Hepatocellular carcinoma and type 2 diabetes mellitus: two cases highlighting changes in tumor glycogen content

作     者：Kunio Takegoshi Eikichi Okada Kazuhiro Nomoto Kouji Nobata Takuro Sawasaki Mitsuhiro Terada Hirofumi Terakawa Takashi Kobayashi Kazuhisa Yabushita Tatsuho Sugimoto Shintaro Terahata 

作者机构：Takegoshi Internal Medicine Clinic377-7 NomuraTakaokaToyama 933-0014Japan Pathological Division of Takaoka City Hospital4-1 Takara-machiTakaokaToyama 933-8550Japan Pathological Division of Kouseiren Takaoka Hospital5-10 EirakuchoTakaokaToyama 933-8555Japan Radiological Division of Kouseiren Takaoka Hospital5-10 EirakuchoTakaokaToyama 933-8555Japan Gastroenterological Division of Kouseiren Takaoka Hospital5-10 EirakuchoTakaokaToyama 933-8555Japan Surgical Division of Takaoka City Hospital4-1 Takara-machiTakaokaToyama 933-8550Japan Gastroenterological Division of Kanazawa Seirei Hospital1 Chome-5-30 NagamachiKanazawaIshikawa 920-0865Japan Pathological Division of Tonami General Hospital1-61 Shintomi-choTonamiToyama 939-1395Japan 

出 版 物：《Hepatoma Research》 (肝癌研究（英文版）)

年 卷 期：2016年第2卷第1期

页      面：26-30页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Glycogen hepatocellular carcinoma hexokinase II steatohepatitis type 2 diabetes mellitus 

摘      要：This article reports two patients with hepatocellular carcinoma(HCC)and type 2 diabetes mellitus(T2DM),who showed marked changes in hepatocellular glycogen *** acid-Schiff(PAS)-positive and diastase-PAS-negative(glycogen-storing)hepatocytes were detected in both background liver parenchyma and in HCC *** HCC tissues,the number of glycogen-storing cells resembling hepatocytes was considerably reduced and unevenly distributed as compared with hepatocytes in background *** be known,changes in hepatocellular glycogen content in T2DM patients have not been previously *** is hypothesized that the reduction in glycogen content in both patients was likely associated with the emergence of Warburg type of glycolysis.