Mayıs UniversityKurupelitSamsunTurkey

Tuberculosis(TB)continues to be one of the major infectious diseases threatening millions of lives worldwide.[1]We encountered a 52-day-old male infant with a anterior mediastinal mass caused by *** admission to our hospital,the infant presented with respiratory distress,wheezing,fever,and *** breath sounds were audible at the apex of the left *** temperature was 38.2℃.

关键词： infant tuberculosis distress

Immunological pathogenesis and treatment of systemic lupus erythematosus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of pediatrics 2020年第1期16卷 19-30页

作者： Lu Pan Mei-Ping Lu Jing-Hua Wang Meng Xu Si-Rui Yang Department of pediatric Rheumatology and allergy The First HospitalJilin UniversityChangchunChina Department of allergy immunology and Rheumatology Children's HospitalZhejiang University School of MedicineHangzhouChina

Background Systemic lupus erythematosis(SLE)is a complex and clinically heterogeneous autoimmune disease.A variety of immunological defects contribute to SLE,including dysregulated innate and adaptive immune response.A clearer understanding of the mechanisms driving disease pathogenesis combined with recent advances in medical science is predicted to enable accelerated progress towards improved SLE-personalized approaches to *** aim of this review was to clarify the immunological pathogenesis and treatment of *** sources Literature reviews and original research articles were collected from database,including PubMed and *** articles about SLE were *** Breakdown of self-tolerance is the main pathogenesis of *** innate and adaptive immune networks are interlinked with each other through cytokines,complements,immune complexes and kinases of the intracellular *** targeted at possible targets of immunity have been assessed in clinical *** of them did not show better safety and efficacy than traditional ***,novel targeting treatments are still being *** Dysregulated immune response plays a critical role in SLE,including innate immunity and adaptive *** agents that aim to specifically target abnormal immune processes were assessing and may bring new hope to SLE patients.

关键词： Immunological pathogenesis Systemic lupus erythematosis Treatment

Effect of early atopic sensitization in children aged 0–2 years on the development of asthma symptoms at 9–11 years of age

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of pediatrics 2022年第11期18卷 753-760页

作者： Himmet Haluk Akar Ebru Nadir Burçin Beken Yakup Yeşil Division of pediatric immunology and allergy University of Istanbul Health SciencesKanuni Sultan Suleyman Training and Research HospitalIstanbulTurkey Division of pediatrics University of Istanbul Health SciencesKanuni Sultan Suleyman Training and Research HospitalIstanbulTurkey Department of pediatric immunology and allergy School of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulTurkey

Background Personal genetic predisposition and early life environmental factors are important for the development of childhood *** aimed to search whether egg,milk and mite sensitizations at 0–2 years old are risk factors for asthma symptoms at 9–11 years *** A total of 210 wheezer children who had specific immunoglobulin(Ig)E in 2010–2012 were included in the study(followed by pediatric allergy).Patients were divided into non-atopic(group 1,n=157)and atopic patients[groups 2–7,n=53(5 patients were in both group 4 and group 5)]based on *** the International Study of Asthma and allergy in Childhood questionnaire,current wheeze(CW,2nd question),exercise wheezing(EW,7th question),and dry cough(DC,8th question)were ***,parental allergies,eczema at 0–2 years,current eosinophil percentage and total IgE were *** Eczema was observed as an important risk factor[CW:odds ratio(OR)=2.83,95%confidence interval(CI)=1.54–5.23,P≤0.001;EW:OR=2.71,95%CI=1.33–5.54,P=0.006;DC:OR=3.03,95%CI=1.47–6.25,P=0.003],whereas having no atopic sensitization at 0–2-year-old(group 1)was found as a significant protective factor for asthma at 9–11 years old(CW:OR=0.32,95%CI=0.15–0.70,P=0.004;EW:OR=0.21,95%CI 0.10–0.44,P≤0.001;DC:OR=0.25,95%CI=0.10–0.59,P=0.002).Conclusion Early personal eczema is a significant risk factor for the development of asthma symptoms at 9–11 years old,whereas not having an allergic sensitization at 0–2 years old(group 1)is an important protective factor.

关键词： Asthma Children Risk factors