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Probing new physics in dimension-8 neutral gauge couplings at e^+e^-colliders

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science China(Physics,Mechanics & Astronomy) 2021年第2期64卷 2-26页

作者： John Ellis Hong-Jian He Rui-Qing Xiao Department of Physics Kings College LondonStrandLondonWC2R 2LSUK theoretical Physics Department CERNCH-1211Geneva 23Switzerland NICPB Rävala 10Tallinn10143Estonia tsung-Dao Lee Institute&school of Physics and Astronomy Shanghai Key Laboratory for Particle Physics and CosmologyShanghai Jiao Tong UniversityShanghai200240China Institute of Modern Physics and Department of Physics Tsinghua UniversityBeijing100084China Center for High Energy Physics Peking UniversityBeijing100871China

Neutral triple gauge couplings(ntGCs)are absent in the standard model effective theory up to dimension-6 operators,but could arise from dimension-8 effective *** this work,we study the pure gauge operators of dimension-8 that contribute to ntGCs and are independent of the dimension-8 operator involving the Higgs *** show that the pure gauge operators generate both ZγZ^*and Zγγ^*vertices with rapid energy dependence∝E^5,which can be probed sensitively via the reaction e^+e^-→Zγ.We demonstrate that measuring the ntGCs via the reaction e^+e^-→Zγfollowed by Z→qq decays can probe the new physics scales of dimension-8 pure gauge operators up to the range(1-5)teV at the CEPC,FCC-ee and ILC colliders with s~(1/2)=(0.25-1)teV,and up to the range(10-16)teV at CLIC with s~(1/2)=(3-5)teV,assuming in each case an integrated luminosity of 5 ab~(-1).We compare these sensitivities with the corresponding probes of the dimension-8 ntGC operators involving Higgs doublets and the dimension-8 fermionic contact operators that contribute to the e^+e^-Zγvertex.

关键词： neutral triple gauge couplings new physics beyond the standard model effective field theory e^+e^-colliders

study of the CKM angle γ sensitivity using flavor untagged Bs0→D（*）0φ decays

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Chinese Physics C 2021年第2期45卷 60-96页

作者：敖冬 D.Decamp 钱文斌 s.Ricciardi H.sazak s.t'Jampens V.tisserand 王子睿杨振伟张舒楠周晓康 university of Chinese Academy of sciences Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRS stFC Rutherford Appleton Laboratory Université Clermont Auvergne CNRS/IN2P3LPC Center for High Energy Physics Tsinghua University school of Physics state Key Laboratory of Nuclear Physics and technology Peking University

A sensitivity study on the measurement of the CKM angle y from B→Dφ decays is conducted using the D-meson reconstructed in the quasi flavour-specific modes Kπ,K3π,and Kππ,as well as CP-eigenstate modes KK and ππ,where the notation Dcorresponds to a Dor *** LHCb experiment is presented as a use case.A statistical uncertainty of approximately 8°-19°can be achieved with the pp collision data collected in the LHCb experiment from 2011 to *** sensitivity to y should be of the order 3°-8° after accumulating 23 fbof pp collision data by 2025,whereas it is expected to improve further by 300 fbby the second half of the 2030 *** accuracy is dependent on the strong parameters rand δ,which together with γdescribe the interference between the leading amplitudes of the B→Dφ decays.

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Multiple hemodynamic effects of endogenous hydrogen sulfide on central nervous system in rats

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Chinese Medical Journal 2011年第21期124卷 3468-3475页

作者： REN Yong-sheng WU sheng-ying WANG Xing-jun YU Fang ZHAO Jing tANG Chao-shu OUYANG Jing-ping GENG Bin Department of Pathophysiology Medical College of Wuhan University Wuhan 430071 China Department of Physiology Hubei University of Medicine Shiyan Hubei 422000 China Department of Physiology and Pathophysiology Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry Peking University Health Sciences Center Beijing 100191 China

