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Comparison between laparoscopic uncut Roux-en-Y and Billroth Ⅱ with Braun anastomosis after distal gastrectomy:A meta-analysis

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World Journal of Gastrointestinal surgery 2022年第6期14卷 594-610页

作者： Ya-Jun Jiao Ting-Ting Lu De-Ming Liu Xue Xiang Liu-Li Wang Shi-Xun Ma Yong-Feng Wang Ya-Qiong Chen Ke-Hu Yang Hui Cai School of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Ningxia ProvinceChina Hui Cai General Surgery Clinical Medical CenterGansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Institution of Clinical Research and Evidence Based Medicine Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Evidence Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Conventional Billroth Ⅱ(BⅡ) anastomosis after laparoscopic distal gastrectomy(LDG) for gastric cancer(GC) is associated with bile reflux gastritis, and Roux-enY anastomosis is associated with Roux-Y stasis syndrome(RSS). The uncut Rouxen-Y(URY) gastrojejunostomy reduces these complications by blocking the entry of bile and pancreatic juice into the residual stomach and preserving the impulse originating from the duodenum, while BⅡ with Braun(BB) anastomosis reduces the postoperative biliary reflux without RSS. Therefore, the purpose of this study was to compare the efficacy and safety of laparoscopic URY with BB anastomosis in patients with GC who underwent radical distal *** To evaluate the value of URY in patients with *** PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, Chinese Biomedical Database, and VIP Database for Chinese Technical Periodicals(VIP) were used to search relevant studies published from January 1994 to August 18, 2021. The following databases were also used in our search: ***, Data Archiving and Networked Services, the World Health Organization International Clinical Trials Registry Platform Search Portal(https://***/clinical-trials-registry-platform/the-ictrp-search-portal), the reference lists of articles and relevant conference proceedings in August 2021. In addition, we conducted a relevant search by Reference Citation Analysis(RCA)(https://***). We cited highquality references using its results analysis functionality. The methodological quality of the eligible randomized clinical trials(RCTs) was evaluated using the Cochrane Risk of Bias Tool, and the non-RCTs were evaluated using the Newcastle-Ottawa scale. Statistical analyses were performed using Review Manager(Version 5.4).RESULTS Eight studies involving 704 patients were included in this meta-analysis. The incidence of reflux gastritis [odds ratio = 0.

关键词： gastric cancer Laparoscopy Uncut Roux-en-Y Anastomosis Meta-analysis Conventional BillrothⅡ

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Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm

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World Journal of Gastroenterology 2013年第21期19卷 3358-3363页

作者： Kenichi Hirabayashi Giuseppe Zamboni Hiroyuki Ito Masami Ogawa Yoshiaki Kawaguchi Tomohiro Yamashita Toshio Nakagohri Naoya Nakamura Department of Pathology Tokai University School of MedicineIsehara 259-1193Japan Department of Pathology Ospedale Sacro Cuore Don Calabria37024 Negrar VeronaItaly Department of Pathology University of Verona37134 Negrar VeronaItaly Department of Gastroenterology Tokai University School of MedicineIsehara 259-1193Japan Department of Radiology Tokai University School of MedicineIsehara 259-1193Japan Department of Gastroenterological surgery Tokai University School of MedicineIsehara 259-1193Japan

Solid pseudopapillary neoplasm (SPN) is a rare and low-grade malignant pancreatic neoplasm composed of poorly cohesive monomorphic neoplastic cells forming solid and pseudopapillary structures with frequent hemorrhagic-cystic degeneration. Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic exocrine tumor composed of intraductal papillary growth of mucin containing neoplastic cells in the main pancreatic duct or its major branches. In the case presented here, a 53-year-old, Japanese man was found to have multiple cystic lesions and dilatation of the main pancreatic duct in the neck of the pancreas. Histological examination revealed a main-duct and branch-duct type IPMN, of the gastric-type, involving the neck of the pancreas, associated with a 0.5 cm SPN in the caudal side of the IPMN. We diagnosed this case as synchronous SPN and IPMN. As far as we know, only one other case of synchronous SPN and IPMN has been reported. Both the present case and the previously reported case showed abnormal nuclear expression of β-catenin in SPN, whereas IPMN showed no abnormal nuclear expression. These results suggest that β-catenin abnormality is not a common pathogenetic factor of synchronous SPN and IPMN.

