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Cyathula prostrata:A potent source of anticancer agent against daltons ascites in Swiss albino mice

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Asian Pacific Journal of Tropical Medicine 2013年第10期6卷 776-779页

作者： Priya K Krishnakumari S Vijayakumar M psg college of arts and science Kongunadu arts and science college Institute of Biological science Faculty of ScienceUniversity of Malaya

Objective:To evaluate the anticancer activity of the methanolic extract of Cyathula prostrata in Ehrlich ascites carcinoma(EAC)-bearing mice with methotrexate as positive control in the advanced stage of ***:EAC was induced in swiss albino mice by injecting10~6 cell/mL of tumor cell suspension *** methanolic extract of Cyathula prostrata effect on the tumor cell viability,DNA fragmentation and MTT assay were carried ***:Methanolic extract attenuated percentage increased in the cell survival lime when compared to control ***,the effect was less than that of *** and the extracts reversed the tumor-induced alterations in UNA fragmentation and MTT ***:The present study suggests that the methanol extract of Cyathula prostrata has significant anticancer activity and that is comparable to that of methotrexate.

关键词： Antitumor Cyathula prostrata MTT Cancer Ehrlich ascites carcinoma

L-carvone attenuates myocardial injury and dyslipidemia in rats with isoproterenol-induced cardiac hypertrophy

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Asian Pacific Journal of Tropical Biomedicine 2023年第1期13卷 17-25页

作者： Anitha Nagarajan Victor Arokia Doss Department of Biochemistry PSG College of Arts and ScienceCoimbatore-641014Tamil NaduIndia

Objective:To explore the therapeutic efficacy of L-carvone from Mentha spicata *** extracts against isoproterenol-induced cardiac hypertrophy in ***:Isoproterenol(5 mg/kg)was injected intraperitoneally into rats for one month to induce cardiac hypertrophy.L-carvone(25 and 100 mg/kg)was administered orally to treat cardiac *** cardioprotective activity of L-carvone was evaluated by electrocardiogram,histopathological analysis as well as determination of biochemical parameters and enzymatic ***:L-carvone from Mentha spicata *** 25 and 100 mg/kg ameliorated isoproterenol-induced cardiac hypertrophy,as evidenced by reduced QRS interval on electrocardiogram,and decreased heart weight and heart *** addition,both doses of L-carvone markedly lowered the levels of glucose,total protein,low-density lipoprotein cholesterol,aspartate transaminase,alanine transaminase,lactate dehydrogenase,creatine kinase MB,troponin-Ⅰ,N-terminal pro-B type natriuretic peptide and triglycerides while increasing high-density lipoprotein cholesterol and lipase level(P<0.05).Moreover,L-carvone alleviated contraction band necrosis,and reorganized the myofibrils with normal striations and myocytes as well as normal nuclei in cardiac histoarchitecture of rats with isoproterenol-induced cardiac ***:L-carvone from Mentha spicata *** extract can restore abnormal cardiac function and may be further explored as a therapeutic agent against the deleterious effects of cardiac hypertrophy after further evaluation.

关键词： Cardiac hypertrophy L-carvone Dyslipidemia Myocardial injury Isoproterenol Mentha spicata

Optimal control of Hilfer fractional stochastic integrodifferential systems driven by Rosenblatt process and Poisson jumps

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Journal of Control and Decision 2023年第4期10卷 538-546页

作者： K.Ramkumar K.Ravikumar E.M.Elsayed Department of Mathematics with CA PSG College of Arts&ScienceCoimbatoreIndia Department of Mathematics PSG College of Arts&ScienceCoimbatoreIndia Department of Mathematics Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Mathematics Faculty of ScienceMansoura UniversityMansouraEgypt

In this work,the optimal control for a class of Hilfer fractional stochastic integrodifferential systems driven by Rosenblatt process and Poisson jumps has been discussed in infinite dimensional space involving the Hilfer fractional ***,we study the existence and uniqueness of mild solution results are proved by the virtue of fractional calculus,successive approximation method and stochastic analysis ***,the optimal control of the proposed problem is presented by using Balder’s ***,an example is demonstrated to illustrate the obtained theoretical results.