Background Endogenous hydrogen sulfide is a new neuromodulator which takes part in the regulation of central nervous system physiology and diseases. Whether endogenous hydrogen sulfide in the central nervous system regulates cardiovascular activity is not known. In the present study, we observed the hemodynamic changes of hydrogen sulfide or its precursor by intracerebroventricular injection, and investigate the possible roles of endogenous digitalis like factors and sympathetic activity in the regulation. Methods Ninety-four sprague-Dawley rats underwent a right cerebroventricular puncture, then the hydrogen sulfide saturation buffer or its precursor injected by intrcerebroventricular catheter. A heperin-filled catheter was inserted into the right femoral artery or into the left ventricle, and changes of blood pressure or cardiac function recorded by a Powerlab/4s instrument. Phentolamine or metoprolol were pre-injected to observe the possible role in autonomic nerve activity. After rats were sacrificed, plasma was collected and endogenous digitalis-like factors were measured with a commercial radioimmunoassay kit. the aortic, cardiac sarcolemmal vesicles were isolated and the activity of Na＋-K＋-AtPase was measured as ouabain-sensitive AtP hydrolysis under maximal velocity conditions by measuring the release of inorganic phosphate from AtP. Unpaired student＇s ttest for two groups or analysis of variances （ANOVA） for multiple groups were used to compare the differences of the changes. Results Intracerebroventricular injection of hydrogen sulfide induced a transient hypotension, then dramatic hypertenive effects in a dose-dependent manner. Bolus injection of L-cysteine or beta-mercaptopyruvate also increased mean arterial pressure （P 〈0.01）, whereas hydroxylamine-a cystathionine beta synthase inhibitor decreased the arterial pressure （P 〈0.01）. Hydrogen sulfide and L-cysteine increased mean arterial pressure, left ventricular develop pressure and left-ventricle maxim

关键词： central nervous system hydrogen sulfide blood pressure cardiac systolic function endogenous digitalis like factor

Possible novel roles of poly(rC)-binding protein 1 in sH-sY5Y neurocytes: an analysis using a dynamic Bayesian network

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Neuroscience Bulletin 2012年第3期28卷 282-290页

作者： Li-Rong Huo Jian-tao Liang Jun-Hua Zou Lan-Ying Wang Qi Li Xiao-Min Wang Department of Physiology Key Laboratory for Neurodegenerative Disorders of the Ministry of Education Capital Medical University Beijing 100069 China peking university Center of Medical Genetics Beijing 100083 China Xuan Wu Hospital of Capital Medical university Beijing 100053 China Genminix Informatics Ltd. Co. Shanghai 201210 China

Objective Poly（rC）-binding protein 1 （PCBP1） belongs to the heterogeneous nuclear ribonucleoprotein family and participates in transcriptional and translational regulation. Previous work has identified transcripts targeted by both knockdown and overexpression of PCBP1 in sH-sY5Y neuroblastoma cells using a microarray or ProteomeLabtM protein fractionation 2-dimensions （PF-2D） and quadrupole time-of-flight mass spectrometer. the present study aimed to further determine whether these altered transcripts from major pathways （such as Wnt signaling, tGF-β signaling, cell cycling, and apoptosis） and two other genes, H2AFX and H2BFs （screened by PF-2D）, have spatial relationships. Methods the genes were studied by qRt-PCR, and dynamic Bayesian network analysis was used to rebuild the coordination network of these transcripts. Results PCBP1 controlled the expression or activity of the seven transcripts. Moreover, PCBP1 indirectly regulated MAP2K2, FOs, Fst, tP53 and WNt7B through H2AFX or regulated these genes through sAt. In contrast, tP53 and WNt7B are regulated by other genes. Conclusion the seven transcripts and PCBP1 are closely associated in a spatial interaction network.

关键词： PCBP1 RNA interference overexpression Bayesian network

Exploring the social,ethical,legal,and responsibility dimensions of artificial intelligence for health-a new column in Intelligent Medicine

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Intelligent Medicine 2022年第2期2卷 103-109页

作者： Achim Rosemann Xinqing Zhang Centre for Computing and social Responsibility De Montfort UniversityLeicesterUnited Kingdom Department of sociology Philosophy and AnthropologyUniversity of ExeterUnited Kingdom school of Humanities and social sciences Peking Union Medical College&Chinese Academy of Medical SciencesBeijing 100005China

this essay is the starting point of a new column in Intelligent Medicine that invites interdisciplinary perspectives on the social,ethical,legal,and responsibility aspects of the use of artificial intelligence(AI)in medicine and health *** in this column will examine the practical,conceptual,and policy dimensions of the use of AI for health-related purposes from comparative and international *** invite contributions from around the world in all application areas of AI for health,including health care,health research,drug development,health care system management,as well as public health and public health *** column aims to provide a forum for reflective and critical scholarship that contributes to the ongoing academic and policy debates about the development,use,governance,and implications of AI in medical and health care *** launch the column,we first provide an overview of recent approaches that have been developed to identify and address the effects and potential impacts of science and technology innovations on human societies and the *** include ethical,legal,and social implications/aspects(ELsI/A)research,responsible research and innovation(RRI),sustainability transitions research,and the use of international standard-setting instruments for responsible and open science issued by the United Nations Educational,scientific,and Cultural Organization(UNEsCO),the World Health Organization(WHO),and other international *** part two of this essay,we discuss some of the central challenges that arise with regard to the integration of AI and big data analytics in medical and health care *** includes concerns regarding(i)the control,reliability,and trustworthiness of AI systems,(ii)privacy and surveillance,(iii)the impact of AI and automation on health care staffemployment and the nature of clinical work,(iv)the effects of AI on health inequalities,justice,and access to medical care,and(v)challenges rel

