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ISOLATION AND ETTABLISHMENT OF AN ENDOGENOUS RETROVIRUS TRANSFORMED MURINE CD4~- CD8~- EARLY T-CELL LINE WITH THE CAPABILITY OF MULTIPLE LYMPHO-KINE PRODUCTION

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北京大学学报(医学版) 1989年第5期 437-445页

作者：陈慰峰李萌李晨张惠华樊景禹方伟岗 dept. of Immunology dept. of Biophysics Depl. of pathology Beijing Medical University

A murine C2 early T cell line derived from spleen cell cultures of Balb/C mice has been established. C2 cells express the phenotype of Thy-1+CD4-CD8-Slg-, and their growth is exogenous factor-independent. Under electron-microscope examination, virus particles are clearly visualized present in the vacuoles of the cytoplasm near cell membrane and released outside the cells. A high activity of reverse transcriptase encoded by retrovirus RNA has been measured in the virus-enriched compartment isolated from C2 cells. C2 cells are tumourigenic as shown by their ability to cause diffused tumours in nude mice. After stimulation with phorbol ester and calcium ionophore, C2 cells produced a variety of lymphokines, including 1L-2, IL-4, IFNr and MAP with high or moderate activity.

关键词： Tumourigenic early T Cell line Retrovirus Reverse transcriptase Factor-independent growth lymphokines

Review of biological waste management in research,biomedical,and veterinary laboratories in Karachi,Pakistan

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Journal of Biosafety and Biosecurity 2019年第2期1卷 100-104页

作者： Shamsul Arfin Qasmi Bilal A.Khan dept.of pathology Karachi Institute of Medical SciencesKarachiPakistan DUHS KarachiPakistan

*** Healthcare facilities that include laboratories provide services to patients and help in safeguarding public *** also generate a large amount of waste,which can create serious health problems for the public if it is not treated and disposed of as per institutional/local and international *** facilities produce diverse wastes,which include hazardous infectious waste.

关键词： waste services facilities

Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA dept.of Laboratory Medicine&pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

Studying the effect of formic acid and potassium diformate on performance,immunity and gut health of broiler chickens

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Animal Nutrition 2016年第4期2卷 296-302页

作者： Naela M.Ragaa Reda M.S.Korany Nutrition and Clinical Nutrition dept. Fac.Vet.Med. Cairo University pathology dept. Fac.Vet.Med. Cairo University

Our trial was conducted to study the effects of formic acid(FA) and potassium di-formate(KDF) in broiler ration on performance, carcass traits, blood biochemical, intestinal microbial load, histological picture of intestine and immune parameters of broilers. In this study 360 one-day-old broiler chicks were divided to 3 groups with 3 replicates of 40 chicks each. The trial continued for 35 days. The control group was fed only basal diet(G1). Group 2(G2) were fed basal diet supplemented with FA(5 g/kg diet), and group 3(G3) received basal diet supplemented with KDF(5 g/kg diet). The results showed that both FA and KDF significantly increased body weight gain(BWG), dressing percentage of broilers and significantly decreased feed conversion ratio(FCR)(P < 0.05). The highest percent of breast and thigh was observed in G3. The improvement in villus height was observed in G2 and G3 compared with the control one, and the highest was in G3. The results evidence that the using of FA or KDF in broiler feeds have significant effects on performance, immune parameters, and gut health without having any significant effects on blood biochemical. However, KDF is more effective than FA as little amount of FA reaches the small intestine due to metabolism and absorption, whereas KDF permits a proportion of FA to pass through the fore-gut intact and enter the small intestinal tract. In addition, FA has a strong odor and corrosiveness to gastrointestinal tract which limits its use.

关键词： Acidifiers Broiler Growth parameters Gut health

Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?

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World Journal of Gastroenterology 2016年第46期22卷 10198-10209页

作者： Anna Chiara Piscaglia Lucrezia Laterza Valentina Cesario Viviana Gerardi Rosario Landi Loris Riccardo Lopetuso Giovanni Calò Giovanna Fabbretti Massimo Brisigotti Maria Loredana Stefanelli Antonio Gasbarrini Endoscopy and Gastroenterology Unit Depatment of Internal Medicine State Hospital School of Gastroenterology Dept. of Internal Medicine and Gastroenterology "Gemelli" Hospital Catholic University Depatment of pathology "Infermi" Hospital

AIM To evaluate the prevalence of nodular lymphoid hyperplasia(NLH) in adult patients undergoing colonoscopy and its association with known diseases. METHODS We selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome(IBS)-type symptoms or suspected inflammatory bowel disease(IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer *** collection included medical history and final diagnosis. As controls, we considered all colonoscopies performed for the aforementioned indications during the same *** One thousand and one hundred fifty colonoscopies were selected. NLH was rare in asymptomatic individuals(only 3%), while it was significantly more prevalent in symptomatic cases(32%). Among organic conditions associated with NLH, the most frequent was IBD, followed by infections and diverticular disease. Interestingly, 31% of IBS patients presented diffuse colonic NLH. NLH cases shared some distinctive clinical features among IBS patients: they were younger, more often female, and had a higher frequency of abdominal pain, bloating, diarrhoea, unspecific inflammation, self-reported lactose intolerance and metal contact dermatitis. CONCLUSION About 1/3 of patients with IBS-type symptoms or suspected IBD presented diffuse colonic NLH, which could be a marker of low-grade inflammation in a conspicuous subset of IBS patients.

