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World Journal of Clinical Cases 2025年第4期13卷 41-47页

作者： Xing-Po Li Zi-Shan Wang Hong-Xia Yu Shan-Shan Wang Department of Cardiovascular Medicine Huantai County Hospital of Traditional Chinese MedicineZibo 256400Shandong ProvinceChina Department of Cardiovascular Medicine Zibo Hospital of Integrated Traditional Chinese and Western MedicineZibo 255500Shandong ProvinceChina

BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with *** of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle *** FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be *** septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair *** SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary *** resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient *** This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.

关键词： Acute non-ST segment elevation myocardial infarction Cardiac rupture Acute myocardial infarction Free wall rupture Case report

Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 76-89页

作者： Yang Lu Xing-Ming Wang Ze-Shu Li Ai-Juan Wu Wen-Xia Cheng Department of Oncology PKUCare Luzhong HospitalZibo 255400Shandong ProvinceChina Department of Oncology Zibo Maternal and Child Health HospitalZibo 255095Shandong ProvinceChina

BACKGROUND As reported,multiple circular RNAs(circRNAs)interfere with colorectal cancer(CRC)***,circRNA_0001658(circ_0001658)is focused on studying how it works in *** Clarify the expression pattern,biological function,and underlying mechanism of circ_0001658 of CRC *** In CRC-related chip data retrieved using the database named Gene Expression Omnibus,different expressions of circRNAs between CRC and normal tissue samples were *** Real-time PCR and Western blot ensured the analysis on circ_0001658,microRNA-590-5P(miR-590-5p),and methyltransferase-like 3(METTL3)mRNA expressions in tissues and *** counting kit-8 and flow cytometry were used to detect cell proliferation,apoptosis and *** targeting relations between circ_0001658,miR-590-5p,and METTL3 mRNA 3'-untranslated region were under the verification of bioinformatics prediction and dual luciferase-based reporter gene *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were employed on the downstream targets of miR-590-5p using the Database for Annotation,Visualization and Integrated Discovery *** Circ_0001658 and METTL3 mRNA was elevated in CRC tissues and cells,whereas miR-590-5p was ***_0001658 overexpression promoted the proliferation of HT29 cells,inhibited apoptosis,and accelerated the cell *** SW480 cells,knocking down circ_0001658 had the opposite ***_0001658 could specifically bind to miR-590-5p and negatively modulate its expressions;METTL3 is a miR-590-5p target that can be positively regulated by circ *** 0001658 was inversely associated with miR-590-5p expression while positively with METTL3 *** Circ_0001658 regulates the miR-590-5p/METTL 3-axis to increase CRC cell growth and decrease apoptosis.

关键词： Circ_0001658 miR-590-5p METTL3 Colorectal cancer Proliferation

Retraction note to:Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole:A randomized controlled trial

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World Journal of Gastroenterology 2023年第1期29卷 221-222页

作者： Qing-Hua Sun Hong-Yan Wang Shi-Dong Sun Xin Zhang Han Zhang Department of Gastroenterology Peking University Third HospitalBeijing 100191China Department of Gastroenterology PKUCare Luzhong HospitalZibo 255400Shandong ProvinceChina

We have decided to retract the above article for further consideration due to a data labelling error.

关键词： Retraction note

Analysis of The Impact of Excellent Event Management on the Safety of Patients and Clinical Caregivers

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Journal of Clinical and Nursing Research 2024年第4期8卷 169-173页

作者： Linlin He Junwei Guo Jinxia Liu pkucare zibo hospital Zibo 255000Shandong ProvinceChina

Objective: To investigate the impact of excellent event management in improving patient safety and nursing staff care satisfaction. Methods: The study was analyzed by retrospective comparison, and routine management from January 2022 to December 2022 was set as the control group, and excellent event management from January 2023 to January 2024 was set as the study group. The differences in nursing outcomes between both groups were compared. Results: The rate of adverse events in the study group (0.61%) was lower than that in the control group (0.96%), and the rate of excellent events in the study group (2.57%) was higher than that in the control group (0.97%) (P < 0.05). Meanwhile, the satisfaction level of nursing safety in the study group reached 98.81%, which was much higher than in the control group (92.21%) (P < 0.05). Conclusion: Nursing excellent event management had a positive impact on improving patient care safety satisfaction, reducing the rate of adverse events, and increasing the rate of reporting excellent events.