关键词： Artificial intelligence Health Ethical,legal and social implications Responsible research and innovation Global ethics Governance of emerging technologies

Applications and prospects of cryo-EM in drug discovery

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Military Medical Research 2023年第6期10卷 848-861页

作者： Kong-Fu Zhu Chuang Yuan Yong-Ming Du Kai-Lei sun Xiao-Kang Zhang Horst Vogel Xu-Dong Jia Yuan-Zhu Gao Qin-Fen Zhang Da-Ping Wang Hua-Wei Zhang Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of structural Biology St.Jude Children’s Research HospitalMemphisTN 38105USA Center for Protein science and Crystallography School of Life SciencesFaculty of ScienceChinese University of Hong KongHong Kong 999077China Interdisciplinary Center for Brain Information the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina Faculty of Life and Health sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina shenzhen-Hong Kong Institute of Brain science-shenzhen Fundamental Research Institutions Shenzhen 518055GuangdongChina shenzhen Institute of Advanced technology Chinese Academy of SciencesShenzhen 518055GuangdongChina state Key Lab for Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhou 510275China Cryo‑EM Facility Center Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Orthopedics Shenzhen Intelligent Orthopaedics and Biomedical Innovation PlatformGuangdong Provincial Research Center for Artifcial Intelligence and Digital Orthopedic TechnologyShenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhen 518000GuangdongChina Guangdong Provincial Key Laboratory of Advanced Biomaterials Southern University of Science and TechnologyShenzhen 518055GuangdongChina

Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time-and effort-consuming. structural biology has been demonstrated as a powerful tool to accelerate drug development. Among different techniques, cryo-electron microscopy(cryo-EM) is emerging as the mainstream of structure determination of biomacromolecules in the past decade and has received increasing attention from the pharmaceutical industry. Although cryo-EM still has limitations in resolution, speed and throughput, a growing number of innovative drugs are being developed with the help of cryo-EM. Here, we aim to provide an overview of how cryo-EM techniques are applied to facilitate drug discovery. the development and typical workflow of cryo-EM technique will be briefly introduced, followed by its specific applications in structure-based drug design, fragment-based drug discovery, proteolysis targeting chimeras, antibody drug development and drug repurposing. Besides cryo-EM, drug discovery innovation usually involves other state-of-the-art techniques such as artificial intelligence(AI), which is increasingly active in diverse areas. the combination of cryo-EM and AI provides an opportunity to minimize limitations of cryo-EM such as automation, throughput and interpretation of mediumresolution maps, and tends to be the new direction of future development of cryo-EM. the rapid development of cryo-EM will make it as an indispensable part of modern drug discovery.

关键词： Cryo-electron microscopy(cryo-EM) Drug discovery structure-based drug design Fragment-based drug discovery Proteolysis targeting chimeras Drug repurposing Artificial intelligence(AI)

Identifier Management of Industrial Internet Based on Multi-Identifier Network Architecture

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ZtE Communications 2020年第1期18卷 36-43页

作者： WANG Yunmin LI Hui XING Kaixuan HOU Hanxu Yunghsiang sHAN LIU Ji sUN tao shenzhen Graduate school Peking UniversityShenzhenGuangdong 518055China Pengcheng Laboratory ShenzhenGuangdong 518000China school of Electrical Engineering and Intelligentization Dongguan University of TechnologyDongguanGuangdong 523808China the Network and Information Center of shenzhen university town ShenzhenGuangdong 518055China

the industrial Internet realizes intelligent control and optimized operation of the industrial system through network *** industrial Internet identifier is the core element to accomplish this *** traditional industrial Internet identifier resolution technologies depend excessively on IP networks,and cannot meet the requirements of ubiquitous resource-restraint Internet of things(Iot)*** industrial Internet identifier resolution management strategy based on multi-identifier network architecture is proposed in this paper,which supports content names,identities,locations,apart from the traditional IP *** application of multiple types of identifiers not only solves the problem of IP addresses exhaustion,but also enhances the security,credibility,and availability of the industrial Internet identification resolution *** inter-translation scheme between multiple identifiers is designed to support multiple identifiers and the standard *** present an addressing and routing algorithm for identifier resolution to make it convenient to put our strategy into practice.