关键词： Intraductal papillary mucinous neoplasms Solid pseudopapillary neoplasms pancreatic neoplasms Synchronous neoplasms Pancreas Beta-catenin

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Organoid Technology and Clinical Applications in Digestive System Cancer

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Engineering 2022年第2期8卷 123-130页

作者： Xiaofang Zhao Youhai Jiang Chunliang Liu Minghui Hou Hongyang Wang Jing Fu Fudan University Shanghai Cancer Center Shanghai 200032China International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor BiologyEastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Cancer Research Center The First Affiliated Hospital of USTCDepartment of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Cancers of the digestive system(DS),including esophageal,gastric,colorectal,liver,and pancreatic can-cers,have a high incidence and mortality *** cancer models cannot faithfully recapitu-late the critical features of the original tumor,resulting in the failure of translation from basic research into clinical *** advanced cancer models are in urgent need of pathogenesis exploration and anticancer medicine *** are in vitro cultured three dimensional(3D)self-organizing organotypic structures derived from tissues and pluripotent stem cells,which faithfully mimic the histological features and preserve the genetic heterogeneity of the original *** normal and malignant organoids can now be efficiently established from the DS tissues of *** this review,we summarize the general methods to generate human DS organoids and their applications as a novel model in basic cancer research,preclinical medical practice,and precision medicine.

关键词： Organoid Digestive system cancer Precision medicine

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Interleukin-8, a promising predictor for prognosis of pancreatic cancer

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World Journal of Gastroenterology 2012年第10期18卷 1123-1129页

作者： Ying Chen Min Shi Guan-Zhen Yu Xiao-Ran Qin Gang Jin Peng Chen Ming-Hua Zhu Department of Pathology Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Oncology Changzheng Hospital Second Military Medical University Shanghai 200433 China Shanghai Chempartner Co. Ltd. Shanghai 201203 China Department of General surgery Changzheng Hospital Second Military Medical University Shanghai 200433 China

AIM: To investigate the value of interleukin-8 (IL-8), a pro-inflammatory chemokine, in predicting the prognosis of pancreatic cancer. METHODS: Expression of IL-8 and its receptor CXCR1 was assessed by immunohistochemistry in pancreatic cancer and chronic pancreatitis samples. Enzyme-linked immunosorbent assay was used to detect the serum IL-8 levels in pancreatic cancer patients. Human pancreatic cancer tissues were heterotopically transplanted to the immune-deficiency mice to evaluate the effect of serum IL-8 on the tumorigenesis of the cancer ***: IL-8 and CXCR1 proteins were both overexpressed in pancreatic adenocarcinoma samples (55.6% and 65.4%, respectively) compared with the matched para-cancer tissues (25.9% and 12.3%, P pancreatic cancer patients (271.1 ± 187.7 ng/mL) were higher than in other digestive system tumors, such as gastric cancer (41.77 ± 9.11 ng/mL, P = 0.025), colorectal carcinoma (78.72 ± 80.60 ng/mL, P = 0.032) and hepatocellular carcinoma (59.60 ± 19.80 ng/mL, P = 0.016). In vivo tumorigenesis analysis further proved that tumor tissues from patients with higher serum IL-8 levels grew faster than those with lower IL-8 levels. CONCLUSION: IL-8 can be a fine serum marker for predicting the prognosis pancreatic cancer.

关键词： pancreatic cancer Interleukin-8 CXCR1 Immunohistochemistry Tumor implantation Enzymelinked immunosorbent assay

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Clinical impacts of mesothelin expression in gastrointestinal carcinomas

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World Journal of Gastrointestinal Pathophysiology 2016年第2期7卷 218-222页

作者： Takahiro Einama Futoshi Kawamata Hirofumi Kamachi Hiroshi Nishihara Shigenori Homma Fumihiko Matsuzawa Tatsuzo Mizukami Yuji Konishi Munenori Tahara Toshiya Kamiyama Okio Hino Akinobu Taketomi Satoru Todo Department of General surgery Hokkaido University Graduate School of Medicine Department of Translational Pathology Hokkaido University Graduate School of Medicine Department of Pathology and Oncology Juntendo University School of Medicine Research institute of St.Mary’s Hospital Kurume

Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and ***,mesothelin has been shown to be overexpressed in several human cancers,including virtually all mesothelioma and pancreatic cancer approximately 70% of ovarian cancer and extra bile duc cancer,and 50% of lung adenocarcinomas and gastric *** full-length human mesothelin gene encodes the primary product,a 71-k Da precursor ***71-kD a mesothelin precursor is cleaved into two products40-k Da C-terminal fragment that remains membranebound via glycosylphosphatidylinositol anchor,and a31-kD a N-terminal fragment,megakaryocyte potentiating factor,which is secreted into the *** biologica functions of mesothelin remain largely unknown However,results of recent studies have suggested tha the mesothelin may play a role of cell proliferation and *** pancreatic cancer,mesothelin expression was immunohistochemically observed in all cases,bu absent in normal pancreas and in chronic pancreatitis Furthermore,the expression of mesothelin was correlated with an poorer patient outcome in severa human *** limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer *** present review discusses the expression and function o mesothelin in cancer cells and the utility of mesothelin as a target of cancer therapy.