关键词： Excellent events Quality of care Impact Safety management

Prevalence of Congenital Heart Disease at Extremely High Altitudes in Tibet and the Establishment of a New Free Treatment Model

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Congenital Heart Disease 2022年第6期17卷 709-716页

作者： Shuting Chang Guanzhao Zhang Nengjun Sun Xinpeng Yuan Qingting Wang Lin Zhu Feiyue Zhang Yu Xiu Yang Dong Yonghong Chen Zhanpeng Zhao Xiao Liu Qiang Shao Xiaofeng Xu Anshun Wang Mengjiao Li Bo Li Weifang Medical University WeifangChina Department of Cardiology Shandong University Zibo Central HospitalZiboChina Binzhou Medical University YantaiChina Department of Ultrasound Shandong University Zibo Central HospitalZiboChina Department of Anesthesiology Shandong University Zibo Central HospitalZiboChina Department of Anorectal Surgery Shandong University Zibo Central HospitalZiboChina Department of Obstetrics Shandong University Zibo Central HospitalZiboChina Department of Ultrasonography Qilu Hospital Huantai BranchZiboChina Department of Cardiology Zichuan District HospitalZiboChina Department of Cardiology Zhoucun District HospitalZiboChina Department of Cardiology Zhangdian District HospitalZiboChina Department of Cardiology Boshan District HospitalZiboChina Department of Ultrasound Zibo Municipal HospitalZiboChina Department of Ultrasound Zibo First HospitalZiboChina

Background: This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitudeareas (over 4000 m to even 5000 m above sea level) and explore an aid model for early diagnosis and treatmentfor the Tibetan population. Methods: A total of 2242 students from different schools in Ngamring County,Xigaze City, Tibet from September 2019 to September 2020 were selected for screening. The students were examinedthrough the inquiry of their current medical history and family history, cardiac auscultation and a physicalexamination, in order to screen out the suspected cases of CHD, and then the suspected cases were confirmed bycardiac color ultrasound examinations. After that, positive patients were be transferred to Shandong Province forfree treatment. Results: The prevalence of CHD among children in Ngamring County was 3.70% (83 cases),which is the highest incidence rate ever reported. The most common type of CHD was patent ductus arteriosus(PDA), accounting for 55.42% of the total number of cases screened, followed by atrial septal defect (ASD) andventricular septal defect (VSD), accounting for 28.92% and 12.05%, respectively. The prevalence of CHD in childrenat high altitude was significantly higher than that in children at low altitude. The children with CHD weretransferred to Shandong Province for surgery, the operations were successful and their recoveries went ***: The results show that high altitude is closely related to the prevalence of CHD, and the incidencein Ngamring County is much higher than that in previous reports.

关键词： Tibet high altitude CHD free treatment model

Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial

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World Journal of Gastroenterology 2019年第17期25卷 2110-2121页

作者： Qing-Hua Sun Hong-Yan Wang Shi-Dong Sun Xin Zhang Han Zhang Department of Gastroenterology Peking University Third Hospital Department of Gastroenterology PKUCare Luzhong Hospital

