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Distribution and Contamination of Arsenic in Fish, Gastropods and Bivalves in the Aby and Tendo Lagoons in East of Ivory Coast

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Journal of Environmental Protection 2024年第3期15卷 246-264页

作者： Kouakou Serge Kouassi Stéphane Jean Claon Kossonou Roland N’Guettia Séri Kipré Laurent Dakouo Guei Jokebed Djaman Allico Joseph Laboratory of Biology and Health University of F&eacutelix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire Department of Analytical Sciences and Public Health Faculty of Pharmaceutical and Biological Sciences University of F&eacutelix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire Laboratory of Environmental Sciences (LSE) University of Nangui Abrogoua Abidjan C&ocircte d’Ivoire Department of Medical and Fundamental Biochemistry Institut Pasteur of C&ocircte d’Ivoire Abidjan C&ocircte d’Ivoire

Lagoons are ecosystems for biodiversity and the livelihoods of coastal communities. The main objective of the study was to analyze the variability of arsenic concentrations in gastropods and bivalves in the Aby and Tendo lagoons, taking into account spatial, seasonal and hydrological variations. The study was carried out in four stages spread over two successive hydroclimatic cycles, including two seasons during the rainy season and two more during the dry season. The samples were taken in two areas of the Aby and Tendo lagoons. Arsenic levels were measured by ICP-MS. The results showed that mean arsenic concentrations in the muscles of organisms in Aby Lagoon ranged from 0.01 to 1.26 μg As/g, with a mean and median of 0.17 and 0.06 μg As/g, respectively. Fish had the highest levels of arsenic, followed by crustaceans, while molluscs and plants had lower and comparable concentrations of As. Arsenic concentrations in tilapia and jawbones varied significantly between sites and seasons, with higher concentrations at Tendo and during the rainy season. Arsenic concentrations in gastropods and bivalves were significantly higher than those of other species, with averages of 0.74 and 1.03 mg As/kg, respectively.

关键词： Arsenic Pollution Fish Gastropods Lagoons Health Effect

Ready to migrate?Reading cellular signs of migration in an epithelial to mesenchymal transition model

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BIOCELL 2022年第11期46卷 2353-2356页

作者： TAMARA FERNÁNDEZ-CALERO IGNACIO LÓPEZ MARCOS DAVYT CORA CHALAR RICARDO EHRLICH MÓNICA MARÍN Biochemistry-Molecular Biology Faculty of ScienceUniversidad de la RepúblicaMontevideo11400Uruguay Bioinformatics Unit Institut Pasteur de MontevideoMontevideo11400Uruguay Departamento de Ciencias Exactas y Naturales Universidad Católica del UruguayMontevideo11600Uruguay institut pasteur de Montevideo Montevideo11400Uruguay

The epithelial to mesenchymal transition(EMT)is a cellular program that drives de-differentiation of cells in both physiological and pathological *** of the characteristics of cells describing an EMT is the(re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the *** molecular mechanisms that control the EMT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EMT includes adjustments of the translation machinery and metabolic pathways to cope with a high demand of extracellular components.

关键词： EMT Migration Translation machinery Metabolism

Rodent control to fight plague:field assessment of methods based on rat density reduction

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Integrative Zoology 2021年第6期16卷 868-885页

作者： Soanandrasana RAHELINIRINA Kathryn SCOBIE Beza RAMASINDRAZANA Voahangy ANDRIANAIVOARIMANANA Fanohinjanaharinirina RASOAMALALA Lovasoa Nomena RANDRIANTSEHENO Jerry Sylvio RAKOTONIAINA Olivier GORGÉ Xavier LAMBIN Eric VALADE Sandra TELFER Minoarisoa RAJERISON institut pasteur de Madagascar Plague UnitAntananarivoMadagascar School of Biological Sciences University of AberdeenAberdeenUK Central Laboratory for Plague Ministry of Public HealthAntananarivoMadagascar institut de Recherche Biomédicale des Armées ParisFrance

Rodents represent a serious threat to food security and public *** extent to which rodent control can mitigate the risk from rodent-borne disease depends on both the effectiveness of control in reducing rodent abundance and the impact on disease *** on a plague-endemic region of Madagascar,this study compared the effectiveness of 3 methods:live-traps,snap-traps,and *** interventions were implemented inside houses between May and October *** tiles monitored rodent *** fleas,the vector involved in plague transmission,were *** populations consisted of Rattus rattus and Mus *** terms of trap success,we found that our live-trap regime was more effective than *** all 3 control strategies appeared to reduce in-house rodent activity in the short term,we found no evidence of a longer-term effect,with in-house rodent abundance in treated sites comparable to non-treatment sites by the following *** flea,Synopsyllus fonquerniei,is a key plague vector usually found on rats living *** we found no evidence that its abundance inside houses increased following control,this may have been due to a lack of power caused by significant variation in *** *** presence of *** in houses was more likely when *** abundance on outdoor rats was higher,which in turn correlated with high rat *** results emphasize that control strategies need to consider this connectivity between in-house rat–flea populations and the outdoor populations,and any potential consequences for plague transmission.

