检索结果-南通市图书馆

Post-transcriptional mechanisms controlling neurogenesis and direct neuronal reprogramming

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第9期19卷 1929-1939页

作者： Elsa Papadimitriou Dimitra Thomaidou Department of Neurobiology Hellenic Pasteur InstituteAthensGreece

Neurogenesis is a tightly regulated process in time and space both in the developing embryo and in adult neurogenic niches.A drastic change in the transcriptome and proteome of radial glial cells or neural stem cells towards the neuronal state is achieved due to sophisticated mechanisms of epigenetic,transcriptional,and post-transcriptional *** these neurogenic mechanisms is of major importance,not only for shedding light on very complex and crucial developmental processes,but also for the identification of putative reprogramming factors,that harbor hierarchically central regulatory roles in the course of neurogenesis and bare thus the capacity to drive direct reprogramming towards the neuronal *** major transcriptional programs that orchestrate the neurogenic process have been the focus of research for many years and key neurogenic transcription factors,as well as repressor complexes,have been identified and employed in direct reprogramming protocols to convert non-neuronal cells,into functional *** post-transcriptional regulation of gene expression during nervous system development has emerged as another important and intricate regulatory layer,strongly contributing to the complexity of the mechanisms controlling neurogenesis and neuronal *** particular,recent advances are highlighting the importance of specific RNA binding proteins that control major steps of mRNA life cycle during neurogenesis,such as alternative splicing,polyadenylation,stability,and *** from the RNA binding proteins,microRNAs,a class of small non-coding RNAs that block the translation of their target mRNAs,have also been shown to play crucial roles in all the stages of the neurogenic process,from neural stem/progenitor cell proliferation,neuronal differentiation and migration,to functional ***,we provide an overview of the most prominent post-transcriptional mechanisms mediated by RNA binding proteins and microRNAs during the

关键词： direct neuronal reprogramming in vivo glia-to-neuron conversion microRNAs neurogenesis post-transcriptional regulation RNA binding proteins

The potent osteo-inductive capacity of bioinspired brown seaweed-derived carbohydrate nanofibrous three-dimensional scaffolds

在线全文

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2024年第3期6卷 515-534页

作者： Zahra Dadashi Ouranj Saadi Hosseini Atefeh Alipour Shahin Homaeigohar Shahram Azari Leila Ghazizadeh Mohammadali Shokrgozar Sabu Thomas Saeed Irian Hosein Shahsavarani Department of Cell and Molecular Biology Faculty of Biological SciencesKharazmi UniversityTehran 15719-14911Iran Laboratory of Regenerative Medicine and Biomedical Innovations National Cell Bank of IranPasteur Institute of IranTehran 13169-43551Iran Department of Nanobiotechnology Pasteur Institute of IranTehran 13169-43551Iran School of Science and Engineering University of DundeeDundee DD14HNUK School of Chemical Sciences Mahatma Gandhi UniversityKottayamKeralaIndia Department of Cell and Molecular Biology Faculty of Life Sciences and BiotechnologyShahid Beheshti UniversityTehran 19839-69411Iran iranian Biological Resource Center Academic Center for EducationCulture and Research(ACECR)Tehran ***Iran

This study aimed to investigate the osteo-inductive capacity of a fucoidan polysaccharide network derived from brown algae on human adipose-derived stem cells(HA-MSCs)for bone *** physiochemical properties of the scaffold including surface morphology,surface chemistry,hydrophilicity,mechanical stiffness,and porosity were thoroughly *** in vitro and in vivo measurements implied a superior cell viability,proliferation,adhesion,and osteo-inductive performance of obtained scaffolds compared to using specific osteogenic induction medium with increased irregular growth of calcium crystallites,which mimic the structure of natural *** scaffold was highly biocompatible and suitable for cell *** examinations,such as quantification of mineralization,alkaline phosphatase,gene expression,and immunocytochemical staining of pre-osteocyte and bone markers confirmed that HAD-MSCs differentiate into osteoblasts,even without an osteogenic induction *** study provides evidence for the positive relationship and synergistic effects between the physical properties of the decellularized seaweed scaffold and the chemical composition of fucoidan in promoting the osteogenic differentiation of ***,the natural matrices derived from brown seaweed offers a sustainable,cost-effective,non-toxic bioinspired scaffold and holds promise for future clinical applications in orthopedics.