BACKGROUND Reflux esophagitis(RE) is a common digestive disorder, and its frequent recurrences cause significant physical pain and are financially burdensome to patients. However, studies on the natural history of treated RE are few. Although proton pump inhibitors(PPIs) as the first-line treatment provide notable symptomatic relief, disordered gut microbiota has been observed among PPI users. Probiotics are commonly administered to patients to regulate the disordered intestinal *** To evaluate the therapeutic effects in RE patients treated with a combination of esomeprazole and probiotics [Bacillus subtilis(B. subtilis) and Enterococcus faecium(E. faecium)].METHODS One hundred and thirty-four RE patients were randomized into two groups of 67 subjects each. The probiotics group was administered with esomeprazole 20 mg b.i.d. and live combined B. subtilis and E. faecium enteric-coated capsules 500 mg t.i.d. for eight weeks; the placebo group was administered with esomeprazole 20 mg b.i.d. and placebo for eight weeks. Subsequently, 12-wk follow-up was carried out on patients who achieved both endoscopic and clinical cure. Endoscopy,reflux diagnostic questionnaire(RDQ), gastrointestinal symptom rating scale(GSRS), and lactulose hydrogen breath test were performed to evaluate the therapeutic effects. A difference of P 0.05). However, the GSRS diarrhea syndrome score was decreased significantly in the probiotics group(P = 0.002),and the small intestinal bacterial overgrowth negative rate in the probiotics group was significantly higher than that in the placebo group(P = 0.002). Of 114 endoscopically and clinically cured patients, 96 completed the follow-up. The logrank test showed that the time to relapse was shorter

关键词： Proton pump inhibitors Probiotics Small intestinal bacterial overgrowth Reflux esophagitis Relapse

Delayed complications of intradural cement leakage after percutaneous vertebroplasty:A case report

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World Journal of Clinical Cases 2022年第25期10卷 8998-9003页

作者： Qiu-Hong Ma Guang-Ping Liu Qi Sun Ji-Gang Li Department of Laboratory Zibo Central HospitalZibo 255000Shandong ProvinceChina Department of Orthopedics Zibo Central HospitalZibo 255000Shandong ProvinceChina Department of Translational Medical Center Zibo Central HospitalZibo 255000Shandong ProvinceChina

BACKGROUND Intradural cement leakage following percutaneous vertebroplasty is a rare but acute and devastating complication that usually requires emergent ***,we report a delayed complication of intradural leakage after percutaneous *** SUMMARY A 71-year-old female patient with an L1 osteoporotic compression fracture underwent percutaneous vertebroplasty in *** was referred to our hospital 5 years later due to complaints of progressive weakness and numbness in both legs combined with urinary incontinence and ***,she was suspected to have a spinal meningioma at the level of L1 according to imaging *** pathological tests confirmed that cement had leaked into the dura during the first percutaneous *** Guideline adherence is essential to prevent cement from leaking into the spinal canal or even the *** leakage occurs,urgent evaluation and decompression surgery are necessary to prevent further neurological damage.

关键词： Vertebroplasty Kyphoplasty Cement leakage Complication Case report

Losartan Protects Podocytes against High Glucose-induced Injury by Inhibiting B7-1 Expression

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Current Medical Science 2021年第3期41卷 505-512页

作者： Hui GAO Wen-yan DU Jing LIN Shi-liang HAN Yun-jing ZHANG Xi-feng SUN Department of Urology Zibo Central HospitalZibo 255036China department of Science and Education Zibo Central HospitalZibo 255036China Department of Cardiology Shaanxi Provincial People's Hospital Xi'an 710068China Department of Nephrology Zibo Central HospitalZibo 255036China

The role of B7-1 in podocyte injury has received increasing *** aim of this study was to investigate whether losartan protects podocytes of patients with diabetic kidney disease(DKD)by regulating B7-1 and the underlying *** with streptozotocin-induced DKD were treated with losartan for 8 *** changes in blood and urine were *** were isolated for electron microscopy,immunofluorescence,real-time quantitative PCR(RT-PCR),and Western blot *** mouse podocyte cells were cultured in normal or high glucose medium in the presence or absence of losartan for 48 h,and then the cells were collected for immunofluorescence,PCR,Western blotting and monolayer permeability *** phosphatidylinositol 3-kinase(PI3K)110a subunit and angiotensin II type 1 receptor(AT1R)plasmids were transfected into podocytes,respectively,and then Western blotting was performed to assess the expression of B7-1 *** results showed that losartan ameliorated podocyte structure and function in the rat model of DKD,and reduced the expression of B7-1 *** of PI3K 110a subunit in podocytes attenuated the inhibitory effect of losartan on B7-1 expression in high glucose-stimulated *** expression of B7-1 was significantly increased by overexpression of ATI R and significantly reduced by blocking PI3K 110a *** conclude that losartan protects podocytes against high glucose-induced injury by inhibiting AT1R-mediated B7-1 *** effect is dependent on the AT1R-PI3K 110a subunit pathway.