关键词： Mesothelin Luminal membrane expression Cytoplasmic expression Tumor marker Cancer therapy

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Exocrine drainage in vascularized pancreas transplantation in the new millennium

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World Journal of Transplantation 2016年第2期6卷 255-271页

作者： Hany El-Hennawy Robert J Stratta Fowler Smith Depart-ment of surgery Wake Forest School of Medicine

The history of vascularized pancreas transplantation largely parallels developments in immunosuppression and technical refinements in transplant surgery. From the late-1980 s to 1995, most pancreas transplants were whole organ pancreatic grafts with insulin delivery to the iliac vein and diversion of the pancreatic ductal secretions to the urinary bladder(systemic-bladder technique). The advent of bladder drainage revolutionized the safety and improved the success of pancreas transplantation. However, starting in 1995, a seismic change occurred from bladder to bowel exocrine drainage coincident with improvements in immunosuppression, preservation techniques, diagnostic monitoring, general medical care, and the success and frequency of enteric conversion. In the new millennium, pancreas transplants are performed predominantly as pancreatico-duodenal grafts with enteric diversion of the pancreatic ductal secretions coupled with iliac vein provision of insulin(systemic-enteric technique) although the systemic-bladder technique endures as a preferred alternative in selected cases. In the early 1990 s, a novel technique of venous drainage into the superior mesenteric vein combined with bowel exocrine diversion(portal-enteric technique) was designed and subsequently refined over the next ≥ 20 years to recreate the natural physiology of the pancreas with firstpass hepatic processing of insulin. Enteric drainage usually refers to jejunal or ileal diversion of the exocrine secretions either with a primary enteric anastomosis or with an additional Roux limb. The portal-enteric technique has spawned a number of newer and revisited techniques of enteric exocrine drainage including duodenal or gastric diversion. Reports in the literature suggest no differences in pancreas transplant outcomes irrespective of type of either venous or exocrine diversion. The purpose of this review is to examine theliterature on exocrine drainage in the new millennium(the purported "enteric drainage

关键词： Pancreas transplantation Portal-enteric drainage Simultaneous pancreas-kidney transplant Systemic-bladder drainage Enteric conversion Solitary pancreas transplant Systemic-enteric drainage

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Management of gastric cancer in patients with sinistral portal hypertension

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Chinese Medical Journal 2013年第2期126卷 387-388页

作者： DING Xue-mei JIN Mu-lan ZHOU Yi-ming ZHANG Chuan GAO Jun SUN Wen-bing Department of Hepatobiliary surgery Beijing Chaoyang Hospital Affiliated to CapitalMedical University Beijing 100043 China Department of Pathology Beijing Chaoyang Hospital Affiliated to CapitalMedical University Beijing 100043 China Department ofInterventional Radiology Beijing Chaoyang Hospital Affiliated to CapitalMedical University Beijing 100043 China Department of DigestionBeijing Chaoyang Hospital Affiliated to CapitalMedical University Beijing 100043 China

Sinistral portal hypertension （SPH） is usually caused by pancreatic pathology and is characterized bysplenic vein thrombosis with or without portal vein thrombosis.1 The increased pressure caused by splenic vein occlusion is transmitted via the short gastric and gastroepiploic veins to the portal system. The reversal of blood flow in the left gastric vein results in gastric varices. In patiems with SPH, especially those with occlusion of both the splenic and portal veins, the main or even the only pathway of splenic venous return to the portal vein is via the gastric varices, and these patiems require special management during gastric surgery.

关键词： gastric cancer sinistral portal hypertension management

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Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects

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Journal of Nutritional Oncology 2021年第1期6卷 16-32页

作者： Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Department of Nutrition Daping Hospital&Research Institute of SurgeryThird Military Medical UniversityChongqing 400042China Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina Cancer Center of the First Hospital of Jilin University Changchun 130021JilinChina Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014FujianChina Department of Gastrointestinal surgery Cancer Hospital Affiliated to Guangxi Medical UniversityNanning 530021GuangxiChina Department of surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongChina Department of Clinical Nutrition West China Hospital of Sichuan UniversityChengdu 610041SichuanChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefei 230031AnhuiChina Department of Clinical Nutrition the First Hospital of Hebei Medical UniversityShijiazhuang 050031HebeiChina Department of Gastrointestinal surgery Institute of Gastroenterologythe First Affiliated Hospital of Kunming Medical University 650032KunmingYunnanChina Department of Clinical Nutrition the First People's Hospital of KashiKashi 844000XinjiangChina Department of Clinical Nutrition Chongqing General HospitalChongqing 400014China Department of Colorectal and Anal surgery Huizhou Municipal Central HospitalHuizhou 516001GuangdongChina Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtai 054031HebeiChina Harbin Medical University Cancer Hospital Harbin 150085HeilongjiangChina

Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even ***,there is currently no large data available on the prevalence of malnutrition in Chinese cancer *** study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic *** We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)*** of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal *** patients were enrolled from 72 hospitals located in different regions of *** patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)*** cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,*** From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the *** patients included 12,494(52.9%)males and 11,124(47.1%)*** mean age was 55.8±13.7 *** proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,*** the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2

关键词： Nutritional status Nutritional assessment Malnutrition Patient generated subjective global assessment Body mass index Body weight loss Karnofsky Performance Status score Quality of life

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B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 799-821页

作者： Petar Rasic Maja Jovanovic-Tucovic Marija Jeremic Slavisa M Djuricic Zorica V Vasiljevic Maja Milickovic Djordje Savic Department of Abdominal surgery Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”Belgrade 11000Serbia Institute of Medical and Clinical Biochemistry School of MedicineUniversity of BelgradeBelgrade 11000Serbia Department of Clinical Pathology Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”Belgrade 11000Serbia Faculty of Medicine University of Banja LukaBanja Luka 78000Bosnia and Herzegovina Department of Clinical Microbiology Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”Belgrade 11000Serbia School of Medicine University of BelgradeBelgrade 11000Serbia

The most common digestive system(DS)cancers,including tumors of the gastrointestinal tract(GIT)such as colorectal cancer(CRC),gastric cancer(GC)and esophageal cancer(EC)as well as tumors of DS accessory organs such as pancreatic and liver cancer,are responsible for more than one-third of all cancerrelated deaths worldwide,despite the progress that has been achieved in anticancer *** to these limitations in treatment strategies,oncological research has taken outstanding steps towards a better understanding of cancer cell biological complexity and *** studies led to new molecular target-driven therapeutic *** in vivo and in vitro studies have revealed significant expression of B7 homologue 3(B7-H3)among the most common cancers of the GIT,including CRC,GC,and EC,whereas B7-H3 expression in normal healthy tissue of these organs was shown to be absent or *** molecule is able to influence the biological behavior of GIT tumors through the various immunological and nonimmunological molecular mechanisms,and some of them are shown to be the result of B7-H3-related induction of signal transduction pathways,such as Janus kinase 2/signal transducer and activator of transcription 3,phosphatidylinositol 3-kinase/protein kinase B,extracellular signal-regulated kinase,and nuclear factor-κB.B7-H3 exerts an important role in progression,metastasis and resistance to anticancer therapy in these *** addition,the results of many studies suggest that B7-H3 stimulates immune evasion in GIT tumors by suppressing antitumor immune ***,it was observed that experimental depletion or inhibition of B7-H3 in gastrointestinal cancers improved antitumor immune response,impaired tumor progression,invasion,angiogenesis,and metastasis and decreased resistance to anticancer ***,the high expression of B7-H3 in most common cancers of the GIT was shown to be associated with poor *** this review,we summarize the est

关键词： B7 homologue 3 Gastrointestinal tumors Colorectal cancer gastric cancer Esophageal cancer Targeted therapy

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Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours

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World Journal of Gastroenterology 2005年第2期11卷 155-163页

作者： Antti J. Kivel Jyrki Kivel Juha Saarnio Seppo Parkkila Department of Anatomy and Cell Biology University of OuluFinland Institute of Medical TechnologyUniversity of Tampere and Tampere University HospitalFinland Institute of Dentistry University of HelsinkiFinlandResearch Institute of Military MedicineCentral Military HospitalHelsinkiFinland Department of surgery University of OuluFinland Institute of Medical Technology University of Tampere and Tampere University HospitalFinland Department of Clinical ChemistryUniversity of OuluFinland

Carbonic anhydrases (CAs) catalyse the hydration of C02 to bicarbonate at physiological pH. This chemical interconversion is crucial since HCO3- is the substrate for several biosynthetic reactions. This review is focused on the distribution and role of CA isoenzymes in both normal and pathological gastrointestinal (GI) tract tissues. It has been known for many years that CAs are widely present in the GI tract and play important roles in several physiological functions such as production of saliva, gastric acid, bile, and pancreatic juice as well as in absorption of salt and water in intestine. New information suggests that these enzymes participate in several processes that were not envisioned earlier. Especially, the recent reports on plasma membrane-bound isoenzymes IX and XII have raised considerable interest since they were reported to participate in cancer invasion and spread. They are induced by tumour hypoxia and may also play a role in von Hippel-Lindau (VHL)-mediated carcinogenesis.

关键词： Gastrointestinal tract Gastrointestinal tumour Carbonic anhydrases

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