关键词： Bone tissue engineering Seaweed-derived scaffold Fucoidans HA-MSCs differentiation Osteoblasts

Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第1期32卷 101-125页

作者： ROGHAYEH GHORBANI MAHMOUD GHARBAVI ALI SHARAFI ELHAM RISMANI HAMED REZAEEJAM YOUSEF MORTAZAVI BEHROOZ JOHARI Department of Medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjanIran Nanotechnology Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Zanjan Pharmaceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Department of Pharmaceutical Biotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran Molecular Medicine Department Biotechnology Research CenterPasteur Institute of IranPasteur AvenueTehranIran Department of Radiology Technology School of Allied Medical SciencesZanjan University of Medical SciencesZanjanIran

In the present study,we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer *** decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics *** were loaded on the synthesized Se@BSA@Chi-MTX *** physicochemical characteristics of nanostructures were determined by FTIR,DLS,UV-vis,TEM,EDX,in vitro release,and hemolysis ***,the cytotoxicity properties of them with and without X-irradiation were investigated by uptake,MTT,cell cycle,apoptosis,and scratch assays on the LNCaP cell *** results of DLS and TEM showed negative charge(−9 mV)and nanometer size(40 nm)for Se@BSA@Chi-DEC-MTX NPs,*** results of FTIR,UV-vis,and EDX showed the proper interaction of different parts and the correct synthesis of *** results of hemolysis showed the hemocompatibility of this nanoparticle in concentrations less than 6 mg/*** ODNs release from the nanostructures showed a pH-dependent manner,and the release rate was 15%higher in acidic *** targeted Se@BSA@Chi-labeled ODN-MTX NPs were efficiently taken up by LNCaP cells by targeting the prostate-specific membrane antigen(PSMA).The significant synergistic effects of nanostructure(containing MTX drug)treatment along with X-irradiation showed cell growth inhibition,apoptosis induction(~57%),cell cycle arrest(G2/M phase),and migration inhibition(up to 90%)compared to the *** results suggested that the Se@BSA@Chi-DEC-MTX NPs can potentially suppress the cell growth of LNCaP *** nanostructure system can be a promising approach for targeted drug delivery and chemoradiotherapy in prostate cancer treatment.

关键词： Chemoradiotherapy Combination therapy Decoy oligodeoxynucleotides Myc transcription factor Selenium nanoparticle Prostate cancer

Fatal cases in pediatric patients after post-exposure prophylaxis for rabies:A report of two cases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 39-42页

作者： Hekmatollah Khoubfekr Mohammad Jokar Vahid Rahmanian Hasan Blouch Mohammad Reza Shirzadi Rouzbeh Bashar Department of Public Health Iranshahr University of Medical SciencesIranshahrIran Faculty of Veterinary Medicine Karaj BranchIslamic Azad UniversityKarajIran Department of Public Health Torbat Jam Faculty of Medical SciencesTorbat JamIran Center for Communicable Diseases Control Ministry of Health and Medical EducationTehranIran WHO Collaborating Center for Reference and Research on Rabies Virology DepartmentPasteur Institute of IranTehranIran

Rationale:Rabies is a zoonotic disease with a high mortality,primarily transmitted through the bite of infected mammals,particularly dogs and *** being a well-known disease since ancient times,it continues to cause a significant number of human deaths worldwide,with approximately 65000 fatalities reported *** concerns:We present two fatal cases of rabies in a 12-year-old immigrant boy and a 7-year-old *** first case was subject to a 24-hour delay in receiving appropriate medical attention and rabies preventive measures due to the lack of awareness among emergency hospital staff,leading to the administration of wound dressing *** second case received timely rabies immunoglobulin administration;however,there was a 4-day delay in administering the fourth dose of the rabies vaccine,despite presenting evident symptoms of ***:Postmortem examination of brain samples from both patients confirmed the presence of rabies ***:Post-exposure prophylaxis for ***:Both patients were admitted to the hospital after the manifestation of rabies-related symptoms,with the 12-year-old child seeking medical care 47 days after the animal bite and the 7-year-old child seeking medical care 58 days after the ***,the first patient died after 27 days and the second patient died after 40 days of ***:There is an urgent need for heightened awareness and education among both healthcare professionals and the public regarding the urgency of seeking immediate medical attention after potential rabies *** recognition and initiation of post-exposure prophylaxis are pivotal in preventing the progression of the *** surveillance and reporting systems,coupled with continuous training for healthcare professionals,can contribute to early detection and management of rabies cases.