关键词： fleas Madagascar plague rodents surveillance

Super-resolution imaging and reconstructions of chromosome architecture in yeast and human cell

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Super-resolution imaging and reconstructions of chromosome a...

Romance of the three kingdoms: RORgammat allies with HIF1alpha against FoxP3 in regulating T cell metabolism and differentiation

中国化学会-生物物理化学专业委员会第四届全国生物物理化学会议

作者：郝先 WeberChristian OuyangWei ZimmerChristophe institut pasteur

Chromosomes are arranged non-randomly in the 3 D space of cellular nuclei. This architecture is important to key biological processes including gene expression and DNA repair, but remains poorly understood in detail. Genome-wide chromosome conformation capture(Hi-C) is currently the most powerful experimental technique to probe chromosomal structures. However, this technique does not directly provide a description of high-resolution chromosomal configurations in individual cells and remains blind to the dynamics of chromatin in live cells. In this research, we aim to develop experimental imaging and associated computational approaches to describe the structures and dynamics of chromosomes at high resolution in individual cells. We performed this by combining recent single molecule microscopy approaches with dedicated computational reconstruction methods, partly based on polymer physics. We then used these approaches to study the changes of chromosome configurations and analyze their relationship to gene expression and repair of DNA double strand breaks. This research shows generate new technologies and new fundamental knowledge in the areas of nuclear architecture and function.

关键词： super-resolution imaging chromosome architecture computational reconstruction genome organization

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Protein & Cell 2011年第10期2卷 778-781页

作者： Andy Tsun Zuojia Chen Bin Li Key Laboratory of Molecular Virology&Immunology Unit of Molecular ImmunologyInstitut Pasteur of ShanghaiShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200025China

Regulatory T(Treg)cells play an essential role in immune homeostasis by controlling the function of various immune effector cells,including RAR-related orphan receptor gammat+(RORγt+)T helper 17(Th17)*** box P3(FoxP3)is the master regulator of Treg cell function,while RORγt is the key transcription factor for the induction of the interleukin(IL)-17 family of cytokines during Th17 cell ***3 can directly interact with and negatively regulate the function of RORγt,to determine the balance between induced Treg(iTreg)and Th17 cell *** recent independent studies from the Pan and Chi Labs have shown how hypoxia-inducible factor 1 alpha(HIF1α)is able to tip the balance of T cell differentiation toward the Th17 lineage by responding to the local changes in metabolic shift or an increase in proinflammatory mediators in the *** allying with HIF1α,RORγt wins the fight against FoxP3 and Treg cell commitment.

关键词： FoxP3 RORγt Th17

Multilevel Preconditioners for the Interior Penalty Discontinuous Galerkin Method II-Quantitative Studies

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Communications in Computational Physics 2009年第2期5卷 296-325页

作者： Kolja Brix Martin Campos Pinto Wolfgang Dahmen Ralf Massjung institut fur Geometrie und Praktische Mathematik RWTH Aachen52056 AachenGermany Universite Louis pasteur Institut de Recherche Mathematique AvanceeCNRS UMR 750167084 StrasbourgFrance

This paper is concerned with preconditioners for interior penalty discontinuous Galerkin discretizations of second-order elliptic boundary value *** extend earlier related results in[7]in the following *** concrete realizations of splitting the nonconforming trial spaces into a conforming and(remaining)nonconforming part are identified and shown to give rise to uniformly bounded condition *** asymptotic results are complemented by numerical tests that shed some light on their respective quantitative behavior.