关键词： Hilfer fractional derivative stochastic integrodifferential systems Rosenblatt process Poisson jumps successive approximation optimal control

1α,25-dihydroxyvitamin D_(3) prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital

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World Journal of Gastroenterology 2004年第9期10卷 1268-1275页

作者： Mahendrakumar Chandrasekharappa Banakar Suresh Kanna Paramasivan Mitali Basu Chattopadhyay Subrata Datta Prabir Chakraborty Malay Chatterjee Kalaiselvi Kannan Elayaraja Thygarajan Division of Biochemistry Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Environmental science PSG College of Arts and ScienceCoimbatore 641014TamilnaduIndia

AIM:To investigate the chemopreventive iffects of 1α,25-dihydroxyvitamin D3 in diethylnitrosamine induced,phenobarbital promoted rat ***:The rats were randomly divided into 6 different groups(A-F).Group A,C and E rats received a single intraperitoneal (i.p) injection of diethylnitrosamine (DEN) at a dose of 200 mg/kg body mass in 9 g/L NaCl solution at 4 wk of age ,while group B served as normal vehicle control received normal saline *** a brief recovery of 2 WK, all the DEN treated rats were given phenobarbital (PB) at 0.5g/L daily in the basal diet till WK *** C was started 4 wk prior to DEN injection and continued thereafter till wk 20 at a dose (os) twice a *** E received the treatment of 1α,25-(OH)2D3 at the same dose mentioned as above for 15 *** rats in group D and F received 1α,25-(OH)2D3 alone as in group C without DEN ***:The comet assay showed statistically higher mean values for length to width ratios (L:W) of DNA mass and tailed cells (p<0.01;p<0.01 respectively) in DEN treated rats as compared to their normal *** supplementation of 1α,25-dihydroxyvitaminD3 showed a significant (p<0.01) decrease in L:W ratio of DNA mass tailed ***,1α,25-(OH)2D3 supplementations elevated the super oxide dismutase (SOD) activety,hepatic malondialdehyde(MDA) levle,reduced glutathione (GSH) and glutathione S-transferase (GST) activety (p<0.01,p<0.01,p<0.05 and p<0.05 respectively).As an endpoint marker histological changes were observed to establish the chemopreventive effects of 1α,***:Supplementations of 1α,25-(OH)2D3 has a marked protection against hepatic nodelogenesis,antioxidant enzymes and DNA damages in DEN induced rat hepatocarcinogenesis promoted by phenobarbital.

关键词： antioxidant enzymes histological changes protection against propylene glycol NaCl solution comet assay

A Type D Non-Vacuum Spacetime with Causality Violating Curves, and Its Physical Interpretation

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Communications in Theoretical Physics 2017年第12期67卷 735-740页

作者： Faizuddin Ahmed Ajmal college of arts and science

We present a topologically trivial, non-vacuum solution of the Einstein's field equations in four dimensions,which is regular everywhere. The metric admits circular closed timelike curves, which appear beyond the null curve, and these timelike curves are linearly stable under linear perturbations. Additionally, the spacetime admits null geodesics curve, which are not closed, and the metric is of type D in the Petrov classification scheme. The stress-energy tensor anisotropic fluid satisfy the different energy conditions and a generalization of Equation-of-State parameter of perfect fluid p = ωρ. The metric admits a twisting, shearfree, nonexapnding timelike geodesic congruence. Finally, the physical interpretation of this solution, based on the study of the equation of the geodesics deviation, will be presented.

关键词： exact solution anisotropic fluid closed timelike curves wave propagation and interactions

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Stabilisation analysis of multiple car-following model in traffic flow

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Chinese Physics B 2010年第5期19卷 434-441页

作者：彭光含 college of Physics and Electronic science Hunan University of Arts and Science

An improved multiple car-following model is proposed by considering the arbitrary number of preceding cars, which includes both the headway and the velocity difference of multiple preceding cars. The stability condition of the extended model is obtained by using the linear stability theory. The modified Korteweg-de Vries equation is derived to describe the traffic behaviour near the critical point by applying the nonlinear analysis. Traffic flow can be also divided into three regions： stable metastable and unstable regions. Numerical simulation is in accordance with the analytical result for the model. And numerical simulation shows that the stabilisation of traffic is increasing by considering the information of more leading cars and there is unavoidable effect on traffic flow from the multiple leading cars information.