关键词： Rabies Encephalitis Pediatric patients Rabies prophylaxis Public health awareness

Movement Trend Alterations in the Periaqueductal Gray(PAG)-Employed Ratbot Navigation Are Correlated with Stimulation Parameters

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第2期21卷 866-876页

作者： Sina Khajei Abed Khorasani Mohammad Reza Afarinesh Vahid Sheibani Neuroscience Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKerman***Iran Cognitive Neuroscience Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKerman***Iran

In previous studies,Periaqueductal Gray(PAG)stimulation was used to stop ratbots from *** to the homology between the PAG and the intercollicular nucleus,which has been used for forward movement in birds,we investigated the possibility of PAG application to induce forward locomotion for the first *** a corridor maze,the traveled distances via PAG electrical stimulation were examined in nine Wistar male rats during three sessions.A custom-designed stimulator was developed to apply the *** results showed reductions in responses to stimulation over ***,the traveled distances had negative slopes during the consecutive trials(in 8 out of the 9 rats),and the slope mean was significantly different from *** was a strong correlation between the stimulation parameters(electric Charge per Phase(CPP)and the Number of Pulses(NP))and the observed *** negative Movement Slopes(MS)were highly correlated with the CPP and the NP,as the Pearson's linear correlation coefficients were−0.87 and−0.79,*** MS-CPP coefficients of determination(R-squared)were also between 0.76 and *** addition,the MS-NP coefficients of determination were between 0.63 and ***,it is concluded that the electrical stimulation parameters influence the behavioral outcomes ***,the PAG area may be considered a suitable candidate for forward locomotion control in the future if the area is harnessed effectively to prevent undesirable chaotic behaviors.

关键词： Periaqueductal Gray(PAG) Navigation Ratbot Animal-robot Forward locomotion Movement slope

Experimental investigation into effects of the natural polymer and nanoclay particles on the EOR performance of chemical flooding in carbonate reservoirs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 951-961页

作者： Amir Mohammad Zamani Ashkan Moslemi Kamran Hassani Department of Petroleum Engineering Islamic Azad University Science and Research BranchTehranIran institute of Petroleum Engineering University of TehranTehranIran

This paper aims to investigate the tragacanth gum potential as a natural polymer combined with natural clay mineral(montmorillonite,kaolinite,and illite)nanoparticles(NPs)to form NP-polymer suspension for enhanced oil recovery(EOR)in carbonate *** gravimetric analysis(TGA)tests were conducted initially in order to evaluate the properties of tragacanth ***,scanning electron microscopy(SEM)and energy-dispersive X-ray(EDX)tests were used to detect the structure of clay *** various scenarios,the effects of natural NPs and polymer on the wettability alteration,interfacial tension(IFT)reduction,viscosity improvement,and oil recovery were investigated through contact angle system,ring method,Anton Paar viscometer,and core flooding tests,*** entire experiment was conducted at 25,50,and 75℃,*** to the experimental results,the clay minerals alone did not have a significant effect on viscosity,but the addition of minerals to the polymer solution leads to the viscosity enhancement remarkably,resulting mobility ratio *** clay NPs,the combination of natural polymer and kaolinite results in increased viscosity at all *** wettability alteration was also observed in the case of natural polymer and illite *** in combination with natural polymer showed an ability in reducing ***,the results of displacement experiments revealed that the combination of natural polymer and kaolinite could be the best option for EOR due to its substantial ability to improve the recovery factor.