关键词： B7-1 podocyte losartan diabetic kidney disease(DKD) PI3K 110a subunit angiotensin II type 1 receptor(ATI R)

Designing a risk prognosis model based on natural killer cell-linked genes to accurately evaluate the prognosis of gastric cancer

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BIOCELL 2023年第9期47卷 2081-2099页

作者： GAOZHONG LI FUXIN LI NING WEI QING JIA Department of Gastroenterology Zibo Central HospitalZibo255036China

Background:This study was aimed at identifying natural killer(NK)cell-related genes to design a risk prognosis model for the accurate evaluation of gastric cancer(GC)***:We obtained NK cell-related genes from various databases,followed by Cox regression analysis and molecular typing to identify prognostic *** immune algorithms and enrichment analyses were used to investigate the mutations,immune status,and pathway variations among different *** key prognostic genes were assessed using the least absolute shrinkage and selection operator(Lasso)regression analysis and univariate Cox regression ***,the risk score(RS)prognosis model was constructed based on the selected important prognostic genes.A Receiver Operating Characteristics(ROC)curve was plotted for analyzing the robustness of the ***,the decision and calibration curves were used for assessing the reliability and prediction accuracy of the proposed ***‘pRRophetic’R software package was utilized for predicting the half-maximal inhibitory concentration(IC50)of immunotherapy and chemotherapy ***:We screened 21 prognostic genes and three molecular subtypes and found that the C1 subtype had the worst ***,the pathways promoting tumor proliferation,such as epithelial-mesenchymal transition were significantly *** results also showed that the macrophages in the M2 stage were significantly infiltrated in the C1 subtype,and there was significant overexpression in the C1 subtype,accompanied by a severe inflammatory *** C1 was highly sensitive to drugs like 5-fluorouracil and *** ROC,calibration curve,and decision curve showed that the risk model was robust and strongly ***:Overall,our proposed NK cell-related RS model can be used as a more accurate prediction index for GC patients,providing a valuable contribution to personalized medicine.

关键词： Natural killer cells Gastric cancer Risk model Molecular typing

Diagnostic value of orbicularis oculi muscle electromyography in functional epiphora

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World Journal of Clinical Cases 2020年第14期8卷 3000-3005页

作者： Hui Lu Pei-Dong Liu Xue Yao Zuo-Fen Wang Li-Fen Gao Shao-Peng Wang Department of Ophthalmology Zibo Central HospitalZibo 255000Shandong ProvinceChina Department of Electromyography Zibo Central HospitalZibo 255000Shandong ProvinceChina

BACKGROUND Functional epiphora is a clinical condition which is not due to an anatomic *** studies agree that it involves the action of the orbicularis oculi muscle,particularly its deeper segment(Horner’s muscle),but the exact mechanism is not *** To evaluate the orbicularis oculi muscle in functional epiphora patients using electromyography(EMG).METHODS A total of 8 Chinese patients(16 eyes)with functional epiphora were enrolled in this study,and ten volunteers(10 eyes)were included as normal *** epiphora patients(five eyes)with facial palsy served as positive *** EMG was performed in the deeper segment of orbicularis oculi *** average duration of each EMG waveform was *** The average duration of EMG waveforms in the normal control group,the functional epiphora group,and the facial palsy group were 6.39±0.73 ms,9.39±1.32 ms and 11.2±1.42 ms,*** duration of EMG waveforms was significantly longer in the functional epiphora group than in the normal control group(P<0.05),and shorter than that in the facial palsy group(P<0.05).CONCLUSION These data indicate the presence of neurogenic orbicularis oculi muscle damage in epiphora patients,which may be the cause of functional *** etiology of neurogenic damage in the orbicularis oculi muscle requires further investigation.

关键词： Functional epiphora Electromyography Orbicularis oculi muscle Neurological damage Etiology Treatment