关键词： Interior penalty method energy-stable splittings admissible averaging operators frames multilevel Schwarz preconditioners discontinuous Galerkin methods

Actin nucleator formins regulate the tension-buffering function of caveolin-1

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Journal of Molecular Cell Biology 2021年第12期13卷 876-888页

作者： Xuemeng Shi Daijiao Tang Yifan Xing Shuangshuang Zhao Changyuan Fan Jin Zhong Yanqin Cui Kun Shi Yaming Jiu The Joint Program in Infection and Immunity Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623China The Joint Program in Infection and Immunity Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Unit of Cell Biology and Imaging Study of Pathogen Host Interaction The Center for MicrobesDevelopment and HealthCAS Key Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Unit of Viral Hepatitis CAS Key Laboratory of Molecular VirologyInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China

Both the mechanosensitive actin cytoskeleton and caveolae contribute to active processes such as cell migration,morphogenesis,and vesicular *** distinct actin components are well studied,how they contribute to cytoplasmic caveolae,especially in the context of mechano-stress,has remained ***,we identify two actin-associated mobility stereotypes of caveolin-1(CAV-1)-marked intracellular vesicles,which are characterized as‘dwelling’and‘go and dwelling’.In order to exploit the reason for their distinct dynamics,elongated actin-associated formin functions are *** find drastically decreased density,increased clustering,and compromised motility of cytoplasmic CAV-1 vesicles resulting from lacking actin nucleator formins by both chemical treatment and RNA silencing of formin ***,hypo-osmosis-stimulated diminishing of CAV-1 is dramatically intensified upon blocking *** clustering of CAV-1 vesicles when cells are cultured on soft substrate is also aggravated under formin inhibition ***,we reveal that actin-associated formins are essential for maintaining the dynamic organization of cytoplasmic CAV-1 and importantly its sensitivity upon mechanical *** conclude that tension-controlled actin formins act as a safety valve dampening excessive tension on CAV-1 and safeguarding CAV-1 against mechanical damage.

关键词： caveolin-1 elongated actin filaments formins hypo-osmotic shock matrix stiffness

Evolutionary perspectives on novel coronaviruses identified in pneumonia cases in China

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National Science Review 2020年第2期7卷 239-242页

作者： Xiaoman Wei Xiang Li Jie Cui CAS Key Laboratory of Molecular Virology &Immunology Institut Pasteur of ShanghaiChinese Academy of Sciences Wuhan institute of Virology Center for Biosafety Mega-Science Chinese Academy of Sciences University of Chinese Academy of Sciences

Coronaviruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), are highly transmissible pathogens, and they can be lethal in humans. Bats are believed to be the original sources of these lethal pathogens. In December 2019, a cluster of pneumonia cases was reported in Wuhan and a novel coronavirus (2019-nCoV, now officially named as SARS-

关键词： origin Evolutionary perspectives on novel coronaviruses identified in pneumonia cases in China

National Epidemiology and Evolutionary History of Four Hand, Foot and Mouth Disease-Related Enteroviruses in China from 2008 to 2016

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Virologica Sinica 2020年第1期35卷 21-33页

作者： Xuemin Fu Zhenzhou Wan Yanpeng Li Yihong Hu Xia Jin Chiyu Zhang Pathogen Discovery and Big Data Center CAS Key Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Medical Laboratory of Taizhou Fourth People’s Hospital Taizhou 225300China Viral Disease and Vaccine Translational Research Unit CAS Key Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China

Hand, foot and mouth disease(HFMD) is a major public health concern in China. The most predominant enteroviruses that cause HFMD have traditionally been attributed to enterovirus A71(EVA71) and coxsackievirus A16(CVA16). Since its first large outbreak in 2008, the dominant HFMD pathogens are constantly changing. In 2013 and 2015, CVA6 exceeded both EVA71 and CVA16 to become the leading cause of HFMD in some provinces. However, there still lacks a comprehensive overview on the molecular epidemiology and evolution of HFMD-related enteroviruses at the national level. In this study, we performed systematic epidemiological analyses of HFMD-related enteroviruses using the data of 64 published papers that met the inclusion criteria, and conducted phylogenetic analyses based on 12,080 partial VP1 sequences identified in China before 31 st June 2018. We found that EVA71 prevalence has decreased sharply but other enteroviruses have increased rapidly from 2008 to 2016 and that one subtype of each enterovirus is represented during the epidemic. In addition, four genotypes EVA71_C4, CVA16_B1, CVA6_D and CVA10_C are the most predominant enterovirus strains and collectively they cause over 90% of all HFMD cases in China according to the phylogenetic trees using representative partial VP1 sequences. These four major enterovirus genotypes have different geographical distributions, and they may cocirculate with other genotypes and serotypes. These results suggest that more molecular epidemiological studies should be performed on several enteroviruses simultaneously, and such information should have implications for virological surveillance, disease management, vaccine development and policy-making on the prevention and control of HFMD.

关键词： Enterovirus Hand,foot and mouth disease(HFMD) Molecular epidemiology Evolution Genotype