关键词： identifier resolution industrial Internet inter-translation multiple identifier routing and addressing

HfO_2 Gate Dielectrics for Future Generation of CMOs Device Application

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Journal of semiconductors 2004年第10期25卷 1193-1204页

作者： H.Y.Yu J.F.Kang Ren Chi M.F.Li D.L.Kwong silicon Nano Device Laboratory Department of Electrical & Computer Engineerin gNUSSingapore 119260SingaporeInstitute of MicroelectronicsPeking UniversityBeijing 100871ChinaSilicon Nano Device LaboratoryDepartment of Electrical & Computer Engineerin gNUSSingapore 119260SingaporeSilicon Nano Device LaboratoryDepartment of Electrical & Computer Engineerin gNUSSingapore 119260SingaporeInstitute of MicroelectronicsSingapore 117685SingaporeDepartment of Electrical & Computer EngineeringThe University of TexasAust inTX 78752USA

the material and electrical properties of HfO 2 hi gh-k gate dielectric are *** the first part,the band alignment of H fO 2 and (HfO 2) x(Al 2O 3) 1-x to (100)si substrate and thei r thermal stability are studied by X-ray photoelectron spectroscopy and *** energy gap of (HfO 2) x(Al 2O 3) 1-x,the valence band offset, and the conduction band offset between (HfO 2) x(Al 2O 3) 1-x and the si substrate as functions of x are obtained based on the XPs results .Our XPs results also demonstrate that both the thermal stability and the resist ance to oxygen diffusion of HfO 2 are improved by adding Al to form Hf aluminat *** the second part,a thermally stable and high quality HfN/HfO 2 gate stack is *** changes in equivalent oxide thickness (EOt),gate leakage, and work function (close to si mid-gap) of HfN/HfO 2 gate stack are demonstrat ed even after 1000℃ post-metal annealing(PMA),which is attributed to the super ior oxygen diffusion barrier of HfN as well as the thermal stability of the HfN/ HfO 2 ***,even without surface nitridation prior to HfO 2 depo sition,the EOt of HfN/HfO 2 gate stack has been successfully scaled down to les s than 1nm after 1000℃ PMA with excellent leakage and long-term reliability.t he last part demonstrates a novel replacement gate process employing a HfN dummy gate and sub-1nm EOt HfO 2 gate *** excellent thermal stability of the HfN/HfO 2 gate stack enables its use in high temperature CMOs *** e replacement of HfN with other metal gate materials with work functions adequat e for n- and p-MOs is facilitated by a high etch selectivity of HfN with respe ct to HfO 2,without any degradation to the EOt,gate leakage,or tDDB characteris tics of HfO 2.

关键词： HfO2 CMOs tDDB tEM XPs Al2O3 PMA

Location Privacy in Mobile Big Data:User Identifiability via Habitat Region Representation

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Journal of Communications and Information Networks 2018年第3期3卷 31-38页

作者： Luoyang Fang Xiang Cheng Liuqing Yang Haonan Wang Department of Electrical and Computer Engineering Colorado State UniversityFort CollinsCO 80523USA state Key Laboratory of Advanced Optical Communication systems&Networks School of Electronics Engineering and Computer SciencePeking UniversityBeijing 100871China Department of statistics Colorado State UniversityFort CollinsCO 80523USA

Mobile big data collected by mobile network operators is of interest to many research communities and industries for its remarkable ***,such spatiotemporal information may lead to a harsh threat to subscribers’*** work focuses on subscriber privacy vulnerability assessment in terms of user identifiability across two datasets with significant detail reduced mobility *** this paper,we propose an innovative semantic spatiotemporal representation for each subscriber based on the geographic information,termed as daily habitat region,to approximate the subscriber’s daily mobility coverage with far lesser information compared with original mobility *** daily habitat region is realized via convex hull extraction on the user’s daily spatiotemporal *** a result,user identification can be formulated to match two records with the maximum similarity score between two convex hull sets,obtained by our proposed similarity measures based on cosine distance and permutation hypothesis *** are conducted to evaluate our proposed innovative mobility representation and user identification algorithms,which also demonstrate that the subscriber’s mobile privacy is under a severe threat even with significantly reduced spatiotemporal information.

关键词： mobile big data privacy attack user identification spatiotemporal location privacy