关键词： Inflammatory bowel diseases Functional gastrointestinal diseases Irritable bowel syndrome Colonoscopy Inflammation

Does dyslipidemia worsen the hearing level in diabetics?

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Journal of Otology 2017年第4期12卷 198-201页

作者： Pratap Deepika A. Rajeshwary Shastri U sha M.K. Goutham Sharma Raghav dept of Otorhinolaryngology KSHEMA Nitte University Mangalore 575018 India dept of Audiology and Speech Language pathology Nitte Institute of Speech and Hearing Mangalore 575018 India dept of Medicine KSHEMA Nitte University Mangalore 575018 India

Objective: To identify the effect of dyslipidemia on auditory function detected by Pure Tone Audiometry. To check if dyslipidemia worsens the hearing level in ***: This was a comparative study where 120 subjects between the age group of 20 and 50 years underwent pure tone audiometry, lipid profile and blood sugars. Group 1 consisted of 30 subjects with type 2 diabetes and dyslipidemia; Group 2 had 30 subjects with isolated diabetes;Group 3 had 30 with isolated dyslipidemia and Group 4 included 30 normal subjects as ***: Significant hearing loss was seen only in the group with isolated diabetes(63%). The most common type of hearing loss was high frequency sensorineural hearing loss. When comparison was made between the combinations of different lipid profiles, no association was found to the level of ***: Diabetics are more prone to high frequency hearing loss. Altered lipid profile has no role in causing hearing loss.

关键词： Dyslipidemia Diabetes Pure tone audiometry

A nomogram model integrating LI-RADS features based on MRI for predicting microvascular invasion in hepatocellular carcinoma following Milan criteria

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 2-3页

作者：钟文新 dept Radiol Huazhong Univ Sci&Technol Union Shenzhen HospShenzhen 518052

Objective To establish and verify a nomogram model based on MRI liver imaging reporting and data system (LI-RADS) features for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC)following the Milan *** A retrospective analysis was conducted on data from 118 HCC patients(121 lesions) confirmed by pathology from June 2016 to June 2022 at the Third Affiliated Hospital of Soochow University.

关键词： invasion hepatocellular microvascular

Comparative study of ^(18)F-PSMA-1007,^(18)F-FDG PET/CT and mpMRI in the diagnosis of prostate cancer

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 66-67页

作者：姜一逸 dept Nucl Med Affil Taizhou People's HospNanjing Med UnivTaizhou 225300

Objective To compare the diagnostic efficacy of ^(18)Fprostate specific membrane antigen(PSMA)-1007 PET/CT,18F-FDG PET/CT and multi-parameter MRI(mpMRI)in prostate cancer(PCa).Methods Retrospective analysis was conducted on data from 22 patients((72.6±6.2)years)with pathologically confirmed PCa in the Affiliated Taizhou People's Hospital of Nanjing Medical University between April 2021 and September *** patients underwent 18F-PSMA-1007 PET/CT,18F-FDG PET/CT,and mpMRI examination within 30 d,and the imaging parameters were collected,including PSMASUVnax FDG-SUV_(max),minimum apparent diffusion coefficient(ADC_(min)),mean apparent diffusion coefficient(ADC_(mean)),PSMA-SUV_(max)/ADCm,in PSMA-SUV ma ADC_(mean),FDG-SUV_(max)/ADC_(min),FDG-SUVmV_(max)/ADC,nean Patientswere divided into groupsbasedonthe International Society of Urological pathology(ISUP)grading(≤3 vs>3)and serum total prostate specific antigen(TPSA;≤20μg/L us>20μg/L).

关键词： PET/CT PSMA diagnosis

Monoclonal antibodies that target the immunogenic proteins expressed in colorectal cancer

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World Journal of Gastrointestinal Oncology 2014年第6期6卷 170-176页

作者： Myron Arlen Philip Arlen Gene Coppa Jim Crawford XuePing Wang Olga Saric Alex Dubeykovskiy Ernesto Molmenti Department of Surgery Division of Surgical Oncology and the Dept. of Pathology North Shore University HospitalManhasset NY 11030 United States Manhasset NY and Precision Biologics Great Neck NY 11021 United States

In an attempt to improve upon the end results obtained in treating colorectal cancer it was apparent that the earlier the diagnosis that could be obtained, the better the chance for obtaining desired results. In the case of more advanced tumors typified by later stage colorectal cancer, surgical debulking is an important part of the treatment strategy. Here the use of additional therapeu-tic modalities including chemotherapy and present day immunotherapy has failed to accomplish the desired im-provements that have been sought after. Adjuvant ther-apy, has offered little to the overall survival. The concept of early detection is now recognized as the initial step in reaching proper end results and can readily be demon-strated from colorectal cancer studies. Here survival has been found to be a reflection of the stage at which the tumor is first identified and treated. When specific mono-clonals targeting colorectal cancer are employed diagnos-tically, we have been able to demonstrate detection of colorectal cancer at its inception as a premalignant lesion, such that genotypic features can be identified before the phenotypic appearance of cancer can be noted.

关键词： Colorectal cancer Monoclonal antibodies Immunohistochemistry Antibody dependent cell cytotoxicity Tumor associated antigens