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Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis

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World Journal of Gastroenterology 2014年第13期20卷 3597-3608页

作者： Mio Kobayashi Yuko Kakuda Kenichi Harada Yasunori Sato Motoko Sasaki Hiroko Ikeda Mitsuhiro Terada Munenori Mukai Shuichi Kaneko Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of MedicineKanazawa 920-8640Japan division of Pathology Kanazawa University HospitalKanazawa 920-8641Japan Department of Gastroenterology Kouseiren Takaoka HospitalTakaoka 933-8555Japan Department of Pathology Kouseiren Takaoka HospitalTakaoka 933-8555Japan Department of Gastroenterology Kanazawa University Graduate School of MedicineKanazawa 920-8640 Japan

AIM:To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis(AIH)and primary biliary cirrhosis(PBC)with AIH ***:Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were *** activity of periportal and lobular inflammation was scored0(none or minimal activity)to 4(severe),and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored *** infiltration of mononuclear cells positive for CD20,CD38,CD3,CD4,and CD8 and positive for immunoglobulins(IgG,IgM,and IgA)at the periportal areas(interface hepatitis)and in the hepatic lobules(lobular hepatitis)were semiquantitatively scored in immunostained liver sections(score 0-6).Serum aspartate aminotransferase(AST),immunoglobulins,and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual ***:Lobular hepatitis,hepatitic rosette formation,and emperipolesis were more extensive and frequent in AIH than in ***3+,CD4+,and CD8+cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in *** degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC,but to a lesser degree in ***20+cells were mainly found in the portal tracts and,occasionally,at the interface in both *** AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration,specifically CD38+cells in *** correlation existed between autoantibodies and inflammatory cell infiltration in PBC or *** most AIH cases were IgG-predominant at the interface,PBC cases were divided into IgM-predominant,IgM/IgGequal,and IgG-predominant types,with the latter sharing several features with ***:These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with inte

关键词： Primary biliary cirrhosis Autoimmune hepa-titis Interface hepatitis Lobular hepatitis Plasma cell subclass

Combined choriocarcinoma, neuroendocrine cell carcinoma and tubular adenocarcinoma in the stomach

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World Journal of Gastroenterology 2008年第20期14卷 3269-3272页

作者： Yasumitsu Hirano Takuo Hara Hiroshi Nozawa Kaeko Oyama Naohiro Ohta Kenji Omura Go Watanabe Hideki Niwa Department of General and Cardiothoracic Surgery Kanazawa University Graduate school of Medical Science 13-1 Takara-machi Kanazawa 920-8641 Japan Department of Surgery Kouseiren Takaoka Hospital5-10 Eiraku-chou Takaoka 933-8555 Japan Department of Pathology Kouseiren Takaoka Hospital 5-10 Eiraku-chou Takaoka 933-8555 Japan

We described a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma. An 85-year-old man visited our hospital because of appetite loss. Gastric fiberscopy revealed a large tumor occupying the cardial region and anterior wall of the gastric body. The patient underwent total gastrectomy with lymphnode dissection and partial resection of the liver. Choriocarcinoma, small cell carcinoma and tubular adenocarcinoma existed in the gastric tumor. The choriocarcinomatous foci contained cells positive for beta-subunit of human chorionic gonadotropin （B-hCG） and human placental lactogen mainly in syncytiotrophoblastic cells. The small cell carcinomatous loci contained cells positive for synaptophysin, neuron-specific enolase （NSE）, and chromogranin A. The prognosis for gastric adenocarcinoma with choriocarcinoma and neuroendocrine cell carcinoma is exceedingly poor. This patient died about 2 mo after the first complaint from hepatic failure. This is the first reported case of gastric cancer with these three pathological features.

关键词： Gastric cancer Choriocarcinoma Neuroen-docrine cell carcinoma Tubular adenocarcinoma Combined carcinoma

Hepatocellular carcinoma and type 2 diabetes mellitus: two cases highlighting changes in tumor glycogen content

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Hepatoma Research 2016年第1期2卷 26-30页

作者： Kunio Takegoshi Eikichi Okada Kazuhiro Nomoto Kouji Nobata Takuro Sawasaki Mitsuhiro Terada Hirofumi Terakawa Takashi Kobayashi Kazuhisa Yabushita Tatsuho Sugimoto Shintaro Terahata Takegoshi Internal Medicine Clinic 377-7 NomuraTakaokaToyama 933-0014Japan pathological division of takaoka City hospital 4-1 Takara-machiTakaokaToyama 933-8550Japan pathological division of kouseiren takaoka hospital 5-10 EirakuchoTakaokaToyama 933-8555Japan Radiological division of kouseiren takaoka hospital 5-10 EirakuchoTakaokaToyama 933-8555Japan Gastroenterological division of kouseiren takaoka hospital 5-10 EirakuchoTakaokaToyama 933-8555Japan Surgical division of takaoka City hospital 4-1 Takara-machiTakaokaToyama 933-8550Japan Gastroenterological division of Kanazawa Seirei hospital 1 Chome-5-30 NagamachiKanazawaIshikawa 920-0865Japan pathological division of Tonami General hospital 1-61 Shintomi-choTonamiToyama 939-1395Japan

This article reports two patients with hepatocellular carcinoma(HCC)and type 2 diabetes mellitus(T2DM),who showed marked changes in hepatocellular glycogen *** acid-Schiff(PAS)-positive and diastase-PAS-negative(glycogen-storing)hepatocytes were detected in both background liver parenchyma and in HCC *** HCC tissues,the number of glycogen-storing cells resembling hepatocytes was considerably reduced and unevenly distributed as compared with hepatocytes in background *** be known,changes in hepatocellular glycogen content in T2DM patients have not been previously *** is hypothesized that the reduction in glycogen content in both patients was likely associated with the emergence of Warburg type of glycolysis.

关键词： Glycogen hepatocellular carcinoma hexokinase II steatohepatitis type 2 diabetes mellitus

Hepatocellular carcinoma and type 2 diabetes mellitus: cytokeratin 8/18 expression in hepatocellular carcinoma and glycogen-storing hepatocytes

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Hepatoma Research 2016年第1期2卷 229-230页

作者： Kunio Takegoshi Eikichi Okada Qin Su Takegoshi Internal Medicine Clinic TakaokaToyama 933-0014Japan pathological division of takaoka City hospital TakaokaToyama 933-8550Japan Cell Marque Sigma-AldrichRocklinCA 95677USA

Sir,We have reported two patients with hepatocellular carcinoma(HCC)and type 2 diabetes mellitus(T2DM),who showed abundant glycogen in their liver parenchyma but a marked reduction of glycogen content in HCC.[1]It was suggested that the latter was associated with appearance of a Warburg type glycolysis[1]and discussed in some detail.[2]

关键词： hepatocellular mellitus diabetes