关键词： Chemical flooding Tragacanth gum Clay nanoparticle Wettability IFT

Dynamics of a rotating ring-stiffened sandwich conical shell with an auxetic honeycomb core

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 963-982页

作者： S.JAHANGIRI A.GHORBANPOUR ARANI Z.KHODDAMI MARAGHI Department of Solid Mechanics Faculty of Mechanical EngineeringUniversity of KashanKashan ***Iran Faculty of Engineering Mahallat Institute of Higher EducationMahallat ***Iran

The free vibration analysis of a rotating sandwich conical shell with a reentrant auxetic honeycomb core and homogenous isotropic face layers reinforced with a ring support is *** shell is modeled utilizing the first-order shear deformation theory(FSDT)incorporating the relative,centripetal,and Coriolis accelerations alongside the initial hoop tension created by the *** governing equations,compatibility conditions,and boundary conditions are attained using Hamilton’s *** trigonometric functions,an analytical solution is derived in the circumferential direction,and a numerical one is presented in the meridional direction via the differential quadrature method(DQM).The effects of various factors on the critical rotational speeds and forward and backward frequencies of the shell are *** present work is the first theoretical work regarding the dynamic analysis of a rotating sandwich conical shell with an auxetic honeycomb core strengthened with a ring support.

关键词： free vibration conical shell rotating shell ring support auxetic honeycomb

Synthesis of boron nitride nanorod and its performance as a metalfree catalyst for oxidative desulfurization of diesel fuel

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第4期68卷 120-132页

作者： Tanaz Ghanadi Gholamreza Moradi Alimorad Rashidi Catalyst Research Center Faculty of Chemical and Petroleum EngineeringRazi UniversityKermanshahIran Nanotechnology Research Center Research Institute of Petroleum Industry(RIPI)TehranIran

In order to reduce the sulfur compounds in diesel fuel,boron nitride(BN)has been used as a novel metal-free catalyst in the present *** nanocatalyst was synthesized via template-free approach followed by heating treatment at 900℃ in nitrogen atmosphere that the characteristics of the sample were identified by the X-ray diffraction,Fourier-transform infrared spectroscopy,Raman spectroscopy,field emission scanning electron microscopy,transmission electron microscopy,atomic force microscopy,and N2 adsorption-desorption *** results of structural and morphological analysis represented that BN has been successfully *** efficacy of the main operating parameters on the process was studied by using response surface methodology based on the Box-Behnken design *** prepared catalyst showed high efficiency in oxidative desulfurization of diesel fuel with initial sulfur content of 8040 mg·kg^(-1)*** statistical analysis,a significant quadratic model was obtained to predict the sulfur removal as a function of efficient *** maximum efficiency of 72.4%was achieved under optimized conditions at oxidant/sulfur molar ratio of 10.2,temperature of 71℃,reaction time of 113 min,and catalyst dosage of 0.36 ***,the reusability of the BN was studied,and the result showed little reduction in activity of the catalyst after 10 times ***,a plausible mechanism was proposed for oxidation of sulfur compounds on the surface of the *** present study shows that BN materials can be selected as promising metal-free catalysts for desulfurization process.

关键词： Desulfurization Boron nitride(BN)nanostructure Experimental design BoxeBehnken

Seismic control of multi-degrees-of-freedom structures by vertical mass isolation method using MR dampers

在线全文

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2024年第2期23卷 503-510页

作者： Mohamad Shahrokh Abdi Masoud Nekooei Mohammad-Ali Jafari Department of Civil Engineering Marivan BranchIslamic Azad UniversityMarivan ***Iran Department of Civil Engineering Science and Research BranchIslamic Azad UniversityTehran ***Iran Structural Department of Transmission and Distribution Research Center Niroo Research Institute(NRI)Tehran ***Iran

Vertical mass isolation(VMI)is one of the novel methods for the seismic control of *** this method,the entire structure is assumed to consist of two mass and stiffness subsystems,and an isolated layer is located among *** this study,the magnetorheological damper in three modes:passive-off,passive-on,and semi-active mode with variable voltage between zero and 9 volts was used as an isolated layer between two ***-degrees-of-freedom structures with 5,10,and 15 floors in two dimensions were examined under 11 pairs of near field *** each level,the displacement of MR dampers was taken into *** responses of maximum displacement,maximum inter-story drift,and maximum base shear in controlled and uncontrolled buildings were compared to assess the suggested approach for seismic control of the *** to the results,the semi-active control method can reduce the response by more than 12%compared to the uncontrolled mode in terms of maximum displacement of the mass subsystem of the *** method can reduce more than 16%and 20%of the responses compared to the uncontrolled mode in terms of maximum inter-story drift and base shear of the structure,respectively.

关键词： seismic control vertical mass isolation base shear magnetorheological damper semi-active control