关键词： traffic flow optimal velocity model numerical simulation

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Energy-Aware Scheduling for Tasks with Target-Time in Blockchain based Data Centres

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Computer Systems science & Engineering 2022年第2期40卷 405-419页

作者： I.Devi G.R.Karpagam Department of Computer science and Engineering PSG College of TechnologyCoimbatore641004India

Cloud computing infrastructures have intended to provide computing services to end-users through the internet in a pay-per-use *** extensive deployment of the Cloud and continuous increment in the capacity and utilization of data centers(DC)leads to massive power *** intensifying scale of DCs has made energy consumption a critical *** paper emphasizes the task scheduling algorithm by formulating the system model to minimize the makespan and energy consumption incurred in a data ***,an energy-aware task scheduling in the Blockchain-based data center was proposed to offer an optimal solution that minimizes makespan and energy *** estab-lished model was analyzed with a target-time responsive precedence scheduling *** observations were analyzed and compared with the traditional scheduling *** outcomes exhibited that the developed solution incurs better performance with a response to resource utilization and decreasing energy *** investigation revealed that the applied strategy considerably enhanced the effectiveness of the designed schedule.

关键词： Cloud computing taskscheduling blockchain energy-aware virtual machine

A new traffic model with the consideration of coupling effect with two lanes

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Chinese Physics B 2009年第2期18卷 468-474页

作者：彭光含孙棣华何恒攀 college of Automation Chongqing University college of Physics and Electronic science Hunan University of Arts and Science

This paper introduces a new two-lane high-order continuum model by embedding the two delay time scales con- tinuum traffic model presented by Xue （2003 Phys. Rev. E 68 066123） into the multi-lane model proposed by Daganzo （1997 Transpn. Res. B 31 83） with the consideration of the coupling effect between the vehicles of two lanes in instantaneous traffic situation and lane-change effect. In the novel model, the coupling effect of two lanes and phenomena of lane change, which were not discussed in Daganzo＇s model and Xue＇s model, are taken into account. Numerical simulation shows that it is in accordance with real traffic flow. This obviously indicates that the new phenomenon and behaviour are analogous results as single lane presented by Xue, and the proposed model is more reasonable on two lanes. Furthermore, the generation rate between two lanes is also investigated. The results show that the formation and diffusion of traffic shock wave can be better simulated on two lanes.

关键词： traffic model two lanes numerical simulation

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Free radical scavenging potential of Lagenaria siceraria(Molina) Standl fruits extract

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Asian Pacific Journal of Tropical Medicine 2013年第1期6卷 20-26页

作者： Vijayakumar Mayakrishnan Selvi Veluswamy Krishnakumari Shanmuga Sundaram Priya Kannappan Noorlidah Abdullah Institute of Biological science Faculty of ScienceUniversity of MalayaKuala Lumpur-50603Malaysia Department of Biochemistry Kongunadu Arts and ScienceCoimbatore-641029TamilnaduIndia Department of Biochemistry.psg college of arts and science Coimbatore-641029TamilnaduIndia

Objective:To elucidate free radical scavenging activity of ethanolic extract Lagenaria siceraria （***）（Molina） ***:The free radical scavenging activity of the L siceraria （Molina） fruit extract was assayed by usingα,α-diphenyl-β-picrylhydrazyl（DPPH）. 2,20-azinobis 3-ethyl henzothiazoline-6-sulfonate（ABTS）,FRAP,reducing power,chelating ability andβ-carotene bleaching ***:The IC50values of DPPH and ABTS radicalscavenging activity was found to be 1.95 mg/mL and 19 mg/mL,*** ferrous chelation assay,the percentage of inhibition was found to be 89.21%.The reducing power of ethanolic extract of L siceraria（Molina） fruit was 0.068 at 1 mg/mL and increased to 0.192 at 5 mg/mL Theβ-carotene linoleate bleaching assay was 46.7%at 5 mg/mL and antioxidant activity using FRAP at 0.305 for 1 mg/mL to 0.969 for 5 mg/mL Conclusions:The results indicate that L siceraria （Molina） fruit could be an important sources of natural radical scavengers.

关键词： Lagenaria siceraria Antioxidant DPPH ABTS Free radical