Organoid Technology and Clinical Applications in Digestive System Cancer

作     者：Xiaofang Zhao Youhai Jiang Chunliang Liu Minghui Hou Hongyang Wang Jing Fu Xiaofang Zhao;Youhai Jiang;Chunliang Liu;Minghui Hou;Hongyang Wang;Jing Fu

作者机构：Fudan University Shanghai Cancer CenterShanghai 200032China International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver CancerMinistry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor BiologyEastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Cancer Research CenterThe First Affiliated Hospital of USTCDepartment of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031China Department of OncologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2022年第8卷第2期

页      面：123-130页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (81902904, 82073411, 81830054, and 81988101) the China Postdoctoral Science Foundation (2019M661373) 

主　　题：Organoid Digestive system cancer Precision medicine 

摘      要：Cancers of the digestive system(DS),including esophageal,gastric,colorectal,liver,and pancreatic can-cers,have a high incidence and mortality *** cancer models cannot faithfully recapitu-late the critical features of the original tumor,resulting in the failure of translation from basic research into clinical *** advanced cancer models are in urgent need of pathogenesis exploration and anticancer medicine *** are in vitro cultured three dimensional(3D)self-organizing organotypic structures derived from tissues and pluripotent stem cells,which faithfully mimic the histological features and preserve the genetic heterogeneity of the original *** normal and malignant organoids can now be efficiently established from the DS tissues of *** this review,we summarize the general methods to generate human DS organoids and their applications as a novel model in basic cancer research,preclinical medical practice,and precision medicine.